Institutional Animal Care and Use Committee

Additional Resources

Policy for Reporting NIH-supported Vertebrate Animal Research

  1. ARRIVE (Animal Research: Reporting of In Vivo Experiments) checklist

Pain and Distress:

  1. USDA Pain and Distress Categories
  2. Grimace Scales
  3. The Rat Grimace Scale (abstract with links to full article)

Assistance with the "Alternatives" Search and the "3 R's of Replacement, Reduction and Refinement":

  1. Meeting Requirements for Alternatives Searches
  2. ALTWEB - Center for Alternatives to Animal Testing, The Johns Hopkins University
  3. European Centre for the Validation of Alternatives Methods (ECVAM)
  4. Information on Alternatives Databases - hosed by the Norwegian Reference Centre for Laboratory Animal Science and Alternatives
  5. National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) University of California for Animal Alternatives

Calculating Animal Numbers:

  4. Lab Animal Article Re Determining Sample Size
  5. Examples of Tables to Include for Explanation of Animal Numbers


  1. Recommendations for Collection of Blood Samples


  1. AVMA Guidelines for Euthanasia of Animals
  2. Humane methods of Euthanasia by Species

Humane endpoints in laboratory animal experimentation

Score Sheets for Humane Endpoints

Guidelines for Monitoring of EAE Models

Guidelines for Rodent Anesthesia using Open-Drop Exposure to Isoflurane