H. Dean Hosgood

H. Dean Hosgood, Ph.D.

  • Associate Professor, Department of Epidemiology & Population Health (Epidemiology)
  • Atran Foundation Chair in Epidemiology & Population Health
  • Director, Global Environmental Health, Global Health Center
  • Associate Director, Population and Clinical Sciences, Clinical Research Training Program
  • Research Director, Medical Student Global Health Program
  • Co-Director, Ph.D. Concentration in Clinical Investigation
  • Co-Leader, Montefiore Einstein Comprehensive Cancer Center, Cancer Epidemiology Prevention & Control Program
  • Division Head, Division of Epidemiology, Department of Epidemiology & Population Health

Area of research

  • Cancer Epidemiology; Environmental Epidemiology; Genetic and Genomic Susceptibility; Global Health; Hematologic Malignancies; Lung Cancer; Never Smokers; non-Hodgkin Lymphoma; Noninvasive Biomarkers

Email

Phone

Location

  • Albert Einstein College of Medicine Jack and Pearl Resnick Campus 1300 Morris Park Avenue Belfer Building 1309A Bronx, NY 10461

Lab of H. Dean Hosgood



Research Profiles

Professional Interests

Dr. Hosgood is an Associate Professor and the Atran Foundation Chair in Epidemiology and Population Health at the Albert Einstein College Medicine in the Bronx, NY.  He is also the director of Global Environmental Health for the Global Health Center, co-leader of the Cancer Epidemiology Prevention & Control Program of the Montefiore Einstein Cancer Center, and co-director of the Ph.D. in Clinical Investigation. A graduate of Carnegie Mellon University (Chemistry), he received his master's degree (Environmental Health Sciences) and doctorate from Yale University (Epidemiology). Dr. Hosgood was also a pre-doctoral, post-doctoral, and research fellow in the Occupational and Environmental Epidemiology Branch of the Division of Cancer Epidemiology and Genetics at the National Cancer. Dr. Hosgood’s research focuses on identifying associations between environmental exposures and adverse health outcomes, with an emphasis on cancer and gene-environment interactions.  He utilizes advanced population- and clinical-based methods that integrate observational study designs, cutting-edge exposure assessments, and biomarkers of susceptibility (i.e., genetic data) to elucidate the complex mechanisms underlying tumorigenesis. He helped establish the Female Lung Cancer Consortium in Asia (FLCCA), is involved in the Asia Cohort Consortium, and is the Principal Investigator of the Household Air Pollution Consortium, which is studying mortality associated with heating and cooking fuels among ~1,000,000 participants worldwide.

Selected Publications

  1. Hosgood HD, 3rd, Chapman R, Shen M, Blair A, Chen E, Zheng T, Lee KM, He X, Lan Q. Portable stove use is associated with lower lung cancer mortality risk in lifetime smoky coal users. British journal of cancer. 2008/12/02;99(11):1934-9. Epub 2008/11/27. doi: 10.1038/sj.bjc.6604744. PubMed PMID: 19034286; PMCID: PMC2600700
  2. Hosgood HD, 3rd, Liu CS, Rothman N, Weinstein SJ, Bonner MR, Shen M, Lim U, Virtamo J, Cheng WL, Albanes D, Lan Q. Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study. Carcinogenesis. 2010/5/01;31(5):847-9. Epub 2010/02/24. doi: 10.1093/carcin/bgq045. PubMed PMID: 20176654; PMCID: PMC2864414.
  3. Hsiung CA, Lan Q, Hong YC, Chen CJ, Hosgood HD, Chang IS, Chatterjee N, Brennan P, Wu C, Zheng W, Chang GC, Wu T, Park JY, Hsiao CF, Kim YH, Shen H, Seow A, Yeager M, Tsai YH, Kim YT, Chow WH, Guo H, Wang WC, Sung SW, Hu Z, Chen KY, Kim JH, Chen Y, Huang L, Lee KM, Lo YL, Gao YT, Kim JH, Liu L, Huang MS, Jung TH, Jin G, Caporaso N, Yu D, Kim CH, Su WC, Shu XO, Xu P, Kim IS, Chen YM, Ma H, Shen M, Cha SI, Tan W, Chang CH, Sung JS, Zhang M, Yang TY, Park KH, Yuenger J, Wang CL, Ryu JS, Xiang Y, Deng Q, Hutchinson A, Kim JS, Cai Q, Landi MT, Yu CJ, Park JY, Tucker M, Hung JY, Lin CC, Perng RP, Boffetta P, Chen CY, Chen KC, Yang SY, Hu CY, Chang CK, Fraumeni JF, Jr., Chanock S, Yang PC, Rothman N, Lin D. The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. PLoS genetics. 2010/8/01;6(8). Epub 2010/08/1. doi: 10.1371/journal.pgen.1001051. PubMed PMID: 20700438; PMCID: PMC2916850.
  4. Hosgood HD, 3rd, Boffetta P, Greenland S, Lee YC, McLaughlin J, Seow A, Duell EJ, Andrew AS, Zaridze D, Szeszenia-Dabrowska N, Rudnai P, Lissowska J, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Morgenstern H, Rothman N, Hung RJ, Brennan P, Lan Q. In-home coal and wood use and lung cancer risk: a pooled analysis of the International Lung Cancer Consortium. Environmental health perspectives. 2010/12/01;118(12):1743-7. Epub 2010/09/18. doi: 10.1289/ehp.1002217. PubMed PMID: 20846923; PMCID: Pmc3002194.
  5. Hosgood HD, 3rd, Purdue MP, Wang SS, Zheng T, Morton LM, Lan Q, Menashe I, Zhang Y, Cerhan JR, Grulich A, Cozen W, Yeager M, Holford TR, Vajdic CM, Davis S, Leaderer B, Kricker A, Schenk M, Zahm SH, Chatterjee N, Chanock SJ, Rothman N, Hartge P, Armstrong B. A pooled analysis of three studies evaluating genetic variation in innate immunity genes and non-Hodgkin lymphoma risk. British journal of haematology. 2011/3/01;152(6):721-6. Epub 2011/01/22. doi: 10.1111/j.1365-2141.2010.08518.x. PubMed PMID: 21250972; PMCID: Pmc3253820.
  6. Hosgood HD, 3rd, Wei H, Sapkota A, Choudhury I, Bruce N, Smith KR, Rothman N, Lan Q. Household coal use and lung cancer: systematic review and meta-analysis of case-control studies, with an emphasis on geographic variation. International journal of epidemiology. 2011/6/01;40(3):719-28. Epub 2011/02/01. doi: 10.1093/ije/dyq259. PubMed PMID: 21278196; PMCID: PMC3147068.
  7. Hosgood HD, 3rd, Wang WC, Hong YC, Wang JC, Chen K, Chang IS, Chen CJ, Lu D, Yin Z, Wu C, Zheng W, Qian B, Park JY, Kim YH, Chatterjee N, Chen Y, Chang GC, Hsiao CF, Yeager M, Tsai YH, Wei H, Kim YT, Wu W, Zhao Z, Chow WH, Zhu X, Lo YL, Sung SW, Chen KY, Yuenger J, Kim JH, Huang L, Chen YH, Gao YT, Kim JH, Huang MS, Jung TH, Caporaso N, Zhao X, Huan Z, Yu D, Kim CH, Su WC, Shu XO, Kim IS, Bassig B, Chen YM, Cha SI, Tan W, Chen H, Yang TY, Sung JS, Wang CL, Li X, Park KH, Yu CJ, Ryu JS, Xiang Y, Hutchinson A, Kim JS, Cai Q, Landi MT, Lee KM, Hung JY, Park JY, Tucker M, Lin CC, Ren Y, Perng RP, Chen CY, Jin L, Chen KC, Li YJ, Chiu YF, Tsai FY, Yang PC, Fraumeni JF, Jr., Seow A, Lin D, Zhou B, Chanock S, Hsiung CA, Rothman N, Lan Q. Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia. Human genetics. 2012/7/13;131(7):1197-203. Epub 2012/03/01. doi: 10.1007/s00439-012-1144-8. PubMed PMID: 22367405; PMCID: PMC3875137.
  8. Lan Q, Hsiung CA, Matsuo K, Hong YC, Seow A, Wang Z, Hosgood HD, 3rd, Chen K, Wang JC, Chatterjee N, Hu W, Wong MP, Zheng W, Caporaso N, Park JY, Chen CJ, Kim YH, Kim YT, Landi MT, Shen H, Lawrence C, Burdett L, Yeager M, Yuenger J, Jacobs KB, Chang IS, Mitsudomi T, Kim HN, Chang GC, Bassig BA, Tucker M, Wei F, Yin Z, Wu C, An SJ, Qian B, Lee VH, Lu D, Liu J, Jeon HS, Hsiao CF, Sung JS, Kim JH, Gao YT, Tsai YH, Jung YJ, Guo H, Hu Z, Hutchinson A, Wang WC, Klein R, Chung CC, Oh IJ, Chen KY, Berndt SI, He X, Wu W, Chang J, Zhang XC, Huang MS, Zheng H, Wang J, Zhao X, Li Y, Choi JE, Su WC, Park KH, Sung SW, Shu XO, Chen YM, Liu L, Kang CH, Hu L, Chen CH, Pao W, Kim YC, Yang TY, Xu J, Guan P, Tan W, Su J, Wang CL, Li H, Sihoe AD, Zhao Z, Chen Y, Choi YY, Hung JY, Kim JS, Yoon HI, Cai Q, Lin CC, Park IK, Xu P, Dong J, Kim C, He Q, Perng RP, Kohno T, Kweon SS, Chen CY, Vermeulen R, Wu J, Lim WY, Chen KC, Chow WH, Ji BT, Chan JK, Chu M, Li YJ, Yokota J, Li J, Chen H, Xiang YB, Yu CJ, Kunitoh H, Wu G, Jin L, Lo YL, Shiraishi K, Chen YH, Lin HC, Wu T, Wu YL, Yang PC, Zhou B, Shin MH, Fraumeni JF, Jr., Lin D, Chanock SJ, Rothman N. Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nature genetics. 2012/12/01;44(12):1330-5. Epub 2012/11/13. doi: 10.1038/ng.2456. PubMed PMID: 23143601; PMCID: Pmc4169232.
  9. Hosgood HD, 3rd, Farah C, Black CC, Schwenn M, Hock JM. Spatial and temporal distributions of lung cancer histopathology in the state of Maine. Lung cancer (Amsterdam, Netherlands). 2013/10/01;82(1):55-62. Epub 2013/08/06. doi: 10.1016/j.lungcan.2013.06.018. PubMed PMID: 23910905.
  10. Hosgood HD, 3rd, Pao W, Rothman N, Hu W, Pan YH, Kuchinsky K, Jones KD, Xu J, Vermeulen R, Simko J, Lan Q. Driver mutations among never smoking female lung cancer tissues in China identify unique EGFR and KRAS mutation pattern associated with household coal burning. Respiratory medicine. 2013/11/01;107(11):1755-62. Epub 2013/09/24. doi: 10.1016/j.rmed.2013.08.018. PubMed PMID: 24055406; PMCID: PMC3848251.
  11. Hosgood HD, 3rd, Sapkota AR, Rothman N, Rohan T, Hu W, Xu J, Vermeulen R, He X, White JR, Wu G, Wei F, Mongodin EF, Lan Q. The potential role of lung microbiota in lung cancer attributed to household coal burning exposures. Environmental and molecular mutagenesis. 2014/10/01;55(8):643-51. Epub 2014/06/05. doi: 10.1002/em.21878. PubMed PMID: 24895247; PMCID: PMC4217127.
  12. Hosgood HD, 3rd, Song M, Hsiung CA, Yin Z, Shu XO, Wang Z, Chatterjee N, Zheng W, Caporaso N, Burdette L, Yeager M, Berndt SI, Landi MT, Chen CJ, Chang GC, Hsiao CF, Tsai YH, Chien LH, Chen KY, Huang MS, Su WC, Chen YM, Chen CH, Yang TY, Wang CL, Hung JY, Lin CC, Perng RP, Chen CY, Chen KC, Li YJ, Yu CJ, Chen YS, Chen YH, Tsai FY, Kim C, Seow WJ, Bassig BA, Wu W, Guan P, He Q, Gao YT, Cai Q, Chow WH, Xiang YB, Lin D, Wu C, Wu YL, Shin MH, Hong YC, Matsuo K, Chen K, Wong MP, Lu D, Jin L, Wang JC, Seow A, Wu T, Shen H, Fraumeni JF, Jr., Yang PC, Chang IS, Zhou B, Chanock SJ, Rothman N, Lan Q. Interactions between household air pollution and GWAS-identified lung cancer susceptibility markers in the Female Lung Cancer Consortium in Asia (FLCCA). Human genetics. 2015/3/13;134(3):333-41. Epub 2015/01/08. doi: 10.1007/s00439-014-1528-z. PubMed PMID: 25566987 PMCID: PMC5537621
  13. Josyula S, Lin J, Xue X, Rothman N, Lan Q, Rohan TE, Hosgood HD, 3rd. Household air pollution and cancers other than lung: a meta-analysis. Environmental health : a global access science source. 2015/3/15;14:24. doi: 10.1186/s12940-015-0001-3. PubMed PMID: 25890249; PMCID: PMC4377187.
  14. Goedert JJ, Hosgood HD, Biggar RJ, Strickler HD, Rabkin CS. Screening for Cancer in Persons Living with HIV Infection. Trends in cancer. 2016;2(8):416-28. Epub 2016/11/29. doi: 10.1016/j.trecan.2016.06.007. PubMed PMID: 27891533. PMC5120729.
  15. Hosgood HD, Gunter MJ, Murphy N, Rohan TE, Strickler HD. The Relation of Obesity-Related Hormonal and Cytokine Levels With Multiple Myeloma and Non-Hodgkin Lymphoma. Front Oncol. 2018 Apr 16;8:103. doi: 10.3389/fonc.2018.00103. PMID: 29713614 PMCID: PMC5911620.
  16. Wang T, Hosgood HD, Lan Q, Xue X. The Relationship Between Population Attributable Fraction and Heritability in Genetic Studies. Front Genet. 2018 Oct 1;9:352. doi: 10.3389/fgene.2018.00352. eCollection 2018. PMID: 30327663 PMCID: PMC6174220.
  17. Hosgood HD, Hu W, Rothman N, Klugman M, Weinstein SJ, Virtamo J, Albanes D, Cawthon R, Lan Q. Variation in Ribosomal DNA copy number is associated with lung cancer risk in a prospective cohort study. Carcinogenesis. 2019 Mar 12. pii: bgz052. doi: 10.1093/carcin/bgz052. [Epub ahead of print]. PMID: 30859204.
  18. Hosgood HD 3rd, Mongodin EF, Wan Y, Hua X, Rothman N, Hu W, Vermeulen R, Seow WJ, Rohan T, Xu J, Li J, He J, Huang Y, Yang K, Wu G, Wei F, Shi J, Sapkota AR, Lan Q. The Respiratory Tract Microbiome and Its Relationship to Lung Cancer and Environmental Exposures Found in Rural China. Environ Mol Mutagen. 2019 Apr 3. doi: 10.1002/em.22291. [Epub ahead of print] PMID: 30942501.
  19. Cheng H*, Hosgood HD*, Deng L, Ye K, Su C, Sharma J, Yang Y, Halmos B, Perez-Soler R. Survival Disparities in Black Patients With EGFR-mutated Non-small-cell Lung Cancer. Clin Lung Cancer. 2019 Jul 17. pii: S1525-7304(19)30207-4. doi: 10.1016/j.cllc.2019.07.003. [Epub ahead of print]. PMID: 31420240. *co-first authors.
  20. Klugman M, Xue X, Hosgood HD 3rd. Race/ethnicity and lung cancer survival in the United States: a meta-analysis. Cancer Causes Control. 2019 Sep 14. doi: 10.1007/s10552-019-01229-4. [Epub ahead of print]. PMID: 31522320