![Mapping Bone Marrow Nerves]()
Stem cells in the bone marrow multiply and differentiate to form all the cells of the bloodstream—a process regulated by sympathetic nerves that infiltrate the marrow. With a three-year, $1.25 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases, Paul S. Frenette, M.D., will map those nerves to better understand their functions and physiology. In a three-stage experiment, Dr. Frenette and colleagues will define the marrow’s system of nerves, identify how those nerves relay signals and manipulate certain nerves to increase blood cell production (which could help reverse low blood cell counts in patients undergoing marrow-damaging chemotherapy). Dr. Frenette is professor of medicine and of cell biology and director of the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research at Einstein. (1U01DK116312-01)
Posted on: Thursday, January 25, 2018