Solomon L. Moshe, M.D.

Solomon L. Moshé, M.D., is the Charles Frost Chair in Neurosurgery and Neurology, and Professor of Neurology, Neuroscience, and Pediatrics at the Albert Einstein College of Medicine/Montefiore Medical Center in the Bronx, New York. He is also the Vice Chair of the Saul R. Korey Department of Neurology, Director of the Isabelle Rapin Child Neurology Division and Director of Clinical Neurophysiology. His area of expertise is in epilepsy and related disorders.

Since 1979, his research has focused on understanding the mechanisms underlying age and sex-related differences in epilepsy in humans and animal models. Current research interests include studies on the role of subcortical circuitries involved in the control of seizures as a function of age and sex; the consequences of seizures on the developing brain and the development of models of catastrophic epilepsies. His laboratory has patented a model of infantile spasms that can be used to identify novel treatments. He is co principal investigator of a Center Without Walls grant on interdisciplinary research aimed at accelerating the development of disease modifying or prevention therapies for epilepsy following traumatic brain injuries. He is also involved in a large multicenter study examining the consequences of prolonged febrile seizures. He has over 600 publications as well as He has over 600 publications as well over 35 books and monographs.

He has served as President of the International League Against Epilepsy (2009-2013), the American Epilepsy Society (2000-2001), the American Clinical Neurophysiology Society (1996-1997) and the Eastern Association of EEGers (1992-1994). He is the recipient of many awards and honors, including the Teacher-Investigator Development Award from NINDS; the 1995 Jacob Javits Neuroscience Investigator Award from NINDS; the 1984 Michael Prize for Achievements in Epilepsy Research; the 1990 American Epilepsy Society Research Award; the 1999 Ambassador for Epilepsy Award from the International League Against Epilepsy; the 2005 Gloor Award from the American Clinical Neurophysiology Society; the 2007 J.E. Purkyne Honorary Medal in Biomedical Research by the Czech Academy of Sciences; the 2008 Mentor of the Year Award from Albert Einstein College of Medicine; the 2010 Global and Awareness Award from CURE, Citizens United for Research in Epilepsy; the First 2012 Saul R. Korey Award in Translational Science and Medicine, Albert Einstein College of Medicine and the 2017 Bernard Sachs Award from the Child Neurology Society, and the 2023 Lifetime Achievement Award from the International League against Epilepsy.

He has been asked to deliver over 50 several keynote lectures.

Clinical Focus

Dr. Moshé focuses on helping people with epilepsy and related conditions with a special emphasis on children and adolescents.

Research focus

Dr Moshé has focused on translational research to understand the mechanisms underlying age and sex-related differences in epilepsy in humans and animal models. The main goals are to develop individualized treatments today and to prevent and cure epilepsy tomorrow. Current projects include the development of effective means to predict and treat epilepsy after traumatic brain injury and the development of specialized treatments for infants and children with epilepsy.

Book

1. Engel J and Moshé SL, Editors-In-Chief. Epilepsy: A Comprehensive Textbook, 3rd Edition. Wolters Kluwer (2024).

Publications

1. Wirrell E, Tinuper P, Perucca E and Moshé SL. Introduction to the epilepsy syndrome papers. Epilepsia, 63, 1330-1332 (2022) PMID: 35503711
2. Zuberi S, Wirrell E, Yozawitz E, Wilmshurst J, Specchi N, Riney K, Pressler R, Auvin S, Samia P, Hirsch E, Galicchio S, Triki C, Snead O, Wiebe S, Cross H, Tinuper P, Scheffer I, Perucca E and Moshé SL. ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia, 63, 1349-1397 (2022) PMID: 35503712
3. Hirsch E, French J, Scheffer I, Bogacz A, Alsaadi T, Sperling M, Abdulla F, Zuberi S, Trinka E, Specchio N, Somerville E, Samia P, Riney K, Nabbout R, Jain S, Wilmshurst J, Auvin S, Wiebe S, Perucca E, Moshé SL, Tinuper P and Wirrell E. ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia, 63, 1475-1499 (2022) PMID: 35503716
4. Specchio N, Wirrell E, Scheffer I, Nabbout R, Riney K, Samia P, Guerreiro M, Gwer S, Zuberi S, Wilmshurst J, Yozawitz E, Pressler R, Hirsch E, Wiebe S, Cross H, Perucca E, Moshé SL, Tinuper P and Auvin S. International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions. Epilepsia, 63, 1398-1442 (2022) PMID: 35503717
5. Riney K, Bogacz A, Somerville E, Hirsch E, Nabbout R, Scheffer I, Zuberi S, Alsaadi T, Jain S, French J, Specchio N, Trinka E, Wiebe S, Auvin S, Cabral-Lin L, Naiddo A, Perucca E, Moshé SL, Wirrell E and Tinuper P. International League Againist Epilepsy classification and definition of epilepsy syndromes with onset at a variable age: position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia, 63, 1443-1474 (2022) PMID: 35503725
6. Auvin S, Galanopoulou AG, Moshé SL, Potschka H, Rocha L, Walker M. Revisiting the concept of drug-resistant epilepsy. A TASK1 report of the ILAE/AES Translational Task Force. Epilepsia 1-18 2023. 
7. Samfira M, Galanopoulou AS, Nariai H and Moshé SL. EEG-based spatiotemporal dynamics of fast ripple networks and hubs in infantile epileptic spasms. Epilepsia 1-16. 2023. 
8. Scott R, Holmes G and Moshé SL. Do Vaccines Cause Epilepsy? Review of Cases in The National Vaccine Injury Compensation Program. Epilespia 1-60. 2023 PMID: 37914395
9. Lucasius C, Grigorovsky V, Nariai H, Galanopoulou AS, Gursky J, Moshé SL, Bardakjian B. Biomimetic Deep Learning Networks with Applications to Epileptic Spasms and Seizures Prediction. IEEE Transactions on Biomedical Engineering (TBME) 1056-1067. 2023 PMID: 37851549
10. Galanopoulou AS, Auvin S, Moshé SL, Potschka H, Rocha L and Walker M. Response: Drug resistance in epilepsy: a reappraisal of the definition is needed.  Epilepsia 1-2 2023 PMID: 37921052
11. Pease M, Gupta K, Moshé SL, Correa D, Galanopoulou AS, Okonkwo D, Gonzalez-Martinez J, Shutter L, Diaz-Arrasta R, and Castellano J. Insights into epileptogensis from post-traumatic epilepsy.  Nature Reviews Neurology 20, 298-312. 2024. PMID: 38570704
12. Lewis D, Voyvodic J, Shinnar S, Chan S, Bello J, Moshé SL, Nordli Jr D, Frank M, Pellock J, Hesdorffer D, Xu Y, Shinnar R, Seinfeild S, Epstein L, Masur D, Gallentine W, Weiss E, Deng X and Sun S. Hippocampal Sclerosis and Temporal Lobe Epilepsy following Febrile Status Epilepticus: The FEBSTAT Study. Epilepsia 65, 1568-1580. 2024. PMID: 38606600
13. De Meulemeester A, Reid C, Auvin S, Carlen P, Cole A, Szlendak R, Di Sapia R, Moshé SL, Sankar R, O’Brien T, Baulac S, Henshall D, Akman O, Galanopoulou AS. WONOEP appraisal 2022: modeling early-onset epilepsies. Epilepsia 65, 2553-2566. 2024. PMID: 39042520
14. Li C, Casillas-Espinosa P, Grandizoli P, Chi T, Yamkawa G, Silva, Hudson, Liu W, Jones N, Shultz S, Ali I, Mishra U, Cloyd J, Moshé SL, Galanopoulou AS and O’Brien T. Pharmacokinetics and Brain Uptake of Sodium Selenate and Selenium in Naïve Rats and a Lateral Fluid Percussion Injury Rat Model. Journal of Pharmacology Research & Perspectives 1-14. PMID: 39506350
15. Quatraccioni A, Cases-Cunillera S, Balagura G, Coleman M, Rossini L, Mills J, Casillas-Epinosa P, Moshe SL, Sankar R, Baulac S, Noebels J, Auvin S, O’Brien T, Henshall D, Akman O and Galanopoulou AS. WONOEP appraisal: Genetic insights into early-onset epilepsies. Epilepsia 65, 3138-3154. 2024.   
16. Bruckhaus A, Asifriyaz T, Kriukova K, O’Brien T, Agoston D, Staba R, Jones N, Moshé SL, Galanopoulou AS and Dunca D. Exploring Multimodal Biomarker Candidates of Post-Traumatic Epilepsy Following Moderate to Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis. Epilepsia 00, 1-27 2024
17. Nunes M, Yozawitz E, Wusthoff C, Shellhaas R, Olivas-Pena E, Wilmshurst J, Pressler R, Triki C, Hartmann H, Inder T, Boylan G, Valenta K, Moshe SL, Mizrahi E and Abend N. Defining Neonatal Status Epilepticus: A Scoping Review from the ILAE Neonatal Task Force. Epilepsia Open 1-15. 2024. PMID: 39540265
18. Yozawitz E, Cilio M, Mizrahi E, Moon J, Moshé SL, Nunes M, Plouin P, Zuberi S and Pressler R. ILAE Neonatal Seizure Framework to Aide in Determining Etiology. Epileptic Disorders 1-7. 2024. 
19. Sandra O, Wang Y, Coles L, Mowrey W, Li Q, Liu W, Moshé SL and Galanopoulou AS. Efficacy and tolerability of celastrol and edaravone in the multiple-hit rat model of infantile spasms. Epilepsy & Behavior 1-14. 2024. PMID: 39577370.
20. Carapancea E, Eizadkhah D, Santalucia R, Lederer D, Arts F, Lagae L, Moshé SL and Cilio M. Epilepsy phenotype and developmental outcome in girls with mosaicism in X-linked neurodevelopmental disorders. Epileptic Disorders 1-10 2025