Applied research on the development of prognostic / predictive models and collaborative research in epidemiologic and clinical studies. Main focus on tree-based approaches, analysis of correlated data, survival analysis and biomarkers. Collaborative research in cardiovascular diseases and cancer.

1. Ciampi A, Negassa A, Lou Z. Tree-structured prediction for censored survival data and the Cox model. Journal of Clinical Epidemiology 1995; 48: 675-689.
2. Hanley AJ, Negassa A, Edwards DM. GEE Analysis of negatively correlated binary response: A caution. Stat in Med 2000; 19: 715-722.
3. Negassa A, Ciampi A, Abrahamowicz M, Shapiro S, Boivin JF. Validation of tree structured prediction for censored survival data: Its application to prognostic classification. The Journal of Statistical Computation and Simulation 2000; 67: 289-317.
4. Ounpuu S, Negassa A, Yusuf S for The INTER-HEART investigators.  INTER-HEART: A Global study of risk factors for acute myocardial infarction – rational and design. Am Heart J 2001; 141: 711-21.
5. Yusuf S, Negassa A. Choice of clinical outcomes in randomized trials of heart failure therapies: disease-specific or overall outcomes? Am Heart J 2002; 143(1): 22-8.
6. Hanley AJ, Negassa A, Edwards DM, Forrester JE. Statistical analysis using Generalized Estimating Equations (GEE): An orientation. Am J Epidemiol 2003; 157: 364-75.
7. Anker S, Negassa A, Coats AJS, Poole-Wilson PA, and Yusuf S.   Prognostic importance of weight loss in chronic heart failure and the impact of treatment with ACE inhibitors. Lancet 2003; 361, 1077-83.
8. Schlecht NF, Platt R, Negassa A, Duarte-Franco E, Rohan TE, Ferenczy A, Villa LL, Franco EL. Time dependence of the association between human papillomavirus infection and cervical cancer precursor lesions. Am J Epidemiol2003; 158: 878-886.
9. Negassa A, Ciampi A, Abrahamowicz M, Shapiro S and Boivin J-F. Tree Structured Subgroup Analysis for Censored Survival Data: Validation of Computationally Inexpensive Model selection Criteria. STATISTICS AND COMPUTING 2005; 15: 231-239. 
10. Sparano  JA, Negassa A, Lansigan E, Locke R, De Silva CR, and Wiernik PH. Phase I trial of infusional cyclophosphamide, doxorubicin and etoposide plus granulocyte-macrophage colony stimulating factor (GM-CSF) in non-Hodgkin’s lymphoma. Medical Oncology, 2005; 22: 257-268.
11. Fang J, Negassa A, Jeganathan R, Gern R, Alderman M. Revascularization among myocardial infarction patients – impact of neighborhood hospital resources. Journal of Urban Health 2006; 83(6): 1085 -94.
12. Negassa A, Hanley J. The effect of omitted covariates on confidence interval and study power in binary outcome analysis: a simulation study. Contemporary Clinical Trials 2007; 28: 242 - 248.
13. Negassa A, Mornard S, Bang JY, Srinivas VS. Tree-structured Risk Stratification for In-hospital Mortality Following Primary Angioplasty for Acute Myocardial Infarction: A Report From the New York State Precutaneous Coronary Intervention Database. Am Heart J 2007; 154: 322-9.
14. Rohan TE, Negassa A, Chlebowski RT, Habel L, McTiernan A, Wassertheil-Smoller S, Page D L. Conjugated Equine Estrogens and Risk of Benign Proliferative Breast Disease: a Randomized, Controlled Trial. JNCI 2008; 100: 563 – 571.
15. Rohan TE, Negassa A, Chlebowski RT, Habel L, McTiernan A, Wassertheil-Smoller S, Page DL. Estrogen plus Progestin and Risk of Benign Proliferative Breast Disease: a Randomized, Controlled Trial. Cancer Epidemiol. Biomarkers Prev. 2008; 17: 2337-2343.
16. Negassa A, Mornard S, Srinivas VS. A Simple Prognostic Classification Model for Post-procedural Complications Following Percutaneous Coronary Intervention for Acute Myocardial Infarction (From the New York State Percutaneous Coronary Intervention Database). Am J Cardiol 2009; 103: 937-942.
17. Brandwein-Gensler M, Smith RV, Wang B, Penner C, Theilken A, Broughel D, Schiff B, Owen RP, Smith J, Sarta C, Hebert T, Nason R, Ramer M, DeLacure M, Hirsch D, Myssiorek D, Heller K,  Prystowsky M,  Schlecht N  and Negassa A. Validation of the histologic risk model in a new cohort of patients with head and neck squamous cell carcinoma.  AmJ Surg Pathol. 2010; 34(5): 676-88.
18. Negassa A, Fang J. Neighborhood Variation in Rate of Revascularization among Acute Myocardial Infarction Patients in New York City. Cardiol Res Pract. 2011; doi:  10.4061/2011/348527.
19. Selim AM, Mazurek JA, Iqbal M, Wang D, Negassa A and Zolty R. Mortality and Readmission Rates in Patients Hospitalized for Acute Decompensated Heart Failure: A Comparison Between Cardiology and General-Medicine Service Outcomes in an Underserved Population. Clin Cardiol. 2015; doi: 10.1002/clc.22372.
20. Dicpinigaitis P, Lee CA, Dicpinigaitis  A, Negassa A. EFFECT OF ELECTRONIC CIGARETTE USE ON COUGH REFLEX SENSITIVITY. CHEST 2016; 149(1):161-165.