Overview Nathan Shock Center of Excellence The NIA-supported Einstein Nathan Shock Center (E-NSC) represents a collection of nearly 80 internal and external faculty actively engaged in high-impact science and collaborations in the biology of aging, three innovative, state-of-the-art Research Resource Cores, and extensive opportunities for enrichment and training in aging research. The Nathan Shock Center is structured aroundfour research cores Proteostasis of Aging Protein quality control maintenance and homeostasis Director: Ana Maria Cuervo, M.D. Ph.D. and Simone Sidoli, Ph.D. Learn More Health Span Health Span Interventions Core (HSIC) Director: Derek Huffman, Ph.D. Learn More Human Multi-omics Data Human high-throughput omics data sharing and technical advising Directors: Jan Vijg, Ph.D. and Sofiya Milman, M.D. Learn More Research Development Ensuring the future of Biology of Aging through mentoring, P&F funding, and education Director: David Fooksman, Ph.D. and Esperanza Arias-Perez, Ph.D. Learn More Training Einstein's Institute for Aging Research is committed to the development the next generation scientists in the biology of aging. Training programs are available for graduate and postdoctoral candidates. Learn More Publications See More Defective chaperone-mediated autophagy in the retinal pigment epithelium of age-related macular degeneration patients Evidence for improved DNA repair in long-lived bowhead whale Chaperone-mediated autophagy controls brown adipose tissue thermogenic activity Divergent accumulation patterns of SNVs and INDELs reveal negative selection in noncancerous cells Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome
