COURSE DESCRIPTION:
The course focuses on the fundamentals of developmental biology, stem cells and regenerative medicine. The pathways and processes central to embryogenesis are often reused during tissue regeneration. Moreover, many diseases have their origins in mis-regulation of developmental pathways. A fundamental knowledge of development can thus strengthen your understanding of regenerative biology, aging, and disease. In this course, we will focus on the major principles and appropriate experimental approaches utilized in researching questions in development and stem cell biology.

The course is comprised of lectures, team-based learning discussions and writing sessions. For all aspects of the course, students are highly encouraged to raise their own questions about material presented and to voice their agreement (or dissent!) with thoughts raised during discussions. Course leaders and instructors will make sure that everyone has a chance to participate in the discourse.

COURSE OBJECTIVES:
The goal of this course is for students to get an overview of the state-of-the-art of research in developmental biology and stem cells. Students will learn to critically evaluate literature and seminars, to understand relevant experimental approaches, and to develop logical thinking and good experimental design skills for studying development and stem cell biology.

PREREQUISITES:
None

REQUIRED MATERIALS:
None; ‘Developmental Biology’ by Gilbert et al. or similar standard textbooks can be helpful. Instructors will point out relevant literature for further reading. Material to be studied in advance will be posted with sufficient notice on Canvas.

SUITABLE FOR 1ST YEAR STUDENTS:
Yes.

STUDENT ASSESSMENT:
Grading is primarily based on participation. Course leaders and instructors evaluate participation of student (preparedness, quality of questions and answers) during lecture-based classes and journal club presentations. In case of paper discussions, a student will act as facilitator and will introduce the topic and randomly select students to present figures or answer questions emerging from the ongoing discussion. All students are expected to be part of the paper discussion. The facilitator will summarize conclusions and future directions or details that should be further addressed. Discussion leaders of JCs will receive extra credit.

Additionally, there is a group writing exercise that will comprise 12.5% of the final grade. The class will be divided into groups of 3-4 students each. Each group will write a one-page grant proposal on a development or stem cell topic, and then present it to the class. Grades will be assigned based on the logic and experimental approach of the proposal and presentation.

Attendance and participation in ALL classes are required. Absences must be excused prior to class meeting. More than two absences per term will result in a failing grade for the course.

CREDIT HOURS: 2.5