Dr. Clement Tagoe obtained his medical degree from the University of Ghana Medical School, Ghana, and a PhD in biochemistry from the University of Leeds, UK. His basic science research interests included the study of the role of annexins in cell function and rheumatic diseases, and subsequently the mechanisms of disease in transthyretin amyloidosis using several animal models of transthyretin amyloidosis. His clinical work in the area of transthyretin amyloidosis has greatly illuminated our understanding of the form of amyloidosis associated with the Transthyretin V122I (pV142I) mutation, which is found in about 3 to 4% of African Americans. His current work focuses on the role of autoimmune diseases in fibromyalgia and chronic widespread pain, and in particular the association of these syndromes with autoimmune thyroid disease (AITD). His work also explores the other musculoskeletal and rheumatic manifestations of autoimmune thyroid disease, including the association with peripheral osteoarthritis and spinal osteoarthritis. These autoimmune syndromes can occur in the absence of thyroid dysfunction and are of particular interest to physicians and patients because AITD is by far the commonest autoimmune disease.

Selected Bibliography

1. Clement E. Tagoe, Tejas Sheth, Eugeniya Golub, Karen Sorensen (2019) Rheumatic associations of autoimmune thyroid disease: a systematic review Clin Rheumatol. 2019 Jul;38(7):1801-1809., (1-9) DOI:  10.1007/s10067-019-04498-1

2. Kavisha Patel, Clement Tagoe, Phyllis Bieri, Karen Weidenheim & James M. Tauras (2018): A case of transthyretin amyloidosis with myopathy, neuropathy, and cardiomyopathy resulting from an exceedingly rare mutation transthyretin Ala120Ser (c.418G > T, p.Ala140Ser), Amyloid, DOI: 10.1080/13506129.2018.1491398

3. Daniel R. Jacobson, Alice A. Alexander, Clement Tagoe, W. Timothy Garvey, Scott M.

Williams, Sara Tishkoff, David Modiano, Sodiomon Bienvenu Sirima, Issa Kalidi, Toure A, & Joel N. Buxbaum. The Prevalence and Distribution of the Amyloidogenic Transthyretin (TTR) V122I Allele in Africa  Molecular Genetics & Genomic Medicine Epub 14 July, 2016  DOI: 10.1002/mgg3.231

4. Asha Shrestha, Hillel W. Cohen, Clement E. Tagoe. Association of Autoimmune Thyroid Disease With A Higher Frequency Of Spinal Degenerative Disc Disease Clin Exp Rheumatol. 2016 Mar-Apr;34(2):296-302. Epub 2016 Feb 9. PMID: 26885680

5. Tagoe CE, Zezon A, Khattri S. Rheumatic manifestations of autoimmune thyroid disease: the other autoimmune disease. J Rheumatol. 2012 Jun;39(6):1125-9. Epub 2012 Apr 15.