Research Toward HIV Cure Curing HIV infection is a high priority of the NIH for HIV research. Unfortunately, providing HIV-infected individuals with sustained ART-free viral remission (or functional cure) and/or viral eradication (sterilizing, or classic, cure) is prevented by the capacity of HIV to persist in anatomic sanctuary sites that protect the virus from immune response and ART, even when the virus is undetectable in the circulation. ERC-CFAR investigators are investigating the mechanisms of viral latency and persistence, the development of animal and other surrogate models which predict viral remission or reactivation/rebound of latent virus, and innovative, evidence-based preclinical, translational, and clinical studies of cure interventions. Listed below are NIH-funded studies by ERC-CFAR Investigators researching strategies to cure HIV infection. Investigator Institution NIH Grant Title Marina Caskey Rockefeller U01AI129825 3BNC117 and 10-1074 to suppress HIV-1 replication and reduce the reservoir Marina Caskey Rockefeller U01 AI145921 Immunologic control of HIV-1 through combination bNAbs and biologics. Felipe Diaz-Griffero Einstein R01AI087390 Modulation of retroviral uncoating by cellular factors Felipe Diaz-Griffero Einstein R01AI150455 Regulation of SAMHD1 antiviral activity Harris Goldstein Einstein R01AI145024 Novel biologics designed to mobilize HIV-specific CTL for sustained HIV Remission Theodora Hatziioannou Rockefeller R01AI078788 Overcoming host restriction factors to develop better animal models for HIV/AIDS Ganjam Kalpana Einstein R21AI152826 Single cell RNA-seq and single molecule RNA-FISH approaches to study stochasticity of latent HIV-1 reactivation Vinayaka Prasad Einstein R01DA043169 Effect of drugs of abuse on CNS HIV-1 reservoirs and neuropathogenesis Jeffrey Ravetch Rockefeller R01AI129795 Optimization of Fc effector activity of anti-HIV antibodies to target HIV Reservoir Drew Westmoreland CUNY SPH K01AA029047 The impact of alcohol on PrEP adherence in vulnerable men Hongbin Zhang CUNY SPH R21 AI147933 Obtaining population-based estimates of the timing of antiretroviral therapy initiation using HIV surveillance data: change-point model development, validation, and dissemination
