Dr. Jankauskas is the top expert in mitochondrial biology with a special focus on reactive oxygen species, and quality-control mechanisms, including mitophagy and calcium signaling. During his career, he studied the role of mitochondria in different pathologies including heart failure, type 1 diabetes, obesity and type 2 diabetes, acute kidney injury, and chronic kidney disease. Dr. Jankauskas has deep technical expertise in different visualizing approaches, including confocal microscopy and live imaging.

Selected Publications:

• Circulating levels of cadherins are associated with atherosclerosis and cardiovascular outcomes. Santulli G, Varzideh F, Qin Y, Wang B, Kansakar U, Jankauskas S.S. JMCC Plus. 2024; in press.
• A six-year study in a real-world population reveals an increased incidence of dyslipidemia during COVID-19. Trimarco V.*, Izzo R.*, Jankauskas S.S.* (*:co-First authors), Fordellone M., Signoriello G., Manzi M.V., Lembo M., Gallo P., Esposito G., Piccinocchi R., Rozza F., Morisco C., Mone P., Piccinocchi G, Varzideh F., Trimarco B., Santulli G. Journa of Clinical Investigation (JCI) 134(21):e183777 doi: 10.1172/JCI183777. 2024
• Mechanistic role of mesencephalic astrocyte-derived neurotrophic factor in myocardial ischemia/reperfusion injury. Varzideh F., Wang B., Qin Y., Kansakar U., Santulli G., Jankauskas S.S. Mol Med. 30(1):188. doi: 10.1186/s10020-024-00927-3. 2024
• Exogenous Ketones in Cardiovascular Disease and Diabetes: From Bench to Bedside. Kansakar U., Nieves Garcia C., Santulli G., Gambardella J., Mone P., Jankauskas S.S..* (*:co-corresponding authors), Lombardi A*. J. Clin. Med. 13, 7391. https://doi.org/10.3390/ jcm13237391 2024
• SGLT2 inhibitors and GLP-1 receptor agonists: which is the best anti-frailty drug? Mone P., Ciccarelli M., Jankauskas S.S., Guerra G., Vecchione C., Visco V., Santulli G. Lancet Healthy Longev. 5(9):100632. doi: 10.1016/j.lanhl.2024.08.001. 2024
• Insights into Molecular and Cellular Functions of the Golgi Calcium/Manganese-Proton Antiporter TMEM165. Jankauskas S.S., Varzideh F., Kansakar U., Al Tibi G., Agyapong E.D., Gambardella J., Santulli G. J Biol Chem. 300(8):107567. doi: 10.1016/j.jbc.2024.10756, 2024
• The Dual Endothelin-1 Antagonist Aprocitentan Alleviates Mitochondrial Oxidative Stress in Human Cardiac Fibroblasts. Varzideh F, Jankauskas S.S., Jain U, Soderquist L, Agyapong ED, Kansakar U, Santulli G. Eur Heart J (Cardiovasc Pharmacother). 2024 Jul 8:pvae050. doi: 10.1093/ehjcvp/pvae050.
• Endothelial extracellular vesicles enriched in microRNA-34a predict new-onset diabetes in COVID-19 patients: novel insights for long-COVID metabolic sequelae. Mone P.*, Jankauskas S.S.* (*:co-First authors), Manzi M.V., Gambardella J., Coppola A., Kansakar U., Izzo R., Fiorentino G., Lombardi A., Varzideh F., Sorriento D., Trimarco B., Santulli G., J Pharmacol Exp Ther., 389(1):34-39 2024
• COVID-19 Causes Ferroptosis and Oxidative Stress in Human Endothelial Cells. Jankauskas S.S., Kansakar U., Varzideh F., Avvisato R., Wang X., Matarese A., Marfella R., Ziosi M., Gambardella J., Santulli G. Antioxidants, 12(2), 326, 2023
• Ketone bodies rescue mitochondrial dysfunction via epigenetic remodeling. Gambardella J. Jankauskas S.S., Kansakar U., Varzideh F., Avvisato R., Prevete N, Sidoli S, Mone P, Wang X, Lombardi A, Santulli G. JACC Basic to Translational Science, 8(9):1123-1137, 2023. (with Editorial by Jun Sadoshima)
• Glycation of RyR in circulating lymphocytes predicts the response to cardiac resynchronization therapy. Gambardella J*, Jankauskas S.S* (*:co-First authors), D'Ascia SL, Sardu C, Matarese A, Minicucci F, Mone P, Santulli G. J Heart Lung Transplant. 41(4):438. 2022. (Impact Factor 2021: 13.569)
• Heart failure in diabetes. Jankauskas S.S., Kansakar U., Varzideh F., Wilson S., Mone P., Lombardi A., Gambardella J., Santulli G. Metabolism, 125, 154910, 2021.
• Dysfunction of kidney endothelium after ischemia/reperfusion and its prevention by mitochondria-targeted antioxidant. Jankauskas S.S., Andrianova N.V., Alieva I.B., Prusov A.N., Matsievsky D.D., Zorova L.D., Pevzner I.B., Savchenko E.S., Pirogov Y.A., Silachev D.N., Plotnikov E.Y., Zorov D.B. Biochemistry 81(12), 1538–1548, 2018.
• A long-linker conjugate of fluorescein and triphenylphosphonium as mitochondria-targeted uncoupler and fluorescent neuro-and nephroprotector. Antonenko Y.N., Denisov S.S., Silachev D.N., Khailova L.S., Jankauskas S.S., Rokitskaya T.I., Danilina T.I., Kotova E.A., Korshunova G.A., Plotnikov E.Y., Zorov D.B. BBA, 1860 (11 Pt A), 2463-2473, 2016.
• Mitochondria-targeted antioxidant SkQR1 ameliorates gentamycin induced renal failure and hearing loss. Jankauskas S.S., Plotnikov E.Y., Morosanova M.A., Pevzner I.B., Zorova L.D., Skulachev V.P., and Zorov. D.B. Biochemistry, 77(6), 666-670, 2012.