Heart Failure

Cardiac Transplantation

Mechanical Circulatory Support

Hemolysis

Education and Training

College: University of California, Berkeley

Medical School: New York Medical College

Residency: Emory University Hospital

Fellowships: Emory University Hospital, Montefiore Medical Center/Albert Einstein College of Medicine

Grant Support

Hemolysis and Platelet Activation during Continuous Flow Mechanical Circulatory Support (NIH/NHLBI K23HL145140, PI: Saeed)

Jan 2019-Dec 2023

1. Saeed O, Jakobleff WA, Forest SJ, Chinnadurai T, Mellas N, Rangasamy S, Xia Y, Madan S, Acharya P, Algodi M, Patel SR, Shin J, Vukelic S, Sims DS, Reyes Gil M, Billett HH, Kizer JR, Goldstein DJ, Jorde UP. Hemolysis and Non Hemorrhagic Stroke during Venoarterial Extracorporeal Membrane Oxygenation. The Annals of Thoracic Surgery, 2019.

2. Acharya P, Jakobleff WA, Forest SJ, Chinnaduria T, Mellas N, Patel SR, Kizer JR, Billett HH, Goldstein DJ, Jorde UP, Saeed O. Fibrinogen Albumin Ratio and Ischemic Stroke during Venoarterial Extracorporeal Membrane Oxygenation. ASAIO J. 2019.

3. Jorde UP, Shah A, Sims D, Madan S, Siddiqi N, Luke A, Saeed O, Patel SR, Murthy S, Shin J, Oviedo J, Watts S, Jakobleff WA, Forest SJ, Vukelic S, Belov D, Puius Y, Minamoto G, Muggia V, Carlese A, Leung S, Rahmaniam M, Leff J, Goldstein D. Continuous-Flow Left Ventricular Asssit Device Survival Improves with Multidisciplinary Approah. The Annals of Thoracic Surgery, 2019.

4. Saeed O, Jorde U. Impact and Measurement of Blood Pressure during Continuous Flow Left Ventricular Assist Device Support: The Pressure is On! ASAIO J. 2019.

5. Madan S, Patel SR, Saeed O, Sims DB, Shin JJ, Goldstein DJ, Jorde UP. Outcomes of heart transplantation in patients with human immunodeficiency virus. Am J Transplant. 2019

6. Saeed O, Patel SR, Jorde UP. Bleeding and Angiogenesis during Continuous Flow Left Ventricular Assist Device (CF LVAD) support - Enter the Von Willebrand Matrix. Circulation Heart Failure. 2018.

7. Farooqi KM, Cooper C, Chelliah A, Saeed O, Chai PJ, Jambawalikar SR, Lipson H, Bacha EA, Einstein AJ, Jorde UP.  3D Printing and Heart failure: The Present and the Future. JACC Heart Fail. 2018 Dec 10.

8. Patel SR, Madan S, Saeed O, Sims DB, Shin JJ, Nucci C, Borukhov E, Goldstein DY, Jakobleff W, Forest S, Vukelic S, Murthy S, Reinus J, Puius Y, Goldstein DJ, Jorde UP. Cardiac transplantation from non-viremic hepatitis C donors. J Heart Lung Transplant. 2018.

9. Vukelic S, Vlismas P, Patel SR, Xue X, Shitole S, Saeed O, Sims DS, Chinnadurai T, Shin J, Forset S, Goldstein DJ, Jorde UP. Digoxin is Associated with Decreased Incidence of Angiodysplasia-related Gastrointestinal Bleeding in Patients with Continuous-Flow Left Ventricular Assist Devices. Circulation Heart Failure. 2018.

10. Saeed O, Rangasamy S, Reyes Gil M, Goldstein DJ, Billett HH, Jorde UP, Patel SR.  Speed Reduction Does Not Restore High Molecular Weight Multimers of von Willebrand Factor during HeartMate II Support: An In-Vivo Study. ASAIO J. Sep-Oct 2018.

11. Rangasamy S, Madan S, Saeed O, Goldstein DJ, Jorde UP, Negassa A, Patel SR. Noninvasive Measures of Pulsatility and Blood Pressure During Continuous-Flow Left Ventricular Assist Device. ASAIO J. 2018

12. Saeed O, Rangasamy S, Selevany I, MadanS, Fertel J, Eisenberg R, Aljoudi M, Patel SR, Shin JJ, Sims DB, Reyes Gil M, Goldstein DJ, Slepian MJ, Billett HH, Jorde UP. Sildenafil is Associated with Reduced Device Thrombosis and Ischemic Stroke Despite Low Level Hemolysis on Heart Mate II support. Circulation Heart Failure. 2017.

13. Patel SR, Saeed O, Naftel D, Myers S, Kirklin J, Jorde UP, Goldstein DJ. Outcomes of Restrictive and Hypertrophic cardiomyopathies after LVAD: as INTERMACS Analysis. J Card Fail. 2017 Sep 29. pii: S1071-9164(17)31220-4.

14. Madan S, Saeed O, Vlismas P, Katsa I, Patel SR, Shin JJ, Jakobleff WA, Goldstein DJ, Sims DB,Jorde UP. Outcomes After Transplantation of Donor Hearts With Improving Left Ventricular Systolic Dysfunction. J Am Coll Cardiol. 2017 Sep 5;70(10):1248-1258. 

15. Madan S, Patel SR, Vlismas P, Saeed O, Murthy S, Forest S, Jakobleff W, Sims D, Lamour JM, Hsu DT, Shin J, Goldstein D, Jorde UP. Outcomes of Early Adolescent Donor Hearts in Adult Transplant Recipients. JACC Heart Fail. 2017. S2213-1779(17)30320-7.

16. Patel SR, Oh KT, Ogriki T, Sims D, Shin JJ, Madan S, Saeed O, Goldstein DJ, Jorde UP.  Cessation of Continuous Flow Left Ventricular Assist Device-Related Gastrointestinal Bleeding After Heart Transplantation. ASAIO J. 2017.

17. Madan S, Sims D, Saeed O, Patel SR, Shin JJ, Jorde UP. Association of centre volume and in-hospital mortality in heart failure hospitalisations. Postgrad Med J. 2017.

18. Saeed O., Jorde U. Advances in Continuous Flow Left Ventricular Assist Device Support for End Stage Heart Failure - A Therapy in Evolution.  Cardiology in Review 2016.

19. Jermyn R., Alam A., Kvasic J., Saeed O., Jorde U. Hemodynamic-guided heart-failure management using a wireless implantable sensor: Infrastructure, methods, and results in a community heart failure disease-management program. Clinical Cardiology. 2016 Nov.

20. Patel S.R., Madan S., Saeed O., Algodi M., Luke A., Gibber M., Goldstein D.J., Jorde U.P. Association of Nasal Mucosal Vascular Alterations, Gastrointestinal Arteriovenous Malformations, and Bleeding in Patients With Continuous Flow Left Ventricular Assist Devices. JACC Heart Failure. 2016 Sep 29. pii: S2213-1779(16)30444-9.

21. Madan S., Saeed O., Shin J., Sims D., Goldstein D., Pina I., Jorde U., Patel S. Donor Troponin and Survival after Cardiac Transplantation – An Analysis of the UNOS Registry. Circ Heart Failure. 2016; Jun;9(6).

22. Levin A., Saeed O., Willey, J., Levin C., Fried J., Patel S., Sims D., Nguyen J., Shin J., Topkara V., Colombo P., Goldstein DJ., Yoshifumi N., Takayama H., Uriel N, Jorde U.  Watchful Waiting in CF-LVAD Patients with Ongoing Hemolysis is Associated with an Increased Risk for Cerebrovascular Accidents and Death.  Circ Heart Failure. 2016 May;9(5).

23. Farooqi K., Saeed O., Zaidi A., Sanz J., Nielsen J., Hsu D., Jorde U. 3D Printing to Guide Ventricular Assist Device placement in Adults with Congenital Heart Disease and Heart Failure. JACC Heart Failure. 2016;4: 301-11.

24. Saeed O., Shah A., Kargoli F., Madan S., Levin AP., Patel SR., Jermyn R., Guerrero C., Nguyen J., Sims DB., Shin J., Goldstein D., Jorde U. Antiplatelet Therapy and Adverse Hematologic Events During Heart Mate II Support. Circ Heart Failure. 2016; 9 (1):e002296.

25. Saeed O, Jermyn R, Kargoli F., Madan S., Mannem S, Cecilia N, Hassan S., Farooqui S, Bloom M, Mclarty A, Zolty R, Shin J, D’Alessandro D, Goldstein D, Patel S.  Blood pressure and adverse events during continuous flow left ventricular assist device support.  Circ Heart Failure. 2015; 8(3):551-6.

26. Habib A, Polavarapu R., Karmali V., Guo L., Van Dam R., Cheng A,. Akahori H., Saeed O., Mastaka N., Pachura K., Hong C., Shin E., Kolodgie F., Virmani, Finn AV. The Hepcidin-Ferroportin1 Axis Controls Toll-Like Receptor 4-Dependent Macrophage Inflammatory Responses in Human Atherosclerotic Plaques. Atherosclerosis. 2015; 241(2) 692-700.

27. Saeed O., Gupta A., Gross J, Palma E.  Rate of Cardiovascular Implanted Electronic Device (CIED) re-extraction after recurrent infection. Pacing and Cardiac Electrophysiology. 2014; 37(8): 963-8.

28. Galvao M., Saeed O., Immekus J., Goldstein D., Maybaum S. An International Survey to assess Referral Thresholds for Left Ventricular Assist Device Destination Therapy in Non-Inotrope Dependent patients: Results of the Consensus DT study.  Journal of Cardiac Failure. 2014; 20(7):492-7.

29. Saeed O., Maybaum S., D’Alessandro D., Goldstein D. Patel SR.  Aortic Valve Opening and Thrombotic Events with Continuous Flow Left Ventricular Assist Devices. J Heart Lung Transplant. 2014; 33(1):109-12.

30. Patel SR., Saeed O., Murthy S., Bhatia V., Shin JJ., Wang D., Negassa A., Pullman J., Goldstein D., Maybaum S. Combining Neurohormonal Blockade with Continuous Flow Left Ventricular Assist Device (CF-LVAD) Support for Myocardial Recovery - A Single Arm Prospective Study. J Heart Lung Transplant. 2013; 32(3): 305-12.

31. Saeed O., Bhatia V., Formica P., Browne A., Aldrich TK., Shin JJ., Maybaum S.  Improved exercise performance and skeletal muscle strength after simulated altitude exposure: A novel approach for patients with chronic heart failure. J Card Fail. 2012; 18(5):387-91.

32. Finn AV, Saeed O, Virmani R. Macrophage subsets in human atherosclerosis. Circulation Research. 2012; 110(9):e64.

33. Saeed O., Otsuka F., Polavarapu R., Karmali V., Weiss D., Davis T., Rostad B.,  Pachura K., Adams L., Elliot J., Taylor RW., Narula J., Hong C., Kolodgie F., Virmani R., Finn AV. Pharmacologic suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis. Arterioscler Thromb Vasc Biol. 2012; 32: 299-307.

34. Finn AV., Nakano M., Polavarapu R., Karmali V., Saeed O.,Zhao X., Yazdani S., Davis T., Habib A., Narula J., Kolodgie F, Virmani R. Hemoglobin directs macrophage differentiation and determines lipid uptake human atherosclerotic plaques. J Am Coll Cardiol. 2012; 59(2): 166-177.

35. Wei C., Li L., Torben B., Saeed O., Thabet S., Jansen T., Dikalov S., Weyand C.,Goronzy J., Harrison DG. The role of increased GTP cyclohydrolase-1 expression and tetrahydrobiopterin levels upon T cell activation. J Biol Chem. 2011; 286(16): 13846-51. 

36. Saeed O., Yaghmaie F., Garan SA., Gouw A., Voelker M., Freitag W., Sternberg H., Timiras PS. Insulin like Growth Factor -1 immunoreactive cells are selectively maintained in the paraventricular hypothalamus of calorically restricted mice Intl. J. Dev. Neuroscience. 2007; 25(1):23-8.

37. Yaghmaie F., Saeed O.,Garan S.A., Gouw A., Voelker M., Freitag W., Sternberg H.,  Timiras PS. Age dependent loss of Insulin like Growth Factor -1 immunoreactive cells in the supraoptic hypothalamus is reduced in calorically restricted mice. Intl. J. Dev. Neuroscience. 2006; 24(7):431-6.