TheScientist features a cover article by Vern Schramm, Ph.D., on transition-state analogs, compounds he synthesizes that bind to enzymes and short-circuit specific chemical reactions, and their potential for a powerful new line of drugs. Dr. Schramm is a leader in the field and the article highlights some of his discoveries, including potential treatments for cancer, malaria, gout and an antibiotic that defies resistance. Dr. Schramm is professor and chair of biochemistry and the Ruth Merns Chair in Biochemistry at Einstein.

New Scientist interviews Vern Schramm, Ph.D., about his research on transition state analogs, a class of drugs he has been developing that target and neutralize specific enzymes in order to combat disease. Dr. Schramm is professor and Ruth Merns Chair in Biochemistry at Einstein.

Scientific American reports on the simple, accurate, and highly sensitive test developed by Dr. Vern Schramm that detects and quantifies ricin, an extremely potent toxin with potential use as a bioterrorism agent. Users of the assay would place samples of potentially adulterated food or swabs into a few drops of a mixture of reagents; the mixture will emit light if ricin is present, with higher luminescence indicating greater concentrations of the toxin. This research appears as a featured article in the April 12th issue of Analytical Chemistry. Dr. Schramm is professor and Ruth Merns Chair of Biochemistry.

More coverage on this story

United Press International (UPI)
Indo-Asian News Service (IANS)

United Press International highlights research by Vern Schramm, Ph.D. regarding a study described in Nature Chemical Biology on the development of a new generation of antibiotic compounds that do not provoke bacterial resistance to antibiotics. The compounds work against two notorious microbes: Vibrio cholera, which causes cholera, and E.coli 0157:H7 which is the food contaminant responsible for 110,000 illnesses and 50 deaths each year in the United States. Dr. Schramm is professor and Ruth Merns Chair of Biochemistry.