Mohammad Asad, Ph.D.

I am Mohammad Asad, an instructor in the Department of Neurosurgery.

Our research focuses on glioblastoma (GBM), the most aggressive form of brain tumor. A primary goal is to understand the factors within the tumor microenvironment that contribute to its immunosuppressive nature, ultimately leading to improved therapies for GBM.

We are particularly interested in how tumors induce immune suppression. Our work centers on immunosuppressive monocytes and myeloid-derived suppressor cells (MDSCs). These cells play a crucial role in hindering the immune response by releasing factors that limit the effectiveness of both innate and adaptive immune cells within the tumor. Understanding the specific roles of different immunosuppressive myeloid cell subpopulations and their mechanisms is essential for developing effective treatments.

Additionally, we are investigating the roles of tumor-derived extracellular vesicles (EVs) and other soluble mediators that suppress immune responses. By targeting these interactions, we aim to restore immune function. Our research utilizes both humans and animals, as well as ex vivo and 3D models, including patient-derived tumor samples and immunocompetent murine glioma models.

Identifying the key factors that contribute to the immunosuppressive environment will inform the development of targeted therapies designed to restore immune function and improve treatment effectiveness. Our work will also reveal potential therapeutic targets to disrupt these immunosuppressive mechanisms, ultimately enhancing patient outcomes. Furthermore, my research aims to provide valuable insights into the complex interactions between tumor cells and the immune system, contributing to the broader field of brain tumor research.