Milan Kinkhabwala

Submitted by Anonymous (not verified) on
Milan Kinkhabwala
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Provider
Faculty
Expert
First Name
Milan
Last Name
Kinkhabwala
NPI
1942257282
Faculty ID
10967
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-surgery
einstein-dept-medicine
Languages
Spanish
Gender
Male
Email
mkinkhab@montefiore.org
Phone
718-920-6659
Titles
Type
Academic
Department
Department of Surgery
Rank
Professor
Type
Academic
Department
Department of Medicine
Department Link
Rank
Professor
Division
Hepatology
Type
Clinical
Title
Chief, Transplantation
Tags
me-patientcare-transplant-team
me-patientcare-transplant-programs-pediatric-liver
me-patientcare-surgery-generalsurgery
Type
Clinical
Title
Director, Abdominal Transplantation
Type
Administrative
Title
Chief, Transplant Surgery at Montefiore Medical Center, Department of Surgery
Tags
me-patientcare-cancer-research-therapeutics
Type
Administrative
Title
Director, Abdominal Organ Transplantation, Department of Surgery
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88072 40.88002)
Address Line 1
111 East 210th Street
City
Bronx
State
NY
Zip
10461-2401
Location Title
Montefiore Medical Center
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.85147 40.94383)
Address Line 1
1010 Central Park Avenue
City
Yonkers
State
NY
Zip
10704-1044
Location Title
Montefiore Medical Group-Cross County
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.82894 41.05873)
Address Line 1
555 Taxter Road
City
Elmsford
State
NY
Zip
10523
Location Title
Montefiore at 555 Taxter Road
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8798833 40.8799447)
Building
Rosenthal Pavilion
Room
2
Address Line 1
Montefiore Medical Center
Address Line 3
111 East 210th Street
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Cornell University Medical College
Education Type Label
Fellowship
Education Institution
University of California Los Angeles Medical
Education Type Label
Residency
Education Institution
New York Presbyterian Hospital
Specialties
Areas of Expertise
Cell therapy
Cholangiocarcinoma
Hepatocellular carcinoma
Living-donor liver transplantation
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Kinkhabwala is an active member of Einstein&rsquo;s NIH-funded Marion Bessin Liver Research Center, where he is working to develop new treatments derived from stem cells for liver diseases, including liver cancer. An expert in complex liver surgery, including liver transplantation, he helped establish the Montefiore Einstein Center for Transplantation, where physicians, surgeons, nurses and other clinicians work with scientists to deliver integrated care for patients with organ failure.&nbsp;&nbsp;</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">In addition to transplantation, Dr. Kinkhabwala specializes in hepatobiliary surgery, which involves advanced operative interventions on the liver, bile ducts and gallbladder.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Earlier in his career, Dr. Kinkhabwala established a pancreas transplantation program at Weill Cornell Medical College and co-founded a center for liver disease at Columbia University. He has held leadership roles in the American Society of Transplant Surgeons, the American Society of Transplantation, and the International Liver Transplantation Society. In addition, Dr. Kinkhabwala has participated in several important policy initiatives leading to improvements in the care of living liver donors, including the NIH Adult to Adult Living Donor Liver Transplantation Cohort Study.</span></p>

CHAM Provider
Off
Professional Title
M.D.
Clinical Focus

Transplant Surgery<quillbot-extension-portal></quillbot-extension-portal>

Research Focus

Dr. Kinkhabwala's research is focused on conditions of the liver and issues associated with liver transplantation. He has been a participant in numerous research projects, both investigator-initiated and industry-funded.

EMR ID
4879
Biography

<p>Milan Kinkhabwala, MD, FACS, is Chief, Division of Transplantation Surgery and Professor of Surgery and Medicine at Montefiore Einstein. He is also Director, Hepatobiliary Cancer at Montefiore Einstein Center for Cancer Care and Director, Abdominal Transplantation at Montefiore Einstein Center for Transplantation. He joined the Montefiore team in 2007 to help build the Transplant Center of Excellence, which included the development of a new liver disease program in adults and children.</p><p>In 1985, Dr. Kinkhabwala received his Bachelor of Arts at Cornell University. He then attended Cornell Medical College, where he received his Doctor of Medicine in 1989. Dr. Kinkhabwala began his postgraduate training in 1989 with a 5-year residency in general surgery at New York Hospital, Cornell Medical Center. He then completed a fellowship in transplant/hepatobiliary surgery in 1996 at the University of California Los Angeles School of Medicine.</p><p>Dr. Kinkhabwala's research is focused on conditions of the liver and issues associated with liver transplantation. He has been a participant in numerous research projects, both investigator-initiated and industry-funded. Beginning in 2014, Dr. Kinkhabwala has been a part of a study aimed to evaluate the safety, tolerability and efficacy of an antibody drug in renal transplant patients at high risk of delayed graft function. His work has been published in numerous peer-reviewed journals and books, and has been presented nationally.</p><p>From 2013 to 2015, Dr. Kinkhabwala was named one of Castle Connolly's Top Doctors. In 2014 and 2015, he was also named one of New York Magazine's Top Doctors. Dr. Kinkhabwala has been a member of the Board of Directors, New York Organ Donor Network since 2013.</p><p>He is board certified by the American Board of Surgery, and he is a member of multiple professional societies, including the American College of Surgeons, the American Society of Transplant Surgeons and the International Hepato-Pancreato-Biliary Association.</p>

Is Open Scheduling
Off

Sanjeev Gupta

Submitted by Anonymous (not verified) on
Sanjeev Gupta
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Provider
Faculty
Expert
First Name
Sanjeev
Last Name
Gupta
NPI
1831274315
Faculty ID
8041
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
einstein-dept-pathology
Gender
Male
Email
sanjeev.gupta@einsteinmed.edu
Phone
718-430-3309
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Professor
Division
Hepatology
Type
Academic
Department
Department of Pathology
Department Link
Rank
Professor
Type
Administrative
Title
The Eleazar & Feige Reicher Chair in Translational Medicine, Department of Medicine
Tags
me-patientcare-cancer-research-stem-cell-cancer-biology
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84154 40.84612)
Address Line 1
1250 Waters place
City
Bronx
State
NY
Zip
10461-2720
Location Title
Montefiore at 1250 Waters Place
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Ullmann Building
Room
625
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
Address Line 3
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Education and Trainings
Education Type Label
Medical Education
Education Institution
University of Rajasthan, Sardar Patel Med Coll
Education Type Label
Fellowship
Education Institution
Hammersmith Hospital
Education Type Label
Fellowship
Education Institution
Los Angeles County and Univ of Southern CA
Education Type Label
Fellowship
Education Institution
Jacobi Medical Center
Education Type Label
Residency
Education Institution
Jacobi Medical Center
Education Type Label
Residency
Education Institution
Postgraduate Institute of Medical Educ. & Research
Education Type Label
Residency
Education Institution
Hammersmith Hospital
Professional Interests

<p>Liver regeneration is critical for health. We focus on physiology of liver regeneration during development, early childhood and adulthood to inform mechanistic disruptions in diseases. The latter ranges from acute liver failure, effects of drugs, toxins, alcohol, virus hepatitis, obesity-related metabolic (or nonalcoholic) liver disease, chronic hepatitis, e.g., Wilson disease with copper toxicosis, and allograft rejection. The mechanisms concerning DNA damage response directed by ATM gene and downstream partners are of considerable interest to us.&nbsp; &nbsp; &nbsp;</p>
<p>These aspects are joined with study of cell type-specific contributions as well as aspects of stem cell biology for liver regeneration. We apply cell transplantation approaches to better understand the biology and regenerative potential of various cell types. Expression of therapeutic constructs and transplantation of those cells is another area of investigative interest. We address the role of endogenous stem/progenitor cells in therapeutic development. Tissue engineering to generate auxiliary liver has potential in these areas and is also advancing liver regenerartion in experimental models.</p>
<p>We use a variety of methods, including microarrays or deep sequencing for gene expression, cell and molecular biology methods, and multiple small and large animal models. The findings are integrated with analyses of human tissue and blood samples.</p>
<p>Unique aspects of our work include use of established drugs for mechanistic interrogations and therapeutic applications, and an uncommon depth and breadth of multidisciplinary tools. We collaborate with leading investigators at Einstein or elsewhere as appropriate.</p>

Research Areas
Liver regeneration in health and disease
Biology and differentiation of hepatic stem cells
DNA damage response involving ATM and downstream pathways
Translational studies using liver cell and animal models
Therapeutics including cell and gene therapy
Areas of Expertise
Stem cell research
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Gupta is a pioneer in the development of cell therapy &ndash; treating disease by introducing healthy cells into the body.&nbsp; He has discovered various mechanisms for coaxing transplanted cells to attach to host tissue and multiply, paving the way for treating health problems such as&nbsp; high cholesterol, hemophilia, liver failure, and hepatitis.&nbsp;</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Gupta has successfully manipulated human stem cells to generate liver cells and defined some of the fundamental ways by which gene expression is regulated in stem cells. Dr. Gupta serves as an expert for the National Institutes of Health, U.S. Department of Veterans Affairs, U.S. Department of Defense, Wellcome Trust, and national scientific bodies in over ten countries.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">In the 1990s, Dr. Gupta contributed to the first ever clinical trial of a cell/gene therapy for familial hypercholesterolemia (high cholesterol), which results from a gene defect. He also showed that Wilson&rsquo;s disease (a genetic condition characterized by excessive accumulation of copper in the liver and brain) could potentially be cured by use of cell therapy.&nbsp;</span></p>

CHAM Provider
Off
Professional Title
M.B.,B.S.
M.D.
Selected Publications

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<li>Thirunavukkarasu C, Sharma Y, Tchaikovskaya T, Maslov AY, Gupta S. Transcriptional profiling reveals ataxia telangiectasia mutated pathways regulate joint copper and arsenic toxicity for hepatic metalloplasia and anti-cancer therapies. Life Sci. 2022 Jul 6;120787. doi: 10.1016/j.lfs.2022.120787.&nbsp;</li>
<li>Chang CJ, Ge EJ Bush AI, Casini A, Cobine PA, Cross JR, DeNicola GM, Dou Q, Franz KJ, Gohil VM, Gupta S, Kaler SG, Lutsenko S, Mittal V, Petris MJ, Polishchuk R, Ralle M, Schilsky ML, Tonks NK, Vahdat LK, Van Aelst L, Xi D, Yuan P, Brady DC. Connecting copper and cancer from transition metal signaling to metalloplasia in the clinic. Nat Rev Cancer 2022 Feb;22(2):102-113. doi: 10.1038/s41568-021-00417-2. Epub 2021 Nov 11. PMID: 34764459</li>
<li>Viswanathan P, Gupta P, Sharma Y, Maisuradze L, Bandi S, Gupta S. Caffeine disrupts ataxia telangiectasia mutated gene-related pathways and exacerbates acetaminophen toxicity in human fetal immortalized hepatocytes. Toxicology. 2021 May 7;457:152811. doi: 10.1016/j.tox.2021.152811. PMID: 33971260</li>
<li>Viswanathan P, Sharma Y, Jaber FL, Tchaikovskaya T, Gupta S. Transplanted hepatocytes rescue mice in acetaminophen-induced acute liver failure through paracrine signals for hepatic ATM and STAT3 pathways. FASEB J 2021 Apr;35(4):e21471. doi: 10.1096/fj.202002421R. PMID: 33683737</li>
<li>Jaber FL, Sharma Y, Mui BG, Kapoor S, Gupta S. Tumor necrosis factor directs allograft-related innate responses and its neutralization improves hepatocyte engraftment in rats. Am J Pathol 2021; 191(1):79-89. doi: 10.1016/j.ajpath.2020.09.014. Epub 2020 Oct 27. PMID: 33127336</li>
<li>Viswanathan P, Sharma Y, Gupta S. Ataxia telangiectasia mutated pathway disruption affects hepatic DNA and tissue damage in nonalcoholic fatty liver disease. Exp Mol Pathol. 2020 Apr; 113:104369. doi: 10.1016/j.yexmp.2020.104369. Epub 2020 Jan 7. PMID: 31917286</li>
<li>Gupta P, Sharma Y, Viswanathan P, Gupta S. Cellular receptor signaling and ATM pathway intersections regulate hepatic DNA repair. Cytokine 2020 Mar; 127:154946. doi: 10.1016/j.cyto.2019.154946. Epub 2019 Dec 11. PMID: 31837586</li>
<li>Bandi S, Tchaikovskaya T, Gupta S. Hepatic differentiation in human pluripotent stem cells by developmental stage-specific metabolomics products. Differentiation 2019; 105:54-70. Jan 28;105:54-70. doi: 10.1016/j.diff.2019.01.005. PMID: 30776728.</li>
<li>Kakabadze Z, Karalashvili L, Chakhunashvili D, Havlioglu N, Janelidze M, Kakabadze A, Sharma Y, Gupta S. Decellularized bovine placentome for portacavally-interposed heterotopic liver transplantation in rats. Mater Sci Eng C Mater Biol Appl. 2019 Apr; 97:293-301. doi: 10.1016/j.msec.2018.12.025. Epub 2018 Dec 10. PMID: 30678914.</li>
<li>Yadav N, Jaber FL, Sharma Y, Viswanathan P, Gupta S. Efficient reconstitution of hepatic microvasculature by endothelin receptor antagonism in liver sinusoidal endothelial cells. Hum Gene Ther 2018; Sep 28. doi: 10.1089/hum.2018.166. PMID: 30266073,&nbsp;</li>
<li>Sharma Y, Liu J, Kristian KE, Follenzi A, Gupta S. In Atp7b-/- mice modeling Wilson's disease liver repopulation with bone marrow-derived myofibroblasts or inflammatory cells and not hepatocytes is delterious.&nbsp;<span title="Gene expression">Gene Expr</span>. 2018 Jul 20. doi: 10.3727/105221618X15320123457380. PMID: 30029699</li>
<li>Bandi S, Gupta S, Tchaikovskaya T, Gupta S. Differentiation in stem/progenitor cells along fetal or adult hepatic stages requires transcriptional regulators independently of oscillations in microRNA expression.&nbsp;<span title="Experimental cell research">Exp Cell Res</span>. 2018 Sep 1;370(1):1-12. doi: 10.1016/j.yexcr.2018.06.004. Epub 2018 Jun 6.</li>
<li>Benten D, Kluwe J, Wirth JW, Thiele ND, Follenzi A, Bhargava KK, Palestro CJ, Koepke M, Tjandra R, Volz T, Lutgehetmann M, Gupta S. A humanized mouse model with liver fibrosis following expansion of transplanted hepatic stellate cells in injury and inflammation. Lab Invest 2018 Apr;98(4):525-536. doi: 10.1038/s41374-017-0010-7. Epub 2018 Jan 19.PMID: 29352225.</li>
<li>Viswanathan P, Sharma Y, Gupta P, Gupta S. Replicative stress and alterations in cell cycle checkpoint controls following acetaminophen hepatotoxicity restrict hepatic regeneration. Cell Prolif 2018; Jun;51(3):e12445. doi: 10.1111/cpr.12445. Epub 2018 Mar 5. PMID: 29504225.</li>
<li>Kakabadze Z, Kakabadze A, Chakhunashvili D, Karalashvili L, Berishvili E, Sharma Y, Gupta S. Decellularized human placenta supports hepatic tissue and allows rescue in acute liver failure. Hepatology 2018 May;67(5):1956-1969.&nbsp;PMID: 29211918.&nbsp;</li>
</ul>

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