University Chairman, Department of Cell Biology
Professor, Department of Cell Biology
Judith and Burton P. Resnick Professor
Chanin Bldg., Room 402
718.430.2169
arthur.skoultchi@einsteinmed.org
Research Interest
Selected Publications
Lab Members
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Willcockson, M. A., S. E. Healton, C. N. Weiss, B. A. Bartholdy, Y. Botbol, L. N. Mishra, D. S. Sidhwani, T. J. Wilson, H. B. Pinto, M. I. Maron, K. A. Skalina, L. N. Toro, J. Zhao, C. H. Lee, H. Hou, N. Yusufova, C. Meydan, A. Osunsade, Y. David, E. Cesarman, A. M. Melnick, S. Sidoli, B. A. Garcia, W. Edelmann, F. Macian and A. I. Skoultchi (2021). "H1 histones control the epigenetic landscape by local chromatin compaction." Nature 589(7841): 293-298.
Yusufova, N., A. Kloetgen, M. Teater, A. Osunsade, J. M. Camarillo, C. R. Chin, A. S. Doane, B. J. Venters, S. Portillo-Ledesma, J. Conway, J. M. Phillip, O. Elemento, D. W. Scott, W. Beguelin, J. D. Licht, N. L. Kelleher, L. M. Staudt, A. I. Skoultchi, M. C. Keogh, E. Apostolou, C. E. Mason, M. Imielinski, T. Schlick, Y. David, A. Tsirigos, C. D. Allis, A. A. Soshnev, E. Cesarman and A. M. Melnick (2021). "Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture." Nature 589(7841): 299-305.
Healton, S. E., H. D. Pinto, L. N. Mishra, G. A. Hamilton, J. C. Wheat, K. Swist-Rosowska, N. Shukeir, Y. Dou, U. Steidl, T. Jenuwein, M. J. Gamble and A. I. Skoultchi (2020). "H1 linker histones silence repetitive elements by promoting both histone H3K9 methylation and chromatin compaction." Proc Natl Acad Sci U S A 117(25): 14251-14258.
Sollberger, G., R. Streeck, F. Apel, B. E. Caffrey, A. I. Skoultchi and A. Zychlinsky (2020). "Linker histone H1.2 and H1.4 affect the neutrophil lineage determination." Elife 9.
Willcockson, M. A., S. J. Taylor, S. Ghosh, S. E. Healton, J. C. Wheat, T. J. Wilson, U. Steidl and A. I. Skoultchi (2019). "Runx1 promotes murine erythroid progenitor proliferation and inhibits differentiation by preventing Pu.1 downregulation." Proc Natl Acad Sci U S A 116(36): 17841-17847.
Fyodorov, D. V., B. R. Zhou, A. I. Skoultchi and Y. Bai (2018). "Emerging roles of linker histones in regulating chromatin structure and function." Nat Rev Mol Cell Biol 19(3): 192-206.
Andreyeva, E. N., T. J. Bernardo, T. D. Kolesnikova, X. Lu, L. A. Yarinich, B. A. Bartholdy, X. Guo, O. V. Posukh, S. Healton, M. A. Willcockson, A. V. Pindyurin, I. F. Zhimulev, A. I. Skoultchi and D. V. Fyodorov (2017). "Regulatory functions and chromatin loading dynamics of linker histone H1 during endoreplication in Drosophila." Genes Dev 31(6): 603-616.
Kavi, H., A. V. Emelyanov, D. V. Fyodorov and A. I. Skoultchi (2016). "Independent Biological and Biochemical Functions for Individual Structural Domains of Drosophila Linker Histone H1." J Biol Chem 291(29): 15143-15155.
Geeven, G., Y. Zhu, B. J. Kim, B. A. Bartholdy, S. M. Yang, T. S. Macfarlan, W. D. Gifford, S. L. Pfaff, M. J. Verstegen, H. Pinto, M. W. Vermunt, M. P. Creyghton, P. J. Wijchers, J. A. Stamatoyannopoulos, A. I. Skoultchi and W. de Laat (2015). "Local compartment changes and regulatory landscape alterations in histone H1-depleted cells." Genome Biol 16: 289.
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