Research
Radiation Biology Research Laboratories: Integrated with Physics
Normal Tissue Response to Irradiation
– metabolomics, proteomics and gene expression
Stem cell and cellular regeneration program:
Preparative irradiation for cell transplantation
- Hepatocyte transplantation
- Neural progenitor cell
- Endothelial Cell transplantation
- Bone marrow
- Spinal Cord injury
Medical countermeasures against radiation and nuclear terrorism
- Cell transplantation for radiation injury
- Radiation-induced liver disease
- Radiation-induced gastro-intestinal syndrome
- Radiation-induced lung fibrosis
- Radiation-induced kidney disease
- Radiation-induced CNS damage
Tumor Vaccines and Radiation-enhanced tumor vaccines
- SBRT as an adjuvant to immunotherapy
- High Frequency Ultrasound (HIFU) top ablate tumors and release heat-shock proteins for tumor vaccination
- Development of novel tumor vaccines
- Novel angiogenic vaccines
- Clinical trials of SBRT and immunotherapy
Novel radiosensitizers: ATM and Plk1 as targets
- - Phase I trials of novel chemo-RT
- - Core facility for identifying targets for chemo-RT
Image-guided Stereotactic Radiosurgery
- Radiobiology of large single fraction of RT (intestine, spinal cord, kidney, lung, liver, esophagus, airways and brain tolerance)
- Solid tumors of Liver, lung and pancreas
- Spinal cord and Brain
Onco-Physics Research Laboratories: Integrated with Biology
i) Experimental Oncophysics
Ionizing Radiation
- X-ray, Photons, Heavy Particle, Mixed Beam
- IGRT, Risk Adaptive Biologically Optimized RT
- Motion Management
Non-Ionizing Radiation
- HIFU/LOFU
- ER Stress, UPR
- Immune Modulation
- ChemoRx
- Drug Delivery
- Microbubbles
- Stem Cells
II) Onco-Imaging MRI
- MRS
- PET/CT
- US
- MR/RT Plan
- Optical Imaging
III) Radiation Medicine Research
- Radiogenomics
- Radiation Systems Biology
- Radioimmunology
- Regenerative Medicine
- Osteoimmunology
Integrated Translational Research:
- Target motion management
- Biological treatment planning: Role of PET and PET-CT
- Dynamic biological / adoptive treatment planning
- MRS in cancer treatment and radiation planning
- Integration of targeted therapies and image guided radiation techniques
Clinical Research:
- Development of investigator initiated trials in radiation oncology
- Coordination of multi center protocols in radiation oncology
- Physics Quality Assurance