Yan Tang, Ph.D.

Research Assistant Professor, Department of Medicine (Endocrinology)

yan.tang@einsteinmed.edu

Phone

718-678-1031

Location

Albert Einstein College of Medicine Michael F. Price Center 1301 Morris Park Avenue 369 Bronx, NY 10461

Research Profiles

PubMed.gov Portal

Professional Interests

Diabetes. Obesity. Cardiovascular Disease.

Selected Publications

White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function.

Chung YW, Ahmad F, Tang Y, Hockman SC, Kee HJ, Berger K, Guirguis E, Choi YH, Schimel DM, Aponte AM, Park S, Degerman E, Manganiello VC.

Sci Rep. 2017 Jan 13;7:40445. doi: 10.1038/srep40445.

hosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue.

Ahmad F, Chung YW, Tang Y, Hockman SC, Liu S, Khan Y, Huo K, Billings E, Amar MJ, Remaley AT, Manganiello VC.

Sci Rep. 2016 Jun 20;6:28056. doi: 10.1038/srep28056.

The fructose-2,6-bisphosphatase TIGAR suppresses NF-κB signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC.

Tang Y, Kwon H, Neel BA, Kasher-Meron M, Pessin JB, Yamada E, Pessin JE.

J Biol Chem. 2018 May 18;293(20):7578-7591. doi: 10.1074/jbc.RA118.002727. Epub 2018 Apr 12.

Adipocyte-specific IKKβ signaling suppresses adipose tissue inflammation through an IL-13-dependent paracrine feedback pathway.

Kwon H, Laurent S, Tang Y, Zong H, Vemulapalli P, Pessin JE.

Cell Rep. 2014 Dec 11;9(5):1574-1583. doi: 10.1016/j.celrep.2014.10.068. Epub 2014 Nov 26.

High-fat diet-induced adipocyte cell death occurs through a cyclophilin D intrinsic signaling pathway independent of adipose tissue inflammation.

Feng D, Tang Y, Kwon H, Zong H, Hawkins M, Kitsis RN, Pessin JE.

Diabetes. 2011 Aug;60(8):2134-43. doi: 10.2337/db10-1411. Epub 2011 Jul 6.

Autophagy regulates adipose mass and differentiation in mice.

Singh R, Xiang Y, Wang Y, Baikati K, Cuervo AM, Luu YK, Tang Y, Pessin JE, Schwartz GJ, Czaja MJ.

J Clin Invest. 2009 Nov;119(11):3329-39. doi: 10.1172/JCI39228. Epub 2009 Oct 12.

Reduction of phosphodiesterase 3B gene expression in peroxisome proliferator-activated receptor gamma (+/-) mice independent of adipocyte size.

Ogura T, Osawa H, Tang Y, Onuma H, Ochi M, Nishimiya T, Kubota N, Terauchi Y, Kadowaki T, Makino H.

FEBS Lett. 2003 May 8;542(1-3):65-8.

Differential regulation of gene expression and insulin-induced activation of phosphodiesterase 3B in adipocytes of lean insulin-resistant IRS-1 (-/-) mice.

Hasegawa M, Tang Y, Osawa H, Onuma H, Nishimiya T, Ochi M, Terauchi Y, Kadowaki T, Makino H.

Diabetes Res Clin Pract. 2002 Nov;58(2):79-85.

Phosphodiesterase 3B gene expression is enhanced in the liver but reduced in the adipose tissue of obese insulin resistant db/db mouse.

Tang Y, Osawa H, Onuma H, Nishimiya T, Ochi M, Sugita A, Makino H.

Diabetes Res Clin Pract. 2001 Dec;54(3):145-55.

Adipocyte-specific reduction of phosphodiesterase 3B gene expression and its restoration by JTT-501 in the obese, diabetic KKAy mouse.

Tang Y, Osawa H, Onuma H, Hasegawa M, Nishimiya T, Ochi M, Makino H.

Eur J Endocrinol. 2001 Jul;145(1):93-9.

Improvement in insulin resistance and the restoration of reduced phosphodiesterase 3B gene expression by pioglitazone in adipose tissue of obese diabetic KKAy mice.

Tang Y, Osawa H, Onuma H, Nishimiya T, Ochi M, Makino H.

Diabetes. 1999 Sep;48(9):1830-5.

Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the beta3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes.

Ahmad F, Lindh R, Tang Y, Ruishalme I, Ost A, Sahachartsiri B, Strålfors P, Degerman E, Manganiello VC.

Biochem J. 2009 Dec 10;424(3):399-410. doi: 10.1042/BJ20090842.

Insulin-induced formation of macromolecular complexes involved in activation of cyclic nucleotide phosphodiesterase 3B (PDE3B) and its interaction with PKB.

Ahmad F, Lindh R, Tang Y, Weston M, Degerman E, Manganiello VC.

Biochem J. 2007 Jun 1;404(2):257-68.

Effect of adipocyte beta3-adrenergic receptor activation on the type 2 diabetic MKR mice.

Kim H, Pennisi PA, Gavrilova O, Pack S, Jou W, Setser-Portas J, East-Palmer J, Tang Y, Manganiello VC, Leroith D.

Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1227-36.

Adenovirus-mediated overexpression of murine cyclic nucleotide phosphodiesterase 3B.

Ahmad F, Härndahl L, Tang Y, Holst LS, Manganiello VC.

Methods Mol Biol. 2005;307:93-107.

PMID:: 15988058