Eugene J. Fine, M.D.
- Clinical Professor, Department of Radiology (Nuclear Medicine)
Area of research
- Inhibition of aggressive cancers by an insulin inhibiting ketogenic diet-human trials as well as pre-clinical study. We are also interested in coupling dietary interventions with selected cancer drugs.
Phone
Location
- Jack D. Weiler Hospital 1825 Eastchester Road Bronx, NY 10461
Professional Interests
Dr. Fine's professional interests have centered on:
Non-invasive measurement of physiologic and molecular function, especially with radiotracer technology. This was applied to the heart and especially to measurement of kidney function and its role and contribution to hypertension; and more recently has focused on radiotracers for diagnosis, monitoring, prognosis, and identification of cancers for appropriate therapy.
The effects of dietary and nutritional manipulation, and especially of reducing carbohydrate content, on altering our metabolic environment. Carbohydrate restriction in humans mimics many of the metabolic effects of fasting, and may be systematically studied using appropriate in vitro, cell culture, animal models and in vivo biochemical and radiotracer techniques. Of particular interest is the potential for differential systemic metabolic effects on normal compared to malignant/transformed cells.
Selected Publications
Newer references relate primarily to ketogenic diets and their effects on cancer, diabetes, and other aspects of physiology/pathophysiology
Fine EJ, Segal-Isaacson CJ, Feinman R, Sparano J: Carbohydrate restriction in patients with advanced cancer: a protocol to assess safety and feasibility with an accompanying hypothesis. Commun Oncol 2008;5:22–2
Fine EJ, Miao W, Koba W, Volek JS, Blaufox, MD: Chronic effects of dietary carbohydrate variation on 18F-2, Fluoro 2,deoxy-glucose uptake in rodent heart. Nuclear Med Communications Sep 2009: 30(9):675-80
Fine EJ, Miller A, Quadros EV, Sequeira JM, Feinman RD: Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2. Cancer Cell Intl 2009, 9:14 http://www.cancerci.com/content/9/1/14
Fine EJ, Segal-Isaacson CJ,Feinman RD, Herszkopf S, Romano MC, Tomuta N, Bontempo AF, Negassa A, Sparano JA: Targeting insulin inhibition as a metabolic therapy in advanced cancer: A pilot safety and feasibility dietary trial in ten patients. Nutrition (Elsevier) 2012: Oct;28(10):1028-35. doi:10.1016/j.nut..05.001. Epub 2012 Jul 26.
Fine EJ, Feinman RD: Insulin, carbohydrate restriction and cancer. Expert Reviews in Endocrinology and Metabolism. 2014,
Fine EJ, Feinman R, Miller A: Acetoacetate is a metabolic inhibitor of cancer growth. FASEB Jl. 2015: 29 no. 1 Supplement 725.22
Older references mostly concerning renal function, hypertension diagnosis, nuclear medicine techniques,
Fine EJ, Axelrod M, Gorkin J, et al: Measurement of effective renal plasma flow: A comparison of methods. J.Nucl.Med. 28(9): 1393-1400, 1987.
Kim D, Fine EJ, Silver CE: Preoperative localization or parathyroid lesions using thallium technetium scintiscanning. Surg. Gyn.Obstet. 105:212-216, 1987.
Fabry ME, Raganayagam V, Fine EJ, Nagel RL, Holland S, Gore JC, and Kaul DK: Modelling sickle cell vaso-occlusion in the rat leg: Quantification of trapped sickle cells and correlation with 31-P metabolic 1H MRI changes. Proc.Natl.Acad.Sci. 86:3808-3812, 1989.
Fine EJ and Blaufox MD: The Einstein/Cornell Collaborative Protocol to Assess Efficacyand Methodology in Captopril Scintirenography: Early Results in Hypertensives Without Renovascular Hypertension. Amer.J.Hypertension 4:716S-720S,1991
Nally Jr.,JV, Chen C, Fine EJ, Fommei E, Ghione S, Geyskes GG, Hoffer P, Sfakianakis G: Diagnostic Criteria of Renovascular Hypertension with Captopril Renography. AJH 4:749S-752S, 1991.
Fabry ME, Fine EJ, Rajanayagam V, Factor SM, Gore J, Sylla M, Nagel RL: Demonstration of Endothelial Adhesion of Sickle Cells In Vivo: A Distinct Role for Deformable SS Discocytes. Blood, 79:1602-1611, 1992.
Fine EJ, Blaufox MD, Bongiovanni J, Chun KJ, Heller S, Blumenfeld J: Exercise Renography in Untreated Patients with Essential Hypertension. J.Nucl.Med. 37:838-842; 1996
Taylor Jr.A, Nally J, Aurell M, Blaufox MD, Dondi M, Dubovsky E, Fine EJ, Fommei E, Geyskes G, Granerus G, Kahn D, Morton K, Oei H-Y, Russell C, Sfakianakis G, Fletcher J: Consensus Report on Ace Inhibitor Renography for Detecting Renovascular Hypertension. 37(11):1876-1882; 1996
The AECOM/CUMC Collaborative Hypertension Group consists of Blaufox MD, Fine EJ, Heller SH, Hurley J, Jagust M, Li Yi, Mann S, Pickering T, Rackson M, Rottman GA, Sarkar S, Zanzonico P, Zhang CG: Simultaneous OIH and DTPA Captopril Renography in Essential Hypertension: The Einstein/Cornell Collaborative Hypertension Study in Radionuclides in Nephrourology, (Taylor A, Nally JV, Thomsen H, eds.). Society of Nuclear Medicine, Reston, Va. pp.77-81, 1997.
The AECOM/CUMC Collaborative Hypertension Group consists of Blaufox MD, Fine EJ, Heller SH, Hurley J, Jagust M, Li Yi, Mann S, Pickering T, Rackson M, Rottman GA, Sarkar S, Zanzonico P, Zhang CG: Captopril Renography in Hypertensives with Diminished Renal Function: The Einstein/Cornell Collaborative Hypertension Study in Radionuclides in Nephrourology, (Taylor A, Nally JV, and Thomsen H, eds. Society of Nuclear Medicine, Reston, Va. pp.72-86,1997.
Yi Li, Blaufox MD, Fine EJ on behalf of the Einstein/Cornell Collaborative Study of Renovascular Hypertension: Effect of Captopril on Renal Mean Transit Time (MTT) in Patients with Essential Hypertension (EH) in Radionuclides in Nephrourology, (Taylor A, Nally JV, and Thomsen H, eds.), Society of Nuclear Medicine, pp. 82-87,1997.
Taylor Jr.A, Fletcher JW, Nally J, Blaufox MD, Dubovsky E, Fine EJ, Kahn D, Morton K, Russel C, Sfakianakis G: Society of Nuclear Medicine Procedure Guideline for Diagnosis of Renovascular Hypertension. Published by the Society of Nucl
The Einstein/Cornell Collaborative Hypertension Group-Blaufox MD (Chairman), Fine EJ, Heller SH, Hurley J, Jagust M, Li Yi, Mann SJ, Pickering TG, Zanzonico P, Zhang CG. Writing Committee- Fine EJ (Chairman), Blaufox, MD, Yi Li, Mann SJ. Prospective Study of Simultaneous Orthoiodohippurate and Diethylenetriaminepentaacetic Acid Captopril Renography. J Nucl Med 39:522-528, 1998
Fine EJ, Li Yi, and Blaufox MD: Parenchymal Mean Transit Time Analysis of 99mTc-DTPA Captopril Renography. J Nucl Med 41:1627-1631, 2000
Lee M, Zuckier L, Zalta B, Fine EJ: “The Persistently Absent Bowel Loop A Sign of Mass Effect on the Bowel Detected by Cholescintigraphy”. Clinical Nuclear Medicine 26(11): 939-940, 2001
Feinman R, Fine EJ: Thermodynamics and metabolic advantage of reducing diets. Metabolic Syndrome and Related Disorders 1(3): 209-219, 2003
Feinman RD, Fine EJ: “A calorie is a calorie violates the second law of thermodynamics.” Nutrition Jl. 3: 9-13, 2004
Fine EJ, Feinman RD: Thermodynamics of weight loss diets. Nutrition and Metabolism. 1:15, 2004 (open access: http://www.nutritionandmetabolism.com/content/1/1/15 )
Feinman RD, Fine EJ: Non-equilibrium thermodynamics and energy efficiency in weight loss diets. Theoretical Biology and Medical Modeling. In review, 2007
Fine EJ, Blaufox MD: Quantitation of renal function. Current Concepts in Diagnostic Nuclear Medicine 1(3):12-17, 1984.
Blaufox MD, Fine EJ, Lee H-B, Scharf S: The role of nuclear medicine in clinical urology and nephrology. J.Nucl.Med. 25(5):619-625, 1984.
Fine EJ, Scharf SC, Blaufox MD: The role of nuclear medicinein evaluating the hypertensive patient In Nuclear Medicine Annual (1984), Freeman LM and Weissmann HW (eds.), pp.23-79, Raven Press, New York, 1984.
Fine EJ, Axelrod M, Blaufox MD: Physiologic aspects of diagnostic renal imaging. Sem.Nephr. 5(3):188-206, 1985.
Blaufox MD, Fine EJ, Sherman R, Scharf S: Nephrological applications of radionuclide In Nuclear Medicine in Urology and Nephrology, 2nd edition, O'Reilly PH, Schields RA,Testa HJ (eds.), pp.181-202, Butterworths, London, 1986.
Fine EJ: Parathyroid imaging, its' current status and future role. Sem.Nucl.Med.XVII(4):350-359,1987.
Kim CK, Fine EJ, Blaufox MD: Nonvisualization of both kidneys with I-131 orthoiodohippurate scintigraphy. Sem.Nucl.Med. 18:68-70, 1988.
Fine EJ and Sarkar S: Differential diagnosis of renovascular hypertension through nuclear medicine techniques. Sem.Nucl.Med. XIX, 2:101-115, 1989.
Fine EJ, Blaufox MD: Urological applications of radionuclides In Clinical Urography, Pollack H (ed) pp. 518-557, W.B.Saunders, 1990.
Blaufox MD, Fine EJ: Role of nuclear medicine techniques for evaluating hypertensive disease In Hypertension: Pathophysiology, Diagnosis and Management. JH Laragh and BM Brenner (eds.), Raven Press, Ltd., pp.1509-1534, 1990.
Fine EJ, Britton KE, Nimmon CE: The scintirenogram in hypertensive disease In Evaluation of Renal Function andDisease with Radionuclides, 2nd edition, Blaufox MD (ed.),Karger, Basel, Switzerland, pp.198-247, 1990.
Fine EJ: Assessment of acute and chronic renal failure InEvaluation of Renal Function and Disease with Radionuclides, 2nd edition, Blaufox MD (ed), Karger, Basel, pp.316-349, 1990.
Fine EJ: Interventions in Renal Scintirenography. Sem.Nucl. Med. Vol. XXI, 2:116-127, 1991.
Nally,Jr. JV, Chen C, Fine EJ, Ghione S, Geyskes GG, Hoffer P, Sfakianakis G: Diagnotic criteria of renovascular hypertension with captopril renography: A consensus statement Amer.J.Hypertension, Vol.4:749S-752S, 1991.
Fine EJ: Nuclear Medicine Evaluation of Hypertension. Urologic Radiology 14:85-95, Springer-Verlag, 1992.
Fine EJ: Vascular disorders, with emphasis on hypertension In "Nuclear Medicine in Clinical Diagnosis and Treatment", Murray I and Ell P, eds., Churchill Livingston, London. pp.295-317, 1994.
Blaufox MD, Middleton ML, Fine EJ: Role of Nuclear Medicine Techniques for Evaluating Hypertensive Disease In Hypertension: Pathophysiology, Diagnosis, and Management. 2nd edition. JH Laragh and BM Brenner (eds.), Raven Press, New York, pp.2005-2054, 1995.
Fine EJ: Vascular disorders, with emphasis on hypertension In "Nuclear Medicine in Clinical Diagnosis and Treatment", Murray I and Ell P, eds., Churchill Livingston, 2nd edition; pp.315-337, 1998.
Fine EJ: Interventions in Renal Scintigraphy. Sem.Nucl.Med. 23(2):128-145, 1999.
Prigent A, Cosgriff P, Gates GF, Granerus G, Fine EJ, Itoh K, Peters M, Piepsz A, Rehling M, Rutland M, and Taylor Jr A: Consensus Report on Quality Control of Quantitative Measerements of Renal Function Obtained From the Renogram: International Consensus Committee From the Scientific Committee of Radionuclides in Nephrourology. Sem.Nucl.Med. 23(2):146-159, 1999.
Fine EJ, Blaufox MD, Rossleigh MA: Urological applications of radionuclides In Clinical Urography, Pollack H, McClennan BL, (eds), W.B.Saunders, 2nd edition, pp.621-660, 2000.
Fine EJ, Blaufox MD: “Renal Scintigraphy: Update”. Applied Radiology. 1-6, 2001 (January).
Fine EJ:”Diuretic renography and Angiotensin converting enzyme inhibitor renography.” Radiology Clinics of North America. 39(5):978-995, 2001.
. Fine EJ, Zsabo S: “Vascular disorders with emphasis on hypertension”: Chapter in “Nuclear Medicine in Clinical Diagnosis and Treatment” Ell & Gambhir(eds); Churchill Livingston, 3rd edition, 2004
Fine EJ, Lee D-E, Hawkins M: Sweet Clarity: Less Invasive Measures of Hepatic Glucose Metabolism. Gastroenterology, 2007: 132(2):794-797.
Fine E, Feinman R, Isasi C, Wylie-Rosett J: A new systematic review of low carbohydrate diets. Obesity Research 12 (Supplement): A59 (223-P), 2004