Selected recent original work
Wang, Y., Yeung, Y.G., Langdon, W.Y. and Stanley, E.R. (1996) c-Cbl Is Transiently Tyrosine phosphorylated, Ubiquitinated, and Membrane-targeted following CSF-1 Stimulation of Macrophages. J. Biol. Chem. 271:17-20. PMID: 8550554
Yeung, Y.G., Soldera, S. and Stanley, E.R. (1998) A novel macrophage actin-associated protein (MAYP) is tyrosine phosphorylated following CSF-1 stimulation. J. Biol. Chem. 273:30638 30642. PMID: 9804836
Lee, P.S.W., Wang, Y., Dominguez, M.G., Yeung, Y-G., Murphy, M.A. Bowtell, D.D.L. and Stanley, E.R. (1999) The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation. EMBO J. 18:3616-3628. PMID: PMC1171440
Fernandez, R., Takahashi, F., Liu, Z., Steward, R., Stein, D. and Stanley, E.R. (2000) The Drosophila Shark tyrosine kinase is required for embryonic dorsal closure. Genes and Development 14:604-614. PMID: PMC316420
Pixley, F.J., Lee, P.S.W., Condeelis, J. and Stanley, E.R. (2001) Protein tyrosine phosphatase phi regulates paxillin tyrosine phosphorylation and mediates Colony Stimulating Factor 1 induced morphological changes in macrophages. Mol. Cell. Biol. 21:1795-1809. PMID: PMC86738
Dai, X-M., Ryan, G.R., Hapel, A.J., Dominguez, M.G., Kapp, S., Sylvestre, V. and Stanley, E.R. (2002) Targeted disruption of the mouse CSF-1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased splenic progenitor cell frequencies and reproductive defects. Blood 99:111-120. PMID: 11756160
Yeung, Y-G. and Stanley, E.R. (2003) Proteomic approaches to analysis of the early events in CSF-1 signal transduction. Molecular and Cellular Proteomics 2: 1143-1155. PMID: 12966146
Wyckoff, J., Wang, W., Lin, E.L., Wang, Y., Pixley, F.J., Stanley, E.R., Graf, T., Pollard, J.W., Segall, J. and Condeelis, J. (2004). A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Res. 64(19):7022-7029. PMID: 15466195
Dai X-M, Zong XH, Sylvestre V and Stanley ER. (2004) Incomplete restoration of colony stimulating factor-1 (CSF-1) function in CSF-1-deficient Csf1op/Csf1op mice by transgenic expression of cell surface CSF-1. Blood 103: 1114-1123. PMID: 14525772
Dai, X-M., Zong, X-H., Akhter, M.P. and Stanley, E.R. (2004). Osteoclast deficiency results in disorganized matrix, reduced mineralization, and abnormal osteoblast behavior in developing bone. J. Bone Min. Res. 19(9):1441-1451. PMID: 15312244
Chitu, V., Pixley, F.J., Yeung, Y.G., Macaluso, F., Condeelis, J and Stanley, E.R. (2005). The PCH family member MAYP/PSTPIP2 directly regulates F-actin bundling and enhances filopodia formation and motility in macrophages. Mol. Biol. Cell. 16(6):2947-2959. PMID: PMC1142438
Grosse, J., Chitu, V., Marquardt, A., Hanke, P., Schmittwolf, C., Zeitlmann, L., Schropp, P., Barth, B., Yu, P., Paffenholz, R., Stumm, G., Nehls M., and Stanley E. R. (2006). Mutation of mouse MAYP/PSTPIP2 causes a macrophage autoinflammatory disease. Blood 107(8):3350-3358. PMID: PMC1895761
Biswas, R., Stein, D. and Stanley, E.R (2006). Drosophila Dok is required for embryonic dorsal closure. Development 133(2):217-227. PMID: 16339186
Nandi, S., Akhter, M.P., Seifert, M.F., Dai, X-M. and Stanley, E.R. (2006). Developmental and functional significance of the CSF-1 proteoglycan chondroitin sulfate chain. Blood 107(2):786-795. PMID: PMC1895624
Zeigenfuss, J.S.*, Biswas, R.*, Avery, M.A., Sheehan, A.E., Hong, K., Yeung Y-G., Stanley, E.R.** and Freeman, M.R.** (2008). Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signaling. Nature 453(7197):935-939. PMID: PMC2493287
Huynh, D., Dai, X-M., Nandi, S., Lightowler, S., Trivett, M., Chan, C-K., Bertoncello, I., Ramsay, R.G. and Stanley, E.R. (2009). CSF-1 dependence of Paneth cell development in the mouse small intestine. Gastroenterology 137(1):136-144. PMID: PMC2706482
Patsialou, A., Wyckoff, J., Wang, Y., Goswami, S., Stanley, E.R. and Condeelis J.S. (2009). Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony stimulating factor-1 receptor. Cancer Research 69(24):9498-9506. PMID: PMC2794986
Xiong, Y., Song, D., Cai, Y., Yu, W., Yeung, Y.G., and Stanley, E.R. (2010). A CSF-1 receptor phosphotyrosine 559 signaling pathway regulates receptor ubiquitination and tyrosine phosphorylation. J. Biol. Chem. 286(2):952-960. PMID: PMC3020780
Wei, S., Nandi, S., Chitu, V., Yeung, Y-G., Yu, W., Huang, M., Williams, L.T., Lin, H. and Stanley, E.R. (2010). Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. J Leukoc. Biol. 88(3):495-505. PMID: 20504948
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M.F., Ng, L.G., Stanley, E.R., Samokhvalov, I.M. and Merad, M. (2010) Fate mapping studies reveal that adult microglia derive from primitive macrophages. Science 330(6005):841-845. PMID: 20966214
Sampaio, N., Yu, W., Cox, D., Wyckoff, J., Condeelis, J., Stanley, E.R. and Pixley, F.J. (2011). Phosphorylation of Y721 of the CSF-1R mediates PI3K association to regulate macrophage motility and enhancement of tumor cell invasion. J. Cell Sci. 124(Pt 12):2021-2031. PMID: PMC3104034
Yu, W., Chen, J., X. Ying, Pixley, F.J., Yeung, Y.G., and Stanley, E.R. (2012). Macrophage proliferation is regulated through CSF-1 receptor tyrosines 544, 559 and 807. J. Biol.Chem. 287:13694-704. PMID: 22375015.
Nandi, S., Gokhan,S., Dai, X-M., Wei, S., Enikolopov, G., Lin,H., Mehler, M.F. and Stanley E.R. (2012). The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation. Developmental Biology 367:100-13. PMID: 22542597.
Chitu V., Nacu, V., Charles, J.F., Henne, W.M., McMahon, H.T., Nandi, S., Ketchum, H., Harris, R., Nakamura, M.C., Stanley, E.R. (2012) PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts. Blood 120:3126-35. PMID: 22923495.
Nandi, S., Cioce, M., Yeung, Y.G., Nieves, E., Tesfa, L., Lin, H., Hsu, A.W., Halenbeck R., Cheng, H.Y., Gokhan, S., Mehler, M.F., Stanley, E.R.(2013).Receptor-type protein tyrosine phosphatase zeta is a functional receptor for interleukin-34. J. Biol. Chem. 288:21972-86. PMID: 23744080
Chitu, V., Gokhan, S., Gulinello, M., Branch C.A., Patil, M., Basu, R., Stoddart C., Mehler M.F. and Stanley E.R.(2014) Phenotypic characterization of a Csf1r haploinsuficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP). Neurobiology of Disease, 74C:219-228. PMID: 25497733
Caescu, C.I., Guo,X., Tesfa, L., Bhagat, T.D., Verma, A., Zheng, D. and Stanley, E.R. (2015). Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21. Blood, . Blood, 125:e1-13. PMID:25573988
Chitu, V., Biundo, F., Shlager, G.G.L., Park, E.S., Wang, P., Gulinello, M.E., Gokhan, S., Ketchum, H.C., Saha, K., DeTure, M. A., Dickson, D.W., Wszolek, Z.K., Zheng, D., Croxford, A.L., Becher, B., Sun, D., Mehler M.F. and Stanley E.R. (2020) Microglial homeostasis requires balanced CSF-1/CSF-2 receptor signaling. Cell Reports, 30:3004-3019. PMID: 32130903
Biundo, F., Chitu, V., Shlager, G.G.L., Park, E.S., Gulinello, M.E., Saha, K., Ketchum, H.C., Fernandes, C., Gökhan, Ş., Mehler, M.F. and Stanley E.R. (2021) Microglial reduction of colony stimulating factor-1 receptor expression is sufficient to confer adult onset leukodystrophy. Glia, 69:779-791. PubMed PMID: 33079443
Selected recent reviews
Pixley, F.J. and Stanley, E.R. (2004) CSF-1 Regulation of the Wandering Macrophage: Complexity in action. Trends in Cell Biol. 14:628-638. PMID: 15519852
Chitu, V. and Stanley E. R. (2006). Colony stimulating factor-1 in immunity and inflammation. Current Opinion in Immunology 18(1):39-48. PMID: 16337366
Chitu, V. and Stanley, E.R. (2007). Pombe Cdc15 homology (PCH) proteins: coordinators of membrane-cytoskeletal interactions. Trends in Cell Biol. 17(3):145-156. PMID: 17296299
Stanley, E.R. (2009), “Colony Stimulating Factor-1 Regulation of Macrophages in Development and Disease” in Gordon, S. ed.) Innate Immunity: Host recognition and response in health and disease, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd. London (online at http://www.hstalks.com/bio).
Stanley, E.R. and Chitu, V. (2014). CSF-1 Receptor Signaling in Myeloid Cells. Cold Spring Harb Perspect Biol. 6(6):1-21 PMID: 24890514.
Chitu, V. and Stanley, E.R. (2015). CSF-1 Receptor. In: The PDGF Receptor Family. Chapter 10 of Receptor Tyrosine Kinases: Family and Subfamilies. (D.L. Wheeler and Yarden, Y., eds.), Humana Press, New York. pp 373-538.
Caescu, C.I. and Stanley, E.R. (2015). FLT3. In: The PDGF Receptor Family. Chapter 10 of Receptor Tyrosine Kinases: Family and Subfamilies. (D.L. Wheeler and Yarden, Y., eds.), Humana Press, New York. pp 373-538.
Chitu,V., Gokhan,S., Nandi, S., Mehler, M. and Stanley, E.R. (2016) Emerging roles for the CSF-1 receptor and its ligands in the nervous system. Trends in Neuroscience, 39:378-393.
Chitu,V. and Stanley, E.R. (2017) Regulation of embryonic and postnatal development by the CSF-1 receptor. Curr. Top. Dev. Biol. 123:229-275.
Chitu, V., Gokhan, S., Nandi, S., Mehler, M. and Stanley, E.R. (2016) Emerging roles for the CSF-1 receptor and its ligands in the nervous system. Trends in Neuroscience, 39:378-393.
Chitu, V., Gökhan, Ş. and Stanley, E.R. (2021) Modeling CSF-1 receptor deficiency diseases – how close are we? FEBS J., Jun 19. doi: 10.1111/febs.16085. Online ahead of print. PMID: 34145972
Chitu, V., Biundo, F. and Stanley, E.R. (2021) Colony Stimulating Factors in the Nervous System. Semin Immunol. 54:101511. doi: 10.1016/j.smim.2021.101511. Epub 2021 Nov 4. PMID: 34743926
(last updated 08/02/22)
