Noticias departamentales

Pamela Stanley is an editor and senior author of 8 chapters in the textbook “Essentials of Glycobiology” published by Cold Spring Harbor Laboratory Press in 2022, now in its 4th edition. The group of editors and authors of all 4 editions of EoG received the Distinguished Service Award from the Society of Glycobiology at its annual meeting on Amelia Island, Florida in November 2024. The award is for service to the scientific community in general, and in particular to the community of glycobiologists, for providing a comprehensive textbook which is freely available online at NCBI books upon publication https://www.ncbi.nlm.nih.gov/books/NBK579918/ All proceeds from sales of the print version of the textbook go to a non-profit established by the group of editors to support the publication of next editions of the book. Pamela Stanley was recently elected President of the Consortium of Glycobiology Editors (CGE).

The warmest welcome to the 7 new Ph.D. students who recently declared a thesis lab in our department. We are glad you are here, and we look forward to learning about your research, talent, and ambitions at CB Journal Clubs and WIPs. This highly dynamic and interactive community has so much to offer to our trainees, we are confident that you will soon find Cell Biology a truly exciting place to pursue your graduate studies. Congratulations to our new students and their mentors!

We are excited to welcome to the Cell Biology department the entire Sun lab! Dr. Zijie (ZJ) Sun is an internationally renowned prostate cancer investigator. He came to us from City of Hope National Medical Center, where he was a Professor in the Department of Cancer Biology and Molecular Medicine. Prior to joining City of Hope, Dr. Sun had been a faculty member for 18 years at Stanford University. Dr. Sun’s research program focuses on the molecular mechanisms underlying transcriptional control and cell signaling in development and tumorigenesis. Most recent studies from his lab demonstrate the roles of new stromal niches in prostate development and tumorigenesis. Ongoing projects in his lab are uncovering genomic and epigenetic alterations in controlling development, aging, and tumorigenesis. Dr. Sun joins us as a Professor in the Departments of Oncology and of Cell Biology, and the Director of Prostate Cancer Program at Montefiore Einstein Comprehensive Cancer Center. His laboratory is currently at Ullmann 211 but will soon move to their permanent home at Ullman 511.

Congratulations to Brandon Kim for being selected by the Society for Science as a top 300 Scholar in the 83rd Regeneron Science Talent Search - the nation’s oldest and most prestigious science and mathematics competition for high school seniors. Brandon attends Great Neck South High School and is being mentored by his high school teacher Nicole Spinelli and Cell Biology faculty Lindsay LaFave. His project was selected from a pool of over 2000 applications across the country, underscoring his significant research achievements as a promising, young scientist. Congratulations, Brandon!

Congratulations to Michael Papanicolaou, PhD, and his mentor Julio A. Aguirre Ghiso, on receipt of a Cancer Research Institute Irvington Postdoctoral Fellowship. This prestigious fellowship provides funding to qualified post-doctoral fellows at leading universities around the world who pursue research in fundamental immunology or cancer immunology. In this awarded project, co-mentored by Ross Levine (Sloan Kettering) and XingXing Zhang (Einstein), Michael will investigate how age-related clonal hematopoiesis influences breast cancer dormancy and metastasis. Congratulations, Michael!

The Department of Cell Biology is celebrating the promotion of two of our faculty members to full Professorship with tenure. Congratulations to Dr. Wenjun Guo and Dr. Keisuke Ito! This is a highly deserved recognition that reflects their outstanding expertise and accomplishments in their fields of study as well as their significant contributions to the missions of our medical school.

El Dr. Guo obtuvo su Licenciatura en Ciencias en la Universidad de Nankai y luego un PhD en la Facultad de Medicina Weill Cornell/Instituto Sloan-Kettering de Nueva York. En 2005, se unió al laboratorio del Dr. Robert A. Weinberg en el Instituto Whitehead para su capacitación postdoctoral. En 2011, el Dr. Guo fue contratado por el entonces recién creado Instituto Ruth L. y David S. Gottesman para la Investigación de Células Madre y Medicina Regenerativa y se unió a la facultad de Biología Celular como Profesor Asistente. Sus intereses de investigación son la plasticidad celular en la progresión del cáncer y la metástasis.

After earning both his M.D. and Ph.D. degrees from Keio University, Japan, Dr. Ito came to the United States in 2006 for his postdoctoral training at the Memorial Sloan Kettering Cancer Center. In 2012, Dr. Ito was recruited to Einstein from Harvard Medical School, where he was an Instructor in Medicine, to join Cell Biology and the newly established Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research as an Assistant Professor. Dr. Ito’s research program focuses on hematopoietic homeostasis, covering a variety of topics ranging from stem cell fate decisions to myelodysplastic syndrome, leukemia, and sickle cell disease pathogenesis.

Una vez más, nuestras más cálidas felicitaciones a los doctores Guo e Ito. Apreciamos sinceramente su arduo trabajo y dedicación al departamento y a la comunidad de Einstein.

Postdoctoral fellow Dr. Rama Kadamb from the Aguirre-Ghiso lab gave an oral presentation at the Society for Melanoma Research (SMR) held at Philadelphia (06th-09th Nov 2023). In her talk, she shared findings that NR2F1, a lineage commitment and dormancy regulator transcription factor, critically regulates disseminated cancer cell dormancy in spontaneous uveal melanoma (UM). Her study reveals that NR2F1 epigenetically opposes oncogenic Gq-YAP1 signaling, which drives progression of advanced metastatic disease in UM. These findings help elucidate the mechanism for the longstanding medical mystery surrounding late relapse in UM patients and hold promise for the development of anti-metastatic therapies.

En un logro notable que refleja sus logros sobresalientes como científica médica, la Dra. Kira Gritsman, codirectora del Programa de Biología del Cáncer y Células Madre del Montefiore Einstein Comprehensive Cancer Center y recientemente nombrada Becaria Superior de la Facultad Betty y Sheldon Feinberg en investigación del cáncer, ha sido elegida Miembro Activo de la Sociedad Estadounidense de Investigación Clínica (ASCI) para el año 2024. Esta noticia forma parte del anuncio de la ASCI, donde 100 miembros Activos e Internacionales fueron elegidos para representar la excelencia académica en 50 instituciones diferentes. Este reconocimiento subraya las importantes contribuciones de la Dra. Gritsman a la medicina académica, lo que la convierte en un motivo de orgullo para el departamento de Biología Celular de Einstein. La Dra. Gritsman se unirá oficialmente a este estimado grupo en la Cena de la ASCI y la Ceremonia de Inducción de Nuevos Miembros el 5 de abril de 2024, durante la Reunión Conjunta AAP/ASCI/APSA en el Swissotel Chicago. La ASCI, fundada en 1908, es una de las sociedades médicas honorarias más antiguas y respetadas de los Estados Unidos. ¡Felicitaciones, Dr. Gritsman!

We are thrilled that 9 new graduate students recently declared a thesis lab in our department!! We eagerly welcome you and look forward to learning about your research projects, talent, and ambitions in various departmental forums. With so much to offer to our trainees, we encourage you to explore our diverse research programs, enjoy various departmental activities, and make new friends. We are confident that you will soon find Cell Biology a truly exciting place to pursue your graduate studies. Congratulations to our new students and their mentors!

The Department of Cell Biology was well represented at the 52nd Annual Scientific Meeting of International Society of Experimental Hematology (ISEH), held in Brooklyn, New York, from 17-20 August 2023. This year, the conference featured oral presentations from internationally-renowned scientists, rising young investigators, and many trainees. It is a unique venue showcasing exciting science from around the world and offering networking opportunities for scientists at every career stage. More than 30 trainees and faculty from our department attended (including from the Bouhassira, Gritsman, Ito, Marianovich, Nandakumar, Steidl, Stengel, Will, Ye laboratories), and many gave wonderful talks and/or well-received posters on their ongoing work. Dr. Samuel Taylor, a postdoctoral fellow in the Steidl lab received the prestigious Eugene Cronkite Award (1st Place Post-doc Award), and Dr. Daniel Lucas, an alumnus of our department and currently Associate Professor at Cincinnati Children's Hospital, delivered the Paul S. Frenette Lecture. The meeting ended with a beautiful dinner river cruise around Manhattan and the Statue of Liberty on a gorgeous summer night. Dr. Ulrich Steidl, who served as the 2022-2023 president of ISEH, was one of the main organizers of the meeting. “It has been a great pleasure and honor! A big thank you to all attendees of ISEH2023, ISEH staff, new president Marella de Bruijn and the scientific program committee, and all the many additional volunteers for making this meeting so vibrant and memorable”, said Dr. Ulrich Steidl. “We will be forever grateful.”

¡Felicitaciones al Dr. Robert Coleman por la prestigiosa beca de la Iniciativa Chan Zuckerberg! Esta beca de dos años financiará a un equipo de investigadores de Einstein, liderado por el Dr. Rob Coleman, que incluye al Dr. Louis Hodgson, del Departamento de Farmacología Molecular, y al Dr. Vlad Verkhusha, del Departamento de Genética. El equipo de Einstein formará parte de un consorcio internacional de grupos de investigación que examinará el metabolismo a diferentes escalas. El equipo de Einstein desarrollará herramientas optogenéticas y biosensores de metabolitos que aportarán nuevos conocimientos sobre los mecanismos dinámicos de expresión génica que controlan eventos celulares clave, como el ritmo circadiano. Puede encontrar más información sobre la beca y otros proyectos financiados relacionados. aquí.

Lindsay Gurska, Ph.D. '23, who recently graduated from the Gritsman lab, was a recipient of the 2023 Julius Marmur Graduate Student Research Award. In her thesis project, Lindsay teamed up with her colleagues to show that crizotinib, a drug approved for non-small cell lung cancer, can suppress aberrant signaling in cells of patients with myeloproliferative neoplasm (MPN), setting the framework for initiating clinical testing of crizotinib for MPN patients. Her work has led to several awards, including the American Society of Hematology Abstract Achievement Award, and she was first author on a paper published in Clinical Cancer Research. Congratulations Lindsay and Kira!

Congratulations to Dr. Britta Will for being named one of this year's Leukemia and Lymphoma Society Scholars!

This highly prestigious award honors the innovative research Dr. Britta Will and her group conduct on hematopoietic stem cells and their role in driving two age-related and largely incurable blood cancers: acute myeloid leukemia and myelodysplastic syndromes.

Founded in 1949, the Leukemia and Lymphoma Society (LLS) is the largest voluntary health organization dedicated to fighting blood cancers worldwide. With its core mission to cure leukemia and lymphoma, LLS funds clinically impactful, cutting-edge research. It is also home to a substantial career development program that aims to accelerate the professional advancement of rising stars in the research community.

Our congratulations, Britta and members of the Will Lab!
Link: https://www.lls.org/award-recipient/britta-will

Dr. Britta Will co-organized together with Dr. Alejandro Gutierrez (Boston Children's Hospital / Harvard Medical School) the 2023 Hematologic Malignancies Scientific Research Conference from the Federation of American Societies for Experimental Biology (FASEB). Since its launch in 1995, this highly interactive conference (held every two years) brings together researchers who work on all aspects of hematological malignancies including molecular pathogenesis of blood cancers, control of stem cell function and differentiation, chromatin biology, and new therapeutic strategies.

Britta was the first Einstein investigator elected to organize this prestigious meeting. The conference's 2023 iteration featured 53 oral presentations from internationally leading experts, early-stage investigators, and trainees as well as three lively poster sessions and workshops. The five-day conference drew 160 US-based and international participants and generated a lot of excitement. The program fostered engaged knowledge exchange and interdisciplinary collaborations. Junior investigators and trainees also enjoyed ample networking and career development opportunities. Several members of our own heme-focused groups attended and gave talks on their ongoing work, including Shira Glushakow-Smith (Ph.D. student in the Gritsman lab) and Drs. Marina Konopleva and Ulrich Steidl.

Dr. Weihan Li, a postdoctoral fellow in the laboratory of Dr. Robert H. Singer, has received the prestigious NIH/NIGMS K99/R00 Pathway to Independence Award from NIH/NIGMS. This award will provide 2 years of support for Dr. Li's continued postdoctoral research at Einstein (K99 phase) followed by 3 years of independent funding after he transitions to a tenure-track faculty position (R00 phase). Dr. Li joined Albert Einstein College of Medicine as a postdoctoral fellow in November 2018 after completing his PhD in Biophysics at University of California, San Francisco. Since then, he has developed an improved RNA imaging system that has minimal perturbation to the RNA's stability (Li, W., Maekiniemi, A. et al. Nature Methods 2022), and was recognized with the American Heart Association Postdoctoral Fellowship. Dr. Li's K99/R00 project is entitled "The Spatial Coordination Between Cytosolic and Mitochondrial Translation”. Congratulations Weihan on this first step to a successful future career!

Dra. Britta Will has been named as the new Diane and Arthur B. Belfer Scholar in Cancer Research. This endowed professorship was first established by the late long-time Einstein research supporters and Board members Mr. and Mrs. Belfer in 1998. It supports innovative basic and translational cancer research, and honors key contributions Britta and her team have been making to aid in understanding and targeting of leukemic stem cells in myeloid malignancies. Congratulations to Britta and the Will lab!

¡Felicitaciones al Dr. Ulrich Steidl por recibir la Cátedra Edward P. Evans para Síndromes Mielodisplásicos!

This highly prestigious testament of excellence honors Uli's vision for and most successful implementation of highly collaborative studies of myeloid malignancies at Einstein.

This is a new endowed professorship for Einstein and the eighth for faculty within our department. It was newly established here at Einstein by the Edward P. Evans Foundation, a philanthropic leader in supporting transformational and collaborative biomedical research in Myelodysplastic Syndromes (MDS).

In close collaboration with Dr. Amit Verma (DMB), Uli has created a highly unique and successful environment and fostered a growing team of basic and translational investigators conducting MDS or MDS-related research inside and outside of our department. This “MDS Team” includes Drs. Kristy Stengel, Britta Will, Keisuke Ito, Kira Gritsman, Satish Nandakumar, and Maria Maryanovich from our department of Cell Biology, as well as Teresa Bowman, Aditi Shastri (both DMB), and Marina Konopleva (MolPharm) – some of whom have been awardees of EvansMDS research funding. They are joined by an exceptional clinical team including Drs. Eric Feldman, Mendel Goldfinger, Ioannis Mantzaris, and others at Montefiore. Uli and Amit's efforts were internally recognized and honored by the creation of the Blood Cancer Institute at Montefiore Einstein in 2021.

We are deeply thankful to the Edward P. Evans Foundation for generously supporting Uli's vision and are beyond proud of this external recognition of his outstanding leadership in biomedical sciences. This is another great example of how highly impactful and rewarding team science reaches far beyond departmental borders at Einstein and Montefiore!

Congratulations, Uli - and keep going, MDS Team!!

Julio Aguirre-Ghiso, PhD, es el nuevo titular de la Cátedra Rose C. Falkenstein en Investigación del Cáncer. Julio es un líder internacional en latencia y metástasis de células cancerosas y ha contribuido a un cambio fundamental en el campo de la biología del cáncer al investigar cómo las células cancerosas hibernan, sin ser detectadas, durante largos periodos y qué las hace despertar repentinamente para sembrar metástasis mortales resistentes al tratamiento. Su trabajo está revelando maneras de mantener la latencia residual de las células cancerosas, eliminar las células cancerosas latentes e identificar biomarcadores de la recurrencia del cáncer. Julio es colíder del Programa de Microambiente Tumoral y Metástasis y director fundador del Instituto de Latencia del Cáncer y Microambiente Tumoral del Centro Oncológico Montefiore Einstein (MECC), además de profesor de biología celular, oncología y medicina.

¡Felicitaciones al Dr. Matthew Scharff con motivo de su 90° cumpleaños!
The Department of Cell Biology is pleased to honor Dr. Scharff with this tribute video celebrating his outstanding career. It consists of contributions from some of Dr. Scharff's Einstein colleagues and former trainees. Please view the video here: https://youtu.be/-oqTxFxlne0

El Dr. Scharff es profesor distinguido de biología celular y profesor Harry Eagle de investigación del cáncer. Se incorporó a la facultad del Albert Einstein College of Medicine en 1963 y se ha desempeñado como presidente del Departamento de Biología Celular y director del Albert Einstein Cancer Center. El Dr. Scharff es miembro de la Academia Nacional de Ciencias de los Estados Unidos y de la Academia Estadounidense de las Artes y las Ciencias. Ha recibido numerosos premios por sus logros científicos, su servicio a la comunidad científica y sus habilidades de mentoría, incluido el premio Herzenberg Biolegend de 2015 de la Asociación Estadounidense de Inmunólogos. Ha publicado más de 300 artículos y revisiones científicas y ha capacitado a 70 estudiantes de PhD y becarios posdoctorales.

The Department of Cell Biology would like to extend our warmest congratulations to Jessie Larios-Valencia, a MD/PhD predoctoral candidate in the laboratory of Dr. Wenjun Guo, who was recently awarded an NIH F31 Predoctoral Individual NRSA fellowship. He will be pursuing studies dissecting the role of dedifferentiation in basal-like breast cancer.

Emily Schwenger was awarded a Google Fellowship in the category of Health Research, which will directly support her graduate research in the Steidl Lab for 2-3 years. The award is granted to innovative research in areas relevant to computer science and related fields with the intention of supporting promising PhD candidates of all backgrounds who seek to influence the future of technology. Additional information on the fellowship can be found at https://research.google/outreach/phd-fellowship/. Congratulations Emily!

Dr. Singer received the Lewis S. Rosenstiel award at Brandeis University on April 6th. More info on the award and the star-studded list of past awardees can be found at https://www.brandeis.edu/rosenstiel/rosenstiel-award/
His acceptance talk can be seen at https://ensemble.brandeis.edu/Watch/o3MEz42L

We are very happy to announce the newest addition to the Cell Biology faculty, Dr. Maria Maryanovich. Dr. Maryanovich received her Bachelor of Science from Ort Braude College of Engineering, followed by a Master of Science and a Ph.D. both from the Weizmann Institute of Science in Israel. During her thesis study, she discovered a novel survival role for the pro-apoptotic protein BID in the context of HSC response to DNA damage and HSC maintenance. This work earned her the Elchanan E. Bondi Memorial Award for Outstanding Academic Achievement. In 2014, Dr. Maryanovich joined the laboratory of late Dr. Paul S. Frenette at Einstein for postdoctoral training. Since then, she has been characterizing functional changes in the aging bone marrow, focusing on age-related remodeling of neural-niche interactions. In a very important and novel study, she demonstrated that systemic administration of sympathomimetics was sufficient to rejuvenate both niche and HSC functions in mice. Dr. Maryanovich has received several prestigious recognitions including the EMBO Long-Term Postdoctoral Fellowship, the NYSCF Druckenmiller Fellowship, and the Dennis Shields Postdoctoral Research Award from Einstein. In her independent lab, she will continue the current research theme and extend the work to age-related malignancies, such as AML. Her goal is to uncover new mechanisms underlying age-dependent stem cell dysfunction with the hope that such understanding may facilitate the development of stem cell rejuvenation therapies. Dr. Maryanovich's lab is in Price, Rm 113.

Dr. Yuhong Ma, postdoctoral scientist in the laboratory of Dr. Britta Will, received one of the 2022 American Society of Hematology Scholar Awards! This prestigious and highly competitive three-year award program supports fellows and junior faculty dedicated to careers in hematology research as they transition from their training into careers as independent investigators. The award recognizes and supports Yuhong's exciting work on the role of chaperone-mediated autophagy in leukemic stem cell maintenance. Congratulations, Yuhong!