The Autism and Obsessive Compulsive Spectrum Program at the Albert Einstein College of Medicine and Montefiore Medical Center is dedicated to three broad goals:
- Developing innovative, novel and breakthrough treatments for a unique group of overlapping conditions.
- Clarifying neurobiological mechanisms that underlie core symptom domains across these conditions.
- Providing world-class care to our research participants.
Our Autism and Obsessive Compulsive Spectrum Program currently focuses on Autism Spectrum Disorders (ASD) and Prader-Willi Syndrome (PWS). Obsessive Compulsive Spectrum Disorders such as Obsessive Compulsive Disorder (OCD), Body Dysmorphic Disorder (BDD) is also of interest to the program.
The Autism and Obsessive Compulsive Spectrum Program is located at the Psychiatry Research Institute at Montefiore Einstein (PRIME) in the Van Etten Building of the Albert Einstein College of Medicine.
Our work seeks to bridge and translate basic neuroscience discoveries into innovative experimental therapeutics and new clinical treatments. Our expert group of psychiatrists, psychologists and investigators consider our patients as partners in growing the knowledge base for our field.
Our clinical orientation is translational. We utilize neuroscience discoveries to develop and launch breakthrough treatments. We use behavioral, cognitive and early efficacy biomarker assessments (i.e. eye tracking) to determine the impact of treatments on clinical symptoms and the underlying endophenotype (measures of the condition that lie in-between genes and clinical symptoms). We perform our intensive diagnostic, neuropsychological and safety measures in the Montefiore Einstein Clinical Research Center.
Dr. Hollander has been the PI of 10 federal grants, authored over 500 publications, has over 22,574 citations and an h-index of 84. He is a Director of the International College of Obsessive Compulsive and Spectrum Disorders (ICOCS), and the Clinical TMS Society. He was chair of the DSM-5 Research Planning Agenda for Obsessive Compulsive and Related Disorders. He was director and PI of the NIH STAART Autism Center of Excellence, and PI of the NIMH Psychopharmacology Training Fellowship. The program has received funding from the Department of Defense, and the Orphan Products Division of FDA, for autism, body dysmorphic disorder, and Prader Willi Syndrome. The program has developed targeted treatments for the repetitive behavior domain and the social communication domain of autism spectrum disorder.
Key Collaborators
Our program actively collaborates with the Montefiore Einstein Institute for Clinical and Translational Research (ICTR) and other clinical investigators at Montefiore Einstein.
We were recently awarded funding by the Department of Defense Autism Research Program to study Cannabidivarin (CBDV) vs. Placebo in Children with Autism Spectrum Disorder (ASD). This study is being conducted in collaboration with Dr. Orrin Devinsky, director of NYU Langone’s Comprehensive Epilepsy Center and GW Pharmaceuticals. The primary aim is to compare changes in irritability from baseline to endpoint between the treatment and placebo groups. The secondary aims include comparing repetitive behaviors, social communication, quality of life, and adaptive behavior.
We also received funding from the Orphan Products Division of the Food and Drug Administration to study Intranasal Oxytocin vs. Placebo for the Treatment of Hyperphagia in Children and Adolescents with Prader-Willi Syndrome (PWS). In this study we determined if intranasal oxytocin is effective in reducing hyperphagia in PWS as measured by changes on the Hyperphagia Questionnaire-Clinical Trials (HQ-CT). We will also examine secondary outcomes of changes in repetitive behaviors, quality of life, and salivary oxytocin concentration as well as examine genetic correlates with study outcome.
We also received funding from Eunice Kennedy Shriver National Institute of Child Health and Human Development, part of the National Institutes of Health, to study Long-term Antipsychotic Pediatric Safety (LAPS). In this trial the primary objective is evaluate the long-term pathologic weight changes associated with multi-year risperidone or aripiprazole therapy in 3 –18 y.o. children who have varying durations of prior antipsychotic drug exposure from the start of study Month 0 (M0). The second objective is to evaluate the overall safety of multi-year risperidone and aripiprazole therapy in 3 -18 y.o. children by assessing long-term changes in safety outcomes of special interest, evaluate the potential long-term benefits of risperidone and aripiprazole and estimate pharmacokinetic parameters of risperidone and aripiprazole in normal weight children 6 – <10 years and obese children 6 – <18 years.
Our program has worked with following industry sponsors: GW Pharmaceuticals, Sunovion Pharmaceuticals, F. Hoffmann-La Roche Ltd, Curemark LLC, Takeda, Avanir Pharmaceuticals, Neurocrine Biosciences, Pfizer, Forest Research Institute (now Allergan), Transcept Pharmaceuticals, and Coronado Biosciences
Foundations that have provided funding for our research include the Foundation for Prader-Willi Research and the Simons Foundation Autism Research Initiative (SFARI).
Current Studies:
- Cannabidivarin (CBDV) vs. Placebo in Children with Autism Spectrum Disorder (ASD)
- Cannabidivarin (CBDV) vs. Placebo in Children and Adults up to age 30 with Prader-Willi Syndrome (PWS)
- Caregivers’ perspectives and usage of ketogenic diet for Autism Spectrum Disorder, Prader Willi Syndrome and Rett Syndrome (Survey)
- A Phase 3 Efficacy and Safety Study of Pitolisant in Patients with Prader-Willi Syndrome
- Intranasal Oxytocin vs. Placebo in Children with Prader-Willi Syndrome (PWS)
- A Phase 3, Randomized, Double-Blind, Dose-Ranging Evaluation of Transcutaneous Vagus Nerve Stimulation (tVNS) to Reduce Temper Outbursts in People with Prader-Willi Syndrome
- (PWS)
