Ana Maria Cuervo

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Full Name
Ana Maria Cuervo
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/Cuervo_Ana_Maria_2x.jpg
Type
Faculty
Expert
First Name
Ana Maria
Last Name
Cuervo
Faculty ID
8784
Patient Type
Adult
Department
einstein-dept-developmental-molecular-biology
einstein-dept-medicine
Email
ana-maria.cuervo@einsteinmed.edu
Phone
718-430-2689
Titles
Type
Academic
Department
Department of Developmental & Molecular Biology
Department Link
Rank
Distinguished Professor
Type
Academic
Department
Department of Medicine
Department Link
Rank
Distinguished Professor
Division
Hepatology
Type
Administrative
Title
Robert and Renée Belfer Chair for the Study of Neurodegenerative Diseases
Tags
me-patientcare-cancer-research-stem-cell-cancer-biology
Locations
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Chanin Building
Room
504
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
Address Line 3
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Professional Interests

<p>Dr. Cuervo is co-director of the Einstein Institute for Aging Research, and a member of the Einstein Liver Research Center and Cancer Center. In October 2001 she started her laboratory at Einstein, where she studies the role of protein-degradation in aging and age-related disorders, with emphasis in neurodegeneration and metabolic disorders.</p>
<p>Dr. Cuervo&rsquo;s group is interested in understanding how altered proteins can be eliminated from the cells and their components recycled. Her group has linked alterations in lysosomal protein degradation (autophagy)&nbsp;with different neurodegenerative diseases including Parkinson&rsquo;s, Alzheimer&rsquo;s and Huntington&rsquo;s disease. They have also proven that restoration of normal lysosomal function prevents accumulation of damaged proteins with age, demonstrating this way that removal of these toxic products is possible. Her lab has also pionered studies demonstrating a tight link between autophagy and cellular metabolism. They described how autophagy coordinates glucose and lipid metabolism and how failure of different autophagic pathways with age contribute to important metabolic disorders such as diabetes or obesity.</p>
<p>Dr. Cuervo is considered a leader in the field of protein degradation in relation to biology of aging and has been invited to present her work in numerous national and international institutions, including name lectures as the Robert R. Konh Memorial Lecture, the NIH Director&rsquo;s, the Roy Walford, the Feodor Lynen, the Margaret Pittman, the IUBMB Award, the David H. Murdoxk, the Gerry Aurbach, the SEBBM L&rsquo;Oreal-UNESCO for Women in Science, the&nbsp;C. Ronald Kahn Distinguished Lecture&nbsp;and the Harvey Society Lecture. She has organized and chaired international conferences on protein degradation and on aging, belongs to the editorial board of scientific journals in this topic, and is currently co-editor-in-chief of Aging Cell.</p>
<p>Dr. Cuervo has served in NIH advisory panels, special emphasis panels, and study sections, the NIA Scientific Council and the NIH Council of Councils and &nbsp;has been recently elected member of the NIA Board of Scientific Counselors and member of the of the Advisory Committee to the NIH Deputy Director.. She has received numerous awards for the pioneerign work of her team such as &nbsp;the 2005 P. Benson Award in Cell Biology, the 2005/8 Keith Porter Fellow in Cell Biology, the 2006 Nathan Shock Memorial Lecture Award, the 2008 Vincent Cristofalo Rising Start in Aging Award, the 2010 Bennett J. Cohen Award in Aging Biology, the 2012 Marshall S. Horwitz, MD Faculty Prize for Research Excellence and the 2015 Saul Korey Prize in Translational Medicine Science. She has also received twice the LaDonne Schulman Teaching Award. In 2015 she was elected International Academic of the Royal Academy of Medicine of the Valencia Community and in 2017, she was elected member of the Real Academia de Ciencias Exactas, Fisicas y Naturales. She was elected member of the American Academy of Arts and Sciences in 2018 and member of the National Academy of Science in 2019.</p>

Research Areas
Understanding the molecular basis of malfunctioning of autophagy (cellular quality control system) with age and the contribution of defects on this cellular pathway to age-related disorders such as neurodegeneration, metabolic disorders and cancer.
Specialties
Areas of Expertise
Cancer
Cell biology
Huntington’s disease
Metabolism
Parkinson’s disease
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;">Dr. Cuervo is considered a leader in the field of autophagy&mdash; the process by which cells remove and recycle their waste. The Barcelona, Spain native is also an expert on the cellular biology of aging. Dr. Cuervo has been quoted in numerous publications, including <em>The New York Times</em>, <em>Nature, Science</em>, <em>Scientific American</em>, and <em>The Scientist</em>.&nbsp;</p>
<p class="MsoNormal" style="line-height: 15.6pt;">Dr. Cuervo is co-editor-in-chief of <em>Aging Cell</em> and has served on various National Institutes of Health (NIH) advisory panels and study sections, the National Institute on Aging&rsquo;s Council, and the NIH Council of Councils. She is currently a member of the Advisory Committee to the NIH deputy director, and chair of the NIA Board of Scientific Counselors. She is an elected member of the National Academy of Sciences and of the American Academy of Arts and Sciences.&nbsp;</p>
<p class="MsoNormal" style="line-height: 15.6pt;">Dr. Cuervo&rsquo;s work focuses on the causes of age-related diseases including degenerative disorders such as Alzheimer&rsquo;s disease and Parkinson&rsquo;s disease, metabolic conditions such as diabetes, and cardiovascular disorders. Her goal is to develop therapies that will restore normal cellular housekeeping and thus prevent the accumulation of toxic protein byproducts and the death of affected cells in age-related disorders. Dr. Cuervo was named to the Highly Cited Researchers List (ranking of top 1% cited researchers) since 2018.</p>

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Professional Title
M.D.
Ph.D.
Selected Publications

<p>(selected from &gt;200 per review publications)</p>
<ol>
<li>Cuervo, A.M.*; Stephanis, L.; Freundberg, R.; Lansbury, P.; Sulzer, D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. <em><span style="text-decoration: underline;">Science</span></em>305, 1292-1295, 2004</li>
<li>Kaushik, S.; Massey, A.C.; Kiffin, R., Cuervo, A.M*. Role of lysosomal lipid microdomains in the regulation of chaperone-mediated autophagy. <em><span style="text-decoration: underline;">EMBO J.</span> </em>25, 3921-33, 2006</li>
<li>Zhang, C., Cuervo, AM*. Restoration of chaperone-mediated autophagy in aging improves cellular maintenance and organ function. <em><span style="text-decoration: underline;">Nat. Med.</span> </em>14: 959-65, 2008</li>
<li>Singh, R.; Kaushik, S.; Wang, Y.; Xiang, Y.; Novak, I; Komatsu, M.; Tanaka, K.; Cuervo, A.M*.; Czaja, M.J*.&nbsp; Autophagy regulates lipid metabolism. <em><span style="text-decoration: underline;">Nature</span></em> 458:1131-5, 2009</li>
<li>Martinez-Vicente M, Talloczy Z, Wong E, Tang G, Koga H, de Vries R, Kaushik S, Arias E, Harris S, Sulzer D, Cuervo AM*&nbsp; Cargo recognition failure is responsible for inefficient autophagy in Huntington&rsquo;s Disease. <em><span style="text-decoration: underline;">Nat. Neurosci.</span> </em>13:567-76, 2010</li>
<li>Bandyopadhyay U, Shridar S, Kaushik S, Kiffin R, Cuervo AM*, Identification of regulators of chaperone-mediated autophagy. <em><span style="text-decoration: underline;">Mol Cell</span> </em>39: 535-47, 2010.</li>
<li>Koga H., Kaushik S., Macian F. Verkushka, V. Cuervo AM* A photoconvertible fluorescent reporter to track chaperone-mediated autophagy. <em><span style="text-decoration: underline;">Nat Comm</span></em>&nbsp;2: 386, 2011</li>
<li>Kon, M, Koga, Hl, Kiffin, R., Chapochnick, J. Macian, F, Vartikovski L., Cuervo AM*. Chaperone-mediated autophagy is required for turmor growth. <em><span style="text-decoration: underline;">Science TM</span> </em>3:109ra117, 2011</li>
<li>Wong E, Bejarano E, Hanson HH, Zaarur N, Phillips GR, Sherman MY, Cuervo AM*. Molecular determinants of selective clearance of protein inclusions by autophagy. <em><span style="text-decoration: underline;">Nat Comm</span> </em>3:1240, 2012</li>
<li>Orenstein SJ, Kuo SH, Tasset-Cuevas I, Arias E, Koga H, Fernandez-Carasa I, Cortes, E., Honig, L.S., Dauer, W., Consiglio A, Raya A, Sulzer, D, Cuervo AM. Interplay of LRRK2 with chaperone-mediated autophagy. <em><span style="text-decoration: underline;">Nat. Neurosci.</span> </em>16:394-406, 2013</li>
<li>Anguiano J, Gaerner T, Daas B, Gavathiotis E, Cuervo AM. Chemical modulation of Chaperone-mediated autophagy by novel retinoic acid derivatives. <em><span style="text-decoration: underline;">Nat. Chem. Biol.</span> 9:374-82</em>, 2013</li>
<li>Pampliega O, Orhon I, Patel B, Sridhar S, Diaz-Carretero A, Beau I, Codogno P, Satir B, Satir P, Cuervo AM Functional interaction between autophagy and ciliogenesis. <em><span style="text-decoration: underline;">Nature</span> 502:194-200, 2013 </em></li>
<li>Bejarano, E, Yuste, A, Patel B, Stout, RJ, Spary, D Cuervo AM. <em>Connexins modulate autophagosome biogenesis. <em><span style="text-decoration: underline;">Nat. Cell. Biol.</span></em> 16:401-14, 2014</em></li>
<li>Schneider JL, Suh Y, Cuervo AM*.&nbsp; Deficient chaperone-mediated autophagy in liver leads to metabolic disregulation. <em><span style="text-decoration: underline;">Cell Metab</span>.</em> 20:417-432, 2014</li>
<li>Schneider S, Villarroya J, Diaz A, Patel B, Urbanska AM, Thi MM, Villarroya F, Santambrogio L, Cuervo AM*. Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging. <em><span style="text-decoration: underline;">Aging Cell,</span></em> 14:249-64, 2015</li>
<li>Rui Y-N, Xu Z, Patel B, Chen Z, Chen D, Tito A, David G, Sun Y, Stimming ER, Bellen H, Cuervo AM*, Zhang S*. Huntingtin functions as a scaffold for selective macroautophagy. <em><span style="text-decoration: underline;">Nat. Cell. Biol.</span></em> 17: 262-75, 2015</li>
<li>Park C, Shu Y, Cuervo AM*.Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage. <em><span style="text-decoration: underline;">Nat. Commun.</span> </em>6:6823 doi: 10.1038/ncomms7823, 2015</li>
<li>Kaushik, S. Cuervo AM*. Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis. <em><span style="text-decoration: underline;">Nat. Cell. Biol. </span></em>17: 759-70, 2015</li>
<li>Arias E., Koga H, Diaz A, Mocholi E, Patel B, Cuervo AM*. Lysosomal mTORC2/PHLPP1/Akt regulate chaperone-mediated autophagy. <em><span style="text-decoration: underline;">Mol. Cell</span> </em>59, 270-84, 2015</li>
<li>Kaushik, S. Cuervo AM*. AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA. <span style="text-decoration: underline;"><em>Autophagy.</em> </span>12(2):432-438, 2016</li>
<li>Maus M, Cuk M, Patel B, Lian J, Qimet M, Kaufmann U, Yang J, Horvath R, Hornig-Do H-T, Chrzanowska-Lightowlers ZM, Moore KJ, Cuervo AM, Feske S. Store-Operated Ca2+ Entry Controls Induction of Lipolysis and the Transcriptional Reprogramming to Lipid Metabolism.<span style="text-decoration: underline;"><em>Cell Metab</em></span> 25: 698-712, 2017</li>
<li>Beckerman P, Karchin JB, Park ASD , Dummer P, Soomro I, Boustany-Kari C, Pullen S Qiu C, Miner JH, Hu C-A, Rohacs T, Inoue K, Shuta I, Saleem M, Palmer M, Cuervo AM, Kopp J, Susztak K. Transgenic Expression of Human APOL1 Risk Variants in Podocytes Induces Kidney Disease in Mice. <span style="text-decoration: underline;"><em>Nat Med</em></span> 23: 429-438, 2017</li>
<li>&nbsp;Gomes LR, Menck, CFM, Cuervo AM*, Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation. <em><span style="text-decoration: underline;">Autophagy</span></em> 13: 928-940, 2017</li>
<li>Caballero B, Wang Y, Diaz A, Tasset I, Juste YR, Mandelkow E-, Mandelkow E, Cuervo AM*. Interplay of pathogenic forms of human tau with different autophagic pathways. <em><span style="text-decoration: underline;">Aging Cell</span> </em>17(1): doi: 10.2222/acel.12692, 2017 PMID: 29024336</li>
<li>Gong Z, Tasset I, Diaz A, Anguiano J, Tas E, Cui L, Kuliawat R, Liu H, Kuhn B, Cuervo AM*, Muzumdar R. Humanin is an endogenous activators of chaperone-mediated autophagy. <em><span style="text-decoration: underline;">J Cell Biol</span> </em>&nbsp;&nbsp;217:635-647, 2018 PMID:2918752</li>
<li>Pajares M, Rojo AI, Arias E, Diaz-Carretero A, Cuervo AM, Cuadrado A. Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. <em><span style="text-decoration: underline;">Autophagy</span> </em>doi: 10.1080/15548627.2018.1474992, 2018</li>
<li>Bejarano E, Murray J, Wang X, Pampliega, O, Yin D, Patel B, Yuste A, Wolkoff A, Cuervo AM. Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging. <em><span style="text-decoration: underline;">Aging Cell</span> </em>&nbsp;doi: 10.1111/acel.12777, 2018</li>
<li>Hernandez I, Luna G, Rauch JN, Reis S, Giroux M, Karch CM, Boctor D, Sibih Y, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman G, Cerovac V, Guzman E, Zhou H, Haggarty SJ, Goate A, Fisher SK, Cuervo AM, Kosik KS Farnesyl Transferase Inhibition for the Treatment of Tauopathies.<em><span style="text-decoration: underline;"> Science TM. </span></em>2019 Mar 27;11(485). pii: eaat3005. doi: 10.1126/scitranslmed. aat3005.</li>
<li>Kirchner P, Bourdenx M, Madrigal-Matute J, Tiano S, Diaz A, Barholdy BA, Will B, Cuervo A. Proteome-wide analysis of chaperone-mediated autophagy targeting motifs. <em><span style="text-decoration: underline;">PLOs Biology</span></em>, 17(5):e3000301. doi: 10.1371/journal.pbio.3000301, 2019</li>
<li>Dong S, Aguirre-Hernandez C, Scrivo A, Eliscovich C, Arias E, Bravo-Cordero JJ, Cuervo AM. Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo. <span style="text-decoration: underline;"><em>Nature Comm.</em></span>&nbsp;11(1):645. doi: 10.1038/s41467-019-14164-4, 2020</li>
<li>Dong S, Wang Q, Kao YR, Diaz A, Tasset I, Kaushik S, Thiruthuvanathan V, Zintiridou A, Nieves E, Dzieciatkowska M, Reisz JA, Gavathiotis E, D&rsquo;Alessandro A, Will B, Cuervo AM. Chaperone-mediated autophagy sustains hematopoietic stems cell function. <span style="text-decoration: underline;"><em>Nature</em> </span>591:117-123, 2021&nbsp;</li>
<li>Caballero B, Bourdenx M, Luengo Martin E, Diaz A, Sohn PD, Chen X, Wang C, Juste YR, Wegman S, Patel B, Young ZT, Kuo SY, Rodriguez-Navarro JA, Shao H, Lopez MG, Karch CM, Goate A, Gestwicki JE, Hyman BT, Gan L, Cuervo AM. Inhibition of chaperone-mediated autophagy by acetylated tau promotes disease propagation. <span style="text-decoration: underline;"><em>Nat. Comm.</em></span> 12(1):2238 doi: 10.1038/s41467-021-22501-9, 2021</li>
<li>Bourdenx M, Martin-Segura A, Scrivo A, Rodriguez-Navarro J, Kaushik S, Tasset I, Diaz A, Strom NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement C, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. <span style="text-decoration: underline;"><em>Cell</em> </span>184: 1-19&nbsp; doi: 10.1016/j.cell.2021.03.048, 2021</li>
<li>Juste YR, Kaushik S, Bourdenx M, Aflakpui R, Bandyopadhyay S, Garcia F, Diaz A, Lindenau K, Tu Vincent, Krause GJ, Jafari M, Singh R, Mu&ntilde;<span lang="EN-GB" style="text-align: justify; text-indent: -27pt; font-size: 11pt; line-height: 115%; font-family: Arial, sans-serif;">oz J, Macian F, Cuervo AM. Reciprocal regulation of chaperone-mediated </span><span style="text-align: justify; text-indent: -27pt; font-size: 11pt; line-height: 115%; font-family: Arial, sans-serif;">autophagy and the circadian clock. <em><u>Nat. Cell Biol.</u> 23(12):1255-1270 10.1038/s41556-021-00800-z. 2021, 2022</em></span></li>
<li>Madrigal-Matute J, de Bruijn J, van Kuijk K, Riascos-Bernald DF, Diaz A, Tasset I, Mart&iacute;n-Segura A, Gijbel MJJ, Sander B, Kaushik S, Biessen EAL, Tiano S, Bourdenx M, Krause GJ, McCracken I, Baker A, Jin H, Sibinga N, Bravo-Cordero JJ, Macian F, Singh R, Rensen PCN, Berb&eacute;e JFP, Pasterkamp G, Sluimerc JC, Cuervo AM<span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">.</span> <span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">&nbsp;</span><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">Protective role of chaperone-mediated autophagy against atherosclerosis. </span><em style="font-size: 11pt; text-indent: -27pt; font-family: Arial, sans-serif; text-align: justify;"><u>Proc. Nat. Acad. Sci.</u></em><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;"> Inaugural Paper, 2022</span> <span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">119(14):e2121133119. doi: 10.1073/pnas.2121133119, 2022</span></li>
<li>Barbaro JM, Sidoli S, Cuervo AM, Berman JW. <span style="font-style: italic; font-family: Arial, sans-serif; font-size: 11pt; text-align: justify; text-indent: -27pt; line-height: 115%;">Methamphetamine Dysregulates Macrophage Functions and Autophagy to Mediate HIV Neuropathogenesis.</span> <em style="font-family: Arial, sans-serif; font-size: 11pt; text-align: justify; text-indent: -27pt;"><u>B</u></em><em style="font-family: Arial, sans-serif; font-size: 11pt; text-align: justify; text-indent: -27pt;"><u><span style="font-size: 11pt; line-height: 115%;">iomedicines</span></u></em><span style="font-style: italic; font-family: Arial, sans-serif; font-size: 11pt; text-align: justify; text-indent: -27pt; line-height: 115%;">. 10(6):1257., 2022</span></li>
<li>Krause GJ, Diaz A, Jafari M, Khawaja RR, Agullo-Pascual E, Santiago-Fern&aacute;ndez O, Richards AL, Chen KH, Dmitriev P, Sun Y, See SK, Abdelmohsen K, Mazan-Mamczarz K, Krogan NJ, Gorospe M, Swaney DL, Sidoli S, Bravo-Cordero JJ, Kampmann M, Cuervo AM<span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">. Reduced endosomal microautophagy activity in aging associates with enhanced exocyst-mediated protein secretion. </span><em style="font-size: 11pt; text-indent: -27pt; font-family: Arial, sans-serif; text-align: justify;"><u>Aging Cell.</u> </em><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">e13713. doi: 10.1111/acel.13713, 2022</span></li>
<li>Rovira M, Sereda R, Pladevall-Morera D, Ramponi V, Marin I, Maus M, Madrigal-Matute J, D&iacute;az A, Garc&iacute;a F, Mu&ntilde;oz J, Cuervo AM, Serrano M. The lysosomal proteome of senescent cells contributes to the senescence secretome. <em><u>Aging Cell.</u></em><span style="font-size: 11pt; line-height: 115%;"> e13707. doi: 10.1111/acel.13707, 2022</span></li>
<li>Gomez-Sintes R Xin Q, Diaz A, Garner TP, Cotto-Rios XM, Wu Y, McCabe M, Dong S, Reynolds CA, Patel B de la Villa P, Macian F, Boya P, Gavathiotis E, <span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">Cuervo</span> <span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">AM</span><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">. Targeting NCoR-RAR interaction activates chaperone-mediated autophagy and protects against retinal degeneration. </span><em style="font-size: 11pt; text-indent: -27pt; font-family: Arial, sans-serif; text-align: justify;"><u>Nat. Comm</u></em><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">. 13(1): 4220, doi: 10.1038/s41467-022-31869-1, 2022</span></li>
<li>Kaushik S, Juste YR, Lindenau K, Dong S, Macho-Gonzales A, Santiago-Fernandez O, McCabe M, Singh R, Gavathiotis E, <span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">Cuervo AM</span><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;">. Chaperone-mediated autophagy regulates adipocyte differentiation. </span><em style="font-size: 11pt; text-indent: -27pt; font-family: Arial, sans-serif; text-align: justify;"><u>Sci. Adv.</u></em><span style="font-size: 11pt; text-indent: -27pt; font-style: italic; font-family: Arial, sans-serif; text-align: justify;"> 8 (46) DOI: 10.1126/sciadv.abq2733 , 2022</span></li>
</ol>
<p><em>RECENT REVIEWS</em></p>
<ol>
<li>Kaushik S, Cuervo AM. Proteostasis and aging. <span style="text-decoration: underline;"><em>Nat Med.</em></span> 21:1406-15, 2015</li>
<li>Tekirdag KA, Cuervo AM. Chaperone-mediated autophagy and endosomal microautophagy: joint by a chaperone. <em><span style="text-decoration: underline;">J. Biol. Chem</span>. </em>&nbsp;293:5414-5424, 2018</li>
<li>Kaushik K, Cuervo AM. The coming of age of Chaperone-mediated autophagy. <em><span style="text-decoration: underline;">Nat. Rev. Cell. Mol. Biol.</span></em> Doi: doi.org/10.1038/s41580-018-0001-6, 2018</li>
<li>Scrivo A, Bourdenx M, Pampliega O, Cuervo AM. Selective autophagy as a potential therapeutic target for neurodegenerative disorders. <em><span style="text-decoration: underline;">Lancet Neuro</span></em><span style="text-decoration: underline;">l</span> 17(9):802-815, 2018</li>
<li>Arias E, Cuervo AM. Pros and cons of chaperone-mediated autophagy in cancer. <span style="text-decoration: underline;"><em>Trends. Endocrinol Metab</em></span>. S1043-2760(19)30208-5. doi: 10.1016/j.tem.2019.09.007, 2019</li>
<li>Krause GJ, Cuervo AM. Assessment of mammalian endosomal microautophagy. <span style="text-decoration: underline;"><em>Methods Cell Bio</em></span><em>l</em> 164:167-185, 2021</li>
<li><span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;</span><span style="text-align: justify; text-indent: -22.5pt; font-size: 11pt; font-family: Arial, sans-serif;">Kaushik S, Tasset I, Arias E, Pampliega O, Wong E, Martinez-Vicente M, Cuervo AM. Autophagy and the Hallmarks of Aging. <em><u>Ageing Res Rev.</u></em></span> <span style="text-align: justify; text-indent: -22.5pt; font-size: 11pt; font-family: Arial, sans-serif;">&nbsp;doi: 10.1016/j.arr.2021.101468, 2022</span></li>
<li>Jafari, M., McCabe, M, <strong>Cuervo AM</strong>. <span style="text-align: justify; text-indent: -22.5pt; font-family: Arial, sans-serif; font-size: 11pt;">Chaperone-mediated autophagy: mechanisms and physiological relevance &nbsp;<em><u>Current. Opin. Physiol</u>. </em>Available online 26 September 2022. doi: doi.org/10.1016/j.cophys.2022.100597</span></li>
</ol>

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Charles B. Hall

Submitted by Anonymous (not verified) on
Full Name
Charles B. Hall
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/6913-charles-hall.jpg
Type
Faculty
Expert
First Name
Charles
Last Name
Hall
Faculty ID
6913
Patient Type
Adult
Department
einstein-dept-epidemiology-population-health
einstein-dept-neurology
Email
charles.hall@einsteinmed.edu
Phone
718-430-3724
Titles
Type
Academic
Department
Department of Epidemiology & Population Health
Department Link
Rank
Professor
Tags
me-patientcare-cancer-research-epidemiology
Division
Biostatistics
Type
Academic
Department
The Saul R. Korey Department of Neurology
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Professor
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312
Address Line 1
Albert Einstein College of Medicine
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Jack and Pearl Resnick Campus
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1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Professional Interests

<p>Dr. Charles Hall has been a senior biostatistician for the Einstein Aging Study (EAS) since 2001. The EAS, a longitudinal research study that focuses on the aging brain, is one of the longest running of its kind in the United States. A biostatistician by training, Dr. Hall investigates the connection between cognitive activities and the onset of age-related diseases such as Alzheimer&rsquo;s and dementia. His long-term observational research have shown that brain-stimulating activities have a positive correlation with delayed dementia onset and progression. Such findings support the hypothesis that education along with brain exercise&mdash;through endeavors such as reading, writing, group discussions and crossword puzzles&mdash;can help the brain build up extra defenses to fight off neuronal damage caused by age-related diseases.</p>
<p>In recent years Dr. Hall's main work has been as lead statistician for the World Trade Center (WTC) Health Program at the Fire Department of the City of New York. Dr. Hall has been Principal Investigator on four Cooperative Agreements funded by the National Institute of Occupational Safety and Health that examine respiratory disease, cancer, and mortality in WTC rescue/recovery workers and has contributed to other research on the health effects of the exposure.&nbsp;</p>

Specialties
Areas of Expertise
Change-point models
Cognitive reserve
Longitudinal data analysis
Survival analysis
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Hall is a biostatistician recognized for leading important long-term studies of aging and dementia. His research has shown, for example, that brain-stimulating activities delay the onset of dementia. He is the longtime director of the statistical core of the Einstein Aging Study, one of the longest-running prospective studies of aging in the country. He is also the lead statistician for the data coordinating center of the federally funded World Trade Center (WTC) Medical Monitoring &amp; Treatment Program, which provides free health monitoring and treatment for workers and volunteers involved in the rescue, recovery and clean-up activities at the WTC site in New York City.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">In his aging studies, Dr. Hall has pioneered the use of change-point models &ndash; powerful statistical tools for detecting subtle but meaningful changes in data. He has used these models to show that having more years of formal education or engaging in cognitively stimulating leisure activities appear to protect against developing clinical dementia symptoms.</span></p>

CHAM Provider
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Professional Title
Ph.D.
Selected Publications

<p>&nbsp;</p>
<p>A complete list of publications can be found at <a href="http://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/">NCBI</a… /><br /></p>

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Richard B. Lipton

Submitted by Anonymous (not verified) on
Full Name
Richard B. Lipton
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/b07d5c20-c947-11ed-8462-993dfb204153.jpg
Type
Provider
Faculty
Expert
First Name
Richard
Last Name
Lipton
NPI
1407931728
Faculty ID
7405
CMO Specialties
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-neurology
einstein-dept-psychiatry-behavioral-sciences
einstein-dept-epidemiology-population-health
Gender
Male
Email
richard.lipton@einsteinmed.edu
Phone
718-430-3886
Titles
Type
Academic
Department
The Saul R. Korey Department of Neurology
Department Link
Rank
Professor
Tags
me-patientcare-neurology-about-team
me-patientcare-neurology-programs-headachecenter
me-patientcare-neurology-programs-centerfortheagingbrainteam
Type
Academic
Department
Department of Psychiatry and Behavioral Sciences
Department Link
Rank
Professor
Type
Academic
Department
Department of Epidemiology & Population Health
Department Link
Rank
Professor
Division
Epidemiology
Type
Administrative
Title
Edwin S. Lowe Chair in Neurology
Type
Administrative
Title
Vice Chair, The Saul R. Korey Department of Neurology
Type
Administrative
Title
Director, Montefiore Headache Center
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8444 40.85103)
Address Line 1
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461-1900
Location Title
Montefiore at AECOM
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84154 40.84612)
Address Line 1
1250 Waters place
City
Bronx
State
NY
Zip
10461-2720
Location Title
Montefiore at 1250 Waters Place
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Van Etten
Room
3C12C
Address Line 1
Albert Einstein College of Medicine
Address Line 3
1225 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Education and Trainings
Education Type Label
Medical Education
Education Institution
University of Chicago Pritzker School of Medicine
Education Type Label
Fellowship
Education Institution
Montefiore Medical Center
Education Type Label
Residency
Education Institution
Montefiore Medical Center
Professional Interests

<p>Richard B. Lipton, M.D., is the Edwin S. Lowe Professor and Vice Chair of Neurology, Professor of Epidemiology and Population Health and Professor of Psychiatry and Behavioral Sciences at the Albert Einstein College of Medicine.&nbsp;Dr. Lipton earned his medical degree at the University of Chicago Pritzker School of Medicine. After a medical internship at Northwestern Memorial Hospital, he completed his neurology residency and clinical neurophysiology fellowship at the Albert Einstein College of Medicine. He also completed a fellowship in neuroepidemiology at Columbia University. He is a diplomate of the American Board of Psychiatry and Neurology and a fellow of the American Academy of Neurology.</p>
<p>His research focuses on cognitive aging, Alzheimer&rsquo;s disease and migraine headaches. He is the Principal Investigator of the Einstein Aging Study, an NIH funded Program Project, and collaborates on several R01s.&nbsp; His research focuses on risk factors and biomarkers of cognitive decline and Alzheimer&rsquo;s disease. His recent studies examine cognitive aging across the lifespan with an emphasis on the effects of pain and stress on brain function.</p>
<p>His headache research focuses on the epidemiology of migraine and on clinical trials.&nbsp; His epidemiologic studies have evaluated trigger factors for headache attacks and risk factors for headache progression.&nbsp;Dr. Lipton has published more than 800 original articles, many with trainees.&nbsp; He is a&nbsp;5 time winner of the H.G. Wolff Award for excellence in headache research from the American Headache Society and a two time winner of the Enrico Greppi award from the European Headache Federation.&nbsp; Dr. Lipton is Director of the Montefiore Headache Center, an interdisciplinary subspecialty center focused on headache, patient care,&nbsp;research and education.</p>
<p>Dr. Lipton holds leadership positions in several professional societies. He is a Past-President of the American Headache Society (AHS).&nbsp; He serves on the editorial boards of several journals, including Neurology. He has written 11 books. Dr. Lipton enjoys mentoring medical students, residents, PhD students and fellows.&nbsp; Over the last decade he has mentored 7 CRTP students and&nbsp;10 K-award recipients. He has received both the CRTP Mentor of the Year Award and the Einstein Faculty Mentoring Award.&nbsp;</p>
<p>Dr. Richard Lipton was a speaker at the inaugural Migraine World Summit in 2016. <a id="mb1" title="Lipton at Migraine World Summit 2016" href="http://einstein.yu.edu/departments/neurology/video.asp?videourl=/depart…; target="_blank" rel="noopener videos">Click here for the video.</a></p>

Research Areas
I study migraine headaches, cognitive aging and dementia. My work includes longitudinal population studies that link stress, pain and cognitive performance to genetics, biomarkers and neuroimaging.
Specialties
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">A noted authority on headaches and migraine, Dr. Lipton is director of the Montefiore Headache Center, recognized internationally for its leadership in the diagnosis, classification and treatment of headache disorders. Dr. Lipton is also director of the Einstein Aging Study, which has been examining both normal brain aging and the special challenges of Alzheimer&rsquo;s disease and other dementias since 1980.&nbsp;</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">A prolific researcher and writer, Dr. Lipton has published eight books and more than 600 original articles and reviews. He is a recipient of the Medical Book Award from the British Medical Association for his text<span>&nbsp;</span><em>Headache in Clinical Practice</em>. He is also an associate editor of<span>&nbsp;</span><em>Cephalalgia: An International Journal of Headache</em><span>&nbsp;</span>(the journal of the International Headache Society) and sits on the editorial boards of several journals, including<span>&nbsp;</span><em>Neurology</em>. He is a three-time recipient of the H.G. Wolff Award for excellence in research from the American Headache Society (AHS).&nbsp; Dr. Lipton serves on the advisory council of the International Headache Society and is a former president of the AHS. He is also professor of psychiatry and behavioral sciences and of epidemiology &amp; population health at Einstein.</span></p>

CHAM Provider
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Professional Title
M.D.
Clinical Focus

Dr. Lipton&rsquo;s clinical work focuses on headache medicine, particularly chronic migraine.&nbsp; He is interested in integrative approaches that combine pharmacologic and behavioral treatments with neuromodulatory devices in a patient-centered fashion.&nbsp; The Montefiore Headache Center has a large full-time faculty and trains two fellows in headache medicine annually.

Research Focus

Dr. Lipton's research interests include clinical trials on headache disorders, Alzheimer's disease, and other dementias. I also conduct epidemiologic studies and develop outcome measures in both areas.<quillbot-extension-portal></quillbot-extension-portal>

Selected Publications

<p class="MsoNormal" style="text-autospace: ideograph-numeric ideograph-other;"><strong style="mso-bidi-font-weight: normal;"><u><a href="https://www.ncbi.nlm.nih.gov/myncbi/1dWheFdF_r05E/bibliography/public/"… style="color: windowtext;">https://www.ncbi.nlm.nih.gov/myncbi/1dWheFdF_r05E/bibliography/public/<…;

EMR ID
3377
Is Open Scheduling
Off
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