Research Development Core

The mission of the Research Development Core (RDC) of the E-NSC is to act as a research incubator, developing new avenues of geroscience and gerotherapeutics research and recruiting new investigators in the field. We prioritize efforts to fund promising early-stage and ‘new to aging’ investigators to strengthen the quality, number, and diversity of research faculty conducting aging research at Einstein. The RDC also provides geroscientists worldwide with direct access to the other E-NSC cores, including unique biological samples and state-of-the-art research technologies, thereby increasing our reach and impact outside of Einstein. 

Pilot & Feasibility Awards

The RDC is home to two different pilot and feasibility (P&F) programs, the P&F Incubator Award (internal) and the P&F Accelerator Award (core usage). As its name implies, the Incubator Award helps nurture and “hatch” new geroscientists at Einstein. The Accelerator Award jump-starts new aging efforts by funding NSC core usage by researchers at Einstein and across the country:

  • In the last five years, we funded 20 internal P&F Incubator Awards (previously known as P&F projects). To date, over 50% of awardees have obtained independent funding, shared their findings in peer-reviewed journals, and undertaken new collaborations across the center. We identified promising new faculty with the potential to transition to aging research and assigned senior E-NSC members to closely mentor them on their projects and support new aging-related proposals. Importantly, awardees are integrated into various E-NSC activities.
  • In addition, the RDC has funded 20 P&F Accelerator Awards. This strategy allows us to support many meritorious projects from internal and external investigators with rapid deployment of our cores. Accelerator Awards are evaluated on a rolling basis.

P&F Awardees

Table 1 P&F Internal Grant Awardees 2019-2024
InvestigatorDeptProject TitleMentor

2024

David ZhuRadiologyDeveloping novel mouse brain MRI imaging  to studying aging Huffman
Wei ChenDMB, Medicine Calciprotein particles and vascular aging Milman
Nicholas SibingaDMB, MedicineStudying vascular Aging using hetrochronic parabiosisHuffman
Molly FisherMedicineUrine Extracellular Vesicle Differences in Kidney Aging Michael Ross
J ChoiBiostatisticsMechanisms that link Aging with Cancer Risk Augenlicht

2022

Maria MaryanovichCell BioReactive oxygen species (ROS) as neural signal transducers in the agingBarzilai
Seiya KitamuraBiochemRestoring proteostasis through small molecule-induced degradation of soluble epoxide hydrolaseCuervo
Michael RossDMBThe effects of antiretroviral therapy upon kidney cellular senescencen/a
Jihan BehnanMedicineThe Landscape of Aging in Glioblastoma MicroenvironmentBarzilai
Seiya KitamuraBiochemRestoring proteostasis through small molecule-induced degradation of soluble epoxide hydrolaseCuervo
Nicholas SibingaDMBAtherosclerosis and aging of the vascular walln/a

2021

Angela LombardiM&IPinpointing ER-Phagy in Aging Beta-CellSingh
Laura CheneyPathology Crossroads of HIV in the Aging Brain and AutophagyMilman
David Fooksman PathologyAging Enhances Plasma Cell CompetitionHuffman

2020

Sofia de OliveiraDMBUnderstanding neutrophil function in age-related immunometabolic dysfunctionCuervo
Simone Sidoli BiochemistryIdentifying markers of accessible heterochromatin in centenarians to understand healthspanMilman
Richard KitsisCell BioFundamental senescence-cell death decisions and optimal cell death programs in senolysisn/a
Sayan NandiDMBMicroglial protein Iba1 in age-related mood and cognitive decline and neuronal injuryn/a

2019

Jessica MarSystems & Comp BioCharacterizing heterogeneity in Metformin action in aging mouse liver and adipose at a single-sell resolution using sc-RNA-SEQBarzilai
Fabian DelahayeGeneticsSingle cell on microglian/a