Nuria Martinez-Lopez

Nuria Martinez-Lopez, Ph.D.

  • Research Assistant Professor, Department of Radiation Oncology

Email

Phone

Location

  • Albert Einstein College of Medicine Jack and Pearl Resnick Campus 1300 Morris Park Avenue Ullmann Building 305 Bronx, NY 10461

Research Profiles

Research Profiles

Research Profiles

Selected Publications

  1. Martínez-Chantar, ML., Vázquez-Chantada, M., Ariz, U., Martinez N., Varela, M., Luka, Z., Capdevila, A., Rodríguez, J., Aransay, AM., Matthiesen, R., Yang, H., Calvisi, DF., Esteller, M., Fraga, M., Lu, SC., Wagner, C., Mato, JM. Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology. 2008;47(4):1191-9. PMID: 18318442, PMCID: PMC2405897
  2. Martinez-Lopez, N., Varela-Rey, M., Ariz, U., Embade, N., Vazquez-Chantada, M., Fernandez-Ramos, D., Gomez-Santos, L., Lu, SC., Mato, JM., Martinez-Chantar, ML. S-adenosylmethionine and proliferation: New pathways, new targets. Biochemical Society Transactions. 2008;36 (5):848-52. PMID: 18793149
  3. Vázquez-Chantada, M., Ariz, U., Varela-Rey, M., Embade, N., Martinez-Lopez, N., Fernández-Ramos, D., Gómez-Santos, L., Lamas, S., Lu, SC., Martínez-Chantar, ML., Mato, JM. Evidence for LKB1/AMP-activated protein kinase/endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation. Hepatology. 2009;49(2):608-17. PMID: 19177591, PMCID: PMC2635424
  4. Varela-Rey, M., Fernández-Ramos, D., Martinez-Lopez, N., Embade, N., Gómez-Santos, L., Vázquez-Chantada, M., Rodríguez, J., Luka, Z., Wagner, C., Lu, SC., Martínez-Chantar, ML., Mato, JM. Impaired Liver Regeneration in Mice Lacking Glycine N-Methyltransferase. Hepatology. 2009;50(2):443-52. PMID: 19582817, PMCID: PMC2805126
  5. Vázquez-Chantada, M., Fernández-Ramos, D., Embade, N., Martinez-Lopez, N., Varela-Rey, M., Woodhoo, A., Luka, Z., Wagner, C., Anglim, PP., Finnell, RH., Caballería, J., Laird-Offringa, IA., Gorospe, M., Lu, SC., Mato, JM., Martínez-Chantar, ML. HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. Gastroenterology. 2010;138(5):1943-53. PMID: 20102719, PMCID: PMC2860011
  6. Varela-Rey, M., Martinez-Lopez, N., Fernández-Ramos, D., Embade, N., Calvisi, DF., Woodhoo, A., Rodríguez, J., Fraga, MF., Julve, J., Rodríguez-Millán, E., Frades, I., Torres, L., Luka, Z., Wagner ,C., Esteller,    M., Lu, SC., Martínez-Chantar, ML., Mato, JM. Fatty liver and fibrosis in glycine N-methyltransferase   knockout mice is prevented by nicotinamide. Hepatology. 2010;52(1):105-14. PMID: 20578266, PMCID: PMC2921576
  7. Martinez-Lopez, N*., Varela-Rey, M*., Fernández-Ramos, D., Woodhoo, A., Vázquez-Chantada, M., Embade, N., Espinosa-Hevia, L., Bustamante, FJ., Parada, LA., Rodriguez, MS., Lu, SC., Mato, JM., Martínez-Chantar, ML. Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis. Hepatology. 2010;52(5):1621-31. (*co-first authors) PMID: 20815019, PMCID: PMC2967637
  8. Embade, N., Fernández-Ramos, D., Varela-Rey, M., Beraza, N., Sini, M., Gutiérrez de Juan, V., Woodhoo, A., Martinez-Lopez, N., Rodríguez-Iruretagoyena, B., Bustamante, FJ., de la Hoz, AB., Carracedo, A., Xirodimas, DP., Rodríguez, MS., Lu, SC., Mato, JM., Martínez-Chantar, ML. Murine double minute  2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation. Hepatology. 2012;55(4):1237-48. PMID: 22095636, PMCID: PMC3298572
  9. Kaushik, S., Arias, E., Kwon, H., Martinez-Lopez, N., Athonvarangkul, D., Sahu, S., Schwartz, GJ., Pessin, JE., Singh, R. Loss of autophagy in hypothalamic POMC neurons impairs lipolysis. EMBO Reports. 2012;13(3):258-65. PMID: 22249165, PMCID: PMC3323137
  10. Woodhoo, A., Iruarrizaga-Lejarreta, M., Beraza, N., García-Rodríguez, JL., Embade, N., Fernández-Ramos, D., Martínez-López, N., Gutiérrez-De Juan, V., Arteta, B., Caballeria, J., Lu, SC., Mato, JM., Varela-Rey, M., Martínez-Chantar, ML. Human antigen R contributes to hepatic stellate cell activation and liver fibrosis. Hepatology. 2012 Nov;56(5):1870-82. PMID: 22576182, PMCID: PMC3433583
  11. Martinez-Lopez, N*., García-Rodríguez, JL*., Varela-Rey, M., Gutiérrez, V., Fernández-Ramos, D., Beraza, N., Aransay, AM., Schlangen, K., Lozano, JJ., Aspichueta, P., Luka, Z., Wagner, C., Evert, M., Calvisi, DF., Lu, SC., Mato, JM., Martínez-Chantar, ML. Hepatoma Cells From Mice Deficient in Glycine N-Methyltransferase Have Increased RAS Signaling and Activation of Liver Kinase B1. Gastroenterology. 2012;143(3):787-798. (*co-first authors) PMID: 22687285, PMCID: PMC3429651
  12. Martinez-Lopez, N*., Athonvarangkul, D*., Sahu, S., Coletto, L., Zong, H., Bastie, CC., Pessin, JE., Schwartz. GJ., Singh, R. Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development. EMBO Reports. 2013 Aug 30;14(9):795-803. (*co-first authors)  PMID: 23907538, PMCID: PMC3790054
  13. Martinez-Lopez, N., Athonvarangkul, D., Mishall, P., Sahu, S., Singh, R. Autophagy proteins regulate ERK phosphorylation. Nature Communications. 2013 Nov 18;4:2799. doi: 10.1038/ncomms3799. PMC: 24240988, PMCID: PMC3868163
  14. Martinez-Lopez, N., Singh, R. ATGs: Scaffolds for MAPK/ERK signaling. Autophagy. 2014 Mar;10(3):535-7. PMID: 24412893
  15. Nuria Martinez-Lopez and Rajat Singh. Autophagy and Lipid Droplets in Liver. Annual Review of Nutrition 2015. Vol. 35.