![Investigating Proteins that Regulate Chromosomes]()
The chromosomes of eukaryotic organisms are made of chromatin, a complex of macromolecules consisting of DNA, RNA and proteins. Dmitry Fyodorov, Ph.D., and Arthur Skoultchi, Ph.D., have received a four-year, $1.5 million grant from the National Institute of General Medical Sciences to study the functions of H1 linker histones, a major family of chromatin proteins. Using the fruit fly Drosophila as a model organism, the researchers will investigate how H1 linker histones regulate the structure and activity of chromosomes. H1 histones are essential for normal development, and mutations in H1 histone genes are associated with several human diseases including cancer. Dr. Skoultchi is professor and chair of cell biology and is the Judith and Burton P. Resnick Chair in Cell Biology at Einstein. Dr. Fyodorov is an associate professor of cell biology at Einstein. (1 R01 GM129244-01)
Posted on: Monday, October 15, 2018