Nathan Shock Center of Excellence

The NIA-supported Einstein Nathan Shock Center (E-NSC) represents a collection of nearly 80 internal and external faculty actively engaged in high-impact science and collaborations in the biology of aging, three innovative, state-of-the-art Research Resource Cores, and extensive opportunities for enrichment and training in aging research.

The Nathan Shock Center is structured aroundfour research cores

 

Training

Einstein's Institute for Aging Research is committed to the development the next generation scientists in the biology of aging. Training programs are available for graduate and postdoctoral candidates.

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Publications

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Misfolded GBA/β-glucocerebrosidase impairs ER-quality control by chaperone-mediated autophagy in Parkinson disease

The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development

Resilience to aging is a heterogeneous characteristic defined by physical stressors

Quality Control: Maintaining molecular order and preventing cellular chaos

Heterochronic parabiosis: a valuable tool to investigate cellular senescence and other hallmarks of aging

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking

Single-molecule, quantitative detection of low-abundance somatic mutations by high-throughput sequencing

Protective role of chaperone-mediated autophagy against atherosclerosis

Geroscience-guided repurposing of FDA-approved drugs to target aging: A proposed process and prioritization