Previously focused on the hexosamine biosynthetic pathway as a nutrient sensor, this project now focuses on sirtuins (Sirt), and investigates the following areas:
- Role of hypothalamic Sirt1 in determining insulin action in aging rodents (Barzilai)
- Increased central and peripheral expression of Sirt1 in prevention of metabolic decline and decreased risk for cancer (Sinclair, Nair)
- Effects of resveratrol on insulin action and the inflammatory response of adipose tissue in middle-aged overweight subjects (Hawkins)
- Effects of resveratrol on metabolic and vascular function in subjects with age-related impairment in glucose tolerance, including assessment of adipose and muscle tissue (Crandall)
