Overview Aging has a biology, and this biology drives age-related diseases (Geroscience). We at Einstein have demonstrated that the biology of aging can be targeted in experimental models to delay, stop, and in some examples, reverse manifestations of aging. Our overarching Mission is to make scientific discoveries in geroscience, leveraging on the expertise in our center in studying and targeting the pillars of aging, and to confirm their relevance of new findings to human aging through the unique Gero-human resource created in our center and to translate interventions proven relevant for human to drug discovery efforts. Center of Excellence The institute for Aging Research is the home of two aging centers of international recognition. The Nathan Shock Center of Excellence, focused on the study of the biology of aging and the Einstein Paul F. Glenn Center solely dedicate to understanding the biology behind human Aging. Learn More Nathan Shock Center of Excellence LEARN MORE Research Integrative Physiology Dietary strategies to delay aging Metabolism targeting to delay aging Cell autonomous and non-autonomous aging CNS control of metabolism and aging Cell Biology of Aging Proteostasis DNA repair Response to Stress Inflammaging Stem Cells Genetics of Aging Human Longevity Comparative genomics of longevity Translational Geroscience TAME Human Longevity Studies Clinical Geriatrics Hevolution Partnership on Senescence and Aging PI: Ana Maria Cuervo, MD, PhD Learn More SuperAgers Family Study PI: Sofiya Milman, MD, MS Co-Inv: Nir Barzilai, MD Learn More Genetic Variant-based Drug Discovery Targeting Conserved Pathways of Aging (U19AG056278) Co-PI: Jan Vijg, PhD Co-PI: Nir Barzilai, MD Co-PI: Paul Robbins, PhD; University of Minnesota DNA Repair, Mutations and Cellular Aging (P01AG017242) PI: Jan Vijg, PhD Autophagy in aging: testing geroscience in Alzheimer's disease (P01AG031782) PI: Ana Maria Cuervo, MD, PhD Training Einstein's Institute for Aging Research is committed to the development the next generation scientists in the biology of aging. Training programs are available for graduate and postdoctoral candidates. Learn More Multimedia 2nd Annual Longevity Studies Symposium More Videos Highlights Research Brief Evaluating Possible Anti-Aging Drugs Nir Barzilai, M.D. Mar 11, 2024 News Release Ana Maria Cuervo, M.D., Ph.D., Named Distinguished Professor at Einstein Ana Maria Cuervo, M.D., Ph.D. Nov 06, 2023 News Release Search for Human Longevity Genes Aided by $13.6 Million Grant Renewal Jan Vijg, Ph.D. Nir Barzilai, M.D. Oct 13, 2023 See All Publications See More Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring Concurrent analysis of genome and transcriptome in one single cell Challenges and recommendations for the translation of biomarkers of aging Restoration of LAMP2A expression in old mice leads to changes in the T cell compartment that support improved immune function
