Epilepsy | Montefiore Einstein

Solomon L. Moshe

Read more about Solomon L. Moshe

Solomon L. Moshe

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Provider

Faculty

Expert

First Name

Solomon

Last Name

Moshe

NPI

1396820619

Faculty ID

6831

CMO Specialties

Child Neurology

Epilepsy

Clinical Neurophysiology

Clinical Terms

Autism Spectrum Disorder

Epilepsy

Headaches in Children

Growing Pains

Focal Seizures

Temporal Lobe Epilepsy

Tonic Seizures

Drug Abuse and Intoxication

Autism

Headache

Seizure Disorders

Convulsive Status Epilepticus

Generalized Convulsive Status Epilepticus

Grand Mal Status

Status Epilepticus, Generalized Convulsive

Employment Status

Full Time

Patient Type

Pediatric

Department

einstein-dept-neurology

einstein-dept-pediatrics

einstein-dept-neuroscience

Gender

Male

solomon.moshe@einsteinmed.edu

Phone

718-430-2447

Titles

Type

Academic

Department

The Saul R. Korey Department of Neurology

Department Link

Rank

Professor

Tags

me-neuroscience-pediatricneuroscience-isabellerapindivisionofchildneurology

Locations

Is Primary

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.87885 40.88037)

Address Line 1

3415 Bainbridge Avenue

City

Bronx

State

Zip

10467-2403

Location Title

The Children's Hospital at Montefiore

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.8473621 40.8556768)

Room

316

Address Line 1

Albert Einstein College of Medicine

Address Line 2

Rose F. Kennedy Center

Address Line 3

1410 Pelham Parkway South

City

Bronx

State

Zip

10461

Location Title

Albert Einstein College of Medicine

Education and Trainings

Education Type Label

Medical Education

Education Institution

University of Athens Medical School

Education Type Label

Fellowship

Education Institution

Albert Einstein College of Medicine

Education Type Label

Residency

Education Institution

University of Maryland

Professional Interests

Solomon L. Moshé, M.D., is the Charles Frost Chair in Neurosurgery and Neurology, and Professor of Neurology, Neuroscience, and Pediatrics at the Albert Einstein College of Medicine/Montefiore Medical Center in the Bronx, New York. He is also the Vice Chair of the Saul R. Korey Department of Neurology, Director of the Isabelle Rapin Child Neurology Division and Director of Clinical Neurophysiology. His area of expertise is in epilepsy and related disorders.
 
Since 1979, his research has focused on understanding the mechanisms underlying age and sex-related differences in epilepsy in humans and animal models.  Current research interests include studies on the role of subcortical circuitries involved in the control of seizures as a function of age and sex; the consequences of seizures on the developing brain and the development of models of catastrophic epilepsies. His laboratory has patented a model of infantile spasms that can be used to identify novel treatments. He is co principal investigator of a Center Without Walls grant on interdisciplinary research aimed at accelerating the development of disease modifying or prevention therapies for epilepsy following traumatic brain injuries. He is also involved in a large multicenter study examining the consequences of prolonged febrile seizures.  He has over 600 publications as well as He has over 600 publications as well over 35 books and monographs.
over 35 books and monographs.
 
 He has served as President of the International League Against Epilepsy (2009-2013), the American Epilepsy Society (2000-2001), the American Clinical Neurophysiology Society (1996-1997) and the Eastern Association of EEGers (1992-1994). He is the recipient of many awards and honors, including the Teacher-Investigator Development Award from NINDS; the 1995 Jacob Javits Neuroscience Investigator Award from NINDS; the 1984 Michael Prize for Achievements in Epilepsy Research; the 1990 American Epilepsy Society Research Award; the 1999 Ambassador for Epilepsy Award from the International League Against Epilepsy; the 2005 Gloor Award from the American Clinical Neurophysiology Society; the 2007 J.E. Purkyne Honorary Medal in Biomedical Research by the Czech Academy of Sciences; the 2008 Mentor of the Year Award from Albert Einstein College of Medicine; the 2010 Global and Awareness Award from CURE, Citizens United for Research in Epilepsy; the First 2012 Saul R. Korey Award in Translational Science and Medicine, Albert Einstein College of Medicine and the 2017 Bernard Sachs Award from the Child Neurology Society, <span style="background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">and the 2023 Lifetime Achievement Award from the International League against Epilepsy.
 
He has been asked to deliver over 50 several keynote lectures.
 
Clinical Focus:
Dr. Moshé focuses on helping people with epilepsy and related conditions with a special emphasis on children and adolescents.
 
Research focus
Dr Moshé has focused on translational research to understand the mechanisms underlying age and sex-related differences in epilepsy in humans and animal models. The main goals are to develop individualized treatments today and to prevent and cure epilepsy tomorrow. Current projects include the development of effective means to predict and treat epilepsy after traumatic brain injury and the development of specialized treatments for infants and children with epilepsy.

Research Areas

Studies include of antiepileptogenesis following traumatic brain injury, intractable age specific epilepsies and their consequences, and subcortical circuits involving the control of seizures. Model development.

Expert Tags

Epilepsy

Areas of Expertise

Biological mechanisms underlying epilepsy

Neurophysiology

Pediatric epilepsy

Translational research

Expert Summary

Dr. Moshé is an authority on the mechanisms that underlie the development of epilepsy and on the consequences of the disease in infants and children.
A translational scientist, Dr. Moshé has developed and patented an animal model that replicates human infantile spasms, which can be used to identify novel treatments of this devastating condition. Dr. Moshé has served as President of the International League Against Epilepsy, American Epilepsy Society, the American Clinical Neurophysiology Society, and the Eastern Association of Electroencephalographers.
Dr. Moshé is actively involved in several large, multicenter studies examining the outcomes of prolonged febrile seizure to identify predictive biomarkers of the course of these conditions and response to treatment.
Dr. Moshé has received numerous honors and awards, including the American Epilepsy Society Research Recognition Award, Jacob Javitz Neuroscience Investigator Award from the National Institutes of Health, the Michael Prize,  American Epilepsy Society research award, the CURE (Citizens United for Research in Epilepsy)  Global Awareness Award for leadership in raising the international profile of epilepsy, the Pierre Gloor Award of the American Clinical Neurophysiology Society, and the J.E. Purkyne Honorary Medal for Merit in the BioMedical Sciences of the Czech Academy of Sciences. He is an elected member of the American Neurological Association and the American Pediatric Society.

Research Profile

https://einsteinmed.edu/faculty/6831/Solomon-Moshe

Clinical Profile

https://montefioreeinstein.org/profiles/1396820619/solomon-l-moshe

CHAM Provider

Professional Title

M.D.

Clinical Focus

Dr. Moshé focuses on helping people with epilepsy and related conditions with a special emphasis on children and adolescents

Research Focus

Dr. Moshé has focused on translational research to understand the mechanisms underlying age and sex-related differences in epilepsy in human and animal models. The main goals are to develop individualized treatments today and to prevent and cure epilepsy tomorrow. Current projects include the development of effective means to predict and treat epilepsy after traumatic brain injury and the development of specialized treatments for infants and children with epilepsy.

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/8ef8f50b-2557-4893-9d64-7c286a0ed…

Selected Publications

<ol>
<li> Katsarou A, Moshé SL, Galanopoulou AS.  Interneuronopathies and their role in early life epilepsies and neurodevelopmental disorders.   Epilepsia Open 3: 284-306 (2017). PMID: 29062978</li>
<li>Moshe SL.  The 2017 Sachs lecture: Kindling knowledge in Epilepsy.  Pediatric Neurology 85: 5-12 (2018).  PMID: 29958806</li>
<li>Saletti PG, Ali I, Casillas-Espinonsa PM, Semple BD, Lisgaras C, Moshe SL, Galanopoulou AS. In search of antiepileptogenic treatments for post-traumatic epilepsy.  Neurobiology of Disease 123: 86-99 (2019).  PMID: 29936231</li>
<li>Correa DJ, Kwon C, Connors S, Fureman B, Whittemore V, Jette N, Mathern G and Moshe SL.   For the EpiBioS4RX Public Engagement Core.   Applying participatory action research in traumatic brain injury studies to prevent post-traumatic epilepsy.   Neurobiology of Disease 123: 137-144 (2019).  PMID: 30031158</li>
<li>Molinero I, Galanopoulou AS and Moshe SL.   Rodent models: Where it all started with these “truths”.   European Journal of Paediatric Neurology 61-65 (2020) PMID: 31875833</li>
<li>Ozlem A, Briggs S, Mowrey W, Moshe SL, Galanopoulou AS   Antiepiletogenic effects of rapamycin in a model of infantile spasms due to structural lesions.   Epilepsia, 62,1985-1999, (2021) PMID: 34212374</li>
<li>
<p class="MsoNormal" style="margin: 0in; font-size: 10pt; font-family: 'Times New Roman', serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">Zuberi S, Wirrell E, Yozawitz E, Wilmshurst J, Specchi N, Riney K, Pressler R, Auvin S, Samia P, Hirsch E, Galicchio S, Triki C, Snead O, Wiebe S, Cross H, Tinuper P, Scheffer I, Perucca E and Moshe SL.   ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions.  Epilepsia, 63, 1349-1397 (2022) PMID: 35503712
</li>
<li>
<p class="MsoNormal" style="margin: 0in; font-size: 10pt; font-family: 'Times New Roman', serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">Hirsch E, French J, Scheffer I, Bogacz A, Alsaadi T, Sperling M, Abdulla F, Zuberi S, Trinka E, Specchio N, Somerville E, Samia P, Riney K, Nabbout R, Jain S, Wilmshurst J, Auvin S, Wiebe S, Perucca E, Moshe SL, Tinuper P and Wirrell E.  ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions.  Epilepsia, 63, 1475-1499 (2022) PMID: 35503716
</li>
<li>
<p class="MsoNormal" style="margin: 0in; font-size: 10pt; font-family: 'Times New Roman', serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">Specchio N, Wirrell E, Scheffer I, Nabbout R, Riney K, Samia P, Guerreiro M, Gwer S, Zuberi S, Wilmshurst J, Yozawitz E, Pressler R, Hirsch E, Wiebe S, Cross H, Perucca E, Moshe SL, Tinuper P and Auvin S.  International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions.  Epilepsia, 63, 1398-1442 (2022) PMID: 35503717
</li>
<li>
<p class="MsoNormal" style="margin: 0in; font-size: 10pt; font-family: 'Times New Roman', serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"> Riney K, Bogacz A, Somerville E, Hirsch E, Nabbout R, Scheffer I, Zuberi S, Alsaadi T, Jain S, French J, Specchio N, Trinka E, Wiebe S, Auvin S, Cabral-Lin L, Naiddo A, Perucca E, Moshe SL, Wirrell E and Tinuper P.  International League Againist Epilepsy classification and definition of epilepsy syndromes with onset at a variable age: position statement by the ILAE Task Force on Nosology and Definitions.   Epilespia, 63, 1443-1474 (2022) PMID: 35503725
</li>
<li>
<p class="MsoNormal" style="margin: 0in; font-size: 10pt; font-family: 'Times New Roman', serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">Wirrell E, Nabbout R, Scheffer I, Alsaadi T, Bogacz A, French J, Hirsch E, Jain S, Kaneko S, Riney K, Samia P, Snead O, Somerville E, Specchio N, Trinka E, Zuberi S, Balestrini S, Wiebe S, Cross H, Perucca E, Moshe SL and Tinuper P.   Methodology for classification and definition of epilepsy syndromes with list of syndroms: Report of the ILAE Task Force on Nosology and Definitions.   Epilepsia, 63, 1333-1348 (2022) PMID: 35503715
</li>
<li>
Saletti P, Casillas-Espinosa P, Lisgaras C, Mowrey W, Li Q, Liu W, Brady R, Ali I, Silva J, Yamakawa G, Hudson M, Li C, Braine E, Coles L, Cloyd J, Shultz S, Moshé SL, O’Brien T, Galanopoulou AS for the EpiBioS4RX Group.    TAU phosphorylation patterns in the rat cerebral cortex after traumatic brain injury and sodium selenate effects:  An EpiBioS4Rx Project 2 study.   Journal of Neurotrauma pgs 1-22, (2023.)  PMID: 36950806
</li>
<li>
Saletti P, Mowrey W, Liu W, Li Q, McCullough J, Aniceto R, Lin I-H, Eklund M, Casillas-Espinosa P, Ali I, Santana-Gomez C, Coles L, Shultz S, Jones N, Staba R, O’Brien T, Moshé SL, Agoston D, Galanopoulou AS for the EpiBioS4RX Study Group.     Early preclinical plasma protein biomarkers of brain trauma are influenced by early seizures and levetiracetam.   Epilepsia Open pgs. 586-608 (2023) PMID: 37026764
</li>
<li>
Coles L, Saletti P, Lisgaras C, Casillas-Espinosa P, Liu W, Li Q, Jones N, Shultz S, Ali I, Brady R, Yamakawa G, Hudson M, Silva J, Braine E, Mishra U, Cloyd J, O’Brien T, Moshé SL, Galanopoulou AS for the EpiBioS4RX Study Group.   Levetiracetam Pharmacokinetics and Brain Uptake in a Lateral Fluid Percussion Injury Rat Model.   <span style="background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">Journal of Pharmacology and Experimental Therapeutics pgs 1-30, (2023).  PMID: 37316328
</li>
</ol>

EMR ID

3412

Biography

Solomon L. Moshé, MD, is Vice Chair of Neurology, Director of the Isabelle Rapin Child Neurology Division and Director of Clinical Neurophysiology at Montefiore. He is also the Charles Frost Chair in Neurosurgery and Neurology, Vice Chair, Saul R. Korey Department of Neurology, and Professor of Neurology, Neuroscience and Pediatrics at the Albert Einstein College of Medicine (Einstein). Dr. Moshé’s clinical focus is on epilepsy and electroencephalography with special emphasis on age-related influences on the expression, control and consequences of seizures.After receiving his Doctor of Medicine from the National University of Athens School of Medicine in Greece in 1972, Dr. Moshé began his post-doctoral training at the University Hospital of Maryland. He completed his internship and residency there in pediatrics in 1975. Following this, he pursued a pediatric neurology fellowship at Einstein from 1975 to 1978. He was a visiting epilepsy research fellow at the University of California Los Angeles in 1978, then completed a neurology and neuroscience research fellowship at Einstein in 1979. He was a guest scholar with the EEG department at Columbia Presbyterian Medical Center from 1980 to 198, and with the seizure unit at Children’s Hospital in Boston in 1980.Dr. Moshé’s research focuses on understanding the mechanisms underlying differences in epilepsy in humans and animal models. His laboratory has developed and patented a novel model of human infantile spasms that can be used to identify novel treatments of this devastating condition. He also investigates the consequences of prolonged seizures and methods to accelerate the development of disease modifying or prevention therapies for post-traumatic epilepsy. His extensive body of work has been shared nationally and internationally through peer-reviewed publications, lectures and conferences. He is a member on several editorial boards including Neurobiology of Disease, Pediatric Neurology, Epileptic Disorders, and the Journal of Neurology & Psychology.Dr. Moshé has been recognized with numerous national and international honors and awards, including a 1995 Jacob Javits Neuroscience Investigator Award from the National Institute of Health, the first 2012 Saul R. Korey Award in Translational Science and Medicine, Albert Einstein College of Medicine; the 2017 Bernard Sachs Award from the Child Neurology Society, and election as a foreign member of the Russian Academy of Science in 2017. He is a member of many professional societies including the American Academy of Neurology, the Child Neurology Society, the American Epilepsy Society and the American Association for Advancement of Science.

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