Tirzepatide Has Huge Impact on Weight, Even After Loss From Lifestyle Change MedPageToday - October 16, 2023 Sriram Machineni, M.B.B.S., comments on the results of a study he co-authored on the effectiveness of a phase III trial for tirzepatide, a weight loss drug, which helped study participants lose a significant amount of weight following a diet and exercise program. Dr. Machineni is associate professor of medicine and director of the Fleischer Institute Medical Weight Center at Einstein and Montefiore. Additional coverage includes Medscape