Dr. Jacob Hascalovici, AKA "Dr. Jacob" earned his medical degree from Technion American Medical School in Haifa, Israel, while concurrently completing a doctorate in Neuroscience at McGill University in Montreal, Canada. He also holds a Bachelor of Arts degree in Biology and Computational Biology from Yeshiva University. Dr. Jacob is the co-founder and Chief Medical Officer at Clearing, a first-of-kind comprehensive digital healthcare platform for chronic pain suffers. Prior to co-founding Clearing, Dr. Jacob was a full-time attending Pain Neurologist at the Multidisciplinary Pain Center at Montefiore Medical Center, Bronx, NY. Dr. Jacob completed his Adult Neurology residency and Interventional Pain Medicine fellowship at Albert Einstein College of Medicine/Montefiore Medical Center. He is a diplomat of the American Board of Psychiatry and Neurology in both Adult Neurology and Pain Medicine and is a Clinical Assistant Professor of Neurology, Physical Medicine & Rehabilitation and Anesthesiology at Albert Einstein College of Medicine. Dr. Jacob’s interests include digital health care and telemedicine, craniofacial, musculoskeletal and geriatric pain management. He has authored more than 20 peer reviewed original research articles and book chapters, is a member of multiple pain societies and is involved in multiple ongoing clinical trials in pain management. 

1. Impact of heme oxygenase-1 on cholesterol synthesis, cholesterol efflux and oxysterol formation in cultured astroglia 

Jacob R. Hascalovici, Wei Song, Jacob Vaya, Soliman Khatib, Bianca Fuhrman, Michael Aviram and Hyman M. Schipper (2009) Journal of Neurochemistry 108, 72-81.

2. Heme Oxygenase-1 and Neurodegeneration: Expanding Frontiers of Engagement

Hyman M. Schipper, Wei Song, Hillel Zukor, Jacob R. Hascalovici, David Zeligman (2009) Journal of Neurochemisty 110, 469-485.

3. Brain sterol dys-regulation in sporadic AD and MCI: Relationship to heme oxygenase-1

Jacob R. Hascalovici, Jacob Vaya, Soliman Khatib, Christina Holcroft, Hillel  Zukor, Wei Song, Zoe Arvanitakis, David A. Bennett and Hyman M. Schipper (2009) Journal of Neurochemistry 110, 1241-1253.

4. Schizophrenia-Like Features in Transgenic Mice Overexpressing Human HO-1 in the Astrocytic compartment 

Wei Song, Hillel Zukor, Shih-Hsiung Lin, Jacob R. Hascalovici, Adrienne Liberman, Ayda Tavitian, Jeannie Mui, Hojatollah Vali, Xin-Kang Tong, Sanjeev K. Bhardwaj, Lalit K.

Srivastava, Edith Hamel, and HymanM. Schipper (2012) Journal of Neuroscience 32, 1084110853.

5. Neural HO-1/sterol interactions in vivo: Implications for Alzheimer’s disease   

Jacob R. Hascalovici, Wei Song, Adrienne Liberman, Jacob Vaya, Soliman Khatib, Christina Holcroft, Frank Laferla and Hyman M. Schipper (2014) Neuroscience 280C,40-49.

6. Heme Oxygenase-1: Transducer of Sterol Dys-Regulation in Alzheimer Disease 

Jacob R. Hascalovici, and Hyman M. Schipper (2014) J Glycomics, Lipidomics 4(4); Open Access

7. Teaching Images in Headache: Convexity Subarachnoid Hemorrhage in an Octogenarian Jacob R. Hascalovici, Mellanie Springer, Matthew Robbins (2015) Headache: The Journal of Head and Face Pain, 56(5):895-896

8.  Diffuse symmetric cerebral calcifications: an emerging clinical pivot

Jacob R. Hascalovici and Constantine Farmakidis (2016) Canadian Journal of Neurological Sciences, 44(2):190-191

9. Peripheral nerve blocks for the treatment of headache in older adults: a retrospective study

Jacob R. Hascalovici, Matthew Robbins (2017) Headache: The Journal of Head and Face Pain, 57(1):80-86

10. Emerging Subspecialty in Neurology: Pain Medicine

Nathaniel Schuster, Jacob R. Hascalovici (2018) Neurology, 91(22): 1025-1028

11. A retrospective case series of a novel spinal cord stimulator trial technique with less displacement and migration of the trial leads

Naum Shaparin, Karina Gritsenko, Priya Agrawal, Soo Yeon Kim, Sayed Wahezi, Andrew Gitkind, Jacob R, Hascalovici, Amaresh Vydyanathan, Jeffrey Bernstein, Anis Dizdarevic, Neel Mehta and Andrew Kaufman (2019) Pain Research and Management

12. Needle-through-needle technique in lumbar interlaminar epidural steroid injection: a case report

Linda Zhang, Jacob R, Hascalovici, Naum Shaparin (2020) Pain Practice doi: 10.1111/papr.12897

13. Suspected Status Migrainosus During Flu Season

Aleksandr Isakov, Naum Shaparin and Jacob R. Hascalovici (2020); Ann Headache Med J. 2020. doi:10.30756/ahmj.2020.02.04

14. Clinical Images in Pain Medicine: Soft tissue infection after lumbar epidural steroid injection

Aleksandr Isakov, Naum Shaparin and Jacob R. Hascalovici (2020) Pain Medicine  Volume 21, Issue 10, 2020, Pages 2593–2594

15. The other side of the COVID-19 curve: a model for the safe reintegration of elective interventional pain procedures

Jacob Hascalovici MD, PhD, Naum Shaparin MD MBA (2020) Pain Physician Aug;23(4S):S449-S451

16. Chronic axial lower back pain: the therapeutic benefit of diagnostic lumbar medial branch blocks 

Michelle Yoo, Singh Nair, Ryung Kim, Naum Shaparin and Jacob R. Hascalovici, (2020) in press

17. Developing patient educational material to help patients navigate the NYS medical marijuana program

Ashley Wong DO, Naum Shaparin MD MBA, Jacob Hascalovici MD PhD (2020) Practical Pain Management Link

18. Spondylolesthesis: A rare case of cauda equina syndrome in the midst of a pandemic

Aleksandr Isakov MD, Vijay Yanamadala MD MBA, Reza Yassari MD, Adaobi Udemba NP, Naum Shaparin MD MBA, Jacob R. Hascalovici MD PhD (2021) JBJS Case Connector, in press

19. Expanding frontiers in telehealth: Video assisted at-home application of capsaicin 8% patch.

Naum Shaparin MD MBA, Singh Nair MD, Amaresh Vydyanathan MD, Jacob Hascalovici MD, PhD (2021) Eur J Pain.