Original Communications (selected)
Milman S, Atzmon G, Huffman DM, Wan J, Crandall JP, Cohen P and Barzilai N. Low Insulin-like Growth Factor-1 Level Predicts Survival in Humans with Exceptional Longevity. Aging Cell 2014 Aug;13(4):769-71 PMC4116456
Huffman DM, Farias-Quipildor G, Mao K, Zhang X, Wan J, Apontes P, Cohen P, Barzilai N. Central IGF-1 Restores Whole-Body Insulin Action in a Model of Age-Related Insulin Resistance and IGF-1 Decline Aging Cell. 2016 Feb;15(1):181-86. PMC4717281
Cobb LJ, Lee C, Xiao J, Yen K, Wong RG, Nakamura HK, Mehta HH, Gao Q, Ashur C, Huffman DM, Wan J, Muzumdar RH, Barzilai N, Cohen P. Naturally-occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers Aging 2016 Apr;8(4):796-809 PMC4925829
Tabrizian, T, Wang D, Guan F, Hu Z, Beck A, Delahaye F, Huffman DM. Apc inactivation, but not obesity, synergizes with Pten deficiency to drive intestinal stem cell-derived tumorigenesis. Endocr Relat Cancer 2017 Mar 28 PMC5505256
Burgos ES, Walters RO, Huffman DM, Shechter D. A simplified characterization of S-adenosyl-L-methionine-consuming enzymes with 1-Step EZ-MTase: a universal and straightforward coupled-assay for in vitro and in vivo setting. Chem Sci 2017 8, 6601-6612 PMC5676521
Hudgins AD, Tazearslan C, Tare A, Zhu Y, Huffman DM, Suh Y. Age- and tissue-specific expression of senescence biomarkers in mice. Front Genet 2018 Feb 23;9:59 PMC5829053
Andrew MS*, Huffman DM, Rodriguez-Ayala E, Kent JW, Nava-Gonzalez EJ, Jorge B, Williams NN, Lavianda-Molina HA, Peterson RM, Bastarrachea RA. Removal of Mesenteric Visceral Fat Reverses Insulin Resistance in Baboons. Surg Obes Relat Dis 2018 Mar 9. pii: S1550-7289(18)30127-8. PMC6391994
Mao K, Farias Quipildor G, Tabrizian T, Guan F, Walters RO, Delahaye F, Hubbard GB, Ikeno Y, Ejima K, Li P, Allison DB, Beltran P, Cohen P, Barzilai N, Huffman DM. Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nat Commun 2018 Jun 19;9(1):2394. PMC6008442
Guan F, Tabrizian T, Novaj A, Nakanishi M, Rosenberg DW, Huffman DM. Dietary walnuts protect against obesity-driven intestinal stem cell decline and tumorigenesis Front Nutr 2018 May 31;5:37. PMC5990619
Choi J, Rakhilin N, Gadamsetty P, Joe DJ, Lipkin SM, Tabrizian T, Huffman DM, Shen X, Nishimura N. Rapid recovery of crypt patterns after focal damage requires coordinated cell motion instead of proliferation and is impaired by aging. Sci Rep 2018 Jul 20;8(1):10989. PMC6054609
Walters RO, Arias E, Diaz A, Burgos ES, Guan F, Tiano S, Mao K, Green CL, Qiu Y, Shah H, Wang D, Hudgins AD, Tabrizian T, Tosti V, Shechter D, Fontana L, Kurland IJ, Barzilai N, Cuervo AM, Promislow DEL, Huffman DM. Sarcosine is uniquely modulated by aging and dietary restriction in rodents and humans Cell Rep 2018 Oct 16;25(3):663-676.e6. PMC6280974
Farias-Quipildor G, Mao K, Hu Z, Novaj A, Cui MH, Gulinello M, Branch CA, Gubbi S, Patel K, Moellering DR, Tarantini S, Kiss T, Yabluchanskiy A, Ungvari Z, Sonntag WE, Huffman DM. Central IGF-1 reduces depressive-like behavior and improves cognitive and physical performance with aging preferentially in male mice Geroscience 2019 May 10 PMC6544744
Morrison EJ, Champagne DP, Dzieciatkowska M, Nemkov T, Zimring JC, Hansen KC, Guan F, Huffman DM, Santambrogio L, D'Alessandro A. Parabiosis Incompletely Reverses Aging-Induced Metabolic Changes and Oxidant Stress in Mouse Red Blood Cells. Nutrients. 2019 Jun 14;11(6). pii: E1337. PMC6627295
Book Chapters, Reviews and Editorials
Huffman DM and Barzilai N. Animal Models of Visceral Obesity. Book Chapter from Abdominal Obesity and the Endocannabinoid System: From Basic Aspects to Clinical Management of Related Cardiometabolic Risk. Editor: Jean-Pierre Despres, PhD. Informa Healthcare.
Barzilai N, Huffman DM, Cohen P and Muzumdar RH. The role of IGF-1 and its partners in central and peripheral metabolism: Considerations for extending healthy lifespan. Book Chapter from Research and Perspectives in Endocrine Interactions: IGFs: Local Repair and Survival Factors Throughout the Life Span. Springer Publishing.
Huffman DM and Barzilai N. Contribution of Adipose Tissue to Health-Span and Longevity. Book Chapter from Body Composition and Aging. Editor: Charles Mobbs, PhD, Karger Publishing. Interdiscip Top Gerontol. 2010;37:1-19.
Huffman DM. Exercise as a Calorie Restriction Mimetic: Implications for Improving Healthy Aging and Longevity. Book Chapter from Body Composition and Aging. Editor: Charles Mobbs, PhD, Karger Publishing. Interdiscip Top Gerontol. 2010;37:157-174.
Huffman DM and Barzilai N. Role of visceral adipose tissue in aging. (Invited review) Biochemical and Molecular Mechanisms of Aging: from Model Systems to Human Longevity. Biochemica et Biophysica Acta 2009 Oct; 1790(10):1117-23. PMCID: PMC2779572
Huffman DM and Calvert JW. Exercise to the rescue. J Physiol 2011 589(24): 5919-5920. PMC3286671
Barzilai N, Huffman DM, Muzumdar RH, and Bartke A. Perspectives in Diabetes: The Critical Role of Metabolic Pathways in Aging. Diabetes 2012 61(6): 1315-22. PMCID: PMC3357299
Huffman DM. Editorial Comment to Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells: Making sense of SIRT1 and prostate cancer. Int J Urol 2012 19(1) 79-80.
Denis GV, Huffman DM, and LeBrasseur NK. The Biology of Aging: Role in Cancer, Metabolic Dysfunction and Health Disparities. Book Chapter from Energy Balance and Cancer. Editors: Deborah J. Bowen, Gerald V. Denis, Nathan A. Berger. Springer 2014
Chusyd DE, Wang D, Huffman DM, Nagy TR. Relationships between rodent white adipose fat pads and human white adipose fat depots Front Nutr 2016 Apr 19;3:10 PMC4835715
Huffman DM, Schafer MJ, LeBrasseur NK. Energetic interventions for healthspan and resiliency with aging. Exp Gerontol 2016 May 31 PMC5133182
Milman S, Huffman DM, Barzilai N. The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research. Cell Metab 2016 Jun 14;23(6):980-9 PMCID: PMC4919980
Huffman DM, Justice J, Stout MB, Kirkland JL, Barzilai N, Austad SN. Evaluating Healthspan in Pre-Clinical Models of Aging and Disease: Guidelines, Challenges and Opportunities for Geroscience.Â Gerontol A Biol Sci Med Sci 2016 Aug 16 PMC5055649
Gubbi S, Farias Quipildor G, Barzilai N, Huffman DM, Milman S. IGF-1: The Jekyll & Hyde of the aging brain. 2018 J Mol Endocrinol 2018 Jul;61(1):T171-T185. PMC5988994
Gandy S, Huffman DM. Unexpected systemic phenotypes result from focal combined deficiencies of forebrain insulin receptor/IGF-1 receptor signaling. Proc Natl Acad Sci 2019 Mar 11. PMC6442574