The breakdown of this brain region may accelerate aging

Dongsheng Cai, M.D., Ph.D., discusses his research, published in Nature, that reveals stem cells in the hypothalamus control the rate of aging. Dr. Cai is professor of molecular pharmacology at Einstein.

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Aging is all in your mind. Nature features new research by Dongsheng Cai, M.D., Ph.D., that found the hypothalamus is key to controlling the body’s aging processes. Dr. Cai and his colleagues used a mouse model to track the activity of a molecule that controls DNA transcription and is involved in inflammation. They found that the molecule becomes more active in the hypothalamus region of the brain as the mice aged and that blocking it extended their lifespan. Dr. Cai is professor of molecular pharmacology.

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