Publications

Verma M, Davidsohn MP, Arends CM, Verma D, Sahu S, Pradhan K, Dehghani SS, Murli H, Jasra S, Aggarwal RK, Zhang H, Wysota M, Hosgood D, Verma A, Jaiswal S, Zou Y, Shastri A. Environmental Pollution Triggers Inflammation In Vivo and is Associated With Higher Risk MDS in an Urban Cohort. Am J Hematol. 2026 Feb;101(2):346-349. doi: 10.1002/ajh.70132. Epub 2025 Nov 11. PMID: 41215735.
 


Verma D, Zeig-Owens R, Goldfarb DG, Kravets L, Pradhan K, Rockwell B, Sahu S, Kelly S, Giricz O, Jasra S, Zou Y, Prophete C, Torres LS, Aluri S, Chakraborty S, Kumari R, Gordon-Mitchell S, Wang J, Silver AJ, South TM, Olmstead SD, Hall CB, Sidoli S, Bender R, Landgren O, Greenberger LM, Wickrema A, Madireddy A, Shastri A, Pietras EM, LaFave LM, Nolan A, Cohen MD, Savona MR, Steidl U, Prezant DJ, Verma A. Elevated Clonal Hematopoiesis in 9/11 First Responders Has Distinct Age-related Patterns and Relies on IL1RAP for Clonal Expansion. Cancer Discov. 2025 Dec 2;15(12):2468-2484. doi: 10.1158/2159-8290.CD-24-1590. PMID: 41031953.
 


Verma T, Sahu S, Pradhan K, Aggarwal R, Gordon-Mitchell S, Jasra S, Dehghani SS, Zhang H, Spodek M, Mantzaris I, Konopleva M, Goldfinger M, Verma A, Hosgood D, Verma D, Shastri A, Zou Y. Cigarette smoking is associated with worse prognosis in myelodysplastic syndromes and hematopoietic alterations in murine models. Leuk Lymphoma. 2025 Oct;66(10):1964-1968. doi: 10.1080/10428194.2025.2513675. Epub 2025 Jun 9. PMID: 40488778.
 


Glushakow-Smith SG, Kaur I, Sidoli S, Hemmati S, Angeles E, Sinclair T, Chakraborty S, Battle A, Ames K, Narayanagari SR, Hyka R, Soto M, Tracy M, Vankudoth J, Kitamura S, Miles L, Steidl U, Shastri A, Verma A, Gritsman K. Exploiting an Epigenetic Resistance Mechanism to PI3 Kinase Inhibition in Leukemic Stem Cells. bioRxiv [Preprint]. 2025 Jul 15:2025.07.11.663968. doi: 10.1101/2025.07.11.663968. PMID: 40791365; PMCID: PMC12338508.
 


Wysota M, Pradhan K, Jacobs S, Rosiene J, Hall C, Downward G, Halberstam Y, Shah N, Hosgood D, Shastri A. Fine particulate matter exposure is linked to worse myeloma outcomes in a diverse urban cohort. Blood Cancer J. 2025 Jul 7;15(1):115. doi: 10.1038/s41408-025-01301-0. PMID: 40619445; PMCID: PMC12230138.
 


Rockwell B, Goldfinger M, Mantzaris I, Shastri A, Saunthararajah Y, Gritsman K, Sica AR, Kornblum N, Shah N, Levitz D, Shapiro LC, Gupta R, Munoz A, Dhawan A, Fehn K, Comas M, Verceles J, Cooper DL, Konopleva M, Feldman EJ, Verma A. Metronomic low-dose regimen of decitabine and venetoclax is safe and reduces monocyte burden in chronic myelomonocytic leukemia. Haematologica. 2025 Jul 17. doi: 10.3324/haematol.2024.287253. Epub ahead of print. PMID: 40671491.
 


Aluri S, Ling T, Fraint E, Chakraborty S, Zhang K, Ahsan A, Kravets L, Poigaialwar G, Zhao R, Pradhan K, Cotton A, Bachiashvili K, Yang JI, Budhathoki A, Agarwal B, Gordon Mitchell S, Carbajal M, Sahu S, Boultwood J, Pellagatti A, Steidl U, Wickrema A, Nandakumar S, Shastri A, Suragani RN, Bowman TV, Crispino JD, Vodala S, Verma A. Splicing of erythroid transcription factor is associated with therapeutic response in myelodysplastic syndromes. J Clin Invest. 2025 May 27;135(13):e189266. doi: 10.1172/JCI189266. PMID: 40424086; PMCID: PMC12208544.
 


Edema U, Liu J, Ma MY, Krishnamurthy K, Choudhuri J, Li X, Marhatta A, Qi X, Ma IR, Wang Q, Shastri A, Goldfinger M, Gritsman K, Sica RA, Mantzaris I, Kornblum N, Konopleva M, Wang Y, Shi Y. Immunophenotypic, genetic, and clinical characterization of adult T-cell leukemia/lymphoma: A single tertiary care center experience in the United States. Am J Clin Pathol. 2025 Feb 12;163(2):205-214. doi: 10.1093/ajcp/aqae111. PMID: 39212661.
 


Krishnamurthy K, Shastri A, Wang Y. Intramedullary erythrophagocytosis in myelodysplastic syndrome with heterozygous U2AF1 Q157R variant. EJHaem. 2025 Feb 7;6(1):e1084. doi: 10.1002/jha2.1084. PMID: 39927329; PMCID: PMC11804211.
 


Dehghani SS, Wang Y, Ramesh KH, Cooper D, Verceles JA, Boakye K, Konopleva M, Friedman EW, Shastri A. Atypical chronic myeloid leukemia (CML) with ETV6-ABL1 mutation managed successfully with a third-generation TKI and hematopoietic stem cell transplant. Leuk Lymphoma. 2025 Jan;66(1):147-149. doi: 10.1080/10428194.2024.2403666. Epub 2024 Oct 18. PMID: 39423354.
 


Amaeshi LC, Sofianidi AA, Shastri A, Goldfinger M, Konopleva M, Verma AK, Chaitowitz M, Mantzaris I. A germline FLT3 variant in aplastic anemia. Biomark Res. 2025 Jan 7;13(1):4. doi: 10.1186/s40364-024-00717-3. PMID: 39773519; PMCID: PMC11707911.
 


Mantzaris I, Goldfinger M, Uriel M, Shastri A, Shah N, Gritsman K, Kornblum N, Shapiro LC, Sica A, Munoz A, Chambers N, Dhawan A, Verceles JA, Fehn K, Tirone B, Shah L, Clark S, Zhang C, Kim MY, Cooper DL, Verma A, Konopleva MY, Feldman EJ. Venetoclax plus Daunorubicin and Cytarabine for Newly Diagnosed Acute Myeloid Leukemia: Results of a Phase 1b Study. Blood. 2025 Feb 7:blood.2024026700. doi: 10.1182/blood.2024026700. Epub ahead of print. PMID: 39919267
 


Chakraborty S, Morganti C, Pena BR, Zhang H, Verma D, Zaldana K, Gitego N, Ma F, Aluri S, Pradhan K, Gordon S, Mantzaris I, Goldfinger M, Feldman E, Gritsman K, Shi Y, Hubner S, Qiu YH, Brown BD, Skwarska A, Verma A, Konopleva M, Tabe Y, Gavathiotis E, Colla S, Gollob J, Dey J, Kornblau SM, Koralov SB, Ito K, Shastri A. A STAT3 Degrader Demonstrates Pre-clinical Efficacy in Venetoclax resistant Acute Myeloid Leukemia. bioRxiv [Preprint]. 2024 Aug 7:2024.08.05.599788. doi: 10.1101/2024.08.05.599788. PMID: 39211137; PMCID: PMC11361003
 


Ben-Crentsil NA, Mohammed Ismail W, Balasis ME, Newman H, Quintana A, Binder M, Kruer T, Neupane S, Ferrall-Fairbanks MC, Fernandez J, Lasho TL, Finke CM, Ibrahim ML, McGraw KL, Wysota M, Aldrich AL, Ryder CB, Letson CT, Traina J, McLemore AF, Droin N, Shastri A, Yun S, Solary E, Sallman DA, Beg AA, Ma L, Gaspar-Maia A, Patnaik MM, Padron E. RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis. Cancer Discov. 2024 Aug 27. doi: 10.1158/2159-8290.CD-24-0093. Epub ahead of print. PMID: 39189614
 


Aminov S, Giricz O, Melnekoff DT, Sica RA, Polishchuk V, Papazoglu C, Yates B, Wang HW, Sahu S, Wang Y, Gordon-Mitchell S, Leshchenko VV, Schinke C, Pradhan K, Aluri S, Sohn M, Barta SK, Agarwal B, Goldfinger M, Mantzaris I, Shastri A, Matsui W, Steidl U, Brody JD, Shah NN, Parekh S, Verma A. Immunotherapy-resistant acute lymphoblastic leukemia cells exhibit reduced CD19 and CD22 expression and BTK pathway dependency. J Clin Invest. 2024 Feb 20:e175199. doi: 10.1172/JCI175199. Epub ahead of print. PMID: 38376944.
 


Garcia-Manero G, McCloskey J, Griffiths EA, Yee KWL, Zeidan AM, Al-Kali A, Deeg HJ, Patel PA, Sabloff M, Keating MM, Zhu N, Gabrail NY, Fazal S, Maly J, Odenike O, Kantarjian H, DeZern AE, O'Connell CL, Roboz GJ, Busque L, Buckstein R, Amin H, Randhawa J, Leber B, Shastri A, Dao KH, Oganesian A, Hao Y, Keer HN, Azab M, Savona MR. Oral decitabine-cedazuridine versus intravenous decitabine for myelodysplastic syndromes and chronic myelomonocytic leukaemia (ASCERTAIN): a registrational, randomised, crossover, pharmacokinetics, phase 3 study. Lancet Haematol. 2024 Jan;11(1):e15-e26. doi: 10.1016/S2352-3026(23)00338-1. PMID: 38135371.
 


Wei JX, Shastri A, Sica RA, Mantzaris I, Kornblum N, Shah U, Janakiram M, Gritsman K, Verma A, Goldfinger M, Cooper D, Shah N. Impact of race and ethnicity on early mortality in multiple myeloma: a SEER analysis. Haematologica. 2023 Oct 26. doi: 10.3324/haematol.2023.283304. Epub ahead of print. PMID: 37881838.
 


Vegivinti CTR, Keesari PR, Veeraballi S, Martins Maia CMP, Mehta AK, Lavu RR, Thakur RK, Tella SH, Patel R, Kakumani VK, Pulakurthi YS, Aluri S, Aggarwal RK, Ramachandra N, Zhao R, Sahu S, Shastri A, Verma A. Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative review. Exp Hematol Oncol. 2023 Jul 8;12(1):60. doi: 10.1186/s40164-023-00422-1. PMID: 37422676; PMCID: PMC10329313.
 


Chai J, Choudhuri J, Wang Q, Fang Y, Shi Y, Kamel J, Shah N, Sica RA, Kornblum N, Konopleva M, Mantzaris I, Shastri A, Gritsman K, Verma A, Goldfinger M, Goel S, Wang Y, Tian X. Acute myeloid leukemias with JAK2/STAT mutations are associated with PD-L1 upregulation. Leuk Lymphoma. 2023 Jul 10:1-11. doi: 10.1080/10428194.2023.2232494. Epub ahead of print. PMID: 37424335.
 


Levitz D, Saunthararajah Y, Fedorov K, Shapiro LC, Mantzaris I, Shastri A, Kornblum N, Sica RA, Shah N, Konopleva M, Gritsman K, Braunschweig I, Cooper DL, Pradhan K, Verma A, Feldman EJ, Goldfinger M. A Metabolically Optimized, Noncytotoxic Low-Dose Weekly Decitabine/Venetoclax in MDS and AML. Clin Cancer Res. 2023 Jun 21:OF1-OF7. doi: 10.1158/1078-0432.CCR-23-0842. Epub ahead of print. PMID: 37341641.
 


Gonzalez-Lugo JD, Kambhampati S, Yacoub A, Donnellan WB, Berdeja J, Bhagat P, Fehn K, Remy C, Jasra S, Kazemi M, Pradhan K, Kim M, Mantzaris I, Sica RA, Shah N, Goldfinger M, Kornblum N, Gritsman K, Braunschweig I, Steidl U, Will B, Shastri A, Verma A. Lenalidomide and Eltrombopag for Treatment of Low- or Intermediate-Risk Myelodysplastic Syndrome: Result of a Phase II Clinical Trial. Clin Cancer Res. 2023 Jan 4;29(1):60-66. doi: 10.1158/1078-0432.CCR-22-1457. PMID: 36255372.


Gonzalez-Lugo JD, Kambhampati S, Yacoub A, Donnellan WB, Berdeja J, Bhagat P, Fehn K, Remy C, Jasra S, Kazemi M, Pradhan K, Kim M, Mantzaris I, Sica RA, Shah N, Goldfinger M, Kornblum N, Gritsman K, Braunschweig I, Steidl U, Will B, Shastri A, Verma A. Lenalidomide and Eltrombopag for Treatment of Low- or Intermediate-Risk Myelodysplastic Syndrome: Result of a Phase II Clinical Trial. Clin Cancer Res. 2023 Jan 4;29(1):60-66. doi: 10.1158/1078-0432.CCR-22-1457. PMID: 36255372.
 


Potts KS, Cameron RC, Metidji A, Ghazale N, Wallace L, Leal-Cervantes AI, Palumbo R, Barajas JM, Gupta V, Aluri S, Pradhan K, Myers JA, McKinstry M, Bai X, Choudhary GS, Shastri A, Verma A, Obeng EA, Bowman TV.Cell Rep. 2022 Dec. Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition.PMID: 36516770 
 


Okoye-Okafor UC, Javarappa KK, Tsallos D, Saad J, Yang D, Zhang C, Benard L, Thiruthuvanathan VJ, Cole S, Ruiz S, Tatiparthy M, Choudhary G, DeFronzo S, Bartholdy BA, Pallaud C, Ramos PM, Shastri A, Verma A, Heckman CA, Will B.J Exp Med. 2022 Nov 7. Megakaryopoiesis impairment through acute innate immune signaling activation by azacytidine. PMID: 36053753
 


Adrianzen-Herrera D, Sparks AD, Shastri A, Zakai NA, Littenberg B. Geographic disparities in cardiovascular mortality among patients with myelodysplastic syndromes: A population-based analysis. Cancer Epidemiol. 2022 Oct. PMID : 35970010
 


Jasra S, Giricz O, Zeig-Owens R, Pradhan K, Goldfarb DG, Barreto-Galvez A, Silver AJ, Chen J, Sahu S, Gordon-Mitchell S, Choudhary GS, Aluri S, Bhagat TD, Shastri A, Bejan CA, Stockton SS, Spaulding TP, Thiruthuvanathan V, Goto H, Gerhardt J, Haider SH, Veerappan A, Bartenstein M, Nwankwo G, Landgren O, Weiden MD, Lekostaj J, Bender R, Fletcher F, Greenberger L, Ebert BL, Steidl U, Will B, Nolan A, Madireddy A, Savona MR, Prezant DJ, Verma A. High burden of clonal hematopoiesis in first responders exposed to the World Trade Center disaster. Nat Med 2022 Mar;28. PMID: 35256801


Shastri A, Adrianzen-Herrera DA. Ruxolitinib in CMML: A Case Study of Innovative Trial Design in a Rare Cancer. Clin Cancer Res. 2021 Nov. PMID : 34531297
 


Chakraborty S, Shapiro LC, de Oliveira S, Rivera-Pena B, Verma A, Shastri A. Therapeutic targeting of the inflammasome in myeloid malignancies. Blood Cancer J. 2021 Sep 14. PMID: 34521810
 


Lugo-Gonzalez J, Chakraborty S, Verma A, Shastri A. The Evolution of Epigenetic Therapy in Myelodysplastic Syndromes & Acute Myeloid Leukemia. Seminars in Hematology. Dec 2020. PMID : 33509444
 


Kaur G, Mejia Saldarriaga M, Shah N, Catamero DD, Yue L, Ashai N, Goradia N, Heisler J, Xiao Z, Ghalib N, Aaron T, Cole D, Foreman R, Mantzaris I, Derman O, Bachier L, Sica RA, Kornblum N, Braunschweig I, Shastri A, Goel S, Verma A, Janakiram M. Multiple Myeloma in Hispanics: Incidence, Characteristics, Survival, Results of Discovery, and Validation Using Real-World and Connect MM Registry Data. Clin Lymphoma Myeloma Leuk. 2020 Nov 21. PMID: 33339770
 


Shastri A, Lugo-Gonzalez J, Verma A. Understanding FLT3 Inhibitor Resistance to Rationalize Combinatorial AML Therapies. Blood Cancer Discov. 2020 Dec. PMID :34661152


Adrianzen Herrera D, Pradhan K, Snyder R, Karanth S, Janakiram M, Mantzaris I, Braunschweig I, Budhathoki A, Shah UA, Verma AK, Murthy SB, Shastri AMyelodysplastic syndromes and the risk of cardiovascular disease in older adults: A SEER-medicare analysis. Leukemia. 2019 Dec 16. PMID : 31844145
 


Sridharan A, Schinke CD, Georgiev G, Da Silva Ferreira M, Thiruthuvanathan V, MacArthur I, Bhagat TD, Choudhary GS, Aluri S, Chen J, Pradhan K, Xia Y, Panjikaran M, Sims G, Bhagat CK, Bender R, Keeler L, Graber A, Heuck C, Fletcher FA, Alapat D, Weinhold N, Johnson SK, Wickrema A, Barlogie B, Morgan GJ, Shastri A, Steidl U, Will B, Verma A. Stem cell mutations can be detected in myeloma patients years before onset of secondary leukemias. Blood Advances. 2019 Dec 10; PMID : 31805192
 


Kaner JD, Thibaud S, Jasra S, Wang Y, Janakiram M, Sharma A, Sridharan A, Elias H, Polineni R, Assal A, Weiss L, Braunschweig I, Steidl U, Pradhan K, Shastri A, Chaitowitz M, Zingman B, Will B, Mantzaris I, Verma A. HIV portends a poor prognosis in myelodysplastic syndromes. Leukemia Lymphoma. 2019 Dec. PMID : 3128224
 


Shastri A, Choudhary G, Teixeira M, Gordon-Mitchell S, Ramachandra N, Bernard L, Bhattacharyya S,  Lopez R, Pradhan K, Giricz O, Ravipati G, Wong L, Cole S, Bhagat T, Feld J, Dhar Y, Bartenstein M, Thiruthuvanathan V, Wickrema A, Ye H, Frank D, Pellagatti A, Boultwood J, Zhou T, Kim Y, MacLeod R,Epling-Burnette PK, Ye M, McCoon P, Woessner R, Steidl U, Will B and Verma A. Antisense STAT3 Inhibitor Decreases Viability of Myelodysplastic and Leukemic Stem Cells. Journal of Clinical Investigation, Dec 2018, PMID : 30252677
 


Kao YR, Chen J, Narayanagari SR, Todorova TI, Aivalioti MM, Ferreira M, Ramos PM, Pallaud C, Mantzaris I, Shastri A, Bussel JB, Verma A, Steidl U, Will B. Thrombopoietin receptor-independent stimulation of hematopoietic stem cells by eltrombopag. Science Translational Medicine. Sept 2018. PMID : 30209246
 


Snyder R, Libby T, Raciti P, Amin B, Jacobson M, Rakheja D, Fleming K, Bartenstein M, Zhu C, Goel S, Verma AK, Shastri A. Myelodysplastic Syndrome and Sweets Syndrome Are Associated with a Mutation in Isocitrate Dehydrogenase 1. Anticancer Research. April 2018, PMID : 29599340
 


Shastri A; Verma A; Eltrombopag reduces clinically relevant thrombocytopenic events in higher risk MDS and AML. Lancet Haematology. Jan 2018, PMID : 29241763
 


Kanna S; Choudhary G; Ramachandran N; Steidl U; Verma AK; Shastri A. STAT3 inhibition as a therapeutic strategy for leukemiaLeuk Lymphoma. 2017 Nov 22. PMID : 29164994
 


Darbinyan K*; Shastri, A*; Budhathoki, A*; Helbig, D; Pradhan K et all. Hispanic Ethnicity is Associated with Younger Age at Presentation and Worse Survival in Acute Myeloid Leukemia. Blood Advances. * Equally Contributed 2017 Oct. PMID: 29296859
 


Shastri A; Mantaris I; Yu Y; Janakiram M; Verma A; Barta SK. Sites of Extranodal Invovlement Are Prognostic I n Patients with Stage 1 Follicular Lymphoma: An Analysis of the Surveillance, Epidemiology and End Results Database. Oncotarget. 2017 Jul 14. PMID: 29108238
 


Shastri A; Budhathoki A; Barta S; Kornblum N; Derman O; Battini R; Raghupathy R; Verma A; Frenette P; Braunschweig I; Janakiram M. Stimulation of Adrenergic Activity by Desipramine Enhances Hematopoietic Stem and Progenitor Cell Mobilization along with G-CSF in Multiple Myeloma. Am J Hematol. 2017 Jul 4. PMID: 28675459
 


Shastri A; Will B; Steidl U; Verma A. Stem Cell Alterations In Myelodysplastic Syndromes. Blood, 2017 Feb, PMID: 28159737
 


Schinke, C, Giricz O, Li W, Shastri A, Gordon S, Barreyro L, Bhagat T, Bhattacharya S, Will B, Steidl U, Verma A. IL-8/CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells,
Blood, 2015 Mar, PMID: 25810490
 


Shastri A, Shastri SS. Cancer screening and prevention in low-resource environments.
Nature Reviews Cancer, 2014 Dec; PMID: 25355377
 


Daver N,* Shastri A,* Kadia T, Quintas-Cardama A, Pemmaraju N, Jabbour E, Konopleva M, O’Brien S, Pierce S, Cortes J, Kantarjan H, Verstovsek S. Phase II study of pomalidomide in combination with prednisone in patients with myelofibrosis and significant anemia.
Leukemia Research 2014 Jul, PMID: 25047979 * Equally Contributed