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Associate Professor
Department of Cell Biology
Price Bldg., Room 122
(718) 678-1276
wenjun.guo@einsteinmed.org
Research Interest
Recent Publications
Biosketch
Lab Members
Position
Stem Cell Institute
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1- Cui J, Zhang C, Lee JE, Bartholdy BA, Yang D, Liu Y, Erler P, Galbo PM Jr, Hodge DQ, Huangfu D, Zheng D, Ge K, Guo W. (2023) MLL3 loss drives metastasis by promoting a hybrid epithelial-mesenchymal transition state. Nature Cell Biology 2023 Jan 5. doi: 10.1038/s41556-022-01045-0. Online ahead of print. (PMID: 36604594).
2- Christin JR, Wang C, Chung CY, Liu Y, Dravis C, Tang W, Oktay MH, Wahl GM, Guo W. (2020) Stem cell determinant SOX9 promotes lineage plasticity and progression in basal-like breast cancer. Cell Reports 31(10):107742. doi: 10.1016/j.celrep.2020.107742. (PMID: 32521267).
3- Hodge DQ, Cui J, Gamble MJ, Guo W. (2018) Histone variant macroH2A1 plays an isoform-specific role in suppressing epithelial-mesenchymal transition. Scientific Reports 8:841. DOI: 10.1038/s41598-018-19364-4.
4- Wang C, Christin JR, Oktay MH, Guo W. (2017) Lineage-biased stem cells maintain estrogen-receptor-positive and -negative mouse mammary luminal lineages. Cell Reports 18: 2825-2835.
5- Zhang Z, Christin JR, Wang C, Ge K, Oktay MH, Guo W. (2016) Mammary-stem-cell-based somatic mouse models reveal breast cancer drivers causing cell fate dysregulation. Cell Reports 16: 3146-3156.
6- Guo W. (2014) Breast cancer stem cells: regulatory networks, stem cell niches, and disease relevance. Stem Cells Translational Medicine 3:942-948.
7- Guo W, Keckesova Z, DonaherJ, Shibue T, Tischler V, Reinhardt F, Itzkovitz S, Noske A, Zürrer-Härdi U, Bell G, Tam WL, Mani SA, van Oudenaarden A, Weinberg RA. (2012) Slug and Sox9 cooperatively determine the mammary stem cell state. Cell 148: 1015-1028.
8- Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou A, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campell LL, Polyak K, Brisken C, Yang J, Weinberg RA. (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133: 704-715. (*: equal contribution.)
9- Guo W, Pylayeva Y, Pepe A, Yoshioka T, Muller WJ, Inghirami G, Giancotti FG. (2006) Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 126: 489-502.
Complete list of publications: https://www.ncbi.nlm.nih.gov/sites/myncbi/18k98nnpg-x/bibliography/41035311/public/?sort=date&direction=descending
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