Gary J. Schwartz

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First Name

Gary

Last Name

Schwartz

Faculty ID

9621

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<p>Gary J. Schwartz, Ph.D., studies how the gut and the brain interact with each other to regulate food intake and associated metabolic processes.&nbsp; Dr. Schwartz and his colleagues aim to identify therapeutic targets for eating behaviors associated with obesity, diabetes and related diseases.</p>
<p>Our research focuses on the sensory neural controls of energy homeostasis in health and disease. We use rodent models to examine how food stimuli act at oral and gastrointestinal sites to affect food intake, energy balance, and gastrointestinal physiology.We approach this problem from multiple levels of analysis including behavioral, physiological, neurophysiological, and molecular-genetic. We have identified the type of food stimuli that activate vagal and splanchnic sensory fibers supplying the gut, and have revealed the extent to which these stimuli influence gut-brain communication. Our most recent efforts involve the analysis of gut-brain communication in the control of energy homeostasis in mouse models of obesity and diabetes.We have identified neurons in the periphery, brainstem and hypothalamus that integrate food-elicited signals with peptide signals that have profound effects food intake and metabolism. Data from these studies reveal that central hypothalamic and brainstem neuropeptides affect food intake and body weight by modulating the neural potency of food stimulated signals from the mouth and gut. This novel, synthetic conceptual framework is critical because it links forebrain hypothalamic structures, long known to be involved in the control of energy balance, to the sensory and motor systems in the brainstem that control ingestion, digestion, and metabolic processing of food. Future studies will use genetic mouse models of obesity and diabetes with targeted conditional neuropeptide/ receptor knockdown or replacement to determine how central neuropeptide signaling affects the neural processing of metabolic sensory signals critical to energy homeostasis.</p>

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<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Schwartz studies how the gut and the brain act together to determine how much people eat. He has identified sites in the gastrointestinal tract and brain that detect nutrients and has discovered how these regions are linked to food intake, obesity and diabetes. He also studies gastric-bypass surgery and the key neural and hormonal mechanisms responsible for the significant and long-lasting improvements in body weight, food intake and diabetes following the procedure.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Schwartz is Director of the Einstein-Mount Sinai Diabetes Research Center Animal Physiology Core at Einstein and Director of the Animal Phenotyping Core of the Columbia University- Einstein New York Obesity Research Center. He also serves on multiple NIH study sections and on scientific grant review panels of the United States Department of Veterans Affairs, American Diabetes Association, Endocrine Fellows Foundation and Obesity Society. He is a member of the editorial boards of several journals, including&nbsp;<em>Diabetes</em>,&nbsp;<em>Endocrinology </em>and serves as an associate editor of the&nbsp;<em>American Journal of Physiology, Endocrinology &amp; Metabolism Section</em>.</span></p>

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Jeffrey E. Pessin

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First Name

Jeffrey

Last Name

Pessin

Faculty ID

10953

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Adult

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<p>The Pessin laboratory is analyzing insulin signaling at the molecular level, the regulation of glucose uptake and metabolism at the cellular, molecular level and the integrative systems of metabolism in normal and pathophysiologic states in genetic rodent models. Our efforts have been focused on three major aspects of insulin signaling and insulin sensitivity. These areas include the molecular mechanisms of adipose tissue inflammation leading to fibrosis and programmed cell death, the regulation of insulin/nutriebt signaling in the regulation of liver gluconeogenesis and lipogenesis and there dysregulation in states of insulin resistance.</p>
<p>One major laboratory project is the investigation of adipocyte progenitor cells, adipocyte programmed cell death and adipose tissue fibrosis that is induced by high fat feeding. In these studies, we have utilized a variety of experimental approaches including genetically engineered mice, Fluorescent Activated Cell Sorting (FACS) analyses and sorting along RNA-Seq and single nuclei RNA-Seq. In these analyses we isolated a variety of inflammatory specific cell types within adipose tissue and have taken extensive use of RNAseq technology to characterize the expression profiles of these various cell subsets. This approach has allowed us to develop a functional understanding of the signaling interplay between the adipose tissue immune cell types to determine the specific role each cell is playing in the inflammatory response. In collaboration with the laboratory of Kosaku Shinoda we are exploring the relationship between metabolism, autophagy and energy balance in adipocyte lineage determination (brown, beige and white) as a potential therapeutic approach for both diabetes and obesity.&nbsp;</p>
<p>A second major laboratory project is based upon our recent findings in collaboration with the laboratory of Fajun Yang that in the fed state CDK8/CycC complex directly phosphorylates the nuclear form of SREBP-1c that induces an E3 ligase mediated ubiquitination and proteasome-mediated degradation of SREBP-1c. This process is one of several that is required to maintain nuclear SREBP1-c at very low levels thereby suppresses lipogenic gene expression and lipogenesis. However, n the fed state, CDK8/CycC proteins are rapidly down regulated through a mTORC1 dependent pathway leading to increased SREBP-1c stability and increased lipogenic gene expression and lipogenesis. During the past two years, we have developed a robust research team, several key mouse genetic models, human liver biopsy speciments and cell based approaches to investigate the regulation of liver gluconeogenesis abd lipogenesis in normal and pathophysiologic states of insulin resistance, obesity and non-alcoholic fatty liver disease (NFALD). In these approaches we perform various high-through put DNA sequencing technologies (ie: RNA-seq, single cell RNA-seq, ChIP-seq, 3 dimensional DNA conformation capture (Hi-C) that are used to directly assess the epigenetic basis of normal and pathological liver metabolic funciton.</p>
<p>We have also initiated new studies to examine the development of heart failure in diabetic cardiomyopathy. New data from the laboratory indicates that increasing glycolytic rate in cardiomyocytes markedly protects the heart from myocardial infarction. In collaboration with the laboratory of Gaetano Santulli, we are examining the mechanistic basis for this novel observation as a means to specifcally prevent heart damage and failure that progressively occurs following myocardial infarction.</p>
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<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Pessin directs the Einstein-Mount Sinai Diabetes Research Center, one of only sixteen NIH-funded diabetes centers of its kind in the country. He guides the research of more than 90 scientists investigating type 1 (formerly juvenile) and type 2 (formerly adult-onset) diabetes. The center also includes training programs and community-based activities in the Bronx. Dr. Pessin&rsquo;s own research focuses on insulin signaling and the mechanisms contributing to the onset of type 1 diabetes.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Pessin also studies how adult progenitor cells (cells that have the capacity to differentiate into a specific cell type) influence the development of fat tissue and how mechanical signals influence stem cell development. The findings from such research have led to animal models for studying insulin resistance and diabetes.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Pessin is associate editor of Diabetes, the peer-reviewed journal of the American Diabetes Association, and the former editor-in-chief of<span>&nbsp;</span><em>Endocrinology</em><span>&nbsp;</span>and the <em>American Journal of Physiology - Endocrinology and Metabolism</em>. He has received the Eli Lilly Outstanding Investigator Award of the American Diabetes Association and the Mary Jane Kugel Award of the Juvenile Diabetes Research Foundation International.</span></p>

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<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif;"><a href="https://pubmed.ncbi.nlm.nih.gov/33812059/"><span style="color: #0071bc;">The Mediator complex kinase module is necessary for fructose regulation of liver glycogen levels through induction of glucose-6-phosphatase catalytic subunit (G6pc).</span></a></span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif; color: #212121;">Youn DY, Xiaoli AM, Zong H, Okada J, Liu L, Pessin J,&nbsp;<strong>Pessin JE</strong>, Yang F.</span><span style="font-family: 'Times New Roman', serif; color: #4d8055;">Mol Metab. 2021 Jun;48:101227. doi: 10.1016/j.molmet.2021.101227. Epub 2021 Mar 31.PMID:&nbsp;33812059&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif;">&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif;"><a href="https://pubmed.ncbi.nlm.nih.gov/33667344/"><span style="color: #0071bc;">Conversion of the death inhibitor ARC to a killer activates pancreatic &beta; cell death in diabetes.</span></a></span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif; color: #212121;">McKimpson WM, Chen Y, Irving JA, Zheng M, Weinberger J, Tan WLW, Tiang Z, Jagger AM, Chua SC Jr,&nbsp;<strong>Pessin JE</strong>, Foo RS, Lomas DA, Kitsis RN.</span><span style="font-family: 'Times New Roman', serif; color: #4d8055;">Dev Cell. 2021 Mar 22;56(6):747-760.e6. doi: 10.1016/j.devcel.2021.02.011. Epub 2021 Mar 4.PMID:&nbsp;33667344</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif;">&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif;"><a href="https://pubmed.ncbi.nlm.nih.gov/32848017/"><span style="color: #0071bc;">ATG16L1 autophagy pathway regulates BAX protein levels and programmed cell death.</span></a></span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif; color: #212121;">Chen F, Amgalan D, Kitsis RN,&nbsp;<strong>Pessin JE</strong>, Feng D.</span><span style="font-family: 'Times New Roman', serif; color: #4d8055;">J Biol Chem. 2020 Oct 30;295(44):15045-15053. doi: 10.1074/jbc.RA120.013999. Epub 2020 Aug 26.PMID:&nbsp;32848017&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif;">&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif;"><a href="https://pubmed.ncbi.nlm.nih.gov/32635651/"><span style="color: #0071bc;">The Impact of Single-Cell Genomics on Adipose Tissue Research.</span></a></span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif; color: #212121;">Deutsch A, Feng D,&nbsp;<strong>Pessin JE</strong>, Shinoda K.</span><span style="font-family: 'Times New Roman', serif; color: #4d8055;">Int J Mol Sci. 2020 Jul 5;21(13):4773. doi: 10.3390/ijms21134773.PMID:&nbsp;32635651&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif;">&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif;"><a href="https://pubmed.ncbi.nlm.nih.gov/32570757/"><span style="color: #0071bc;">FAM83G Is a Novel Inducer of Apoptosis.</span></a></span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif; color: #212121;">Okada J, Sunaga N, Yamada E, Saito T, Ozawa A, Nakajima Y, Okada K,&nbsp;<strong>Pessin JE</strong>, Okada S, Yamada M.</span><span style="font-family: 'Times New Roman', serif; color: #4d8055;">Molecules. 2020 Jun 18;25(12):2810. doi: 10.3390/molecules25122810.PMID:&nbsp;32570757&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif;">&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif;"><a href="https://pubmed.ncbi.nlm.nih.gov/32075912/"><span style="color: #0071bc;">Regulation of gene expression during the fasting-feeding cycle of the liver displays mouse strain specificity.</span></a></span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif; color: #212121;">Chi Y, Youn DY, Xiaoli AM, Liu L, Pessin JB, Yang F,&nbsp;<strong>Pessin JE.</strong></span><span style="font-family: 'Times New Roman', serif; color: #4d8055;">J Biol Chem. 2020 Apr 10;295(15):4809-4821. doi: 10.1074/jbc.RA119.012349. Epub 2020 Feb 19.PMID:&nbsp;32075912&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif; vertical-align: top;"><span style="font-family: 'Times New Roman', serif; color: #5b616b;">7</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif;">&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif;"><a href="https://pubmed.ncbi.nlm.nih.gov/32051343/"><span style="color: #0071bc;">SNAP23 depletion enables more SNAP25/calcium channel excitosome formation to increase insulin exocytosis in type 2 diabetes.</span></a></span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif; color: #212121;">Liang T, Qin T, Kang F, Kang Y, Xie L, Zhu D, Dolai S, Greitzer-Antes D, Baker RK, Feng D, Tuduri E, Ostenson CG, Kieffer TJ, Banks K,&nbsp;<strong>Pessin JE</strong>, Gaisano HY.</span><span style="font-family: 'Times New Roman', serif; color: #4d8055;">JCI Insight. 2020 Feb 13;5(3):e129694. doi: 10.1172/jci.insight.129694.PMID:&nbsp;32051343&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif;">&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif;"><a href="https://pubmed.ncbi.nlm.nih.gov/31979355/"><span style="color: #0071bc;">Dapagliflozin Inhibits Cell Adhesion to Collagen I and IV and Increases Ectodomain Proteolytic Cleavage of DDR1 by Increasing ADAM10 Activity.</span></a></span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif; color: #212121;">Okada J, Yamada E, Saito T, Yokoo H, Osaki A, Shimoda Y, Ozawa A, Nakajima Y,&nbsp;<strong>Pessin JE</strong>, Okada S, Yamada M.</span><span style="font-family: 'Times New Roman', serif; color: #4d8055;">Molecules. 2020 Jan 23;25(3):495. doi: 10.3390/molecules25030495.PMID: 31979355&nbsp;</span></p>

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Meredith A. Hawkins

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First Name

Meredith

Last Name

Hawkins

NPI

1922189356

Faculty ID

1982

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Full Time

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Adult

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Female

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<p>Dr. Meredith Hawkins is Professor of Medicine and Associate Director of the Einstein-Mt. Sinai Regional Diabetes Research Center. She holds the Harold and Muriel Block Chair in Medicine. Dr. Hawkins earned her M.D. degree <em>cum laude</em> from the University of Toronto and a Master of Science in Clinical Research Methods <em>cum laude</em> from the Albert Einstein College of Medicine. She has served as Associate Editor of the <em>American Journal of Physiology</em>, and as Secretary Treasurer of the American Federation of Medical Research. Dr. Hawkins' current research interests include the effects of nutrient deficiency and excess on the pathogenesis of diabetes mellitus, central regulation of glucose metabolism, nutritional regulation of adipose tissue inflammation, and hypoglycemia-associated autonomic failure.</p>
<p>Dr. Hawkins is a Beeson Scholar of the American Federation of Aging Research, and has received research grants from the National Institutes of Health (continually since 1999), the American Diabetes Association, the Juvenile Diabetes Foundation International and the Diabetes Action Foundation International. She is the recipient of numerous honors and awards, including the Junior Physician Scientist Award (2001) and the Outstanding Investigator Award (2012) from the American Federation of Medical Research, the Novartis Young Investigator award in Diabetes Research (2007), and election to the American Society for Clinical Investigation (2012). She recently served on the Congressionally-appointed National Clinical Care Commission.&nbsp;</p>
<p>Dr. Hawkins founded and directs Einstein's Global Diabetes Institute (<a href="/centers/global-health/global-diabetes-institute/">http://www.einstein.yu.edu/centers/global-health/global-diabetes-instit…;, with the goal of building strategic partnerships in medical research and education to combat the burgeoning global diabetes epidemic.</p>

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<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Hawkins specializes in diabetes, with a particular emphasis on the dramatic rise of the disease worldwide. She has traveled the globe investigating diabetes since 1996 and is the founding director of the Global Diabetes Institute (GDI) at Einstein, which conducts diabetes education and training for healthcare workers in South and Central America, Eastern Europe, Africa and Asia.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Hawkins also studies the role of nutrients and inflammation in the development of prediabetes and diabetes and is currently investigating the impact of vitamin D on the development and management of the disease.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">In collaboration with researchers in India, Dr. Hawkins is investigating malnutrition diabetes, a little understood form of the disease that particularly affects the developing world.&nbsp;Dr. Hawkins is one of the organizers of an annual international conference for continuing medical education that alternates between Asia and Africa.&nbsp;Under Dr. Hawkins&rsquo; leadership, the GDI has partnered with faculty at Uganda&rsquo;s leading medical school to improve diabetes care in hospitals and clinics throughout the country. An NIH-funded researcher, Dr. Hawkins has received the Novartis Young Investigator in Diabetes and the Junior Physician Scientist Award of the American Federation of Medical Research.</span></p>

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<p>Past 3 years:</p>
<ol>
<li>
<p>Carey M, Lontchi-Yimagou E, Mitchell W, Reda S, Zhang K, Kehlenbrink S, Koppaka S, Maginley SR, Aleksic S, Bhansali S, Huffman DM, Hawkins M. Central KATP channels modulate glucose effectiveness in humans and rodents. Diabetes. 2020 Jun;69(6):1140-1148. doi: 10.2337/db19-1256. PMID: 32217610 (Selected as Editor&rsquo;s Choice by Science Translational Medicine, 29 Apr 2020: Vol. 12, Issue 541, eabb5677).</p>
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<li>
<p>Lontchi-Yimagou E, Aleksic S, Hulkower R, Gospin R, Goyal A, Kuo B, Mitchell WG, You JY, Upadhyay L, Carey M, Sandu OA, Gabriely I, Shamoon H, Hawkins M. Plasma epinephrine contributes to the development of experimental hypoglycemic-associated autonomic failure. Journal of Clinical Endocrinology and Metabolism 2020 Nov 1;105(11):dgaa539. doi: 10.1210/clinem/dgaa539.PMID: 32915987</p>
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<li>
<p>Lontchi-Yimagou E, Kang S, Goyal A, You J-Y, Carey M, Rosen E, Kishore P, Hawkins M. Insulin Sensitizing Effects of Vitamin D Mediated through Reduced Adipose Tissue Inflammation and Fibrosis in Humans and Mice. Molecular Metabolism 2020 Dec;42:101095. doi: 10.1016/j.molmet.2020.101095. Epub 2020 Oct 10. PMID: 33045433&nbsp;</p>
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<p>Brightwell CR, Kulkarni AS, Paredes W, Zhang K, Perkins JB, Gatlin KJ, Custodio M, Farooq H, Zaidi B, Pai R, Buttar RS, Tang Y, Melamed ML, Hostetter TH, Pessin JE, Hawkins M, Fry CS, Abramowitz MK. Muscle fibrosis and maladaptation occur progressively in CKD and are rescued by dialysis. JCI Insight. 2021 Dec 22;6(24):e150112. doi: 10.1172/jci.insight.150112. PMID: 34784301</p>
</li>
<li>
<p>Cefalu WT, Andersen DK, Arreaza-Rub&iacute;n G, Pin CL, Sato S, Verchere CB, Woo M, Rosenblum ND; Symposium planning committee, moderators, and speakers. Heterogeneity of Diabetes: &beta;-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes Care. 2022 Jan 1;45(1):3-22. doi: 10.2337/dci21-0051. PMID: 34782355</p>
</li>
<li>
<p>Lontchi-Yimagou E, DasGupta R, Kehlenbrink S, Koppaka S, Carey M, Stein DT, Thomas N, Hawkins M. An Atypical form of diabetes in low BMI individuals. Diabetes Care 2022 45(6):1428-1437. doi: 10.2337/dc21-1957. PMID: 35522035 (In the top 5% of all research outputs scored by Altmetric: as of July 13, 2023, the paper has received 8,874 reads and has been picked up by 94 news outlets.)</p>
</li>
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<p>Lontchi-Yimagou E, Anoop S, Kurian ME, Ye K, Kehlenbrink S, Thomas N, Hawkins M. Response to Comment on Lontchi-Yimagou et al. An Atypical Form of Diabetes Among Individuals With Low BMI. Diabetes Care 2022;45:1428-1437. Diabetes Care. 2022 Nov 1;45(11):e159-e160. doi: 10.2337/dci22-0031.PMID: 36318676</p>
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<p>Herman WH, Schillinger D, Bolen S, Boltri JM, Bullock A, Chong W, Conlin PR, Cook JW, Dokun A, Fukagawa N, Gonzalvo J, Greenlee MC, Hawkins M, Idzik S, Leake E, Linder B, Lopata AM, Schumacher P, Shell D, Strogatz D, Towne J, Tracer H, Wu S. The National Clinical Care Commission Report to Congress: Recommendations to Better Leverage Federal Policies and Programs to Prevent and Control Diabetes. Diabetes Care. 2023 Feb 1;46(2):255-261. doi: 10.2337/dc22-1587. PMID: 36701592</p>
</li>
<li>
<p>Greenlee MC, Bolen S, Chong W, Dokun A, Gonzalvo J, Hawkins M, Herman WH, Leake E, Linder B, Conlin PR. The National Clinical Care Commission Report to Congress: Leveraging Federal Policies and Programs to Improve Diabetes Treatment and Reduce Complications. Diabetes Care. 2023 Feb 1;46(2):e51-e59. doi: 10.2337/dc22-0621. PMID: 36701593</p>
</li>
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<p>Cook J, Hawkins M, Pajvani UB. Liver insulinization as a driver of triglyceride dysmetabolism. Nature Medicine. 2023 (e-publication 17 July 2023)</p>
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</li>
</ol>

EMR ID

4098

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Jill P. Crandall

https://assets.montefioreeinstein.org/profiles/images/physphoto/Crandall_Jill_MD_420x504.jpg

First Name

Jill

Last Name

Crandall

NPI

1548359896

Faculty ID

4535

CMO Specialties

Clinical Terms

Employment Status

Full Time

Patient Type

Adult

Department

Gender

Female

Email

Phone

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Locations

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Professional Interests

<p>Jill P. Crandall, MD completed her medical training at SUNY Downstate Medical Center and both internal medicine residency and endocrinology fellowship at Columbia Presbyterian Medical Center. Following fellowship, she worked at St. Luke&rsquo;s-Roosevelt Hospital (with Dr. Xavier Pi-Sunyer) and then Mt. Sinai School of Medicine before being recruited to Einstein in 2001.&nbsp;</p>
<p>Dr. Crandall is Professor of Medicine at Albert Einstein College of Medicine, where she is director of the Diabetes Clinical Trials Unit and a principal investigator for several NIH sponsored clinical trials, including the Diabetes Prevention Program Outcome Study (for which she holds several national leadership positions, including Executive Committee membership) and the Glycemia Reduction Approaches in Diabetes (GRADE) study.&nbsp; She is Director of the Einstein-Sinai Diabetes Center&rsquo;s Translational Research Core. Her research interests focus on age-related changes in glucose metabolism and the relationship between hyperglycemia and cardiovascular risk. &nbsp;Dr. Crandall has served on several grant review panels (NIH and ADA) and is active as a journal reviewer, including as Associate Editor of the Journal of Gerontology (2005-2012) and member of the editorial board for the Journal of Diabetes and its Complications.&nbsp;</p>

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Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;">An expert in diabetes prevention, Dr. Crandall is director of the Diabetes Clinical Trials Unit at Einstein and Montefiore and a principal investigator for several NIH-sponsored clinical trials, including the Diabetes Prevention Program Outcome Study (for which she holds several national leadership positions, including Executive Committee membership), Glycemia Reduction Approaches in Diabetes (GRADE) and the PERL (Preventing Early Renal Loss) study.&nbsp;</p>
<p class="MsoNormal" style="line-height: 15.6pt;">Dr. Crandall&rsquo;s research focuses on age-related changes in glucose metabolism and the relationship between high blood-sugar levels (hyperglycemia) and cardiovascular risk. She currently serves on the American Diabetes Association&rsquo;s Professional Practice Committee. Dr. Crandall is an attending physician at the Montefiore Medical Center Diabetes Clinic and maintains an active consultative practice in endocrinology.</p>

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Clinical Focus

Dr. Crandall's clinical focus is on the treatment of type 1 and type 2 diabetes as well as related metabolic disorders.

Research Focus

Dr. Crandall&rsquo;s research interests focus on age-related changes in glucose metabolism and the relationship between hyperglycemia and cardiovascular risk.

Elsevier Profile

Lab Website Link

Selected Publications

<ol>
<li>Schmidt AM, Hori O, Chen JX, Li JF, <strong>Crandall</strong>, J, Zhang J, Cao R, Yan SD, Brett J, Stern D. Advanced glycation end-products interacting with their endothelial receptor induces expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice.&nbsp; A potential mechanism for the accelerated vasculopathy of diabetes.&nbsp; <em>J Clin Invest</em> 1995;96:1395-403.</li>
<li> Schmidt AM, <strong>Crandall J</strong>, Hori O, Cao R and Lakatta E.&nbsp; Elevated plasma levels of vascular cell adhesion molecule-1 (VCAM-1) in diabetic patients with microalbuminuria: a marker of vascular dysfunction and progressive vascular disease.&nbsp; <em>British J Haematology</em> 1996;92:747-50.</li>
<li> Engel S, <strong>Crandall J</strong>, Basch C, Zybert P and Wylie-Rosett J. Computer-assisted nutrition education increases knowledge and self-efficacy of medical students.&nbsp; <em>The Diabetes Educator</em> 1997;23:545-49.</li>
<li> Rauch U, <strong>Crandall J,</strong> Osende J, Fallon J, Cheseboro J, Fuster V, Badimon J.&nbsp; Increased thrombus formation relates to ambient blood glucose and leukocyte count in diabetes mellitus Type 2. <em>Amer J Cardiol</em> 2000;86:246-249.</li>
<li> Osende J, Badimon J, Fuster V, Herson P, Rabito P, Vidhun R, Zaman A, Rodriguez O, Lev E, Rauch U, Helft G, Fallon J, <strong>Crandall J.</strong>&nbsp; Blood thrombogenicity in type 2 diabetes mellitus is associated with glycemic control.&nbsp;&nbsp; <em>J Am Coll Cardiol</em> 38:1307-12, 2001.</li>
<li> Vlassara H, Cai W, <strong>Crandall J</strong>, Goldberg T, Oberstein R, Dardaine V, Peppa M, Rayfield E.&nbsp; Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy.&nbsp; <em>PNAS</em> 99:15596-15601, 2002.</li>
<li> Sambola A,Osende J, Hathcock J, Degen M, Nemerson Y, Fuster V, <strong>Crandall J</strong>, Badimon J.&nbsp; Role of risk factors in the modulation of tissue factor activity and blood thrombogenicity.&nbsp; <em>Circulation </em>107:973-77, 2003.</li>
<li> Haffner S, <strong>Crandall J,</strong> Horton E, Barrett-Connor E, Temprosa E, Mather K, Goldberg R, Krakoff J, Ratner R, Orchard T, Fowler S, Marcovina S, for the DPP Research Group. The effect of intensive lifestyle and metformin on inflammation and coagulation in participants with impaired glucose tolerance. <em>Diabetes </em>2005 May; 54(5):1566-1572.</li>
<li><strong> Crandall J</strong>, Schade D, Ma Y,&nbsp; Fujimoto W, Barrett-Connor E, Fowler S, Dagogo-Jack S, Andres R&nbsp; for the DPP Research Group.&nbsp; The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes.&nbsp; <em>J Gerontology</em> 2006;61:1075-81.</li>
<li> Walker E, Molitch M, Kramer K, Kahn S, Ma Y, Edelstein S, Smith K, Johnson M, Kitabchi A, <strong>Crandall J</strong>, for the DPP Research Group.&nbsp; Adherence to preventive medication: predictors and outcomes in the Diabetes Prevention Program.&nbsp; <em>Diabetes Care</em> 2006;29:1997-2002.</li>
<li> Cohen HW, <strong>Crandall JP</strong>, Halipern SM, Billett HH. Aspirin resistance associated with HbA1c and obesity in diabetic patients<em>. Journal of Diabetes and its Complications</em> 2008;22:224-228.</li>
<li> Mather K, Goldberg R, Crandall J, Goldstein B, Marcovina S, Edelstein S, Kahn S, Bray G, Funahashi T. for the DPP Research Group. Adiponectin and change in adiponectin predict diabetes outcomes in the DPP.&nbsp; <em>Diabetes</em> 2008;57:980-986.</li>
<li>&nbsp; Perreault L, Barrett-Connor E, <strong>Crandall J</strong>, Carnethon M, Horton E, Marrero D, Dagogo-Jack S, Ma Y, for the DPP Research Group.&nbsp; Sex differences in diabetes risk and the effect of intensive lifestyle modification the DPP.&nbsp; <em>Diabetes Care</em>, 2008;31:1416-21.</li>
<li> Atzmon, G., Pollin, T.I., <strong>Crandall, J</strong>., Tanner, K., Schechter, C.B., Scherer, P.E., Rincon, M., Siegel, G., Katz, M., Lipton, R.B., Shuldiner, A.R., Barzilai, N.&nbsp; Adiponectin levels and genotype: a potential regulator of life-span in humans.&nbsp; <em>J Geron A Biol Sci</em>, 2008; 63:447-53.</li>
<li> Rajpathak SN, Wylie-Rosett J, Kabat G, Gunter M, Rohan TE and <strong>Crandall J</strong>. Biomarkers of body iron stores and risk of developing diabetes. <em>Diabetes Obes Metab</em> 2009; 11(5):472-9.&nbsp; PMID: 19207293</li>
<li> Molitch M, Barrett-Connor E, <strong>Crandall J</strong>, Das S, Goldberg R, Haffner S, Florez H, Knowler W, Orchard T, Ratner R, Temprosa E. Changes in Albumin Excretion in the Diabetes Prevention Program. <em>Diabetes Care</em> &nbsp;32:720-5, 2009.</li>
<li> <strong> Crandall J</strong> , Shamoon H, Cohen HW,&nbsp; Reid&nbsp; M, Gajavelli&nbsp; S, Trandafirescu G, Tabatabaie V and Barzilai N. Post-challenge Hyperglycemia in Older Adults is Associated with Increased Cardiovascular Risk Profile.&nbsp; <em>J Clin Endocrinol Metab</em> 2009; 94(5):1595-601.&nbsp; PMCID: PMC2684470</li>
<li> <strong>Crandall J</strong>, Polsky S, Howard A, Perreault L, Bray G, Barrett-Connor E, Brown J, Whittington T, Foo S, Ma Y, Edelstein S.&nbsp; Alcohol consumption and diabetes risk in the Diabetes Prevention Program.&nbsp; <em>Am J Clin Nutri, </em>2009; 90:595-601.&nbsp; PMCID: PMC2728644</li>
<li> Rajpathak S, <strong>Crandall JP</strong>, Wylie-Rosett J, Kabat TE, Rohan TE, Hu FB. The role of iron in type 2 diabetes in humans. <em>Biochim Biophys Acta</em>&nbsp; 2009 1790:671-81.</li>
<li> Rajpathak S, Kumbhani D, Alderman M, <strong>Crandall J</strong>, Barzilai N, Ridker P. Statin Therapy and Risk of Developing Type 2 Diabetes: A Meta-analysis.&nbsp; <em>Diabetes Care</em> 2009; 32:1924-9.&nbsp; PMCID: PMC2752935</li>
<li> Schechter CB, Barzilai N, <strong>Crandall JP</strong>, AtzmonG. &nbsp;Reduced Cholesteryl Ester Transfer Protein Levels Is Associated with Decreased Blood Pressure. &nbsp;<em>Mayo Clinic Proceedings</em>, 85:522-6, 2010.</li>
<li> Krakoff J, Clark J, <strong>Crandall JP</strong>, Wilson C, Molitch M, Brancati F, Edelstein S, Knowler WC.&nbsp; Effects of metformin and weight loss on serum alanine aminotransferase activity in the Diabetes Prevention Program.&nbsp; <em>Obesity </em>&nbsp;18:1762-7, 2010.</li>
<li> Rajpathak S, Wassertheil-Smoller S, <strong>Crandall J</strong>, Liu S, Ho G.&nbsp; Hepatocyte growth factor and clinical diabetes in postmenopausal women.&nbsp; <em>Diabetes Care</em> 2010;33:2013-15.</li>
<li> Rajpathak S, Liu Y, Ben-David O, Reddy S, Atzmon G, <strong>Crandall J</strong>, Barzilai N.&nbsp; Lifestyle factors among people with exceptional longevity.&nbsp; <em>J Am Geriatr Society</em>, 2011 59(8):1509-12.</li>
<li> Florez H, Ma Y, <strong>Crandall JP</strong>, Perreault L, Marcovina SM, Bray GA, Saudek CD, Barrett-Connor E, Knowler WC; for the Diabetes Prevention Program Research Group. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21852284">Parental Longevity and Diabetes Risk in the Diabetes Prevention Program.</a>&nbsp; <em>J Gerontol A Biol Sci Med Sci</em>. 2011 Aug 17. &nbsp;PMID:21852284</li>
<li> Kim C, Edelstein SL, <strong>Crandall JP</strong>, Dabelea D, Kitabchi AE, Hamman RF, Montez MG, Perreault L, Foulkes MA, Barrett-Connor E; Diabetes Prevention Program Research Group. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21709591">Menopause and risk of diabetes in the Diabetes Prevention Program.</a>&nbsp; <em>Menopause</em>. 2011 Aug;18(8):857-68. PMID:21709591</li>
<li> Sokol SI, Grushko M, Srinivas VS, <strong>Crandall JP</strong>. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21936883">The relationship between vitamin D deficiency, post challenge hyperglycemia, and endothelial function in healthy older adults.</a> <em>J Diabetes</em>. 2012 Mar;4(1):102-3. PMID:21936883</li>
<li> <strong>Crandall JP</strong>, Trandafirescu G, Oram V, Kishore P, Hawkins M, Reid M, Cohen H, Barzilai N.&nbsp; Pilot study of resveratrol in older adults with impaired glucose tolerance.&nbsp; <em>J Gerontol A Biol Sci Med Sci </em>2012 Dec;67(12):1307-12. &nbsp;PMID:22219517</li>
<li> <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Davis%20NJ%22%5BAuthor%5D">D… NJ</a>, <strong><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Crandall%20JP%22%5BAuthor%5D… JP</a></strong>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Gajavelli%20S%22%5BAuthor%5D… S</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Berman%20JW%22%5BAuthor%5D">… JW</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Tomuta%20N%22%5BAuthor%5D">T… N</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Wylie-Rosett%20J%22%5BAuthor… J</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22Katz%20SD%22%5BAuthor%5D">Ka… SD</a>. Differential effects of low-carbohydrate and low-fat diets on inflammation and endothelial function in diabetes. <em><a title="Journal of diabetes and its complications." href="http://www.ncbi.nlm.nih.gov/pubmed/22036100">J Diabetes Complications.</a></em> 2011 Nov;25(6):371-6. PMID:22036100.</li>
<li> Tabatabaie V, Atzmon G, Rajpathak SN, Freeman R, Barzilai N, <strong>Crandall J</strong>.&nbsp; Exceptional longevity is associated with decreased reproduction. <em>Aging</em> 2011 Dec; 3(12):1202-5. PMID:22199025</li>
<li> Bray G, Edelstein S, <strong>Crandall JP, </strong>et al. and DPP Research Group. <a href="http://www.ncbi.nlm.nih.gov/pubmed/22442396">Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study.</a> <em>Diabetes Care</em><em>.</em> 2012 Apr;35(4):731-7 PMID:22442396</li>
<li> Lai JY, Atzmon G, Melamed ML, Hostetter TH, <strong>Crandall JP</strong>, Barzilai N, Bitzer M. Family history of exceptional longevity is associated with lower serum uric acid levels in Ashkenazi Jews.&nbsp; <em><a title="Journal of the American Geriatrics Society." href="http://www.ncbi.nlm.nih.gov/pubmed/22429185">J Am Geriatr Soc.</a></em> 2012 Apr;60(4):745-50. PMID:22429185</li>
<li> Sokol SI, Srinivas V, <strong>Crandall JP</strong>, Kim M, Tellides G, Lebastchi A, Yu Y, Gupta AK, Alderman MH. <a href="http://www.ncbi.nlm.nih.gov/pubmed/23184900">The effects of vitamin D repletion on endothelial function and inflammation in patients with coronary artery disease.</a> <em>Vasc Med</em>. 2012 Dec;17(6):394-404. PMID:23184900.</li>
<li> Esterson YB, Kishore P, Koppaka S, Li W, Zhang K, Tonelli J, Lee DE, Kehlenbrink S, Lawrence S, <strong>Crandall J</strong>, Barzilai N, Hawkins M. &nbsp;<a href="http://www.ncbi.nlm.nih.gov/pubmed/23089338">Fatty Acid-induced production of plasminogen activator inhibitor-1 by adipose macrophages is greater in middle-aged versus younger adult participants.</a>&nbsp; <em>J Gerontol A Biol Sci Med Sci.</em> 2012 Dec;67(12):1321-8. PMID:23089338</li>
<li> <strong>Crandall JP</strong>, Barzilai N.&nbsp; <a href="http://www.ncbi.nlm.nih.gov/pubmed/23520278">Exploring the promise of resveratrol: where do we go from here?</a> <em>Diabetes</em>. 2013 Apr;62(4):1022-3.PMID:23520278.</li>
<li> Genuth S, Backlund JY, Bayless M, Bluemke DA, Cleary PA, <strong>Crandall J</strong>, Lachin JM, Lima JA, Miao C, Turkbey EB. <a href="http://www.ncbi.nlm.nih.gov/pubmed/23520132">Effects of Prior Intensive versus Conventional Therapy and History of Glycemia on Cardiac Function in Type 1 Diabetes in the DCCT/EDIC.</a> <em>Diabetes</em>. 2013 Mar 21. PMID: 23520132</li>
<li> <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Agarwal%20C%5BAuthor%5D&amp;cau… C</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Cohen%20HW%5BAuthor%5D&amp;caut… HW</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Muzumdar%20RH%5BAuthor%5D&amp;c… RH</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Heptulla%20RA%5BAuthor%5D&amp;c… RA</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Renukuntla%20VS%5BAuthor%5D&amp… VS</a>, <strong><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Crandall%20J%5BAuthor%5D&amp;ca… J</a></strong>. Obesity, hyperglycemia and endothelial function in inner city Bronx adolescents: a cross-sectional study<em>.</em><em> <a title="International journal of pediatric endocrinology." href="http://www.ncbi.nlm.nih.gov/pubmed/24164965">Int J Pediatr Endocrinol.</a></em> 2013 Oct 29;2013(1):18. &nbsp;PMID:24164965</li>
<li> Milman S, Schulder-Katz M, Deluty J, Zimmerman ME, <strong>Crandall JP</strong>, Barzilai N, Melamed ML, Atzmon G <a href="http://www.ncbi.nlm.nih.gov/pubmed/24383816">Individuals with Exceptional Longevity Manifest a Delayed Association Between Vitamin D Insufficiency and Cognitive Impairment.</a>&nbsp; <em>J Am Geriatr Soc</em>. 2014 Jan 2. doi: 10.1111/jgs.12601. PMID:24383816</li>
<li> Milman S, Atzmon G, <strong>Crandall J</strong>, Barzilai N. <a href="http://www.ncbi.nlm.nih.gov/pubmed/24350928">Phenotypes and Genotypes of High Density Lipoprotein Cholesterol in Exceptional Longevity.</a> <em>Curr Vasc Pharmacol</em>. 2013 Dec 18. PMID:24350928</li>
<li> Halter JB, Musi N, McFarland Horne F, <strong>Crandall JP</strong>, Goldberg A, Harkless L, Hazzard WR, Huang ES, Kirkman MS, Plutzky J, Schmader KE, Zieman S, High KP. Diabetes and cardiovascular disease in older adults: current status and future directions " <em>Diabetes&nbsp;</em> 2014 63:2578-2589. DOI: 10.2337/db14-0020 PMID: 25060886</li>
<li> Milman S, Atzmon G, Huffman DM, Wan J, <strong>Crandall JP</strong>, Cohen P, Barzilai N. <a href="http://www.ncbi.nlm.nih.gov/pubmed/24618355">Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity.</a> <em>Aging Cell</em>. 2014 Aug;13(4):769-71. doi: 10.1111/acel.12213. PMID: 24618355</li>
<li> Knowler WC, Edelstein SL Goldberg RB, Ackermann RT, <strong>Crandall JP</strong>, Florez JC, Fowler SE, Herman WH, Horton ES, Kahn SE, Mather KJ, Nathan DM.&nbsp; <a href="http://www.ncbi.nlm.nih.gov/pubmed/25336746">HbA1c as a Predictor of Diabetes and as an Outcome in the Diabetes Prevention Program: A Randomized Clinical Trial.</a>&nbsp; <em>Diabetes Care</em>. 2014 Oct 21. pii: DC_140886.PMID: 25336746</li>
<li> Phelan S, Kanaya AM, Ma Y, Vittinghoff E, Barrett-Connor E, Wing R, Kusek JW, Orchard TJ, <strong>Crandall JP</strong>, Montez MG, Brown JS; Diabetes Prevention Program Research Group. <a href="http://www.ncbi.nlm.nih.gov/pubmed/25352018">Long-term prevalence and predictors of urinary incontinence among women in the Diabetes Prevention Program Outcomes Study.</a> <em>Int J Urol</em>. 2015Feb;22(2):206-12. doi: 10.1111/iju.12654. PubMed PMID:25352018; PubMed Central PMCID: PMC4387889.</li>
<li> Ayers E, Barzilai N, <strong>Crandall JP</strong>, Milman S, Verghese J. Association of exceptional parental longevity and physical function in aging. <em>Age</em> (Dordr). 2014;36(4):9677. doi: 10.1007/s11357-014-9677-5.PMID: 24997018 [PubMed - in process]</li>
<li> Eny KM, Lutgers HL, Maynard J, Klein BE, Lee KE, Atzmon G, Monnier VM, van Vliet-Ostaptchouk JV, Graaff R, van der Harst P, Snieder H, van der Klauw MM, Sell DR, Hosseini SM, Cleary PA, Braffett BH, Orchard TJ, Lyons TJ, Howard K, Klein R, <strong>Crandall JP</strong>, Barzilai N, Milman S, Ben-Avraham D; LifeLines Cohort Study Group; DCCT/EDIC Research Group, Wolffenbuttel BH, Paterson AD. GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence. <em>Diabetologia</em>. 2014 Aug;57(8):1623-34. PMID: 24934506 [PubMed - in process]</li>
<li> Snyder PJ, Ellenberg SS, Cunningham GR, Matsumoto AM, Bhasin S, Barrett-Connor E, Gill TM, Farrar JT, Cella D, Rosen RC, Resnick SM, Swerdloff RS, Cauley JA, Cifelli D, Fluharty L, Pahor M, Ensrud KE, Lewis CE, Molitch ME, <strong>Crandall JP</strong>, Wang C, Budoff MJ, Wenger NK, Mohler ER 3rd, Bild DE, Cook NL, Keaveny TM, Kopperdahl DL, Lee D, Schwartz AV, Storer TW, Ershler WB, Roy CN, Raffel LJ, Romashkan S, Hadley E.The Testosterone Trials: Seven coordinated trials of testosterone treatment in elderly men. <em>Clin Trials</em>. 2014 Mar 31;11(3):362-375.PMID: 24686158</li>
<li> Hamman R, Horton E, Barrett-Connor E, Bray G, Christohpi C, <strong>Crandall J</strong>, Florez J, Fowler S, Goldberg R, Kahn S, Knowler W, Lachin J, Murphy M, Venditti E.&nbsp; Factors affecting the decline in incidence of diabetes in the Diabetes Prevention Program Outcome Study (DPPOS).&nbsp; <em>Diabetes</em> 2015;64:989-98.</li>
<li> Nathan D, Barrett-Connor E, <strong>Crandall JP</strong>, Edelstein S, Goldberg R, Horton ES, Knowler WC, Mather KJ, Orchard TJ, Pi-Sunyer X, Schade D, Temprosa, M for the Diabetes Prevention Program Research Group.&nbsp;Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study.&nbsp;<em>Lancet Diabetes Endocrinol.&nbsp;</em>2015;3(11):866-75.&nbsp; PMCID:PMC4623946</li>
<li> Cunningham GR, Stephens-Shields AJ, Rosen RC, Wang C, Ellenberg SS, Matsumoto AM, Bhasin S, Molitch ME, Farrar JT, Cella D, Barrett-Connor E, Cauley JA, Cifelli D, <strong>Crandall JP</strong>, Ensrud KE, Fluharty L, Gill TM, Lewis CE, Pahor M, Resnick SM, Storer TW, Swerdloff RS, Anton S, Basaria S, Diem S, Tabatabaie V, Hou X, Snyder PJ. Association of sex hormones with sexual function, vitality, and physical function of symptomatic older men with low testosterone levels at baseline in the testosterone trials. <em>J Clin Endocrinol Metab</em>. 2015Mar;100(3):1146-55. doi: 10.1210/jc.2014-3818. PubMed PMID:25548978; PubMed Central PMCID: PMC4333035.</li>
<li> Phelan S, Kanaya AM, Ma Y, Vittinghoff E, Barrett-Connor E, Wing R, Kusek JW, Orchard TJ, <strong>Crandall JP</strong>, Montez MG, Brown JS; Diabetes Prevention Program Research Group. Long-term prevalence and predictors of urinary incontinence among women in the diabetes Prevention Program Outcome Study. Int J Urol. 2015 Feb;22(2):206-12. doi: 10.1111/iju.12654. PMID: 2535201853.</li>
<li> Cauley JA, Fluharty L, Ellenberg SS, Gill TM, Ensrud KE, Barrett-Connor E,Cifelli D, Cunningham GR, Matsumoto AM, Bhasin S, Pahor M, Farrar JT, Cella D, Rosen RC, Resnick SM, Swerdloff RS, Lewis CE, Molitch ME, <strong>Crandall JP, </strong>Stephens-Shields AJ, Strorer TW, Wang C, Anton S, Basaria S, Diem S, TabatabaieV, Dougar D, Hou X, Snyder PJ. Recruitment and Screening for the Testosterone Trials. <em>J Gerontol A Biol Sci Med Sci</em>. 2015 Sep;70(9):1105-11. PubMed PMID: 25878029.</li>
<li> Snyder PJ, Bhasin S, Cunningham GR, Matsumoto AM, Stephens-Shields AJ, Cauley &nbsp;JA, Gill TM, Barrett-Connor E, Swerdloff RS, Wang C, Ensrud KE, Lewis CE, Farrar JT, Cella D, Rosen RC, Pahor M, <strong>Crandall JP</strong>, Molitch ME, Cifelli D, Dougar D, Fluharty L, Resnick SM, Storer TW, Anton S, Basaria S, Diem SJ, Hou X, Mohler ER 3rd, Parsons JK, Wenger NK, Zeldow B, Landis JR, Ellenberg SS; Testosterone Trials Investigators. Effects of Testosterone Treatment in Older Men. <em>N Engl J Med</em>. 2016 Feb 18;374(7):611-24. PubMed PMID:26886521.</li>
<li> Aroda VR, Edelstein SL, Goldberg RB, Knowler WC, Marcovina SM, Orchard TJ,Bray GA, Schade DS, Temprosa MG, White NH, <strong>Crandall JP</strong>; Diabetes Prevention Program Research Group. Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study. <em>J Clin Endocrinol Metab.</em> 2016 Feb 22:jc20153754. [Epub ahead of print] PubMed PMID: 26900641.</li>
<li> Roshandel D, Klein R, Klein BE, Wolffenbuttel BH, van der Klauw MM, van Vliet-Ostaptchouk JV, Atzmon G, Ben-Avraham D, <strong>Crandall JP,</strong> Barzilai N, Bull SB, Canty AJ, Hosseini SM, Hiraki LT, Maynard J, Sell DR, Monnier VM, Cleary PA,Braffett BH; DCCT/EDIC Research Group, Paterson AD. A New Locus for Skin Intrinsic Fluorescence in Type 1 Diabetes also Associated with Blood and Skin Glycated Proteins. <em>Diabetes</em>. 2016 Apr 12. pii: db151484. PubMed PMID: 27207532.&nbsp;</li>
<li> Cunningham GR, Stephens-Shields AJ, Rosen RC, Wang C, Bhasin S, Matsumoto AM, Parsons JK, Gill TM, Molitch ME, Farrar JT, Cella D, Barrett-Connor E, Cauley JA, Cifelli D, <strong>Crandall JP</strong>, Ensrud KE, Gallagher L, Zeldow B, Lewis CE, Pahor M, Swerdloff RS, Hou X, Anton S, Basaria S, Diem SJ, Tabatabaie V, Ellenberg SS, Snyder PJ. Testosterone treatment and sexual function in older men with low testosterone levels. J Clin Endocrinol Metab. 2016 Aug;101(8):3096-104. doi: 10.1210/jc.2016-1645.PMID: 27355400</li>
<li> Barzilai N, <strong>Crandall JP</strong>, Kritchevsky SB, Espeland MA.&nbsp; Metformin as a tool to target aging.&nbsp; Cell Metabolism 2016; 23:1060-5.</li>
</ol>

<p>&nbsp;Books &amp; Chapters</p>
<ol>
<li><strong>Crandall J </strong>and Tuck C.&nbsp; <span style="text-decoration: underline;">Rational In-patient Management of Diabetes </span>&nbsp;&nbsp;Division of Endocrinology, Columbia University College of Physicians and Surgeons. 1994 (1^st edition), 2001 (2^nd edition).</li>
<li><strong></strong> Smith D and <strong>Crandall J</strong>.&nbsp; Exercise training in special populations: Diabetes; in <span style="text-decoration: underline;">Cardiac Rehabilitation in the Twenty-First Century</span>. Wenger, Smith, Ed.&nbsp;&nbsp; Marcel Dekker, Inc. New York 1999.</li>
<li><strong>Crandall J</strong> and Shamoon H.&nbsp; Prevention of Type 2 Diabetes; in <span style="text-decoration: underline;">Therapy for Diabetes Mellitus and Related Disorders</span>, (4th Edition).&nbsp; American Diabetes Association, 2004.</li>
<li><strong>Crandall J</strong> and Barzilai N.&nbsp; Diabetes Mellitus; in <span style="text-decoration: underline;">The Merck Manual of Health and Aging</span>.&nbsp; Merck ResearchLaboratories, New Jersey, 2004.</li>
<li><strong>Crandall J</strong>.&nbsp; Diabetes Mellitus and other disorders of carbohydrate metabolism; in <span style="text-decoration: underline;">The Merck Manual</span> (18^th edition).&nbsp; Merck Research Laboratories, New Jersey, 2006.</li>
<li><strong>Crandall J.</strong> Type 2 Diabetes: Geriatric Considerations; in <span style="text-decoration: underline;">Type 2 Diabetes: Principles and Practice</span> (2^nd edition), Goldstein &amp; Muller-Wielnad, editors. 2007.</li>
<li><strong>Crandall J</strong> and Shamoon H.&nbsp; Diabetes Mellitus; in <span style="text-decoration: underline;">Cecil Textbook of Medicine</span>, Elsevier, (25^th edition) 2015.&nbsp;</li>
</ol>

EMR ID

4364

Biography

<p>Jill P. Crandall, MD, is Professor and Jacob A. and Jeanne E. Barkey Chair in Medicine and Chief, Division of Endocrinology at Montefiore Einstein. Her clinical focus is on the treatment of types 1 and type 2 diabetes as well as related metabolic disorders.</p><p>In 1975, Dr. Crandall received her Bachelor of Arts in anthropology at State University of New York at Binghamton. She received her Bachelor of Science in health services (physician assistant program) in 1977 at State University of New York at Stony Brook, earning highest school honors. In 1988, she earned her Doctor of Medicine at State University of New York Health Sciences Center at Brooklyn, and began her postgraduate training the same year with an internship and residency at Presbyterian Hospital, completing it in 1991. She continued her post-graduate training at Columbia University College of Physicians and Surgeons, completing her fellowship in endocrinology in 1994.</p><p>Dr. Crandall&rsquo;s research interests focus on age-related changes in glucose metabolism and the relationship between hyperglycemia and cardiovascular risk. As the director of the Diabetes Clinical Trials Unit (DCTU), Dr. Crandall serves as the principal investigator for several NIH-sponsored clinical trials in the field of diabetes and metabolism. Most notable is her work with the Diabetes Prevention Program Outcome Study, for which she holds several national leadership positions, including Executive Committee membership and Co-Chair of a collaboration with the National Cancer Institute to study the effect of long-term metformin treatment or lifestyle modification on cancer incidence. Her specific interests include the prevention of type 2 diabetes, the treatment of diabetes in older adults and the prevention of diabetes complications. Dr. Crandall is also director of the Translational Research Core of the <a href="https://einsteinmed.edu/centers/diabetes-research">Einstein-Mount Sinai Diabetes Research Center (ESDRC)</a>. She serves on the editorial board for the <em>Journal of Diabetes and Its Complications</em> and reviews submissions to several publications, including <em>Diabetes Care, the Journal of Clinical Endocrinology and Metabolism</em>, and the <em>Annals of Internal Medicine</em>. She is active in the American Diabetes Association and has served on the Professional Practice and Grant Review committees.</p><p>Dr. Crandall has received many recognitions throughout her career, including the Glenn Award for Research in Biological Mechanisms of Aging from the Glenn Foundation for Medical Research, and the William Dock, MD Master Teacher Award in Medicine from SUNY Downstate Medical Center.</p>

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