Aging Research Cores

The Cellular Aging and Technology Core (CATC) provides resources to conduct research on cellular drivers of aging, specifically autophagy, proteostasis, senescence, and mitochondria function. In addition to offering a range of assays, reagents, and samples, CATC provides consultation on experimental design, data analysis and interpretation, and can coordinate efforts across the institute’s other cores.

CATC assays and tools are:

• Optimized for drug discovery
• Use functional high-content microscopy platforms and ultrastructural mophrometric analysis
• Adaptable to multiple cell types, including human
• Include data mining and indexes
• Available to institute members, outside academic institutions, private institutions, industry, and foundations

Assays include:

• Functional fluorescent reporters & assessments
• Biomedical & image-based readouts
• Data mining

The Preclinical Aging Models Core (PAMC) offers access to a propriety mouse model to evaluate human aging. An extensively validated approach allows PAMC to precisely monitor the animal model lifespan and measure the impact of an intervention, by measuring stamina, coordination, memory, and metabolism.  

PAMC can create a custom preclinical workflow to measure:

• physical function, including grip strength, fine motor coordination, blood pressure monitoring, and frailty index.
• metabolic function, through body composition and endocrine profiling.
• cognitive and behavioral phenotyping, using mazes, AI-driven continuous monitoring home cages, and physical challenge assays.