Overview Nathan Shock Center of Excellence The NIA-supported Einstein Nathan Shock Center (E-NSC) represents a collection of nearly 80 internal and external faculty actively engaged in high-impact science and collaborations in the biology of aging, three innovative, state-of-the-art Research Resource Cores, and extensive opportunities for enrichment and training in aging research. The Nathan Shock Center is structured aroundfour research cores Proteostasis of Aging Protein quality control maintenance and homeostasis Director: Ana Maria Cuervo, M.D. Ph.D. Learn More Health Span Physiologic phenotyping through lifespan Director: Derek Huffman, Ph.D. Learn More Human Multi-omics Data Human high-throughput omics data sharing and technical advising Directors: Jan Vijg, Ph.D. and Nir Barzilai, M.D. Learn More Research Development Ensuring the future of Biology of Aging through mentoring, P&F funding, and education Director: Sofiya Milman, M.D. Learn More Training Einstein's Institute for Aging Research is committed to the development the next generation scientists in the biology of aging. Training programs are available for graduate and postdoctoral candidates. Learn More Publications See More Insulin and leptin oscillations license food-entrained browning and metabolic flexibility Calorie restriction and calorie-restriction mimetics activate chaperone-mediated autophagy Correction to: Genome integrity as a potential index of longevity in Ashkenazi Centenarian's families Hypothalamic MRI-derived microstructure is associated with neurocognitive aging in humans Cognitive reserve proxies are associated with age-related cognitive decline - Not age-related gait speed decline