biomarkers-core-2017-10-14

Biomarker Analytic Research Core

Biomarkers are playing an increasingly important role in clinical and translational research, especially as we move toward an era of personalized medicine in both the prevention and treatment of disease. The Biomarker Analytic Research Core (BARC) — the central laboratory for the ICTR, DRC and the Biorepository — provides sophisticated tools and expertise for Einstein and Montefiore investigators from the initial study planning stage through analysis and data output.

Services

Facility services include:

  • State-of-the-art mass spectrometry analysis, including stable isotopes, as well as research-grade determination of lipids, and metabolic markers for a variety of human subjects and animal model projects.
  • High-throughput robotics for semi-automated high-quality sample preparation and analysis by immunoassay and liquid chromatography–mass spectrometry (LC/MS).
  • Support for novel developmental projects featuring applications of LC/MS and two-site bead-based assays.
  • Research quality analysis of metabolites for human and animal samples using an Olympus AU400 autoanalyzer.
  • Advanced training in analytical chemistry.

In addition to its isotope dilution LC/MS assays, BARC has already validated and made available quantitative measurement of 25(OH)2 vitamin D, androstenedione and testosterone via LC/MS. Other dual-use assays for steroids are under development, including ultrahigh sensitivity salivary cortisol, estradiol, and progesterone which will support both clinical care and research use. BARC also offers a novel method for LC/MS measurement of C-peptide, and is currently the reference lab for an ongoing clinical trial measuring insulin secretion.

All samples processed are labeled with barcoded cryolabels for easy identification. Records of samples and data are seamlessly integrated and tracked, and are remotely accessible via a secure research database.

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Service Requests

Before bringing samples to the facility, please visit our iLab page which will provide you with pricing for all available services.

Available Assays

  • Alanine Aminotransferase (ALT)
  • Albumin
  • Alkaline Phosphatase (ALP)
  • Apolipoprotein A1
  • Apolipoprotein B
  • Aspartate Aminotransferase (AST)
  • Beta-Hydroxybutyrate, Serum
  • Bicarbonate
  • Bilirubin, Direct
  • Bilirubin, Total
  • Calcium, Serum
  • Calcium, Urine
  • Chloride, Serum
  • Chloride, Urine
  • Cholesterol
  • Creatinine, Serum
  • Creatinine, Urine
  • Cystatin C
  • D-Dimer
  • Gamma-Glutamyl Transpeptidase
  • Glucose
  • Glycerol, Free
  • HDL Cholesterol, Direct
  • High Sensitivity CRP
  • Lactate
  • Lactate Dehydrogenase
  • LDL Cholesterol, Calculated
  • LDL Cholesterol, Direct
  • Magnesium
  • Microalbumin
  • Microalbumin/Creatinine ratio, Urine
  • Non-Esterified Free Fatty Acids, Total
  • Phosphorous, Serum
  • Phosphorous, Urine
  • Potassium, Serum
  • Potassium, Urine
  • Prealbumin
  • Protein, Total
  • Sodium, Serum
  • Sodium, Urine
  • Triglycerides
  • Urea Nitrogen, Blood
  • Urea Nitrogen, Urine
  • A2 Macroglobulin, Human ELISA
  • Adiponectin, Human RIA
  • Adiponectin, HMW Human ELISA
  • Adiponectin, Mouse ELISA
  • BDNF, Human ELISA
  • Bone Trap, Human ELISA
  • C-Peptide, Human ELISA
  • C-Peptide, Human RIA
  • C-Peptide, Rat ELISA
  • CK 18 (M65), Human ELISA
  • CK 18 Frag (M30), Human ELISA
  • Corticosterone ELISA
  • Cortisol ELISA
  • DHEAS, Human ELISA
  • E-Selectin, Human ELISA
  • Estrone, Human ELISA
  • FGF-21, Human ELISA
  • FGF-23 (C-Term), Human ELISA
  • FGF-23 (Intact), Human ELISA
  • Follicle Stimulating Hormone, Human ELISA
  • Free Testosterone, Human ELISA
  • Ghrelin (Total), RIA
  • GLP-1 (Total), Human ELISA
  • Glucagon 10ul ELISA
  • Glucagon ELISA
  • Growth Hormone, Human ELISA
  • Growth Hormone, Rat/Mouse ELISA
  • Hyaluronic Acid, Human ELISA
  • H. pylori IgG, Human ELISA
  • ICAM, Human ELISA
  • IGF-1, Human ELISA
  • IGF-1, Rat/Mouse ELISA
  • IGF-2, Human ELISA
  • IGFBP-1, Human ELISA
  • IGFBP-3, Human ELISA
  • IL-1 beta, high sensitivity, Human ELISA
  • IL-10, Human ELISA
  • IL-6, Human Chemiluminescence ELISA
  • IL-8, Human ELISA
  • Insulin, Human ELISA
  • Insulin, Human Specific RIA
  • Insulin, Mouse ELISA
  • Insulin, Mouse US ELISA
  • Insulin, Rat ELISA
  • Insulin, Rodent Chemiluminescence ELISA
  • Leptin, Human ELISA
  • Leptin, Human RIA
  • Leptin, Mouse ELISA
  • Leptin, Rat ELISA
  • LTB4, Human ELISA
  • Lutenizing Hormone, Human ELISA
  • NGAL, Human ELISA
  • Osteoprotegerin, Human ELISA
  • PAI-1, Human ELISA
  • Pancreatic Polypeptide, Human ELISA
  • Pepsinogen I, Human ELISA
  • Pepsinogen II, Human ELISA
  • PLA2G7, Human ELISA
  • Proinsulin, Human RIA
  • Proinsulin, Mouse ELISA
  • PYY (3-36) Specific, Human RIA
  • RBP4, Human ELISA
  • Resistin, Human ELISA
  • Resistin, Mouse ELISA
  • Sex Hormone Binding Globulin, Human ELISA
  • sRage, Human ELISA
  • Testosterone, Human ELISA
  • TIMP-1, Human ELISA
  • Tissue Factor, Human ELISA
  • TNF-alpha, Human ELISA
  • TNF-alpha, Rat ELISA
  • VEGF, Human ELISA
  • Vitamin D Binding Protein, Human ELISA
  • YKL-40, Human ELISA

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