Sylvia O. Suadicani, Ph.D.
- Professor, Department of Urology
- Professor, Department of Molecular Pharmacology
- Assistant Professor, Dominick P. Purpura Department of Neuroscience
Area of research
- Urogenital Dysfunction in Diabetes, Multiple Sclerosis, Spinal Cord Injury, Estrogen Deficiency, Aging, Overactive & Underactive Bladder, Female Sexual Dysfunction; Chronic Pelvic Pain; Interstitial Cystitis; Bladder Cancer
Phone
Location
- Albert Einstein College of Medicine Jack and Pearl Resnick Campus 1300 Morris Park Avenue Forchheimer Building R744 Bronx, NY 10461
Research Profiles
Professional Interests
Dr. Suadicani is an expert in the area of intracellular and intercellular signaling with a strong background in Cellular Biology, Physiology and Pharmacology. Her research currently focuses on the investigation of mechanisms contributing to development of benign bladder dysfunction, particularly the involvement of pannexin 1 (Panx1) channels and purinergic signaling in the development of diabetic cystopathy, interstitial cystitis, neurogenic bladder in Multiple Sclerosis and spinal cord injury, and in mechanisms leading to development of Urologic Chronic Pelvic Pain.
Dr. Suadicani’s general interest and expertise in the pathophysiology of cell signaling have also led to collaborations with faculty from other departments at Einstein and abroad. Examples of ongoing collaborations are studies conducted with Dr. Kelvin P. Davies (Department of Urology, Einstein) to better understand mechanisms that underlie development of benign urologic conditions, studies with Dr. David C. Spray (Department of Neuroscience, Einstein) focused on pelvic pain, studies with Dr. Mia M. Thi (Department of Orthopaedic Surgery, Einstein) to investigate the effects of diabetes on bone cell mechanosensing and transduction, and studies with Drs. David J. Sharp (Department of Physiology & Biophysics, Einstein) and Kelvin Davies to identify new targets to treat acute spinal cord injury and associated bladder and erectile dysfunction.
Selected Publications
1. SUADICANI, S.O., BROSNAN, C.F. & SCEMES, E. (2006) P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling. J. Neuroscience, 26(5):1378-1385.
2. SCEMES, E., SUADICANI, S.O., DAHL, G. & SPRAY, D.C. (2007) Connexin and pannexin mediated cell–cell communication. Neuron Glia Biology, 3: 199–208. (PMCID: PMC2656403)
3. SUADICANI, S.O., URBAN-MALDONADO, M., TAR, M.T., MELMAN A., SPRAY, D.C. (2009) Effects of ageing and streptozotocin-induced diabetes on connexin43 and P2 purinoceptor expression in the rat corpora cavernosa and urinary bladder. BJU Int 103(12):1686-1693.
4. SUADICANI, S.O., IGLESIAS, R., SPRAY, D.C., SCEMES, E. (2009) Point mutation in the mouse P2X7 receptor affects intercellular calcium waves in astrocytes ASN NEURO Apr 14;1(1). pii: e00005. doi: 10.1042/AN20090001. (PMCID: PMC2695581)
5. SUADICANI, S.O., CHERKAS, P.S., ZUCKERMAN, J., SMITH, D.N., SPRAY, D.C., HANANI, M. (2010) Bidirectional calcium signaling between satellite glial cells and neurons in cultured mouse trigeminal ganglia. Neuron Glia Biol. (6):1-9. (NIHMS179590).
6. CALENDA G., SUADICANI, S.O., IGLESIAS, R., SPRAY, D.C., MELMAN, A., DAVIES, K.P. (2011) Silencing MaxiK activity in corporal smooth muscle cells initiates compensatory mechanisms to maintain calcium homeostasis. J Sex Med. Jan 26. [Epub ahead of print] PMID: 21269393.
7. CALENDA, G., TONG, Y., KANIKA, N.D., TAR, M.T., SUADICANI, S.O., ZHANG, X., MELMAN, A, ROUGENOUT, C, DAVIES K.P. (2011) Reversal of diabetic vasculopathy in a rat model of type 1 diabetes by opiorphin-related peptides. Am J Physiol Heart Circ Physiol. 2011 Oct; 301(4):H1353-9.
8. SUADICANI, S.O., IGLESIAS, R., WANG, J. DAHL, G. SPRAY, D.C., SCEMES, E. (2012) ATP signaling is deficient in cultured pannexin1-null mouse astrocytes. Glia. 60(7): 1106-1116.
9. NEGORO, H., KANEMATSU, A., DOI, M., SUADICANI, S.O., MATSUP, M., IMAMURA, M., OKINAMI, T., NISHIKAWA, N., OURA, T., MATSUI, S., SEO, K., TAINAKA, M., URABE, S., KIYOKAGE, E., TODO, T., OKAMURA,H., TABATA, Y., OGAWA, O. (2012) Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm. Nat Commun. May 1; 3:809.
10. THI, M.M., Islam, S., SUADICANI, S.O., SPRAY, D.C. (2012) Connexin43 and Pannexin1 Channels in Osteoblasts: Who is the ‘‘hemichannel’’? J Membr Biol. 245(7): 401-9. Epub Jul 15
11. SPRAY, D.C., HANSTEIN, R., STOUT R.J., SUADICANI, S.O., Thi, M.M. (2013) Gap junctions and Bystander Effects: Good Samaritans and executioners. WIREs Membr. Transp. Signal., 2:1-15 (PMCID: in process)
12. HANSTEIN R., NEGORO H., PATEL N.K., CHAROLLAIS A., MEDA P., SPRAY D.C., SUADICANI S.O., SCEMES E. (2013) Promises and pitfalls of a Pannexin1 transgenic mouse line. Front Pharmacol. 9;4:61. (PMCID: PMC3648696).
13. LUTZ, S.E., GONZALEZ-FERNANDEZ, E., VENTURA, J.C.C., PEREZ-SAMARTIN, A., TARASSISHIN, l., NEGORO, H., PATEL, N.K., SUADICANI, S.O., LEE, S.C., MATUTE, C. and SCEMES, E. (2013) - Contribution of Pannexin1 to experimental autoimmune encephalomyelitis. PloS One. 8(6): e66657.
14. NEGORO H., LUTZ S.E., LIOU L.S., KANEMATSU A., OGAWA O., SCEMES E., SUADICANI S.O. (2013) Pannexin 1 involvement in bladder dysfunction in a multiple sclerosis model. Sci Rep., 3:2152. (PMCID: PMC3701900).
15. THI M.M., SUADICANI S.O., SCHAFFLER M.B., WEINBAUM S., SPRAY D.C. (2013) Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require αVβ3 integrin. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21012-7.
16. CHI, Y., SUADICANI, S.O. and SCHUSTER, V.L. (2014) Regulation of prostaglandin EP1 and EP4 receptor signaling by carrier-mediated ligand reuptake. Pharma. Res. Per., 2 (4): e00051.
17. NEGORO, H., URBAN-MALDONADO, M., LIOU, L.S., SPRAY, D.C., THI, M.M. and SUADICANI, S.O. (2014) - Pannexin 1 channels play essential roles in urothelial mechanotransduction and intercellular signaling. PLoS ONE 9(8): e106269 (PMCID: PMC4149561).