Bin Zhou, M.D., Ph.D.
Professor, Department of Genetics
Professor, Department of Pediatrics
Professor, Department of Medicine (Cardiology)
Dr. Zhou's focuses on molecular and cellular mechanisms in cardiovascular
development and diseases. He and colleagues apply an integrated approach of mouse
genetics, developmental embryology, cell and molecular biology to study how
cardiovascular precursor cells are specified and differentiated into different
cardiovascular tissues during development and regeneration. They are currently working
on four projects: endocardial cell specification and differentiation, transcriptional
regulation of cardiac valve development, modeling of heart valve diseases, and
epigenetic and genetic regulation of heart and coronary vessel development. full bio>>
Key Publications
- Marika L. Osterbur, Renjian Zheng. Robert Marion, Christine Walsh, Thomas V. McDonald (2015) An interdomain hERG mutation produces an intermediate long QT syndrome Human Mutation.
- Teraya M. Donaldson, Li-Min Ting, Chenyang Zhan, Wuxian Shi, Renjian Zheng, Steven C. Almo, Kami Kim (2014) Structural Determinants of the 5′-Methylthioinosine Specificity of Plasmodium Purine Nucleoside Phosphorylase PLoS One. 9(1): e84384
- Yamini Krishnan, Yan Li, Renjian Zheng, Vikram Kanda, Thomas Vincent McDonald. (2012) Mechanisms underlying the protein-kinase mediated regulation of the HERG potassium channel synthesis Biochimica et Biophysica Acta 1823(8):1273-84.
- Yamini Krishnan , Renjian Zheng, Cristine Walsh, Yingying Tang, Thomas V. McDonald (2012) Partially dominant mutant channel defect corresponding with intermediate LQT2 phenotype Pacing Clin Electrophysiol. 35(1):3-16.
- Yi Bao, Louis M Weiss, Yan Fen Ma, Michael P Lisanti, Herbert B Tanowitz, Bhaskar C Das, Renjian Zheng, and Huan Huang (2010) Molecular cloning and characterization of mitogen-activated protein kinase 2 in Trypanosoma cruzi Cell Cycle. 9(14): 2888–2896.
- Xiao-Qin Ren, Gong Xin Liu, Louise E. Organ-Darling, Renjian Zheng, Karim Roder, Hitesh K. Jindal, Jason Centracchio, Thomas V. McDonald, and Gideon Koren (2010) Pore mutants of HERG and KvLQT1 downregulate the reciprocal currents in stable cell lines Am J Physiol Heart Circ Physiol. 299(5):H1525-34.
- Renjian Zheng, Keith Thompson, Edmond Obeng-Gyimah, Dana Ellise, Jerri Chen
and Thomas V. McDonald (2010) Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunits Biochem J. 428(1):75-84..
Funding
- Wu B, Wang Y, Lui W, Langworthy M, Tompkins KL, Hatzopoulos AK, Baldwin, HS, Zhou B. Nfatc1 Coordinates Valve Endocardial Cell Lineage Development Required for Heart Valve Formation. Circ Res 109:183-192, 2011
- Wu B, Zhang Z, Lui W, Chen X, Moreno-Rodriquez RA, Wang Y, Chamberlain A, Markwald RA, O’Rourke B, Sharp DJ, Lenz J, Baldwin HS, Chang CP, Zhou B. Endocardial Cells Form the Coronary Arteries by Angiogenesis through Myocardial to Endocardial VEGF Signaling. Cell 151:1083-1096. 2012 (with Commentary by Cell and Faculty 1000 recommended article)
- Wang Y, Wu B, Chamberlain AA, Lui W, Koirala P, Susztak K, Klein D, Taylor V, Zhou B. Endocardial to myocardial Notch-Wnt-Bmp axis regulates early heart valve development. PLoS ONE 8(4):e60244. 2013
- Zhang Z, Zhou B. Accelerated Coronary Angiogenesis by Vegfr1-Knockout Endocardial Cells PLoS ONE 8(7):e70570, 2013
- Chamberlain AA, Lin M, Lister RL, Maslov AA, Wang Y, Suzuki M, Wu B, Greally, JM, Zheng D, Zhou B. DNA methylation is developmentally regulated for genes essential for cardiogenesis. J Am Heart Assoc 2014 Jun 19;3(3):e000976
