systems-and-computational-biology

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Yinghao Wu Lab

Welcome to Dr. Wu's Computational Laboratory of Cell Biophysics

Our lab is in the Department of Systems and Computational Biology at Albert Einstein College of Medicine.

We are focusing on how cells form interactions through the clustering of membrane receptors on their surfaces and how these inter-cellular interactions modulate the succedent signal transduction.

Starting from physical and chemical principles, we are developing multi-scale computational models to bridge the gap between molecular and cellular behaviors, and furthering integrating experimental information from optical, biophysical and structural measurements into our models.

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Research

The aggregation of membrane receptors during cell adhesion initiates the elaborate networks of signaling pathways. The complexities of the networks originate from the spatial-temporal interactions of their numerous cellular components.

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Lab Members

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Publications

  1. J. Chen and Y. Wu , "A Multiscale Computational Model for Simulating the Kinetics of Protein Complex Assembly". Methods Mol Biol. (2018) 1764:401-411.
  2. J. Chen, B. Wang and Y. Wu , "Structural Characterization and Function Prediction of Immunoglobulin-like Fold in Cell Adhesion and Cell Signaling". Journal of Chemical Information and Modeling (2018) Feb 26;58(2):532-542.
  3. J. Chen, S. C. Almo and Y. Wu , "General principles of binding between cell surface receptors and multi-specific ligands: A computational study". PLoS Computational Biology (2017) Oct 10;13(10):e1005805. doi: 10.1371/journal.pcbi.1005805.

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