William R. Jacobs Jr., Ph.D.

Tiwari S, Casey R, Goulding CW, Hingley-Wilson S, Jacobs WR Jr. (2019) Infect and Inject: How Mycobacterium tuberculosis Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1. Microbiol Spectr. PMID: 31172908

Porcelli, S.S, Jacobs WR Jr. (2019). Eacting Edward Jenner's Revenge: The quest for a new tuberculosis vaccine. Sci Trasl Med. PMID: 31043569

Vilcheze C, Jacobs WR Jr. (2019). The Isonizid Paradigm of Killing, Resistance, and Persistence in Mycobcaterium Tuberculosis. J Mol Biol. PMID: 30797860

O'Donnell MR, Larsen MH, Brown TS, Jain P, Munsamy V, Wolf A, Uccellini L, Karim F, D'Olivera T, Mathema B, Jacobs WR, Pym A. (2019). Early Detection of emergent drug resistant tuberculosis (XDR-TB) by flow cytometry-based phenotyping and whole genome sequencing. Antimicrob Agents Chemother. PMCID: PMC6437479

Shen L., Frencher J., Huang D., Wang W., Yang E., Chen C.Y., Zhang Z., Wang R., Qaqish A., Larsen M.H., Shen H., Porcelli S.A., Jacobs W.R., Jr., Chen Z.W. (2019). Immunization of Vγ2Vδ2 T cells programs sustained effector memory responses that control tuberculosis in nonhuman primates. Proc Natl Acad Sci U.S.A. 116 (13): 6371-6378. PMID: 30850538

Johndrow CT, Goldberg MF, Johnson AJ, Ng TW, Kunnath-Velayudhan S, Lauvau G, Kaplan DH, Gossel GH, Kadolsky UD, Yates AJ, Chan J, Jacobs WR Jr, Porcelli SA. (2018). Suppresion of Th1 Priming by TLR2 Agonists during Cutaneous Immunization is Mediated by Recruited CCR2+ Monocytes. J Immunol. 201(12):3604-3616. PMID: 30455402

Bhatt K, Machado H, Osorio NS, Sousa J, Cardoso F, Magalhaes C, Chen B, Chen M, Kim J, Singh A, Ferreira CM, Castro AG, Torrado E, Jacobs WR Jr, Bhatt A, Saraiva M. (2018). A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis. mSphere. 3(5). PMCID: PMC6211224

Tiwari S, vanTonder AJ, Vilcheze C, Mendes V, Thomas SE, Malek A, Chen B, Chen M, Kim J, Blundell TL, Parkhill J, Weinrick B, Berney M, Jacobs WR Jr. (2018). Arginine-deprived-induced ozidative damage sterilizes Mycobacterium tuberculosis. PNAS. 115(39):9779-9784. PMCID: PMC6166831

Kennedy SC, Johnson AJ, Bharrham S, Linderstam Arlehamn CS, XU J, Garforth SJ, Chan J, Jacobs WR Jr, Settle A, Almo SC, Porcelli SA. (2018). Identification of Mycobacterial Ribosomal Proteins as Targets for CD4+ T Cells that Enhance Protective Immunity in Tuberculosis. Infection and Immunity. 86(9). PMCID: PMC6105890

Vilcheze C, Copelan J, Keiser, Weisbrod T, Washington J, Jain P, Malek A, Weinrick B, Jacobs WR Jr. (2018). Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxothrophy. MBio. 9(3). PMCID: PMC5974470

Harbut MB, Yang B, Liu R, Yano T, Vilcheze C, Cheng B, Lockner J, Guo H, Yu C, Franzblau SG, Petrassi HM, Jacobs WR Jr., Rubin H, Chatterjee AK, Wang F. (2018). Small Molecules Targeting Mycobacterium tuberculosis Type II NADH Dehydrogenase Exhibit Antimycobacterial Activity. Angew Chem Int Ed Engl. 57(13):3478-3482. PMCID: PMC6066186

Vilcheze C, Weinrick B, Leung LW, Jacobs WR Jr. (2018). Plasticity of Mycobacterium tuberculosis NADH dehydrogenases and their role in virulence. PNAS. 115(7):1599-1604. PMCID: PMC5816213

Vilcheze C, Kim J, Jacobs WR Jr. (2018). Vitamin C potentiates the killing of Mycobacterium tuberculosis by the first-line tuberculosis drugs isoniazid and rifampicin in mice. Antimicrob Agents Chemother. PMCID: PMC5826150

Burn, C., Ramsey, N., Garforth, S.J., Almo, S., Jacobs, W.R., Jr. and Herold, B.C. (2018). An HSV-2 single-cycle candidate vaccine deleted in glycoprotein D, DeltagD-2, protects male mice from lethal skin challenge with clinical isolates of HSV-1 and HSV-2. J Infect Dis. PMCID: PMC5853290

Retamal-Diaz, A., Weiss, K.A., Tognarelli, E.I., Freire, M., Bueno, S.M., Herold, B.C., Jacobs, W.R., Jr. and Gonzalez, P.A. (2017). US6 Gene Deletion in Herpes Simplex Virus Type 2 Enhances Dendritic Cell Function and T Cell Activation. Front Immunol. (8)1523. PMCID: PMC5686121