Publications:
The discovery and development of IP3 receptor modulators: an update.
Gambardella J, Morelli MB, Wang X, Castellanos V, Mone P, Santulli G.
Expert Opin Drug Discov. 2021; in press. doi: 10.1080/17460441.2021.1858792.
What
is linking COVID-19 and endothelial dysfunction? Updates on
nanomedicine and bioengineering from the 2020 AHA Scientific Sessions.
Gambardella J, Santulli G.
Eur Heart J (CVP). 2020 Dec 30:pvaa145. doi: 10.1093/ehjcvp/pvaa145.
Thyroid hormones regulate both cardiovascular and renal mechanisms underlying hypertension.
Jankauskas SS, Morelli MB, Gambardella J, Lombardi A, Santulli G.
J Clin Hypertens. 2020; in press. doi: 10.1111/jch.14152.
Vitamin C and Cardiovascular Disease: An Update.
Morelli MB, Gambardella J, Castellanos V, Trimarco V, Santulli G.
Antioxidants. 2020;9(12):1227. doi: 10.3390/antiox9121227.
Exploiting
GRK2 Inhibition as a Therapeutic Option in Experimental Cancer
Treatment: Role of p53-Induced Mitochondrial Apoptosis.
Gambardella J, Fiordelisi A, Santulli G, Ciccarelli M, Cerasuolo FA, Sala M, et al.
Cancers. 2020;12(12):3530. doi: 10.3390/cancers12123530.
miR-98 Regulates TMPRSS2 Expression in Human Endothelial Cells: Key Implications for COVID-19.
Gambardella J*, Matarese A*, Sardu C, Santulli G.
BioMedicines. 2020;8(11):462. doi: 10.3390/biomedicines8110462.
Metabolic Flexibility of Mitochondria Plays a Key Role in Balancing Glucose and Fatty Acid Metabolism in the Diabetic Heart.
Gambardella J, Lombardi A, Santulli G.
Diabetes. 2020;69(10):2054-2057. doi: 10.2337/dbi20-0024.
Role of Endothelial G Protein-Coupled Receptor Kinase 2 in Angioedema.
Gambardella J, Sorriento D, Bova M, Rusciano M, Loffredo S, Wang X, Petraroli A, Carucci L, Mormile I, Oliveti M, Morelli MB, et al.
Hypertension. 2020;76(5):1625-1636. doi: 10.1161/HYPERTENSIONAHA.120.15130.
Genetics of adrenergic signaling drives coronary artery calcification.
Gambardella J, Wang X, Mone P, Khondkar W, Santulli G.
Atherosclerosis. 2020;310:88-90. doi: 10.1016/j.atherosclerosis.2020.07.025.
Implications of AB0 blood group in hypertensive patients with covid-19.
Sardu C, Marfella R, Maggi P, Messina V, Cirillo P, Codella V, Gambardella J, Sardu A, Gatta G, Santulli G, Paolisso G.
BMC Cardiovasc Disord. 2020 Aug 14;20(1):373. doi: 10.1186/s12872-020-01658-z.
Arginine and Endothelial Function.
Gambardella J, Khondkar W, Morelli MB, Wang X, Santulli G, Trimarco V.
BioMedicines. 2020;8(8):277. doi: 10.3390/biomedicines8080277.
miR-7 Regulates GLP-1-Mediated Insulin Release by Targeting β-Arrestin 1.
Matarese A, Gambardella J, Lombardi A, Wang X, Santulli G.
Cells. 2020;9(7):1621. doi: 10.3390/cells9071621.
Cardiac BIN1 Replacement Therapy Ameliorates Inotropy and Lusitropy in Heart Failure by Regulating Calcium Handling.
Gambardella J, Wang XJ, Ferrara J, Morelli MB, Santulli G.
JACC (BTS). 2020;5(6):579-581. doi: 10.1016/j.jacbts.2020.03.018.
Standardizing translational microbiome studies and metagenomic analyses.
Gambardella J, Castellanos V, Santulli G.
Cardiovasc Res. 2020 Jun 22:cvaa175. doi: 10.1093/cvr/cvaa175.
Hypertension,
Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial
Disease? A Comprehensive Evaluation of Clinical and Basic Evidence.
Sardu C, Gambardella J, Morelli MB, Wang X, Marfella R, Santulli G.
J Clin Med. 2020;9(5):1417. doi: 10.3390/jcm9051417.
Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure.
Ciccarelli M, Sorriento D, Fiordelisi A, Gambardella J, Franco A, Del Giudice C, et al.
ESC Heart Fail. 2020;7(4):1571-1584. doi: 10.1002/ehf2.12706.
Inositol 1,4,5-Trisphosphate Receptors in Human Disease: A Comprehensive Update.
Gambardella J, Lombardi A, Morelli MB, Ferrara J, Santulli G.
J Clin Med. 2020;9(4):1096. doi: 10.3390/jcm9041096.
Calcium supplements: Good for the bone, bad for the heart? A systematic updated appraisal.
Morelli MB, Santulli G, Gambardella J.
Atherosclerosis. 2020 Mar;296:68-73. doi: 10.1016/j.atherosclerosis.2020.01.008.
Pathophysiological mechanisms underlying the beneficial effects of physical activity in hypertension.
Gambardella J, Morelli MB, Wang XJ, Santulli G.
J Clin Hypertens. 2020;22(2):291-295. doi: 10.1111/jch.13804.
Antidiabetic and Cardioprotective Effects of Pharmacological Inhibition of GRK2 in db/db Mice.
Cipolletta E, Gambardella J, Fiordelisi A, et al.
Int J Mol Sci. 2019;20(6):1492. doi: 10.3390/ijms20061492.
GRKs and β-Arrestins: "Gatekeepers" of Mitochondrial Function in the Failing Heart.
Sorriento D, Gambardella J, Fiordelisi A, et al.
Front Pharmacol. 2019;10:64. doi: 10.3389/fphar.2019.00064.
Parathyroid
Hormone Causes Endothelial Dysfunction by Inducing Mitochondrial ROS
and Specific Oxidative Signal Transduction Modifications.
Gambardella J, De Rosa M, Sorriento D, Prevete N, et al.
Oxid Med Cell Longev. 2018 Dec 19;2018:9582319. doi: 10.1155/2018/9582319.
A Novel Small Peptide Inhibitor of NFκB, RH10, Blocks Oxidative Stress-Dependent Phenotypes in Cancer.
Gambardella J, Ciccarelli M, Del Giudice C, Fiordelisi A, De Rosa M, et al.
Oxid Med Cell Longev. 2018;2018:5801807. doi: 10.1155/2018/5801807.
Dietary
fat is a key determinant in balancing mitochondrial dynamics in heart
failure: a novel mechanism underlying the obesity paradox.
De Rosa M, Gambardella J, Shu J, Santulli G.
Cardiovasc Res. 2018 Jun 1;114(7):925-927. doi: 10.1093/cvr/cvy074.
GRK2 moderates the acute mitochondrial damage to ionizing radiation exposure by promoting mitochondrial fission/fusion.
Franco A, Sorriento D, Gambardella J, Pacelli R, Prevete N, Procaccini C, Matarese G, et al.
Cell Death Discov. 2018 Feb 14;4:25. doi: 10.1038/s41420-018-0028-7.
Cardiac Nonmyocyte Cell Functions and Crosstalks in Response to Cardiotoxic Drugs.
Gambardella J, et al.
Oxid Med Cell Longev. 2017;2017:1089359. doi: 10.1155/2017/1089359.
Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells.
Lombardi A, Gambardella J, Du XL, Sorriento D, Mauro M, Iaccarino G, Trimarco B, Santulli G.
Sci Rep. 2017;7(1):15823. doi: 10.1038/s41598-017-15283-y.
New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling.
Gambardella J, Trimarco B, Iaccarino G, Santulli G.
Adv Exp Med Biol. 2018;1067:373-385. doi: 10.1007/5584_2017_106.
Mechanistic Role of Kinases in the Regulation of Mitochondrial Fitness.
Sorriento D, Gambardella J, Fiordelisi A, Trimarco B, Ciccarelli M, Iaccarino G, Santulli G.
Adv Exp Med Biol. 2017;982:521-528. doi: 10.1007/978-3-319-55330-6_26.
Functional Role of Mitochondria in Arrhythmogenesis.
Gambardella J, Sorriento D, Ciccarelli M, Del Giudice C, Fiordelisi A, Napolitano L, Trimarco B, Iaccarino G, Santulli G.
Adv Exp Med Biol. 2017;982:191-202. doi: 10.1007/978-3-319-55330-6_10.
Quit smoking to outsmart atherogenesis: Molecular mechanisms underlying clinical evidence.
Gambardella J, Sardu C, Sacra C, Del Giudice C, Santulli G.
Atherosclerosis. 2017 Feb;257:242-245. doi: 10.1016/j.atherosclerosis.2016.12.010.
Integrating diet and inflammation to calculate cardiovascular risk.
Gambardella J, Santulli G.
Atherosclerosis. 2016 Oct;253:258-261. doi: 10.1016/j.atherosclerosis.2016.08.041.
Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy.
Sorriento D, Santulli G, Franco A, Cipolletta E, Napolitano L, Gambardella J, Gomez-Monterrey I, et al.
J Cardiovasc Transl Res. 2015;8(8):493-502.
Stanislovas S. Jankauskas, PhD
Publications:
Targeting the phenotypic switch of vascular smooth muscle cells to tackle atherosclerosis.
Kansakar U, Jankauskas SS, Gambardella J, Santulli G.
Atherosclerosis. 2021;324:117-120.
Thyroid hormones regulate both cardiovascular and renal mechanisms underlying hypertension.
Jankauskas SS, Morelli MB, Gambardella J, Lombardi A, Santulli G.
J Clin Hypertens. 2020 Dec 29. doi: 10.1111/jch.14152.
A
Combination of Kidney Ischemia and Injection of Isolated Mitochondria
Leads to Activation of Inflammation and Increase in Mortality Rate in
Rats.
Plotnikov EY, Jankauskas SS, Zinovkin RA, Zorova LD, et al.
Bull Exp Biol Med. 2020;169(2):213-217. doi: 10.1007/s10517-020-04853-2.
Evolving complexity of MIF signaling.
Jankauskas SS, Wong DWL, Bucala R, et al.
Cell Signal. 2019;57:76-88. doi: 10.1016/j.cellsig.2019.01.006.
Mechanisms of Age-Dependent Loss of Dietary Restriction Protective Effects in Acute Kidney Injury.
Andrianova NV, Jankauskas SS, Zorova LD, Pevzner IB, Popkov VA, et al.
Cells. 2018;7(10):178. doi: 10.3390/cells7100178.
Aged kidney: can we protect it? Autophagy, mitochondria and mechanisms of ischemic preconditioning.
Jankauskas SS, Silachev DN, Andrianova NV, Pevzner IB, Zorova LD, et al.
Cell Cycle. 2018;17(11):1291-1309. doi: 10.1080/15384101.2018.1482149.
Bacterial Therapy and Mitochondrial Therapy.
Popkov VA, Plotnikov EY, Silachev DN, Zorova LD, Pevzner IB, Jankauskas SS, Zorov SD, et al.
Biochemistry. 2017;82(12):1549-1556. doi: 10.1134/S0006297917120148.
Mitochondrial membrane potential.
Zorova LD, Popkov VA, Plotnikov EY, Silachev DN, Pevzner IB, Jankauskas SS, Babenko VA, et al.
Analytical Biochemistry. 2018;552:50-59. doi: 10.1016/j.ab.2017.07.009.
The
age-associated loss of ischemic preconditioning in the kidney is
accompanied by mitochondrial dysfunction, increased protein acetylation
and decreased autophagy.
Jankauskas SS, Pevzner IB, Andrianova NV, Zorova LD, Popkov VA, Silachev DN, et al.
Sci Rep. 2017;7:44430. doi: 10.1038/srep44430.
Dysfunction of Kidney Endothelium after Ischemia/Reperfusion and Its Prevention by Mitochondria-Targeted Antioxidant.
Jankauskas SS, Andrianova NV, Alieva IB, Prusov AN, Matsievsky DD, et al.
Biochemistry. 2016;81(12):1538-1548. doi: 10.1134/S0006297916120154.
Molecular and Cellular Interactions between Mother and Fetus. Pregnancy as a Rejuvenating Factor.
Popkov VA, Silachev DN, Jankauskas SS, Zorova LD, Pevzner IB, et al.
Biochemistry. 2016;81:1480-1487. doi: 10.1134/S0006297916120099.
Intercellular Signalling Cross-Talk: To Kill, To Heal and To Rejuvenate.
Plotnikov EY, Silachev DN, Popkov VA, Zorova LD, Pevzner IB, Zorov SD, Jankauskas SS, Babenko VA, Sukhikh GT, Zorov DB.
Heart Lung Circ. 2017;26:648-659.
Mitochondrial Aging: Is There a Mitochondrial Clock?
Zorov DB, Popkov VA, Zorova LD, Vorobjev IA, Pevzner IB, Silachev DN, Zorov SD, Jankauskas SS, Babenko VA, Plotnikov EY.
J Gerontol A Biol Sci Med Sci. 2017;72(9):1171-1179. doi: 10.1093/gerona/glw184.
Mechanisms of Inflammatory Injury of Renal Tubular Cells in a Cellular Model of Pyelonephritis.
Morosanova MA, Plotnikov EY, Zorova LD, Pevzner IB, Popkov VA, Silachev DN, Jankauskas SS, Babenko VA, Zorov DB.
Biochemistry. 2016;81:1240-1250.
Do Mitochondria Have an Immune System?
Popkov VA, Zorova LD, Korvigo IO, Silachev DN, Jankauskas SS, Babenko VA, Pevzner IB, Danilina TI, et al.
Biochemistry. 2016;81(10):1229-1236.
A
long-linker conjugate of fluorescein and triphenylphosphonium as
mitochondria-targeted uncoupler and fluorescent neuro- and
nephroprotector.
Antonenko YN, Denisov SS, Silachev DN, Khailova LS, Jankauskas SS, Rokitskaya TI, et al.
Biochim Biophys Acta. 2016;1860(11 Pt A):2463-2473.
Quantification of mitochondrial morphology in situ.
Popkov VA, Plotnikov EY, Zorova LD, Pevzner IB, Silachev DN, Babenko VA, Jankauskas SS, Zorov SD, Zorov DB.
Tsitologiia. 2016;58(9):699-706.
Diseases and Aging: Gender Matters.
Popkov VA, Plotnikov EY, Silachev DN, Zorova LD, Pevzner IB, Jankauskas SS, Zorov SD, Babenko VA, Zorov DB.
Biochemistry. 2015;80(12):1560-70.
Mitodiversity.
Popkov VA, Plotnikov EY, Lyamzaev KG, Silachev DN, Zorova LD, Pevzner IB, Jankauskas SS, Zorov SD, Babenko VA, Zorov DB.
Biochemistry. 2015;80(5):532-41. doi: 10.1134/S000629791505003X.
Microbiota and mitobiota. Putting an equal sign between mitochondria and bacteria.
Zorov DB, Plotnikov EY, Silachev DN, Zorova LD, Pevzner IB, Zorov SD, Babenko VA, Jankauskas SS, et al.
Biochemistry. 2014;79(10):1017-31.
Lithium salts -- simple but magic.
Plotnikov EY, Silachev DN, Zorova LD, Pevzner IB, Jankauskas SS, Zorov SD, Babenko VA, Skulachev MV, Zorov DB.
Biochemistry. 2014;79(8):740-9.
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Urna Kansakar, PhD
Publications:
Targeting the phenotypic switch of vascular smooth muscle cells to tackle atherosclerosis.
Kansakar U, Jankauskas SS, Gambardella J, Santulli G.
Atherosclerosis. 2021;324:117-120.
European Heart Journal Cardiovascular Pharmacotherapy). 2021. In press.
Phosphorylation of the proline-rich domain of WAVE3 drives its oncogenic activity in breast cancer.
Kansakar U, et al.
Sci Rep. 2021;11(1):3868.
Elucidating the molecular signaling pathways of WAVE3.
Kansakar U, et al.
Ann Transl Med. 2020;8(14):900.
WAVE3 phosphorylation regulates the interplay between PI3K, TGF-β, and EGF signaling pathways in breast cancer.
Wang W, Kansakar U, et al.
Oncogenesis. 2020;9(10):87.
Role of Kindlin-2 in cancer progression and metastasis.
Wang W, Kansakar U, et al.
Ann Transl Med. 2020;8(14):901.
An
enzyme-based electrochemical biosensor probe with sensitivity to detect
astrocytic versus glioma uptake of glutamate in real time in vitro.
Scoggin JL, Tan C, Nguyen NH, Kansakar U, et al.
Biosens Bioelectron. 2019;126:751-757.
Integration of a Copper-Containing Biohybrid (CuHARS) with Cellulose for Subsequent Degradation and Biomedical Control.
Karan A, Darder M, Kansakar U, et al.
Int J Environ Res Public Health. 2018;15:844.
Fahimeh Varzideh, PhD
Publications:
European Heart Journal Cardiovascular Pharmacotherapy). 2021. In press.
Oxygen-rich Environment Ameliorates Cell Therapy Outcomes of Cardiac Progenitor Cells for Myocardial Infarction. Montazeri L, Kowsari-Esfahan R, Pahlavan S, Sobat M, Rabbani S, Ansari H, Varzideh F, Barekat M, Rajabi S, Navaee F, et al.
Mater Sci Eng C Mater Biol Appl. 2021;121:111836.
Biomaterials. 2018;154:99-112.
Pasquale Mone, MD
Publications:
Hyperglycemia drives restenosis in STEMI patients.
Pasquale Mone, Jessica Gambardella, Fabio Minicucci, Angela Lombardi, Ciro Mauro, Gaetano Santulli.
Diabetes Care. 2021; in press.
miR-24 targets the transmembrane glycoprotein Neuropilin-1 in human brain microvascular endothelial cells.
Pasquale Mone, Jessica Gambardella, Xujun Wang, Stanislovas S. Jankauskas, Alessandro Matarese, Gaetano Santulli.
Noncoding RNA. 2021;7(1):9. doi: 10.3390/ncrna7010009.
Cognitive dysfunction correlates with physical impairment in frail patients with acute myocardial infarction.
Pasquale Mone, Jessica Gambardella, Antonella Pansini, Giuseppe Martinelli, Fabio Minicucci, Ciro Mauro, Gaetano Santulli.
Aging Clin Exp Res. 2021; in press. doi: 10.1007/s40520-021-01897-w.
Chronic kidney disease: Definition, updated epidemiology, staging, and mechanisms of increased cardiovascular risk.
Scott Wilson, Pasquale Mone, Stanislovas S. Jankauskas, Jessica Gambardella, Gaetano Santulli.
J Clin Hypertens. 2021;23(4):831-834. doi: 10.1111/jch.14186.
Impact of thrombus aspiration in frail STEMI patients.
Pasquale Mone, Jessica Gambardella, Antonella Pansini, Mario Rizzo, Ciro Mauro, Fabio Minicucci, Gaetano Santulli.
Aging Clinical and Experimental Research 2021; in Press. doi: 10.1007/s40520-021-01848-5.
The discovery and development of IP3 receptor modulators: an update.
Jessica Gambardella, Marco Morelli, Xujun Wang, Vanessa Castellanos, Pasquale Mone, Gaetano Santulli.
Expert Opin Drug Discov. 2021 Jan 6:1-10. doi: 10.1080/17460441.2021.1858792.
Genetics of adrenergic signaling drives coronary artery calcification .
Jessica Gambardella, Xujun Wang, Pasquale Mone, Wafiq Khondkar, Gaetano Santulli.
Atherosclerosis. 2020;310:88-90.
Xujun Wang, MD
Publications:
The discovery and development of IP3 receptor modulators: an update.
Gambardella J, Morelli MB, Wang X, Castellanos V, Mone P, Santulli G.
Expert Opin Drug Discov. 2021 Jan 6:1-10. doi: 10.1080/17460441.2021.1858792.
Role of Endothelial G Protein-Coupled Receptor Kinase 2 in Angioedema.
Gambardella J, Sorriento D, Bova M, Rusciano M, Loffredo S, Wang X, Petraroli A, Carucci L, Mormile I, Oliveti M, Morelli M, et al.
Hypertension. 2020 Nov;76(5):1625-1636.
Genetics of adrenergic signaling drives coronary artery calcification.
Gambardella J, Wang X, Mone P, Khondkar W, Santulli G.
Atherosclerosis. 2020 Oct;310:88-90.
miR-7 Regulates GLP-1-Mediated Insulin Release by Targeting β-Arrestin 1.
Matarese A, Gambardella J, Lombardi A, Wang X, Santulli G.
Cells. 2020 Jul 6;9(7):1621. doi: 10.3390/cells9071621.
Cardiac BIN1 Replacement Therapy Ameliorates Inotropy and Lusitropy in Heart Failure by Regulating Calcium Handling.
Gambardella J, Wang X, Ferrara J, Morelli MB, Santulli G.
JACC Basic Transl Sci. 2020 Jun 22;5(6):579-581.
Arginine and Endothelial Function.
Gambardella J, Khondkar W, Morelli MB, Wang X, Santulli G, Trimarco V.
Biomedicines. 2020 Aug 6;8(8):277. doi: 10.3390/biomedicines8080277.
Hypertension,
Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial
Disease? A Comprehensive Evaluation of Clinical and Basic Evidence.
Sardu C, Gambardella J, Morelli MB, Wang X, Marfella R, Santulli G.
J Clin Med. 2020 May 11;9(5):1417. doi: 10.3390/jcm9051417.
Pathophysiological mechanisms underlying the beneficial effects of physical activity in hypertension.
Gambardella J, Morelli MB, Wang X, Santulli G.
J Clin Hypertens. 2020 Feb;22(2):291-295. doi: 10.1111/jch.13804.
Cardiomyocyte-derived exosomal microRNA-92a mediates post-ischemic myofibroblast activation both in vitro and ex vivo.
Wang X, Morelli MB, Matarese A, Sardu C, Santulli G.
ESC Heart Fail. 2020 Feb;7(1):284-288. doi: 10.1002/ehf2.12584.
Functional role of gut microbiota and PCSK9 in the pathogenesis of diabetes mellitus and cardiovascular disease.
Morelli MB, Wang X, Santulli G.
Atherosclerosis. 2019 Oct;289:176-178.