My research interest is Integrins B1 function of Diabetes. Crucial role of Integrins B1 signaling events in mediating cross-talk to Insulin action in vivo. 

1）Ho D, Zhao X, Yan L, Yuan C, Zong H, et al. Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance. Diabetes. 2015 Mar 2;PubMed PMID: 25732192.

（2）Kwon H, Laurent S, Tang Y, Zong H, Vemulapalli P, et al. Adipocyte-specific IKKβ signaling suppresses adipose tissue inflammation through an IL-13-dependent paracrine feedback pathway. Cell Rep. 2014 Dec 11;9(5):1574-83. PubMed PMID:  25466256; PubMed Central PMCID: PMC4268106

（3）Shemesh A, Wang Y, Yang Y, Yang GS, Johnson DE, et al. Suppression of leucine supplementation. Am J Physiol Regul Integr Comp Physiol. 2014 Nov 15;307(10):R1251-9. PubMed PMID: 25231351; PubMed Central PMCID:  PMC4233288.

（4）Xiaoping Zhao, Xiaoli, Haihong Zong, Arian Abdulla, Ellen S.T. Yang, Qun Wang, Jun-Yuan Ji, Jeffrey E. Pessin, Bhaskar C. Das,              and Fajun Yang Inhibition of SREBP Transcriptional Activity by a Boron-Containing Compound Improves Lipid Homeostasis in Diet-Induced Obesity Diabetes July 2014 63:7 2464-2473

（5）Nuria MartinezDLopez, Diana Athonvarangkul, Srabani Sahu, Luisa Coletto, Haihong Zong,Jeffrey E Pessin, Gary J Schwartz, Rajat Singh. Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development. EMBO reports(2013)14,795-803

（6）Adi Shemesh, Arian Abdulla ,Fajun Yang , Streamson C. Chua, Jeffrey E Pessin, Haihong Zong （Corresponding author）. The Antidepressant Trans-2-Phenylcyclopropylamine Protects Mice from High-Fat-Diet-Induced Obesity. PLoS One. 2014 Feb 21;9(2):e89199.

（7）Ting-Wen A. Lee,Hyokjoon Kwon, Haihong Zong, Eijiro Yamada, Manu Vatish,Jeffrey E. Pessin, and Claire C. Bastie.     Fyn Deficiency Promotes a Preferential Increase in Subcutaneous Adipose Tissue Mass and Decreased Visceral Adipose Tissue Inflammation. Diabetes 2013 Jan 15

（8）Haihong Zong, Michal Armoni, Chava Harel, Eddy Karnieli, Jeggrey E Pessin. Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance. Am J Physiol Endocrinol Metab. 2012 Mar 1 302(5):E532-9

（9）Daorong Feng, Yan Tang, Hyokjoon Kwon, Haihong Zong,   Meredith Hawkins, Richard N. Kitsis and Jeffrey E. Pessin. High-Fat Diet–Induced Adipocyte Cell Death Occurs Through a Cyclophilin D Intrinsic Signaling Pathway Independent of Adipose Tissue Inflammation. Diabetes 2011 Aug; 60(8):2134-43

（10）Ping Huang, Oladapo Yeku, Haihong Zong, Jeffery E. Pessin Michael A Frohman. Phosphatidylinositol 4-Phosphate 5-Kinase a deficiency alters dynamics of glucose- stimulated insulin secretion and protects against Type II diabetes and obesity in mice. Diabetes. 2011 Feb; 60(2):454-63

（11）Ling Li, Yan Yang,         Gangyi Yang, Chunming Li, Mengliu Yang, Hua Liu and  Haihong Zong. The role of JAZF1 on Lipid metabolism and related genes in virto. Metabolism. 2011 Apr; 60(4):523-30

（12）Maria D’Apolito, Xueliang Du, Haihong Zong, Alessandra Catucci, Luigi Maiuri, Tiziana Trivisano, Massimo Pettoello-Mantovani, Angelo Campanozzi, Valeria Raia, Jeffrey E. Pessin, Michael Brownlee and Ida Giardino. Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure. J Clin Invest. 2010; 120(1):203–213

（13）Haihong Zong , Cheng-Chun Wang, Bhavapriya Vaitheesvaran, Irwin J. Kurland, Wanjin Hong and Jeffrey E. Pessin. Enhanced Energy Expenditure, Glucose Utilization And Insulin Sensitivity In VAMP8 Null Mice. Diabetes 2011 Jan; 60(2):454-63(PMCID: PMC3012186)

（14） Mengliu Yang, Gangyi Yang, Dong Jun, Liu Yang, Haihong Zong, Hua Liu, Li L. Elevated plasma levels of chemerin in newly diagnosed type2 diabetes mellitus with hypertension. J investing Med. 2010 Oct: 58(7): 883-6

（15）Ke Li, Ling Li, Mengliu Yang, Haihong Zong, Hua Liu and Gangyi Yang. Effects of rosiglitazone on fasting plasma fibroblast growth factor-21 levels in patients with type 2 diabetes mellitus. Eur J Endocrinol   2009 Sep;161(3):391-5.

（16）Sun Qin, Li Ling, Li Renzhe, Yang Mengliu, Liu Hua, Michael J. Nowicki c, Haihong

Zong,    Jun Xu, Gangyi Yang. Overexpression of visfatin/PBEF/Nampt alters whole-body insulin sensitivity and lipid profile in rats. Ann Med. 2009; 41(4): 311-20.

（17）Séverine Groh, Haihong Zong, Matthew M. Goddeeris, David Venzke, Connie S. Lebakken, Jeffrey E. Pessin, and Kevin P. Campbell. The adipose dystrophin glycoprotein complex: implications for metabolic defects in muscular dystrophies. JBC 2009 Jul, 17; 284(29): 19178-82

（18）Haihong Zong, Claire Bastie, Reinhard Fassler, Kevin Campbell and Jeffrey E. Pessin. Insulin Resistance in Striated Muscle Specific Integrin Beta1 Receptor Subunit Knockout Mice. JBC 2009 Feb 13; 284(7): 4679-88

（19）Claire Bastie, Haihong Zong, Jun Xu, Bhavin Busa, Stefan Judex, Irwin J. Kurland, and Jeffrey E. Pessin.             A novel role for the Src Kinase Family Member Fyn in the integrative metabolic regulation of peripheral tissue fatty acid oxidation. Cell Metab. 2007 May; 5(5): 371-81.

（20）Richard M. Reznick, Haihong Zong, Ji Li, Katsutaro Morino, Irene K. Moore, Hannah J. Yu, Zhen-Xiang Liu, Lawrence H. Young, and Gerald I. Shulman. Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis.          Cell Metab. 2007; 5(2):151

（21）Haihong Zong, JianMing Ren, Lawrence H. Young, Marc Pypaert, James Mu, Morris J Birnbaum and Gerald I. Shulman. AMP Kinase is required for Mitochondrial Biogenesis in Skeletal Muscle in Response to Chronic Energy Deprivation. PNAS. 2002 Dec 10; 99(25): 15983-15987.

（22）Chunli Yu, Yan Chen, Haihong Zong and Gerald I Shulman. Mechanism by which Fatty acids Inhibit Insulin Activation of IRS-1 Associated Phosphatidytlinostol

3-kinsae activate in muscle. JBC. 2002 Dec 27; 277(52): 50230-6.

（23）Jason K.Kim Ariel Zisman, Haihong Zong, and Gerald I Shulman. Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. JCI 2001. 108:153-16