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Molecular Imaging
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Siemens Inveon PET/SPECT/CT
The Laboratory for Molecular Imaging resides on the 3rd floor of the Gruss MRRC building and houses a Siemens Inveon multimodality SPECT/CT with docked PET animal scanning instrument, as well as a R4 Rodent PET Scanner.
The laboratory operates as a core facility of the Gruss Magnetic Resonance Research Center through the Department of Radiology.
The following grant should be acknowledged in all publications: NIH S10RR029545, “MicroPET/SPECT/CT Animal Imaging Device,” which supported the purchase of the Inveon imaging scanner.
Multimodality Molecular Imaging
Positron Emission Tomography (PET) is a non-invasive molecular imaging technique which provides quantitative, longitudinal, three-dimensional functional images of health and disease. F-18 is the most commonly used radioactive tracer for PET studies and is routinely used in our microPET laboratory, along with Cu-64 and I-124 tracers.
The docked Inveon system permits sequential metabolic (PET/SPECT) and anatomic (CT) studies of the same animal without repositioning. In addition, independent CT, SPECT, or CT imaging studies can be performed.
Single-photon emission computed tomography (SPECT) tracers such as 99mTc, 123I, 111In, and 201Tl permit targeting of hypoxia, apoptosis, inflammation, and membrane-bound integrins.
Imaging and Animal Monitoring
Software is available to co-register images from the different modalities. A BioVet (m2m imaging) physiological monitoring and heating system and portable isoflurane anesthesia systems are associated with the scanner. Inveon 3D Visualization and Analysis software permits co-registration of multimodality images.
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MOLECUBES PET/SPECT/CT
The MOLECUBES PET/SPECT/CT platform is a modular preclinical molecular imaging system designed for small animal research. It integrates PET, SPECT, and CT modalities to enable quantitative in vivo imaging of metabolic, functional, and anatomical processes.
System Architecture
The system is built on a modular design enabling flexible combination of PET, SPECT, and CT imaging units:
- Modular scanner design: PET, SPECT, and CT modules can operate independently or in combined configurations.
- High-resolution CT subsystem: Provides anatomical reference for multimodal image fusion.
- Quantitative imaging platform: Supports absolute tracer quantification for preclinical studies.
- Compact benchtop design: Optimized for laboratory space efficiency and ease of use.