Gaetano Santulli's Lab


The P.I.

Gaetano Santulli, MD, PhD

Associate Professor of Cardiology
Associate Professor of Molecular Pharmacology






Dr. Santulli's Hirsch Index: 52 (i10 index: 106)  






Our Best Papers (covers):COVERS_SANTULLI_LAB  






161) Hyperglycemia drives restenosis in STEMI patients. 

Pasquale Mone, Jessica Gambardella, Fabio Minicucci, Angela Lombardi, Ciro Mauro, Gaetano Santulli.

Diabetes Care. 2021; in press.


160) Role of endothelial miR-24 in COVID-19 cerebrovascular events.  

Jessica Gambardella, Antonietta Coppola, Raffaele Izzo, Giuseppe Fiorentino, Bruno Trimarco, Gaetano Santulli.

Critical Care. 2021; in press.


159) Cognitive impairment in frail elderly with hypertension: role of hyperglycemia. 

Pasquale Mone, Jessica Gambardella, Antonella Pansini, Antonio de Donato, Giuseppe Martinelli, Eugenio Boccalone, Alessandro Matarese, Salvatore Frullone, Gaetano Santulli.

Cells. 2021; in press.


158) Functional role of miR-155 in the pathogenesis of diabetes mellitus and its complications.  

Stanislovas S. Jankauskas, Jessica Gambardella, Celestino Sardu, Angela Lombardi, Gaetano Santulli.  

Noncoding RNA. 2021;7(3):39. doi: 10.3390/ncrna7030039. 


157) SGLT2 inhibitors in cardiovascular medicine.  

Fahimeh Varzideh, Urna Kansakar, Gaetano Santulli. 

Eur Heart J (Cardiovascular Pharmacotherapy). 2021;7(4):e67-e68.  


156) A Retinoic Acid Receptor β2 agonist improves cardiac function in a heart failure model.

Xiao-Han Tang*, Jessica Gambardella* (*co First Author), Stanislovas S. Jankauskas, Xujun Wang, et al.

JPET. 2021; in press. doi: 10.1124/jpet.121.000806.


155) miR-24 targets the transmembrane glycoprotein Neuropilin-1 in human brain microvascular endothelial cells.

Pasquale Mone, Jessica Gambardella, Xujun Wang, Stanislovas S. Jankauskas, Alessandro Matarese, Gaetano Santulli.

Noncoding RNA. 2021;7(1):9. doi: 10.3390/ncrna7010009.


154) Targeting the phenotypic switch of vascular smooth muscle cells to tackle atherosclerosis.

Urna Kansakar, Stanislovas Jankauskas, Jessica Gambardella, Gaetano Santulli.

Atherosclerosis. 2021;324:117-120.


153) Cognitive dysfunction correlates with physical impairment in frail patients with acute myocardial infarction.  

Pasquale Mone, Jessica Gambardella, Antonella Pansini, Giuseppe Martinelli, Fabio Minicucci, Ciro Mauro, Gaetano Santulli.

Aging Clin Exp Res. 2021; in press. doi: 10.1007/s40520-021-01897-w. 


152) Mitochondrial remodeling and dynamic inter-organellar contacts in cardiovascular physiopathology.  

Gaetano Santulli, Giovanni Monaco, Valentina María Parra, Giampaolo Morciano. 

Front Cell Dev Biol. 2021;9:679725. doi: 10.3389/fcell.2021.679725. 


151) Inclisiran: a new milestone on the PCSK9 road to tackle cardiovascular risk.

Gaetano Santulli, Stanislovas S. Jankauskas, Jessica Gambardella.

Eur Heart J CVP. 2021 Feb 28:pvab014. doi: 10.1093/ehjcvp/pvab014.


150) Chronic kidney disease: Definition, updated epidemiology, staging, and mechanisms of increased cardiovascular risk. 

Scott Wilson, Pasquale Mone, Stanislovas S. Jankauskas, Jessica Gambardella, Gaetano Santulli.

J Clin Hypertens. 2021;23(4):831-834. doi: 10.1111/jch.14186. 


149) In patients with early AF and CV conditions, early rhythm-control therapy vs. usual care reduced CV events at 5 years.

Gaetano Santulli.

Ann Intern Med. 2021;174(1):JC6.doi: 10.7326/ACPJ202101190-006. 


148) Impact of thrombus aspiration in frail STEMI patients. 

Pasquale Mone, Jessica Gambardella, Antonella Pansini, Mario Rizzo, Ciro Mauro, Fabio Minicucci, Gaetano Santulli. 

Aging Clinical and Experimental Research 2021; in press. doi: 10.1007/s40520-021-01848-5. 


147) Thyroid hormones regulate both cardiovascular and renal mechanisms underlying hypertension.

Stanislovas Jankauskas, Marco Morelli, Jessica Gambardella, Angela Lombardi, Gaetano Santulli.

J Clin Hypertens. 2021;23(2):373-381. doi: 10.1111/jch.14152.


146) What is linking COVID-19 and endothelial dysfunction? Updates on nanomedicine and bioengineering from the 2020 AHA Scientific Sessions.

Jessica Gambardella, Gaetano Santulli.

Eur Heart J (CVP). 2021;7(3):e2-e3. doi: 10.1093/ehjcvp/pvaa145.


145) The discovery and development of IP3 receptor modulators: an update.

Jessica Gambardella, Marco Morelli, Xujun Wang, Vanessa Castellanos, Pasquale Mone, Gaetano Santulli.

Expert Opin Drug Discov. 2021 Jan 6:1-10. doi: 10.1080/17460441.2021.1858792.


144) Effects of Chronic Supplementation of L-Arginine on Physical Fitness in Water Polo Players.  

Jessica Gambardella, et al.

Oxid Med Cell Longev. 2021;2021:6684568. doi: 10.1155/2021/6684568. 


143) Exploiting GRK2 Inhibition as a Therapeutic Option in Experimental Cancer Treatment: Role of p53-Induced Mitochondrial Apoptosis.

Jessica Gambardella, et al.

Cancers. 2020;12(12):3530.


142) Role of endothelial GRK2 in angioedema.

Jessica Gambardella, et al.

Hypertension. 2020;76(5):1625-1636.


141) miR-98 regulates TMPRSS2 expression in human endothelial cells: Key implications for COVID-19.

Jessica Gambardella*, Alessandro Matarese*, Celestino Sardu, Gaetano Santulli.

BioMedicines. 2020;8(11):462. doi:10.3390/biomedicines8110462.


140) Genetics of adrenergic signaling drives coronary artery calcification. 

Jessica Gambardella, Xujun Wang, Pasquale Mone, Wafiq Khondkar, Gaetano Santulli. 

Atherosclerosis. 2020;310:88-90.


139) Metabolic flexibility of mitochondria plays a key role in balancing glucose and fatty acid metabolism in the diabetic heart. 

Jessica Gambardella, Angela Lombardi, Gaetano Santulli. 

Diabetes. 2020;69(10):2054-2057.


138) Standardizing translational microbiome studies and metagenomics analyses. 

Jessica Gambardella, Vanessa Castellanos, Gaetano Santulli. 

Cardiovascular Research. 2020;117(3):640-642.


137) Arginine and endothelial function. 

Jessica Gambardella, et al.

BioMedicines. 2020;8(8):277.


136) No Pleiotropic Effects of Linagliptin on Atherosclerotic Plaques: Case Closed. 

Mouaz H. Al-Mallah, Fabien Hyafil, Gaetano Santulli.

Atherosclerosis. 2020;305:61-63. doi: 10.1016/j.atherosclerosis.2020.05.009.


135) Vitamin C and Cardiovascular Disease: An Update.

Marco Morelli*, Jessica Gambardella*, Vanessa Castellanos, Valentina Trimarco, Gaetano Santulli.

Antioxidants. 2020;9(12):1227. doi: 10.3390/antiox9121227.


134) miR-7 regulates GLP-1-mediated insulin release by targeting Beta-Arrestin 1. 

Alessandro Matarese, Jessica Gambardella, Angela Lombardi, Xujun Wang, Gaetano Santulli. 

Cells. 2020;9(7):1621.


133) Hypertension, thrombosis, kidney failure, and diabetes: Is COVID-19 an endothelial disease? A comprehensive evaluation of clinical and basic evidence. 

Celestino Sardu, Jessica Gambardella, Marco B. Morelli, Xu Jun Wang, Raffaele Marfella, Gaetano Santulli. 

J Clin Med. 2020;9(5):1417. doi: 10.3390/jcm9051417.


132) Cardiac BIN1 replacement therapy ameliorates inotropy and lusitropy in heart failure by regulating calcium handling. 

Jessica Gambardella, Xu Jun Wang, John Ferrara, Marco B. Morelli, Gaetano Santulli. 

JACC BTS. 2020;5(6):579-581.


131) Is Endothelial Dysfunction the Concealed Cornerstone of COVID-19? 

Gaetano Santulli, Marco B. Morelli, Jessica Gambardella.

BMJ. 2020; online only.


130) Pathophysiological mechanisms underlying the beneficial effects of physical activity in hypertension.

Jessica Gambardella, Marco B. Morelli, Xu Jun Wang, Gaetano Santulli. 

J Clin Hypertens. 2020;22(2):291-295.


129) COVID-19 and endothelial dysfunction.

Jessica Gambardella, Celestino Sardu, Gaetano Santulli. 

JAMA. 2020; Online only letter.


128) Implications of AB0 blood group in hypertensive patients with COVID-19. 

Celestino Sardu, Raffaele Marfella, Paolo Maggi, Vincenzo Messina, Paolo Cirillo, Vinicio Codella, Jessica Gambardella, Antonio Sardu, Gianluca Gatta, Gaetano Santulli and Giuseppe Paolisso.

BMC Cardiovasc Disord. 2020;20(1):373. doi: 10.1186/s12872-020-01658-z. 


127) Inositol 1,4,5-Trisphosphate Receptors in Human Disease: A Comprehensive Update. 

Jessica Gambardella, Angela Lombardi, Marco B. Morelli, John Ferrara, Gaetano Santulli. 

J Clin Med. 2020 Apr 12;9(4). pii: E1096.


126) A small molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy. 

Dulguun Amgalan, Thomas P. Garner, Ryan Pekson, Xiaotong F. Jia, Mounica Yanamandala, Victor Paulino, Felix G. Liang, J. Jose Corbalan, Jaehoon Lee, Yun Chen, George S. Karagiannis, Luis Rivera Sanchez, Huizhi Liang, Swathi-Rao Narayanagari, Kelly Mitchell, Andrea Lopez, Victoria Margulets, Marco Scarlata, Gaetano Santulli, Aarti Asnani, Randall T. Peterson, Rachel B. Hazan, John S. Condeelis, Maja H. Oktay, Ulrich Steidl, Lorrie A. Kirshenbaum, Evripidis Gavathiotis, Richard N. Kitsis.

Nature Cancer. 2020;1(3):315-328. doi: 10.1038/s43018-020-0039-1.


125) In acute HF, intensive and sustained vasodilation did not reduce a composite of death or readmission at 180 days. 

Gaetano Santulli. 

Ann Intern Med. 2020; in press.


124) Modulation of SERCA in patients with persistent atrial fibrillation treated by epicardial thoracoscopic ablation: The CAMAF Study.

Celestino Sardu, Gaetano Santulli, Germano Guerra, Maria Consiglia Trotta, Matteo Santamaria, Cosimo Sacra, Nicola Testa, Valentino Ducceschi, Gianluca Gatta, Michele D’ Amico, Ferdinando Carlo Sasso, Giuseppe Paolisso, Raffaele Marfella.

J Clin Med. 2020;9(2):544; doi: 10.3390/jcm9020544.


123) Calcium supplements: Good for the bone, bad for the heart? A systematic updated appraisal. 

Marco Bruno Morelli, Gaetano Santulli, Jessica Gambardella.

Atherosclerosis. 2020; in press. doi: 10.1016/j.atherosclerosis.2020.01.008.


122) In AF and stable CAD, rivaroxaban reduced cardiovascular events and mortality more than rivaroxaban plus an antiplatelet agent in AF and stable CAD.

Gaetano Santulli. 

Ann Intern Med. 2020;172(2):JC6. doi: 10.7326/ACPJ202001210-006.


121) Cardiosomal microRNAs are essential in post-infarction myofibroblast phenoconversion.

Marco B. Morelli, Jun Shu, Celestino Sardu, Alessandro Matarese, Gaetano Santulli. 

Int. J. Mol. Sci. 2020, 21(1), 201.


120) Angiopoietin-like proteins as therapeutic targets for cardiovascular disease: focus on lipid disorders.

Marco Bruno Morelli, Christopher Chavez, Gaetano Santulli. 

Expert Opin Ther Targets. 2020;24(1):79-88. doi: 10.1080/14728222.2020.1707806.


119) Cardiomyocyte-derived exosomal microRNA-92a mediates post-ischemic myofibroblast activation both in vitro and ex vivo.

Xujun Wang, Marco Bruno Morelli, Alessandro Matarese, Celestino Sardu, Gaetano Santulli. 

European Society of Cardiology – Heart Failure (ESC-HF); The Official Journal of the Heart Failure Association (HFA). 2020;7(1):284-288. doi: 10.1002/ehf2.12584.


118) Safety in numbers: identifying multiple targets for beta cell proliferation.

Gaetano Santulli. 

Science Translational Medicine. 2019;11(475). doi: 10.1126/scitranslmed.aaw5312.


117) Catheter ablation improved quality of life more than drug therapy at 1 y in symptomatic atrial fibrillation.

Gaetano Santulli. 

Ann Intern Med. 2019;171(2):JC10. doi: 10.7326/ACPJ201907160-010


116) We are what we eat: Impact of food from short supply chain on metabolic syndrome.

Gaetano Santulli, Valeria Pascale, Rosa Finelli, Valeria Visco, Rocco Giannotti, Angelo Massari, Carmine Morisco, Michele Ciccarelli, Maddalena Illario, Guido Iaccarino, Enrico Coscioni.

J Clin Med. 2019;8(12). pii: E2061. doi: 10.3390/jcm8122061.


115) Pre-eclampsia and future cardiovascular diseases: How to assess the risk? 

Gaetano Santulli, Mouaz H. Al-Mallah.

Atherosclerosis. 2019;290:136-137. doi: 10.1016/j.atherosclerosis.2019.07.004.


114) In type 2 diabetes, intensive glucose control for 5.6 years did not differ from usual care for major CV events at 14 years. 

Gaetano Santulli. 

Ann Intern Med. 2019 Sep 17;171(6):JC31. doi: 10.7326/ACPJ201909170-031.


113) Heparanase in health and disease: the neglected housekeeper of the cell? 

Jun Shu, Gaetano Santulli. 

Atherosclerosis. 2019;283:124-126. doi: 10.1016/j.atherosclerosis.2019.01.017.


112) Exosomal microRNA: The revolutionary endogenous Innerspace nanotechnology.

Gaetano Santulli. 

Science Translational Medicine. 2018;10(467):eaav9141. 


111) Why is chronic obstructive pulmonary disease linked to atrial fibrillation? A systematic overview of the underlying mechanisms. 

Alessandro Matarese, Celestino Sardu, Jun Shu, Gaetano Santulli. 

Int J Cardiol. 2019;276:149-151. doi: 10.1016/j.ijcard.2018.10.075.


110) Diabetes, body fat, skeletal muscle, and hypertension: The ominous chiasmus? 

Jun Shu, Alessandro Matarese, Gaetano Santulli. 

J Clin Hypertens. 2019;21(2):239-242.


109) Stroke prevention: Learning from the master (and COMMANDER). 

Gaetano Santulli. 

Science Translational Medicine. 2018;10(459):eaav0340. doi: 10.1126/scitranslmed.aav0340.

Invited commentary on “Rivaroxaban in patients with heart failure, sinus rhythm, and coronary disease” NEJM. 2018;379(14):1332-1342.


108) Dietary fat is a key determinant in balancing mitochondrial dynamics in heart failure: A novel mechanism underlying the obesity paradox. 

Matteo De Rosa, Jessica Gambardella, Jun Shu, Gaetano Santulli. 

Cardiovasc. Res. 2018;114(7):925-927. doi: 10.1093/cvr/cvy074.


107) Connecting myofibroblasts and cardiomyocytes via extracellular vesicle-associated microRNA: A short-distance affair.

Xiao H, Shiu PKT, Shu J, Santulli G, Gheybi M, Conn SJ, Bogard B, Hubé F, Taube JH, Mani SA, Song L, Calin GA, Zhang S.

Non-coding RNA. 2018;18;4.


106) Cardioprotective effects of autophagy: Eat your heart out, heart failure! 

Gaetano Santulli. 

Science Transl. Med. 2018;10(443). pii: eaau0462. doi: 10.1126/scitranslmed.aau0462


105) Update on peripheral artery disease: Epidemiology and evidence based facts.

Jun Shu, Gaetano Santulli.  

Atherosclerosis. 2018;275:379-381. doi: 10.1016/j.atherosclerosis.2018.05.033


104) In diabetes with no CVD, aspirin reduced serious vascular events but increased major bleeding at 7.4 years. 

Gaetano Santulli. 

Ann Intern Med. 2018;169(12):JC67. doi: 10.7326/ACPJC-2018-169-12-067.

Invited commentary on "Effects of aspirin for primary prevention in persons with diabetes mellitus" NEJM. 2018;379:1529-39.


103) The lymphatic border patrol outwits inflammatory cells in myocardial infarction.

Gaetano Santulli.  

Science Translational Medicine. 2018; Vol. 10, Issue 451, eaau7379; doi: 10.1126/scitranslmed.aau7379. (Editors' Choice)


102) The amino-terminal domain of GRK5 inhibits cardiac hypertrophy through the regulation of calcium/calmodulin dependent transcription factors. 

Daniela Sorriento, Gaetano Santulli, Michele Ciccarelli, Angela Serena Maione, Maddalena Illario, Bruno Trimarco, Guido Iaccarino.

Int J Mol Med. 2018;19(3). pii: E861. doi: 10.3390/ijms19030861.


101) Ryanodine Receptor calcium leak in circulating B-lymphocytes as a biomarker in heart failure.

Alexander Kushnir, Gaetano Santulli, Steven R. Reiken, Ellie Coromilas, Sara J. Godfrey, Danielle L. Brunjes, Paolo C. Colombo, Melana Yuzefpolskaya, Seth I. Sokol, et al.

Circulation. 2018; 138(11):1144-1154.

F1000 recommended article. 


100) Overlooking cardiac dysfunction triggered by immune checkpoint inhibitors: Caution, trespassers will be ventilated! 

Gaetano Santulli. 

Science Translational Medicine. 2018;10(435):eaat3888. doi: 10.1126/scitranslmed.aat3888.


99) Effectiveness of new generation drug-eluting stents in ostial right coronary artery lesions. 

Matteo De Rosa, Gaetano Santulli.  

International Journal of Cardiology. 2018;254:84-86.


98) Ryanodine receptor structure and function in health and disease.

Gaetano Santulli, Daniel R. Lewis, Andrew Marks, and Joachim Frank.

Subcellular Biochemistry. 2018;87:329-352.

F1000 recommended article. 


97) Endothelial cells: The heart attack of the Clones. 

Gaetano Santulli.  

Science Translational Medicine. 2018;10(427):eaar7529. doi: 10.1126/scitranslmed.aar7529.


96) Mechanistic role of Beta2 adrenergic receptor in glucose homeostasis. 

Gaetano Santulli and Guido Iaccarino.

Circulation.2017; doi: 10.7916/D89310HZ.


95) Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells. 

Angela Lombardi, Jessica Gambardella, Xue-Liang Du, Daniela Sorriento, Maurizio Mauro, Guido Iaccarino, Bruno Trimarco, Gaetano Santulli.  

Sci. Reports. 2017;7:15823.


94) Quit smoking to outsmart atherogenesis: Molecular mechanisms underlying clinical evidence 

Jessica Gambardella, Celestino Sardu, Cosimo Sacra, Carmine Del Giudice, Gaetano Santulli. 

Atherosclerosis. 2017;257:242-245.


93) Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure.

Angela Lombardi, Bruno Trimarco, Guido Iaccarino, Gaetano Santulli.  

Cell Commun. 2017 Nov 13;15(1):47. doi: 10.1186/s12964-017-0203-0.


92) Opposite effects of Beta2-adrenoceptor gene deletion on insulin signaling in liver and skeletal muscle. 

Ersilia Cipolletta, Carmine Del Giudice, Gaetano Santulli, Bruno Trimarco, Guido Iaccarino.

Nutr Metab Cardiovasc Dis. 2017;27:615-623. doi: 10.1016/j.numecd.2017.05.011.


91) Physiology and pathophysiology of excitation-contraction coupling: the functional role of ryanodine receptor.

Gaetano Santulli, Daniel R. Lewis, et al.

J Muscle Res Cell Motil. 2017;38:47-45.


90) Mechanistic role of kinases in the regulation of mitochondrial fitness. 

Daniela Sorriento, Jessica Gambardella, Antonella Fiordelisi, Bruno Trimarco, Michele Ciccarelli, Guido Iaccarino, Gaetano Santulli. 

Adv Exp Med Biol. 2017;982:521-528. doi: 10.1007/978-3-319-55330-6-26.


89) Linking inflammation and beta cell death: the functional role of microRNA.

Cyrinne Achour, Baptiste Bogard, Florent Hubé, Sendurai A. Mani, Gaetano Santulli and Joseph H. Taube.

Non-Coding RNA. 2017;3(2):21.


88) Effects of alpha-lipoic acid on multiple cytokines and biomarkers and recurrence of atrial fibrillation within one year of catheter ablation. 

Celestino Sardu, Gaetano Santulli, Matteo Santamaria, Michelangela Barbieri, Cosimo Sacra, Pasquale Paolisso, Fabio D’Amico, Nicola Testa, Igor Caporaso, Giuseppe Paolisso, Raffaele Marfella, Maria Rosaria Rizzo.

Am J Cardiol. 2017;119:1382-1386.


87) Functional role of mitochondria in arrhythmogenesis. 

Jessica Gambardella, Daniela Sorriento, Michele Ciccarelli, Carmine Del Giudice, Antonella Fiordelisi, Luigi Napolitano, Bruno Trimarco, Guido Iaccarino, Gaetano Santulli. 

Adv Exp Med Biol. 2017;982:191-202. doi: 10.1007/978-3-319-55330-6_10.


86) Dietary components and metabolic dysfunction: Translating preclinical studies into clinical practice. 

Gaetano Santulli.

Nutrients. 2016;13;8(10). pii: E632.


85) Childhood obesity and education. 

Gaetano Santulli. 

The Lancet (Diabetes & Endocrinology). 2016;4(11):957. 


84) Intracellular calcium release channels: an update. 

Gaetano Santulli, Ryutaro Nakashima, et al.

J of Physiol. 2017;595:3041-3051.


83) The possible role of chromosome X variability in hypertensive familiarity. 

Michele Ciccarelli, Rosa Finelli, Gaetano Santulli, Natalia Rivera, et al.

Journal of Human Hypertension (Nature Publishing Group). 2017;31:37-42. 


82) Integrating diet and inflammation to calculate cardiovascular risk. 

Jessica Gambardella, Gaetano Santulli. 

Atherosclerosis. 2016,253:258-261. doi: 10.1016/j.atherosclerosis.2016.08.041.


81) Telemonitoring in heart failure patients treated by cardiac resynchronisation therapy with defibrillator (CRT-D): the TELECART Study. 

Celestino Sardu, Matteo Santamaria, Maria Rosaria Rizzo, Michelangela Barbieri, Mauro di Marino, Giuseppe Paolisso, Gaetano Santulli, Raffaele Marfella.

Int J Clinical Practice. 2016;70:569-76.


80) Microbiome and MicroRNA mediate the communication between gut and vasculature. 

Daniel Gautheret, Joseph Taube, Sendurai A. Mani, Gaetano Santulli, Diego Cuerda-Gil, R. Keith Slotkin, et al.

Non-Coding RNA. 2016;2(3)9.


79) Maintenance of normal blood pressure is dependent on IP3R1-mediated regulation of eNOS.

 Qi Yuan*, Jingyi Yang*, Gaetano Santulli* (*co-First Authorship; Corresponding Author), Steven Reiken, Anetta Wronska, Mindy Kim, Brent W. Osborne, et al.

PNAS USA. 2016;113:8532-8537.


78) Adrenergic signaling in heart failure and cardiovascular aging. 

Gaetano Santulli and Guido Iaccarino.

Maturitas. 2016;93:65-72. 


77) Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation.  

Stefan Matecki, Haikel Dridi, Boris Jung, Nathalie Saint, Steven R. Reiken, Valérie Scheuermann, Ségolène Mrozek, Gaetano Santulli, Alisa Umanskaya, Basil J. Petrof, Samir Jaber, et al.

PNAS USA. 2016;113(32):9069-74 (Direct Submission)


76) MicroRNAs distinctively regulate vascular smooth muscle and endothelial cells: functional implications in angiogenesis, atherosclerosis, and in-stent restenosis. 

Gaetano Santulli.  

Adv Exp Med Biol. 2015;887:53-77.


75) Micromanipulating the behavior via microRNA: New lessons from Drosophila. 

Ioana Berindan-Neagoe, George Adrian Calin, Claire Francastel, Florent Hubé, and Gaetano Santulli.

Non-Coding RNA2015;1:285-288. 


74) Mitochondrial calcium overload is a key determinant in heart failure. 

Gaetano Santulli, Wenjun Xie, et al.

PNAS USA. 2015;112:11389-94(with Editorial Commentary)

F1000 recommended article. 

Highly cited article (Thomson Reuters: Top 1% in Biomedicine) 


73) Models for preclinical studies in aging-related disorders: One is not for all. 

Gaetano Santulli, Consuelo Borras, Jean Bousquet, Laura Calzà, Antonio Cano, Maddalena Illario, Claudio Franceschi, Giuseppe Liotta, William D. Molloy, et al.

Transl Med @ UniSa. 2016;13:4-12. 


72) Mechanistic role of microRNAs in coupling lipid metabolism and atherosclerosis. 

Jan Novák, Veronika Olejníčková, Nikola Tkáčová, and Gaetano Santulli.  

Adv Exp Med Biol. 2015;887:79-100.


71) An interview with Gaetano Santulli. 

Gaetano Santulli.

European Medical Journal (EMJ) 2015;3.2:35-37.


70) microRNAs and endothelial (dys) function.

Gaetano Santulli.

J Cell Physiol. 2015;231:1638–1644. (Invited Review)


69) A leaky endoplasmic reticulum calcium channel impairs insulin secretion 

Gaetano Santulli. 

JCI Impact 2015;May Issue:p10. Editor’s picks.


68) Essential roles of intracellular calcium release channels in muscle, brain, and metabolism. 

Gaetano Santulli et al.

Current Molecular Pharmacology 2015;8:206-22.


67) Exploiting microRNA specificity and selectivity: Paving a sustainable path towards precision medicine. 

Gaetano Santulli. 

Adv Exp Med Biol. 2015;888:1-3.


66) Targeting the CaMKII/ERK interaction in the heart prevents cardiac hypertrophy. 

Ersilia Cipolletta, Maria Rosaria Rusciano, Angela Serena Maione, Gaetano Santulli, Daniela Sorriento, et al.

PLoS One. 2015;10(6):e0130477.


65) Integrating GRK2 and NFkappaB in the pathophysiology of cardiac hypertrophy.

Daniela Sorriento, Gaetano Santulli, Antonietta Franco, et al.

J Card Transl Res. 2015; 8:493-502.


64) Mitochondrial oxidative stress promotes atrial fibrillation. 

Wenjun Xie*, Gaetano Santulli* (*co-First Authorship), Steven R. Reiken, Qi Yuan, Brent W. Osborne, et al.

Sci Reports2015;5:11427.


63) Mitochondrial calcium overload and oxidative stress in cardiomyocytes are linked by microRNA. 

Claire Francastel, Florent Hubé, Sendurai Mani, Gaetano Santulli, et al.

Non-Coding RNA2015;1:167-169. 


62) Calcium release channel RyR2 regulates insulin release and glucose homeostasis.

Gaetano Santulli, Gennaro Pagano, Celestino Sardu, Wenjun Xie, Steven R. Reiken, Salvatore L. D'Ascia, Michele Cannone, Nicola Marziliano, Bruno Trimarco, Theresa A. Guise, et al.

Journal of Clinical Investigation. 2015;125(5):1968-1978.

Highly cited article (Thomson Reuters: Top 1% in Biomedicine) 


61) A Fleeting Glimpse Inside microRNA, Epigenetics, and Micropeptidomics.

Gaetano Santulli. 

Adv Exp Med Biol. 2015;887:1-14.


60) Application of microRNAs in diagnosis and treatment of cardiovascular disease. 

Anetta Wronska, Iwona Kurkowska-Jastrzebska, Gaetano Santulli.

Acta Physiol. 2015;213(1):60-83. 

Highly cited article (Thomson Reuters: Top 1% in Biomedicine) 


59) Beta-blockers in diabetic patients with heart failure.

Gaetano Santulli.  

JAMA Intern Med. 2015;175(4):657.


58) Effects of low-carbohydrate and low-fat diets. 

Gaetano Santulli.  

Ann Intern Med. 2015;162(5):392.


57) Functional role of Calstabin2 in age-related cardiac alterations. 

Qi Yuan*, Zheng Chen*, Gaetano Santulli* (*co-First Authorship), Lei Gu, Zhi-Guang Yang, Zeng-Qiang Yuan, et al.

Sci Reports.2014;4:7425.  


56) Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging. 

Alisa Umanskaya*, Gaetano Santulli* (*co-First Authorship), Wenjun Xie, et al.

PNAS USA. 2014;111:15250-5. 


55) MicroRNA-directed gene delivery selectively targets VSMCs to prevent restenosis. 

Gaetano Santulli.

Journal of Clinical Investigation. 2014;online. 


54) Diabetes Ask1ng for trouble: Terminating microRNA biogenesis in ER stress.

Manuela Ferracin, Daniel Gautheret, Florent Hubé, Sendurai A. Mani, John S. Mattick, Ulf Andersson Ørom, Gaetano Santulli, R. Keith Slotkin, et al.

Non-Coding RNA. 2015;1:87-93. 


53) Myoregulin is a novel modulator of calcium handling and excitation–contraction coupling: Hunting for Easter eggs in the concealed microproteome.

Manuela Ferracin, Daniel Gautheret, Florent Hubé, Sendurai Mani, John Mattick, Ulf Andersson Ørom, Gaetano Santulli, R. Keith Slotkin, Zofia Szweykowska-Kulinska, Joseph H. Taube, et al.

Non-Coding RNA. 2015;1:87-93. 


52) An interview with Gaetano Santulli. 

Freddy T. Nguyen, Chirag Patel,Gaetano Santulli.

JCI Impact 2014; September Issue:p10. Editor’s picks.


51) A selective microRNA-based strategy inhibitS restenosis while preserving endothelial function. 

Gaetano Santulli, Anetta Wronska, Kunihiro Uryu, Thomas G. Diacovo, Melanie Gao, Steven O. Marx, Jan Kitajewski, Jamie M. Chilton, Kemal Marc Akat, Thomas Tuschl, et al.

Journal of Clinical Investigation. 2014;124:4102-4114 (with Editorial Commentary). 

Highly cited article (Thomson Reuters: Top 1% in Biomedicine) 


50) Functional role of miRNA in cardiac resynchronization therapy. 

Celestino Sardu, Raffaele Marfella, Gaetano Santulli, Giuseppe Paolisso.

Pharmacogenomics. 2014;15:1159-1168.


49) Chest pain, panic disorder and coronary artery disease: A systematic review. 

Gastão Luiz Fonseca Soares-Filho, Oscar Arias-Carrión, Gaetano Santulli, Adriana C. Silva, Sergio Machado, et al.

CNS Neurol Disord Drug Targets. 2014;13:992-1001.


48) CaMKII protects MKP-1 from proteasome degradation in endothelial cells. 

Michele Ciccarelli, Maria Rusciano, Daniela Sorriento, Maria Felicia Basilicata, Gaetano Santulli, Pietro Campiglia, et al. 

Cell Signal. 2014;26:2167-74.


47) Trafficking GRK2: Cellular and metabolic consequences of GRK2 subcellular localization. 

Daniela Sorriento, Michele Ciccarelli, Gaetano Santulli, Maddalena Illario, Bruno Trimarco, and Guido Iaccarino.

Transl Med @ UniSa. 2014;10: 3–7.


46) Impact of diabetes mellitus on the clinical response to cardiac resynchronization therapy in elderly people. 

Celestino Sardu, Raffaele Marfella and Gaetano Santulli.

J Card Transl Res.2014;7:362-368. 


45) Atrial fibrillation and MicroRNAs. 

Gaetano Santulli, Guido Iaccarino, Nicola De Luca, Bruno Trimarco and Gianluigi Condorelli.

Frontiers in Physiology. 2014;24;5:15. 


44) Metabolic syndrome is associated with a poor outcome in patients affected by outflow tract premature ventricular contractions treated by catheter ablation. 

Celestino Sardu, Giovanni Carreras, Spyridon Katsanos, Vasileios Kamperidis, Maria Caterina Pace, Maria Beatrice Passavanti, Ilaria Fava, Pasquale Paolisso, Gorizio Pieretti, Giovanni Francesco Nicoletti, Gaetano Santulli, Giuseppe Paolisso and Raffaele Marfella.

BMC Card Disord. 2014;14:176. (Highly accessed).


43) Adrenal signaling in heart failure: Something more than a distant ship's smoke on the horizon. 

Gaetano Santulli.  

Hypertension. 2014;63:215-6.


42) Angiopoietin-like proteins: A comprehensive look. 

Gaetano Santulli.  

Frontiers in Endocrinology. 2014;2;5:4.


41) Tailoring mTOR-based therapy: molecular evidence and clinical challenges. 

Gaetano Santulli et al.

Pharmacogenomics. 2013;14:1517-26. 


40) Myocardial perfusion imaging study of CO2-induced panic attack. 

Gastão LF. Soares-Filho, Sergio Machado, Oscar Arias-Carrión, Gaetano Santulli, Claudio T. Mesquita, et al.

Am J Card. 2013;113:384-8. 


39) Imaging atrial arrhythmic intracellular calcium in intact heart. 

Wenjun Xie, Gaetano Santulli, Xiaoxiao Guo, Melanie Gao, et al.

J Mol Cell Cardiol. 2013;64:120-3.


38) Physical activity ameliorates cardiovascular health in elderly subjects: the functional role of the β adrenergic system. 

Gaetano Santulli, Michele Ciccarelli, Bruno Trimarco and Guido Iaccarino.

Frontiers in Physiology. 2013;4:209.


37) G-Protein-coupled receptor kinase 2 and hypertension: Molecular insights and pathophysiological mechanisms. 

Gaetano Santulli, Bruno Trimarco and Guido Iaccarino.

High Blood Press & Cardiovasc Prev. 2013;20:5-12. (Editorial comment on this Article).


36) The essential role of β2-adrenergic receptor in glucose homeostasis.

Gaetano Santulli and Guido Iaccarino.

PLoS One. 2013;e-pages. 


35) Pinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes. 

Gaetano Santulli and Guido Iaccarino.

Immun Ageing. 2013;15;10:10 (Highly accessed).


34) Epidemiology of cardiovascular disease in the 21st century: Updated numbers and updated facts. 

Gaetano Santulli.  

JCvD. 2013;1:1-2.


33) Angiogenesis in chronic obstructive pulmonary disease: A translational appraisal.

Alessandro Matarese, Gaetano Santulli.

Nature Prec. 2012; 


32) Development of atrial fibrillation in recipients of cardiac resynchronization therapy: the role of atrial reverse remodelling. 

Gaetano Santulli, Salvatore D’ascia, Cristofaro D’ascia.

Can J Cardiol. 2012;28:245.e17–245.e18.


31) the impact of left ventricular size on response to cardiac resynchronization therapy. 

Gaetano Santulli, Salvatore D’ascia, Cristofaro D’ascia.

Am Heart J.2012;163:e11.


30) CaMK4 gene deletion induces hypertension. 

Gaetano Santulli, Ersilia Cipolletta, Daniela Sorriento, Carmine Del Giudice, Antonio Anastasio, Sara Monaco, et al.

JAHA. 2012;1:e001081.


29) Coronary heart disease risk factors and mortality. 

Gaetano Santulli.

Journal of the American Medical Association - JAMA. 2012; 307:1137.


28) Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo. 

Daniela Sorriento, Gaetano Santulli, Carmine Del Giudice, Antonio Anastasio, Bruno Trimarco, and Guido Iaccarino.

Hypertension. 2012;60:129-136.


27) Role of cardiac resynchronization therapy in the development of new-onset atrial fibrillation: A single-center prospective study.

Gaetano Santulli, Massimo Chiariello, Cristofaro D’Ascia, and Salvatore D’Ascia.

Nature Prec.2012; 


26) Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus. 

Gaetano Santulli.

Neurology. 2012;78:840.


25) Atrial remodelling in echocardiographic super-responders to cardiac resynchronization therapy. 

Gaetano Santulli, Cristofaro D’Ascia.

Heart. 2012;98:517.


24) Age-related impairment in insulin release: the essential role of Beta2 Adrenergic Receptor. 

Gaetano Santulli, Angela Lombardi, Daniela Sorriento, Antonio Anastasio, Carmine Del Giudice, Pietro Formisano, et al.

Diabetes. 2012;61:692-701.


23) Atrial function in patients undergoing CRT. 

Gaetano Santulli, Salvatore D’Ascia, Vittoria Marino, and Cristofaro D’Ascia.

JACC Imaging. 2012;5:124-125.


22) Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis.

Anna Fusco, Gaetano Santulli, Daniela Sorriento, Ersilia Cipolletta, Corrado Garbi, Gerald W. Dorn II, et al.

Cell Signal. 2012;24:468-475.


21) Angiogenesis in chronic obstructive pulmonary disease. 

Alessandro Matarese, Gaetano Santulli.

Transl Med @ UniSa. 2012;3:49–56. 


20) G protein-coupled receptor kinase 2 in patients with acute myocardial infarction. 

Gaetano Santulli, Alfonso Campanile, Letizia Spinelli, Emiliano Assante di Panzillo, Michele Ciccarelli, et al.

Am J Cardiol. 2011;107:1125-1130.


19) Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit.

Gaetano Santulli, Maria Basilicata, Maria De Simone, Carmine Del Giudice, Antonio Anastasio, Daniela Sorriento, et al.

J Transl Med. 2011;9:7 (Highly accessed).


18) Cardiac resynchronization therapy response predicts occurrence of atrial fibrillation in non-ischemic dilated cardiomyopathy. 

Salvatore Luca D’Ascia, Cristoforo D’Ascia, Vittoria Marino, Massimo Chiariello, and Gaetano Santulli.

Int J Clinical Practice. 2011;69:1149-1155.


17) Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. 

Alessia Perino, Alessandra Ghigo*, Enrico Ferrero*, Fulvio Morello*, Gaetano Santulli, George S. Baillie, et al.

Mol Cell. 2011;42:84-95.


16) Impaired neoangiogenesis in Beta2-adrenoceptor gene-deficient mice: restoration by intravascular human Beta2-adrenoceptor gene transfer and role of NFκB and CREB transcription factors. Michele Ciccarelli, Daniela Sorriento, Gaetano Santulli, RuiHai Zhou, Andrea Eckhart, Karsten Peppel, Walter J. Koch, et al.

British J Pharmacology. 2011;162:712-721.


15) Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-kappaB-dependent hypertrophic gene expression. 

Daniela Sorriento*, Gaetano Santulli* (*co-First Authorship), Anna Fusco, Antonio Anastasio, et al.

Hypertension. 2010;56:696-704.


14) The GPIIIA PlA2 polymorphism is associated with an increased risk of cardiovascular adverse events. 

Gennaro Galasso, Gaetano Santulli, Federico Piscione, Roberta De Rosa, Raffaele Piccolo, Salvatore Cassese, et al. BMC Card Dis. 2010;10:41.


13) Advanced algorithms can lead to electrocardiographic misinterpretations. 

Salvatore D’Ascia, Gaetano Santulli, Vincenzo Liguori, Vittoria Marino, Massimo Chiariello, et al.

Intern J of Card. 2010;141:e34-e36. 


12) In vivo properties of the proangiogenic peptide QK. 

Gaetano Santulli, Michele Ciccarelli, Gianluigi Palumbo, Alfonso Campanile, Gennaro Galasso, Barbara Ziaco, et al.

J Transl Med. 2009;7:41 (Highly accessed).


11) A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NF-kappa-B activity. 

Daniela Sorriento, Alfonso Campanile, Gaetano Santulli, Eleonora Leggiero, Lucio Pastore, et al.

Mol Cancer. 2009;8:97.


10) The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance.

Ersilia Cipolletta, Alfonso Campanile, Gaetano Santulli, Emma Sanzari, Dario Leosco, Pietro Campiglia, et al.

Cardiovasc Res. 2009;84:407-415.


9) Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression. 

Oriente F., Iovino S., Cassese A., Romano C., Miele C., Troncone G., Balletta M., Perfetti A., Santulli G., Iaccarino G., et al.

Diabetologia. 2009;52:2642-2652.


8) The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα.

Daniela Sorriento, Michele Ciccarelli, Gaetano Santulli, Alfonso Campanile, Giovanna G. Altobelli, Vincenzo Cimini, et al.

PNAS USA. 2008;195:17818-17823.


7) Enhanced GRK2 Expression and Desensitization of βAR Vasodilatation in Hypertensive Patients. 

Raffaele Izzo, Ersilia Cipolletta, Michele Ciccarelli, Alfonso Campanile, Gaetano Santulli, Gianluigi Palumbo, et al.

Clinical and Translational Science. 2008;1:215-220.


6) Endothelial alpha-1 adrenergic receptors regulate neo-angiogenesis. 

Michele Ciccarelli, Gaetano Santulli, Alfonso Campanile, Gennaro Galasso, Pasquale Cervèro, et al.

British J Pharmacology. 2008;153:936-946.


5) The PlA1/A2 polymorphism of glycoprotein IIIa and cerebrovascular events in hypertension: Increased risk of ischemic stroke in high-risk patients.

Francesca Lanni, Gaetano Santulli, Raffaele Izzo, Speranza Rubattu, Bastianina Zanda, Massimo Volpe, et al.

J Hypertension. 2007;25:551-556.


4) Endothelial β2 adrenergic signaling to AKT: Role of Gi and SRC.

Michele Ciccarelli, Ersilia Cipolletta, Gaetano Santulli, et al.

Cell Signal. 2007;19:1949-1955.


3) G Protein-Coupled Receptor Kinases and Hypertension: A Review of Disease Mechanisms 

Guido Iaccarino, Alfonso Campanile, Gaetano Santulli, Francesco Zuppieri, and Walter J. Koch.

High Blood Pressure & Cardiovascular Prevention. 2006;13(Issue 4):151-158.


2) Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression - A novel role for the endothelial adrenergic system 

Guido Iaccarino, Michele Ciccarelli, Daniela Sorriento, Gennaro Galasso, Alfonso Campanile, Gaetano Santulli, Ersilia Cipolletta, Vincenzo Cerullo, et al.

Circ Res. 2005; 97:1182-1189.


1) AKT Participates in Endothelial Dysfunction in Hypertension. 

Guido Iaccarino, Michele Ciccarelli, Daniela Sorriento, Ersilia Cipolletta, Vincenzo Cerullo, Gianni Luigi Iovino, Alessandro Paudice, Andrea Elia, Gaetano Santulli, Alfonso Campanile, Oreste Arcucci, Lucio Pastore, Francesco Salvatore, et al.

Circulation. 2004; 109:2587-2593.







-MITOCHONDRIAL REMODELING AND DYNAMIC INTER-ORGANELLAR CONTACTS IN CARDIOVASCULAR PHYSIOPATHOLOGY. eds. Frontiers. Editors: Gaetano Santulli, Giovanni Monaco, Valentina Parra, Giampaolo Morciano (2021); in press.


-MITOCHONDRIAL DYNAMICS IN CARDIOVASCULAR MEDICINE. Hardcover Book (646 pages) – eds. Springer-Nature. Editor: Gaetano Santulli (2017).

-DIET AND METABOLIC DYSFUNCTON. Hardcover Book – eds. MDPI, Basel, Switzerland. Adapted from the Special Issue published in Nutrients. Editor: Gaetano Santulli (2017).

-microRNA: FROM MOLECULAR BIOLOGY TO CLINICAL PRACTICE. Hardcover Book – 3 volumes, eds. Springer Editor: Gaetano Santulli (2016).

-ADRENAL GLANDS: FROM PATHOPHYSIOLOGY TO CLINICAL PRACTICE. Hardcover Book, eds. Nova Publishers Inc. Editor: Gaetano Santulli (2015).

-ANGIOGENESIS: INSIGHTS FROM A SYSTEMATIC OVERVIEW. Hardcover Book, eds. Nova Publishers Inc. Editor: Gaetano Santulli (2013).


-Book chapters:  

-Gaetano Santulli, et al. microRNAs in diabetes. In “MicroRNA: From Bench to Bedside”. Editor: Dr. J. Xiao; eds. Elsevier (2021); in press.

-Gaetano Santulli, Daniel Lewis, Andrew Marks, and Joachim Frank. Ryanodine receptor structure and function in health and disease. In “Membrane-bound Macromolecular Protein Complexes: Structure and Function”. Editors: Dr. J. Robin Harris and E. Boekema; eds. Springer-Nature (2018).

-Daniela Sorriento, Gaetano Santulli, et al. The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium/Calmodulin Dependent Transcription Factors. In “Calcium Signaling in Human Health and Diseases”. Editor: F. Moccia, eds. MDPI (2018).

-Jessica Gambardella, Bruno Trimarco, Guido Iaccarino, and Gaetano Santulli (Corresponding Author). New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling. In “Heart Failure: From Research to Clinical Practice”. Editor: Shaidul Islam (Karolinska Institutet), eds. Springer-Nature (2017).

-M. Ciccarelli, D. Sorriento, E. Coscioni, G. Iaccarino, G. Santulli (Corresponding Author). Adrenergic Receptors. In “Endocrinology of the heart in health and disease”. Editors: JC. Schisler, CH. Lang, MS. Willis, eds. Elsevier (2016).

-G. Santulli, (Corresponding Author) et al. Essential roles of intracellular calcium release channels in muscle, brain and metabolism. In “50th Anniversary of Calcium Channel Research: Biomedical Perspectives”. eds. Bentham Science, Potomac, MD, USA (2015).

-Gaetano Santulli. The adrenergic system in cardiovascular metabolism and aging. In “The cardiovascular adrenergic system”. Hardcover Book, Editor: A. Lymperopoulos, eds. Springer (2018).

-Gaetano Santulli. Sympathetic Nervous System Signaling in Heart Failure and Cardiac Aging. In “Pathophysiology and Pharmacotherapy of Cardiovascular Disease”. Editor: G. Jagadeesh, eds. Springer (2015).

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