Most relevant publications:
Soldner, F. & Jaenisch, R. Stem Cells, Genome Editing, and the Path to Translational Medicine. Cell, 175, 615-632 (2018)
Soldner, F., Stelzer, Y., Shivalila, C. S., Abraham, B. J., Latourelle, J. C., Barrasa, M. I., Goldmann, J., Myers, R. H., Young, R. A. & Jaenisch, R. Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression. Nature 533, 95–99 (2016).
Soldner, F., Laganière, J., Cheng, A. W., Hockemeyer, D., Gao, Q., Alagappan, R., Khurana, V., Golbe, L. I., Myers, R. H., Lindquist, S., Zhang, L., Guschin, D., Fong, L. K., Vu, B. J., Meng, X., Urnov, F. D., Rebar, E. J., Gregory, P. D., Zhang, H. S. & Jaenisch, R. Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations. Cell 146, 318–331 (2011).
Soldner, F.*, Hockemeyer, D.*, Beard, C., Gao, Q., Bell, G. W., Cook, E. G., Hargus, G., Blak, A., Cooper, O., Mitalipova, M., Isacson, O. & Jaenisch, R. Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell 136, 964–977 (2009).
Hockemeyer, D.*, Soldner, F.*, Beard, C., Gao, Q., Mitalipova, M., Dekelver, R. C., Katibah, G. E., Amora, R., Boydston, E. A., Zeitler, B., Meng, X., Miller, J. C., Zhang, L., Rebar, E. J., Gregory, P. D., Urnov, F. D. & Jaenisch, R. Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat Biotechnol 27, 851–857 (2009).
Hockemeyer, D.*, Soldner, F.*, Cook, E. G., Gao, Q., Mitalipova, M. & Jaenisch, R. A drug-inducible system for direct reprogramming of human somatic cells to pluripotency. Cell Stem Cell 3, 346–353 (2008).
(* Equally contributing authors)
Additional publications:
Fanning, S., Haque, A., Imberdis, T., Baru, V., Barrasa, M. I., Nuber, S., Termine, D., Ramalingam, N., Ho, G. P. H., Noble, T., Sandoe, J., Lou, Y., Landgraf, D., Freyzon, Y., Newby, G., Soldner, F., Terry-Kantor, E., Kim, T. E., Hofbauer, H. F., Becuwe, M., Jaenisch, R., Pincus, D., Clish, C. B., Walther, T. C., Farese, R. V. Jr., Srinivasan, S., Welte, M. A., Kohlwein, S. D., Dettmer, U., Lindquist, S., Selkoe, D. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson. Mol Cell 73, 1001-1014 (2019)
Oh, C.-K., Sultan, A., Platzer, J., Dolatabadi, N., Soldner, F., McClatchy, D. B., Diedrich J.K., Yates J.R. 3rd, Ambasudhan R., Nakamura T., Jaenisch R., Lipton S.A. S-Nitrosylation of PINK1 Attenuates PINK1/Parkin- Dependent Mitophagy in hiPSC-Based Parkinson’s Disease Models. Cell Reports 21(8), 2171–2182. (2017)
Brennand, K. J., Marchetto, M. C., Benvenisty, N., Brüstle, O., Ebert, A., Izpisúa Belmonte, J. C., Kaykas, A., Lancaster, M. A., Livesey, F. J., McConnell, M. J., McKay, R. D., Morrow, E. M., Muotri, A. R., Panchision, D. M., Rubin, L. L., Sawa, A., Soldner, F., Song, H., Studer, L., Temple, S., Vaccarino, F. M., Wu, J., Vanderhaeghen, P., Gage, F. H. & Jaenisch, R. Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Stem Cell Reports 5, 933–945 (2015).
Stelzer Y., Shivalila C.S., Soldner F., Markoulaki S. & Jaenisch R. Tracing dynamic changes of DNA methylation at single-cell resolution. Cell 163, 218-29 (2015).
Dettmer U., Newman A.J., Soldner F., Luth E.S., Kim N.C., von Saucken V.E., Sanderson J.B., Jaenisch R., Bartels T. & Selkoe D. Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun, 7314 (2015).
Soldner F. & Jaenisch R. Dissecting risk haplotypes in sporadic Alzheimer's disease. Cell Stem Cell 16, 341-2 (2015)
Flierl A., Oliveira L.M., Falomir-Lockhart L.J., Mak S.K., Hesley J., Soldner F., Arndt-Jovin D.J., Jaenisch R., Langston J.W., Jovin T.M. & Schüle B. Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication. PLoS One 9, e112413 (2014).
Ryan, S. D., Dolatabadi, N., Chan, S. F., Zhang, X., Akhtar, M. W., Parker, J., Soldner, F., Sunico, C. R., Nagar, S., Talantova, M., Lee, B., Lopez, K., Nutter, A., Shan, B., Molokanova, E., Zhang, Y., Han, X., Nakamura, T., Masliah, E., Yates, J. R., III, Nakanishi, N., Andreyev, A. Y., Okamoto, S.-I., Jaenisch, R., Ambasudhan, R. & Lipton, S. A. Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-InducedDysfunction in MEF2-PGC1a Transcription. Cell 155, 1351–1364 (2013).
Chung, C. Y., Khurana, V., Auluck, P. K., Tardiff, D. F., Mazzulli, J. R., Soldner, F., Baru, V., Lou, Y., Freyzon, Y., Cho, S., Mungenast, A. E., Muffat, J., Mitalipova, M., Pluth, M. D., Jui, N. T., Schüle, B., Lippard, S. J., Tsai, L.-H., Krainc, D., Buchwald, S. L., Jaenisch, R. & Lindquist, S. Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science 342, 983–987 (2013).
Torikai H., Reik A., Soldner F., Warren E.H., Yuen C., Zhou Y., Crossland D.L., Huls H., Littman N., Zhang Z., Tykodi S.S., Kebriaei P., Lee D.A., Miller J.C., Rebar E.J., Holmes M.C., Jaenisch R., Champlin R.E., Gregory P.D. & Cooper L.J. Toward eliminating HLA class I expression to generate universal cells from allogeneic donors. Blood 122, 1341-9 (2013).
Soldner, F. & Jaenisch, R. Medicine. iPSC disease modeling. Science 338, 1155–1156 (2012).
Major, T., Menon, J., Auyeung, G., Soldner, F., Hockemeyer, D., Jaenisch, R. & Tabar, V. Transgene Excision Has No Impact on In Vivo Integration of Human iPS Derived Neural Precursors. PLoS ONE 6, e24687 (2011).
Hargus, G., Cooper, O., Deleidi, M., Levy, A., Lee, K., Marlow, E., Yow, A., Soldner, F., Hockemeyer, D., Hallett, P. J., Osborn, T., Jaenisch, R. & Isacson, O. Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proceedings of the National Academy of Sciences 107, 15921–15926 (2010).
Guenther, M. G., Frampton, G. M., Soldner, F., Hockemeyer, D., Mitalipova, M., Jaenisch, R. & Young, R. A. Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell 7, 249–257 (2010).
Hanna, J., Cheng, A. W., Saha, K., Kim, J., Lengner, C. J., Soldner, F., Cassady, J. P., Muffat, J., Carey, B. W. & Jaenisch, R. Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proceedings of the National Academy of Sciences 107, 9222–9227 (2010).
Wernig, M., Zhao, J.-P., Pruszak, J., Hedlund, E., Fu, D., Soldner, F., Broccoli, V., Constantine-Paton, M., Isacson, O. & Jaenisch, R. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proceedings of the National Academy of Sciences 105, 5856–5861 (2008).
Leker, R. R., Soldner, F., Velasco, I., Gavin, D. K., Androutsellis-Theotokis, A. & McKay, R. D. G. Long-lasting regeneration after ischemia in the cerebral cortex. Stroke 38, 153–161 (2007).
Androutsellis-Theotokis, A., Leker, R. R., Soldner, F., Hoeppner, D. J., Ravin, R., Poser, S. W., Rueger, M. A., Bae, S.-K., Kittappa, R. & McKay, R. D. G. Notch signalling regulates stem cell numbers in vitro and in vivo. Nature 442, 823–826 (2006).
Seyfried, J., Soldner, F., Kunz, W. S., Schulz, J. B., Klockgether, T., Kovar, K. A. & Wullner, U. Effect of 1-methyl-4-phenylpyridinium on glutathione in rat pheochromocytoma PC 12 cells. Neurochem Int. 36, 489–497 (2000).
Soldner, F., Weller, M., Haid, S., Beinroth, S., Miller, S. W., Wullner, U., Davis, R. E., Dichgans, J., Klockgether, T. & Schulz, J. B. MPP+ inhibits proliferation of PC12 cells by a p21(WAF1/Cip1)-dependent pathway and induces cell death in cells lacking p21(WAF1/Cip1). Exp Cell Res 250, 75–85 (1999).
Seyfried, J., Soldner, F., Schulz, J. B., Klockgether, T., Kovar, K. A. & Wullner, U. Differential effects of L-buthionine sulfoximine and ethacrynic acid on glutathione levels and mitochondrial function in PC12 cells. Neurosci Lett 264, 1–4 (1999).