Department Chair Ulrich G. Steidl, M.D., Ph.D. Professor, Department of Cell Biology Professor, Department of Oncology Professor, Department of Medicine Chair Department of Cell Biology Edward P. Evans Endowed Professor for Myelodysplastic Syndromes Deputy Director, and Associate Director for Basic Science Montefiore Einstein Comprehensive Cancer Center Co-Director, Blood Cancer Institute Interim Director, The Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research 718.430.3437ulrich.steidl@einsteinmed.edu Areas of Research: hematopoiesis; stem cell origin of cancer; leukemia; AML; MDS; hematopoietic stem cells (HSC); (pre)leukemic stem cells (LSC); transcription dynamics; molecular noise; epigenetics; targeted therapy; drug development; translational computational biology View ProfileLab Website All Faculty Julio A. Aguirre-Ghiso, Ph.D. Professor, Department of Cell Biology Professor, Department of Oncology (Medical Oncology) Professor, Department of Medicine (Oncology & Hematology) Rose C. Falkenstein Chair in Cancer Research Director, Institute for Cancer Dormancy and Tumor Microenvironment Co-Leader, Montefiore Einstein Comprehensive Cancer Center Tumor Microenvironment & Metastasis Program 718.678.1246julio.aguirre-ghiso@einsteinmed.edu Areas of Research: Metastasis biology Cancer cell dormancy Signal transduction Extracellular matrix Innate immune cell function tumor and normal organ microenvironment View ProfileLab Website Leonard H. Augenlicht, Ph.D. Professor, Department of Oncology (Medical Oncology) Professor, Department of Medicine (Oncology & Hematology) Professor, Department of Cell Biology 718.430.4247laugenli@montefiore.org View Profile Barbara K. Birshtein, Ph.D. Professor Emerita, Department of Cell Biology Director of Training Grant Support Programs Scientific Director, Training & Educational Grants Office 718.430.2291barbara.birshtein@einsteinmed.edu View ProfileLab Website Eric E. Bouhassira, Ph.D. Professor, Department of Cell Biology Professor, Department of Medicine (Oncology & Hematology) Professor, Department of Oncology (Hematology) Ingeborg and Ira Leon Rennert Professor of Stem Cell Biology and Regenerative Medicine 718.430.2188eric.bouhassira@einsteinmed.edu Areas of Research: Pluripotent stem cells, erythroid differentiation, red blood cells, gene therapy, hemoglobinopathies, genome modification, TTP, hemophilia A View ProfileLab Website Nicholas Chiorazzi, M.D. Adjunct Professor, Department of Cell Biology 516.562.1085nchizzi@northwell.edu View Profile Robert A. Coleman, Ph.D. Associate Professor, Department of Cell Biology 718.430.8623robert.coleman2@einsteinmed.edu View Profile John S. Condeelis, Ph.D. Professor, Department of Cell Biology Professor, Department of Surgery The Judith and Burton P. Resnick Chair in Translational Research Scientific Director, Analytical Imaging Facility Director, Integrated Imaging Program for Cancer Research Director, Department of Surgery Basic and Translational Research 718.430.2718john.condeelis@einsteinmed.edu Areas of Research: Interests are in optical physics, cell biology and biophysics, and cancer biology. Applications of interests are in development of the multiphoton imaging technology used to identify dissemination microenvironments in metastatic tumors. View ProfileLab Website Vera M. DesMarais, Ph.D. Research Professor, Department of Cell Biology Director, Light Microscopy Analytical Imaging Facility 718.430.3547vera.desmarais@einsteinmed.edu View ProfileLab Website Winfried Edelmann, Ph.D. Professor, Department of Cell Biology Professor, Department of Genetics The Joseph and Gertrud Buchler Chair in Transgenic Medicine Faculty Supervisor, Gene Modification Gene Targeting and Transgenic Facilities 718.678.1086winfried.edelmann@einsteinmed.edu Areas of Research: We are studying the roles of DNA mismatch repair (MMR) in genome maintenance and tumor suppression in mouse models of human cancer and the role of MMR in the response of intestinal cancer stem cells to anticancer treatment. View ProfileLab Website Dmitry Fyodorov, Ph.D. Professor, Department of Cell Biology 718.430.4021dmitry.fyodorov@einsteinmed.edu Areas of Research: Packaging DNA into chromatin maintains & compartmentalizes the genome. We examine how nucleosome remodeling factors, histone chaperones & modifying enzymes establish chromatin compartments and shape gene expression patterns. View ProfileLab Website Matthew J. Gamble, Ph.D. Professor, Department of Molecular Pharmacology Professor, Department of Cell Biology 718.430.2942matthew.gamble@einsteinmed.edu Areas of Research: Histone variant macroH2A; Cancer; Cellular senescence; Chromatin structure and function; Transcription; Splicing; Senescence-associated secretory phenotype; Endoplasmic reticulum stress responses; Poly(ADP-ribose) polymerase View ProfileLab Website Kira Gritsman, M.D., Ph.D. Associate Professor, Department of Oncology (Medical Oncology) Associate Professor, Department of Medicine (Oncology & Hematology) Associate Professor, Department of Cell Biology Co-Leader, Montefiore Einstein Comprehensive Cancer Center Stem Cell & Cancer Biology Program Betty and Sheldon Feinberg Senior Faculty Scholar in Cancer Research 929.246.6707kira.gritsman@einsteinmed.edu Areas of Research: roles of signaling pathways in hematopoietic stem cell self-renewal and differentiation, leukemic stem cells, targeting signaling pathways in hematologic malignancies View ProfileLab Website Wenjun Guo, Ph.D. Professor, Department of Cell Biology 718.678.1276wenjun.guo@einsteinmed.edu Areas of Research: Cancer stem cells, mammary stem cells, tumor immune microenvironment, immunotherapy, cellular plasticity, metastasis, therapeutic resistance View ProfileLab Website Rhoda E. Hirsch, Ph.D. Professor Emerita, Department of Oncology (Hematology) Professor Emerita, Department of Medicine (Oncology & Hematology) Professor Emerita, Department of Cell Biology 718.430.3604rhoda.hirsch@einsteinmed.edu Areas of Research: Hemoglobinopathies (e.g., HbE/beta-thalassemia, sickle cell disease, HbC Disease) & pathophysiological mechanisms underlying these morbid & often fatal diseases with a focus on therapeutic design. Acellular giant Hb as a HBOC View Profile Keisuke Ito, M.D., Ph.D. Professor, Department of Cell Biology Professor, Department of Medicine Professor, Department of Oncology (Medical Oncology) Director of Scientific Resources of the Stem Cell Institute 718.678.1278keisuke.ito@einsteinmed.edu Areas of Research: Hematopoietic stem cells (HSCs) and Stem cell fate; Myelodysplastic syndrome (MDS) and hematological malignancies; Stem cell metabolisms and epigenetics; Bone marrow microenvironment; Sickle cell disease and vaso-occlusion View ProfileLab Website Margaret Kielian, Ph.D. Professor, Department of Cell Biology Samuel H. Golding Chair in Microbiology 718.430.3638margaret.kielian@einsteinmed.edu Areas of Research: Areas of research: Virus entry into host cells and virus membrane fusion; virus assembly and exit; virus genome encapsidation; virus protein structure and function; virus cell-to-cell transmission View ProfileLab Website Richard N. Kitsis, M.D. Professor, Department of Medicine (Cardiology) Professor, Department of Cell Biology The Dr. Gerald and Myra Dorros Chair in Cardiovascular Disease Director, Wilf Family Cardiovascular Research Institute 718.430.2609richard.kitsis@einsteinmed.edu Areas of Research: Cell Death and Mitochondrial Biology: Fundamental Mechanisms and Roles in Human Disease View Profile Lindsay M. LaFave, Ph.D. Assistant Professor, Department of Cell Biology 718.430.2090lindsay.lafave@einsteinmed.edu Areas of Research: lung cancer, lung stem cells, cancer predisposition, chromatin biology, single-cell epigenomics, chromatin plasticity, intratumoral heterogeneity, lung adenocarcinoma, gene regulatory networks, spatial profiling, transcription factor biology View ProfileLab Website Maria Marianovich, Ph.D. Assistant Professor, Department of Cell Biology 718.678.1066maria.marianovich@einsteinmed.edu Areas of Research: Hematopoietic stem cell and cancer stem cell microenvironment. Our lab studies mechanisms that regulate the maintenance of bone marrow niches for hematopoietic stem cells during homeostasis, aging, or myeloid malignancy. View ProfileLab Website U. Thomas Meier, Ph.D. Professor, Department of Cell Biology 718.430.3294tom.meier@einsteinmed.edu Areas of Research: Nuclear function and organization: small nucleolar ribonucleoproteins (snoRNPs) and their involvement in inherited disease and cancer. Human reproduction: endometrial receptivity. View ProfileLab Website Satish K. Nandakumar, M.B.B.S., Ph.D. Assistant Professor, Department of Cell Biology 718.430.3021satish.nandakumar@einsteinmed.edu Areas of Research: Germline predisposition to blood cancers, Hematopoietic stem cells, Clonal hematopoiesis, Myeloproliferative neoplasms, Genetic variants, Enhancer elements, CRISPR/Cas9 edited stem cell models, Multiplexed functional assays. View ProfileLab Website Charles C. Query, M.D., Ph.D. Professor, Department of Cell Biology 718.430.4174charles.query@einsteinmed.edu Areas of Research: Our laboratory studies the mechanics of a large RNP machine – the spliceosome – focusing on enzyme-substrate interactions. These studies provide insights allowing us to “reverse engineer” new orthogonal spliceosome systems. View ProfileLab Website Rebeca San Martin, Ph.D. Assistant Professor, Department of Oncology (Medical Oncology) Assistant Professor, Department of Cell Biology 718.430.3366rebeca.sanmartin@einsteinmed.edu Areas of Research: Prostate cancer microenvironment. Bone metastasis and dormancy. Development of alternative in-vitro systems that model progression and metastasis View Profile Matthew D. Scharff, M.D. Distinguished Professor, Department of Cell Biology Distinguished Professor, Department of Medicine (Infectious Diseases) The Harry Eagle Chair in Cancer Research/National Women's Division Faculty Supervisor, Hybridoma 718.430.3527matthew.scharff@einsteinmed.edu Areas of Research: Dr. Scharff studies how antibody diversity is generated and protects from infections. The major focus is on how activation induced deaminase and error prone mismatch repair is targeted to antibody variable region genes in mice and humans and in some huma View ProfileLab Website Carl L. Schildkraut, Ph.D. Professor, Department of Cell Biology 718.430.2097carl.schildkraut@einsteinmed.edu Areas of Research: DNA REPLICATION, ALZHEIMER'S DISEASE, AGING, DNA DAMAGE TO GENES INVOLVED IN NEUROLOGICAL DEVELOPMENT, TELOMERE ROLE IN CHROMOSOME STABILITY View ProfileLab Website David A. Shafritz, M.D. Professor Emeritus, Department of Medicine (Hepatology) Professor Emeritus, Department of Cell Biology Professor Emeritus, Department of Pathology 718.430.2098David.Shafritz@einsteinmed.edu View ProfileLab Website Robert H. Singer, Ph.D. Professor, Department of Cell Biology Professor, Dominick P. Purpura Department of Neuroscience Harold and Muriel Block Chair in Anatomy & Structural Biology 718.430.8646robert.singer@einsteinmed.edu Areas of Research: We study single mRNA molecules from cradle to grave in single living cells using high resolution imaging. We develop trafficking microscopy and approaches to image RNA using fluorescent probes to visualize and quantify mRNA. View ProfileLab Website Arthur I. Skoultchi, Ph.D. Professor, Department of Cell Biology Judith and Burton P. Resnick Chair in Cell Biology 718.430.2169arthur.skoultchi@einsteinmed.edu Areas of Research: Key Words: Chromatin, epigenetics, transcription, proliferation, differentiation, leukemia. We study control of gene expression in mouse embryonic stem cells, normal and leukemic blood cells, and in Drosophila. View ProfileLab Website Pamela Stanley, Ph.D. Professor, Department of Cell Biology The Horace W. Goldsmith Foundation Chair 718.430.3346pamela.stanley@einsteinmed.edu Areas of Research: Roles of mammalian glycans in development, spermatogenesis, immunity and cancer; glycosylation engineering; CHO and mouse glycosylation mutants to identify roles for glycans in growth factor receptor and Notch signaling. View ProfileLab Website Kristy R. Stengel, Ph.D. Assistant Professor, Department of Cell Biology 718.430.2815kristy.stengel@einsteinmed.edu Areas of Research: Gene expression, Cancer, Transcription factors, Epigenetics, Chromatin structure, Targeted protein degradation View ProfileLab Website Britta Will, Ph.D. Associate Professor, Department of Oncology (Medical Oncology) Associate Professor, Department of Medicine (Oncology & Hematology) Associate Professor, Department of Cell Biology Co-Leader, Montefiore Einstein Comprehensive Cancer Center Stem Cell & Cancer Biology Program The Diane and Arthur B. Belfer Faculty Scholar in Cancer Research Director, Preclinical Modeling Montefiore Einstein Comprehensive Cancer Center Blood Cancer Institute 718.430.3786britta.will@einsteinmed.edu Areas of Research: Adult stem cells, blood-forming stem cells, cancer stem cells, aging, metabolism-dependent gene regulation. View ProfileLab Website B. Hilda Ye, Ph.D. Associate Professor, Department of Cell Biology 718.430.3339hilda.ye@einsteinmed.edu Areas of Research: We are studying how transcription regulation and cell signaling events govern lymphocyte differentiation and lymphoma development. The current focus is on diffuse large B-cell lymphoma and adult T-cell leukemia/lymphoma View ProfileLab Website
