<p>John Condeelis' research interests are in optical physics, cell biology and biophysics, cancer biology and mouse models of cancer. He and his collaborators developed the multiphoton imaging technology and animal models used to identify invasion and dissemination micro-environments in breast, pancreas and lung carcinoma. Integration of intravital multiphoton imaging with computational /systems analysis of living breast tumors identified the dominant tumor cell phenotypes contributing to invasion and dissemination during metastasis. This led to the discovery and verification of the paracrine interaction between tumor cells and macrophages in vivo, the role of macrophages in the migration of tumor cells during HGF-dependent tumor cell streaming to blood vessels and the mechanism of tumor cell dissemination from primary tumors via TMEM (Tumor MicroEnvironment of Metastasis) doorways to distant metastatic sites, and from those metastatic sites. Based on these results, cell collection techniques, including the in vivo invasion assay were developed for the collection of migrating and disseminating macrophages and tumor cells. This led to the discovery of the mouse and human invasion signatures, and the TMEM doorway, MenaCalc and MenaINV markers for assessing risk of metastasis and prediction of response in breast cancer patients to both chemotherapy, and receptor tyrosine kinase and tyrosine kinase inhibitors used to suppress metastasis.</p>
<p>He also helped lead the effort to develop a TMEM-activity-MRI for use in standard of care MRI prognosis of breast cancer patients. He is one of the founding co-directors of the Integrated Imaging Program dedicated to the integration and validation of clinical imaging platforms, including digital pathology, with high resolution optical imaging in the Gruss Lipper Biophotonics Center. He has authored more than 350 scientific papers on various aspects of his research.</p>

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Condeelis is a pioneer in developing microscope techniques for use in &ldquo;intravital imaging&rdquo; &ndash; observing the behavior of cells in living animals. His work has led to a clinical test of biopsy tissue to determine whether a woman&rsquo;s breast cancer will spread (metastasize), which could help determine treatment. Because of the test&rsquo;s success, Dr. Condeelis and colleagues have licensed the patent rights to a biotech firm, which is developing the tissue test into a commercial product.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">A fellow of the American Association for the Advancement of Science, Dr. Condeelis is the recipient of the Allen Foundation Scholar Award and the Hirschl Career Scientist Award. He has served on numerous study sections of the National Institutes of Health and the American Cancer Society, as a consultant to the National Cancer Institute, and on the editorial boards of several prominent journals, including the<em>Journal of Cell Biology</em>.</span></p>

<p><strong>Selected Publications 2020-2022</strong> (<a title="View complete list of publications" href="/labs/john-condeelis/publications/">See complete list of publications.)</a></p>
<ul class="no-bullet">
<li>Karagiannis GS, Eddy RJ, Sparano JA, Anampa Mesias J, Rohan TE, Branch CA, Condeelis JS, Entenberg D, Oktay MH. Detection of TMEM Doorways and Their Activity Required for Metastasis. Emerging Technologies for Cancer Detection and DiagnosisIn Submission.</li>
<li>Sanchez LR, Duran CL, Burt J, Lin Y, Eddy R, Harney AS, Entenberg D, Condeelis JS, Oktay MH, Karagiannis GS. The Cxcl12/Cxcr4 Signaling Pathway Biases Breast Cancer Cell Directional Migration toward TMEM Intravasation Doorways. Journal of Leukocyte Biology. In Revision.</li>
<li>Duran C, Surve CR, Ye X, Chen X, Lin Y, Harney AS, Wang Y, Kim G, Sharma VP, Entenberg D, Stanley R, Oktay MH, Condeelis JS. Revealing the signaling events at TMEM doorways provides potential targets for inhibiting breast cancer dissemination. Science Signaling. In Revision.</li>
<li>Lucotti S, Ogitani Y, Kenific C, Geri J, Kim Y, Gu J, Balaji U, Bojmar L, Shaashua Berger L, Song Y, Cioffi M, Lauritzen P, Joseph O, Asao T, Grandgenett P, Hollingsworth M, Peralta C, Pagano A, Molina H, Lengel H, Gilbert Dunne E, Jing X, Schmitter M, Zhang H, Romin Y, Manova K, Paul D, O&rsquo;Reilly E, Jarnagin W, Kelsen D, Jones D, Condeelis J, Pascual V, Matei I, Bussel J, Coller B, Entenberg D, Bromberg J, Simeone D, Lyden D. Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2. Cell. In Review.</li>
<li>Genna A, Alte J, Poletti M, Meirson T, Sneh T, Gendler M, Saleev N, Karagiannis G, Wang Y, Cox D, Entenberg D, Oktay M, Korcsmaros T, Condeelis J, Gil-Henn H. FAK family proteins regulate in vivo breast cancer metastasis via distinct mechanisms. Nature Communications. In Review.</li>
<li>Dalton K, Howley R, Condeelis J, Entenberg D, Borriello L. Visualization of disseminated tumor cells and metastatic outgrowth in the lung at single cell resolution via intravital imaging. In: Gligorijevic B, editor. Intravitial Microscopy: Methods and Protocols Springer; In Review.</li>
<li>Barth ND, Oktay MH, Condeelis JS, Brunton VG, Entenberg D. Ex Vivo Models to Study the Interaction of Immune Cells and Cancer Cells under Therapy. In: Gligorijevic B, editor. Intravitial Microscopy: Methods and Protocols Springer; In Review.</li>
<li>Ye X, Head T, Duran C, Jafari R, Condeelis JS, Oktay MH, Cady N, Entenberg D. Microfluidic imaging windows for direct localized engineering of the in vivo tumor microenvironment In Progress.</li>
<li>Karagiannis GS, Rivera-Sanchez L, Wang Y, Sharma VP, Entenberg D, Oktay MH, Condeelis JS. Mechanisms of MenaINV induction and host response to chemotherapy.In Progress.</li>
<li>Ye X, Jafari R, Duran C, Du W, Lin Y, Surve C, Wang Y, Hoffmann E, Inman D, Ponik S, Oktay M, Condeelis JS, Entenberg D. Intravital Imaging Tissue AlignmentIn Preparation.</li>
<li>Miller A, Parmar P, Duran C, Porcelli S, Zhang J, Condeelis JS, Entenberg D, Oktay MH. The effect of macrophage cancer cell contact and anti-estrogen therapy on induction of stem cell program using SORE6 biosensor in estrogen receptor positive breast cancer cells.In Preparation.</li>
<li>Miller A, Karadal-Ferrena B, Parmar P, Huang C, Lin Y, Ye X, Chen X, Zintiridou A, Shukla S, Eddy R, Condeelis JS, Anampa JM, Entenberg D, Xue X, Rohan TE, Oktay MH. The clinical utility of TMEM doorway score in predicting response to treatment in breast cancer patients with estrogen receptor positive and triple negative breast cancer.In Preparation.</li>
<li>Karadal-Ferrena B, Miller A, Adler E, Ginter PS, D'Alfonso T, Lin Y, Ye X, Chen X, Zintiridou A, Shukla S, Eddy R, Condeelis JS, Anampa JM, Sparano JA, Entenberg D, Xue X, Rohan TE, Oktay MH. A multi-institutional study of TMEM doorway score as prognostic biomarker in a multiracial cohort of breast cancer patients.In Preparation.</li>
<li>Karadal-Ferrena B, DeLuca M, Duran C, Barth N, Jung Y, Eddy R, Lin Y, Chen X, Zintiridou A, Ye X, Karagiannis GS, Condeelis JS, Entenberg D, Oktay MH. TMEM doorway activity and macrophage profile in lung metastasis from breast cancer.In Preparation.</li>
<li>Entenberg D, Kodandaramaiah SB, Ponik SM, Elicieri K. Design considerations for optical intravital imaging windows. J Biomed Opt. In Preparation.</li>
<li>Anampa JM, Flynn DL, Oh S, Sadan S, Xue X, Oktay MH, Condeelis JS, Sparano JA. Phase Ib clinical and pharmacodynamic study of the Tie2 kinase inhibitor rebastinib with paclitaxel or eribulin in HER2-negative metastatic breast cancer.In Preparation.</li>
<li>Yang Y, Wang X, Zhang J. Pirfenidone and nintedanib attenuate pulmonary fibrosis in mice by inhibiting the expression of JAK2. J Thorac Dis. 2024;16(2):1128-40. Epub 20240226. doi: 10.21037/jtd-23-1057. PubMed PMID: 38505034; PMCID: PMC10944717.</li>
<li>Oh SS, Narver HL. Mouse and Rat Anesthesia and Analgesia. Curr Protoc. 2024;4(2):e995. doi: 10.1002/cpz1.995. PubMed PMID: 38406895; PMCID: PMC10914332.</li>
<li>Migulina N, de Hilster RHJ, Bartel S, Vedder RHJ, van den Berge M, Nagelkerke A, Timens W, Harmsen MC, Hylkema MN, Brandsma CA, Burgess JK. 3-D culture of human lung fibroblasts decreases proliferative and increases extracellular matrix remodeling genes. Am J Physiol Cell Physiol. 2024;326(1):C177-C93. Epub 20231113. doi: 10.1152/ajpcell.00374.2023. PubMed PMID: 37955339.</li>
<li>Chioccioli M, Liu S, Magruder S, Tata A, Borriello L, McDonough JE, Konkimalla A, Kim SH, Nouws J, Gonzalez DG, Traub B, Ye X, Yang T, Entenberg DR, Krishnaswamy S, Hendry CE, Kaminski N, Tata PR, Sauler M. Stem cell migration drives lung repair in living mice. Dev Cell. 2024. Epub 20240214. doi: 10.1016/j.devcel.2024.02.003. PubMed PMID: 38377991.</li>
<li>Barth ND, Oktay MH, Condeelis JS, Brunton VG, Entenberg D. Ex Vivo Models to Study the Interaction of Immune Cells and Cancer Cells under Therapy. Nature Protocols Exchange. 2024. doi: <a title="Read article" href="https://doi.org/10.21203/rs.3.pex-2544/v1&quot; target="_blank" rel="noopener">https://doi.org/10.21203/rs.3.pex-2544/v1</a>.</li&gt;
<li>Barron SL, Wyatt O, O'Connor A, Mansfield D, Suzanne Cohen E, Witkos TM, Strickson S, Owens RM. Modelling bronchial epithelial-fibroblast cross-talk in idiopathic pulmonary fibrosis (IPF) using a human-derived in vitro air liquid interface (ALI) culture. Sci Rep. 2024;14(1):240. Epub 20240102. doi: 10.1038/s41598-023-50618-y. PubMed PMID: 38168149; PMCID: PMC10761879.</li>
</ul>

<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; text-align: justify; text-indent: 0.25in;">The major challenge faced by physicians is the prevention and treatment of metastasis, the main reason for cancer mortality.&nbsp;Surprisingly, cancer patients presumed cured after primary tumor removal and therapy, can carry non-proliferating &lsquo;dormant&rsquo; disseminated cancer cells (DCCs) for years before reactivating to form incurable metastasis. I focused on understanding the biology of dormant DCCs and their reactivation, to target them and prevent relapse. My team led a paradigm shift that is revealing novel cancer biology that diverges from the notion that cancer is perpetually proliferating.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; text-align: justify; text-indent: 0.25in;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; text-align: justify; text-indent: 0.25in;">We discovered that a reciprocal crosstalk between DCCs and the microenvironment regulates the inter-conversion between dormancy and proliferation. My lab discovered that an imbalance in p38<span style="font-family: Symbol;">a/b</span>&nbsp;and ERK1/2 signaling regulates lineage commitment transcription factors (TF) and an epigenetic network that determines dormancy induction (<strong><em>Aguirre-Ghiso et al., JCB 1999, Mol Biol Cell 2001, Oncogene 2002, Liu, Aguirre-Ghiso et al., Cancer Cell, 2002, Aguirre-Ghiso et al., Cancer Res 2004,</em></strong>&nbsp;among others). This work led to identify retinoic acid and TGF<span style="font-family: Symbol;">b</span>2 in the microenvironment as inducers of the high p38/ERK-signaling ratio, leading to the finding that dormancy &nbsp;(quiescence) is controlled by mechanisms of adult stem cell quiescence&nbsp;<em>(<strong>Adam et al., Cancer Res 2009</strong>;&nbsp;<strong>Bragado et al., Nat Cell Bio, 2013, Sosa et al., Nat Commun 2015; Fluegen et al., &amp; Nat Cell Bio, 2017; Nobre et al., Nature Cancer 2021</strong>)</em>. These findings have been expanded to reveal that mesenchymal stem cell niches that control hematopoietic stem cell dormancy control dormancy of breast cancer DCCs through a TGFB2 and BMP7-dependent mechanism (<strong><em>Nobre et al.,</em><em>Nat Cancer, 2021</em></strong>). My lab&nbsp;was one of the first to show that tumor-initiating properties and DCC dormancy are dynamically linked by epigenetic states and a transcriptional program that affects the histone code&nbsp;<em>(<strong>Sosa et al., Nat Commun 2015</strong>).</em>&nbsp;This work led to an epigenetic strategy to&nbsp;<em>induce dormancy</em><em>,</em>&nbsp;which is now a clinical trial funded by the V-Foundation and TCI (<strong>NCT03572387</strong>). We also identified a &ldquo;dormancy signature&rdquo; and specific markers enriched in dormant prostate and breast cancer DCCs as well as in the bone marrow of breast cancer patients that predict for prolonged metastasis-free periods (<strong><em>Borgen et al., Breast Cancer Res 2018; Nobre et al., Nature Cancer 2021</em></strong>).&nbsp;We also found how the hypoxic microenvironment in primary tumors primes DCCs epigenetically to become dormant and evade chemotherapy (<strong><em>Fluegen et al., Nat Cell Bio, 2017</em></strong>).</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; text-align: justify; text-indent: 0.25in;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; text-align: justify; text-indent: 0.25in;">My lab&rsquo;s work has propelled new questions to the forefront of cancer research, with the unexpected discovery of the mechanisms that allow dormant breast cancer DCCs and metastasis to be initiated very early during cancer evolution disseminating during pre-malignant stages (<strong><em>Harper and Sosa et al., Nature, 2016 and Hosseini et al., Nature, 2016</em></strong>). We further discovered that&nbsp;innate immune cells are key to launch the early dissemination process and the success on metastatic colonization (<strong><em>Linde et al., Nature Commun. 2018</em></strong>). Our program&rsquo;s impact is further highlighted by the&nbsp;development of successful collaborations with industry that identified pathways (<strong><em>Ranganathan et al., Cancer Ress 2006; 2008; Schewe and Aguirre-Ghiso, PNAS 2008; Cancer Res 2009</em></strong>) and drugs to kill dormant DCCs or induce dormancy of DCCs that are now part of a patent (WO201919111) and developed by a new startup company (HiberCell)(<a style="color: #903638;" href="http://www.hibercell.com/">www.hibercell.com</a&gt;), which is conducting clinical trials developed from our findings&nbsp;(NCT04834778, NCT04995094),identification of potential biomarkers and the development of the first clinical trials to induce dormancy of metastatic disease in prostate cancer&nbsp;(<strong>NCT03572387</strong>).</p>

<p>Julio Aguirre-Ghiso, Ph.D., is an international leader in cancer cell dormancy and metastasis. He has helped lead a major shift in the cancer biology field by investigating how cancer cells hibernate, undetected, for long periods of time and what causes them to suddenly awaken to seed deadly, treatment-resistant metastases.</p>
<p>Dr. Aguirre-Ghiso&rsquo;s work is revealing ways to maintain residual cancer-cell dormancy, kill dormant cancer cells, and identify biomarkers for cancer recurrence. He has founded a start-up company, HiberCell, which is developing treatments to prevent relapse.&nbsp;</p>
<p>Dr. Aguirre-Ghiso is founding director of the <a href="https://montefioreeinstein.org/cancer/research/cdtmi">Cancer Dormancy and Tumor Microenvironment Institute</a> at the Montefiore Einstein Cancer Center. The goal of the institute is to integrate research from a range of specialties&mdash;including the biology of aging, stem cells, epigenetics, and systems biology&mdash;to address how residual cancer cells, aging, lifestyle, genetics, and treatments influence relapse across all cancers.</p>
<p>Dr. Aguirre-Ghiso is a reviewer for top-tier scientific journals and for federal, private, and international agencies.&nbsp; His work has been published in <em>Nature</em>, <em>Nature Cell Biology</em>, <em>Nature Cancer</em>, <em>Science</em>, and <em>Cancer Cell</em>. He is also president of the Metastasis Research Society and has served at several leadership levels at American Association for Cancer Research.</p>

<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 16pt; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal; color: #3c7483;">Pre-Prints Available Online</span></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraph" style="text-indent: -.25in; mso-list: l5 level1 lfo19;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; color: black;"><span style="mso-list: Ignore;">1.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt; color: black;">Deepak K. Singh, Eduardo Farias, Saul Carcamo, Dan Hasson, Dan Sun, Julie Cheung, Ana Rita Nobre, Nupura Kale, Maria Soledad Sosa, Emily Bernstein, Julio A. Aguirre-Ghiso. Epigenetic reprogramming of DCCs into dormancy suppresses metastasis via restored TGF&beta;&ndash;SMAD4 signaling bioRxiv 2021.08.01.454684; doi:&nbsp;</span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1101/2021.08.01.454684"><span style="font-size: 12pt;">https://doi.org/10.1101/2021.08.01.454684</span></a></p&gt;
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="color: black;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpFirst" style="text-indent: -.25in; mso-list: l5 level1 lfo19;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; color: black;"><span style="mso-list: Ignore;">2.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><strong><span style="font-size: 12pt; color: black;">Aguirre-Ghiso JA</span></strong><span style="font-size: 12pt; color: black;">, Nobre AR, Dalla E, et al. A&nbsp;Mesenchymal-like Program of Dormancy controlled by ZFP281 Serves as a&nbsp;Barrier&nbsp;to Metastatic Progression of Early Disseminated Cancer Cells. 18 January&nbsp;2021,&nbsp;PREPRINT (Version 1) available at&nbsp;<strong><em>Research&nbsp;Square.</em></strong>&nbsp;</span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.21203/rs.3.rs-145308/v1"><span style="font-size: 12pt;">https://doi.org/10.21203/rs.3.rs-145308/v1</span></a></p&gt;
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt; color: black;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-list: l5 level1 lfo19;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; color: black;"><span style="mso-list: Ignore;">3.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt; color: black;">Khalil BD, Sanchez R, Rahman T, Rodriguez-Tirado C, Moritsch S, Rodriguez Martinez A, Miles B, Farias E, Mezei M, Cheung JF, Nobre AR, Kale N, Sproll KC, Sosa MS,&nbsp;<strong>Aguirre-Ghiso JA</strong>. A specific agonist of the orphan nuclear receptor NR2F1&nbsp;suppresses metastasis through the induction of cancer cell dormancy.&nbsp;<strong><em>bioRxiv</em></strong>(2021).01.30.428967; doi:&nbsp;</span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1101/2021.01.30.428967"><span style="font-size: 12pt;">https://doi.org/10.1101/2021.01.30.428967</span></a></p&gt;
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt; color: black;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-list: l5 level1 lfo19;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; color: black;"><span style="mso-list: Ignore;">4.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt; color: black;">Borriello L,&nbsp;Coste A, Sharma VP, Karagiannis GS, Lin Y, Wang Y, Ye X, Duran C, Chen X, Dalla E, Singh DK, Oktay MH,&nbsp;<strong>Aguirre-Ghiso JA<em>,&nbsp;</em></strong>Condeelis J, Entenberg D. Primary tumor associated macrophages activate programs of&nbsp;invasion and dormancy in disseminating tumor cells.&nbsp;<strong><em>bioRxiv</em></strong>&nbsp;(2021).02.04.429798; doi:&nbsp;</span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1101/2021.02.04.429798"><span style="font-size: 12pt;">https://doi.org/10.1101/2021.02.04.429798</span></a></p&gt;
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt; color: black;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="text-indent: -.25in; mso-list: l5 level1 lfo19;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; color: black;"><span style="mso-list: Ignore;">5.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt; color: black;">Mitchell Fane, Stephen Douglass, Gretchen Alicea, Marie Webster, Vito Rebecca, Gloria Marino, Yash Chhabra, Filipe Almeida, Brett Ecker, Thomas Beer, Hsin-Yao Tang, Andrew Kossenkov, David Speicher,&nbsp;<strong>Julio Aguirre-Ghiso</strong>, Ashani Weeraratna,&nbsp;&nbsp;</span><span style="font-size: 12pt; color: black;">Stromal Changes In The Aged Lung Induce An&nbsp;Emergence From&nbsp;Melanoma Dormancy, 16 September (2020), PREPRINT (Version 1) available at R<strong><em>esearch&nbsp;Square</em></strong>&nbsp;</span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.21203/rs.3.rs-61165/v1"><span style="font-size: 12pt;">https://doi.org/10.21203/rs.3.rs-61165/v1</span></a></p&gt;
<p class="MsoListParagraphCxSpLast" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt; color: black;">&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 16pt; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal; color: #3c7483;">Peer Reviewed Original Research Contributions&nbsp;</span></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-align: justify; line-height: 24px;"><em>^{<span style="color: black;">&nbsp;</span>}</em></p>
<p class="MsoListParagraphCxSpFirst" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">1.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Di Martino J, Nobre AR, Mondal C, Taha I, Farias EF, Fertig E, Naba A,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Bravo-Cordero JJ. A tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy, 22 June 2021, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-580847/v1].&nbsp;<strong><em>Nature Cancer</em></strong>&nbsp;(2021) (Accepted for Publication)</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">2.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Casanova-Acebes M, Dalla E, Leader A, LeBerichel J, Nikolic J, Morales BM, Brown M, Chang M, Troncoso L, Chen ST, Sastre-Perona A, Park MD, Tabachnikov A, Dhainaut M, Hamon P, Maier B, Sawai CM, Agull&oacute;-Pascual E, Schober M, Brown B, Reizis B, Marron T, Kenigsberg E, Moussion C, Benaroch P,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Merad M. Lineage tracing reveals the unique pro-tumorigenic niche role of tissue-resident macrophages in early cancer lesions.&nbsp;<strong><em>Nature&nbsp;</em></strong>595, 578&ndash;584 (2021).&nbsp;<strong><em><span style="color: #ff6600; background-color: white;">In the top 5% of all research outputs scored by Altmetric</span></em></strong></span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">3.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Nobre R, Risson E, Singh DK, Di Martino JS, Cheung JF, Wang J, Johnson J, Russnes HG, Bravo-Cordero JJ, Birbrair A, Naume B, Azhar M, Frenette PS,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Bone marrow NG2+/Nestin+&nbsp;mesenchymal stem cells drive DTC dormancy via TGF-&beta;2.&nbsp;<strong><em>Nature Cancer</em></strong>&nbsp;2,&nbsp;327&ndash;339 (2021).&nbsp;</span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1038/s43018-021-00179-8"><span style="font-size: 12pt;">https://doi.org/10.1038/s43018-021-00179-8</span></a><span style="font-size: 12pt;">&nbsp;<strong><em><span style="color: #ff6600; background-color: white;">In the top 5% of all research outputs scored by Altmetric</span></em></strong></span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">4.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Lam T,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Geller MA, Aksan A, Azarin SM. Immobilization rapidly selects for chemoresistant ovarian cancer cells with enhanced ability to enter dormancy.&nbsp;<strong><em>Biotechnol Bioeng</em></strong>. (2020) Oct;117(10):3066-3080. doi: 10.1002/bit.27479. Epub 2020 Jul 9.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">5.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt; background-color: white;">Teh JL, Purwin TJ, Han A, Chua V, Patel P, Baqai U, Liao C, Bechtel N, Sato T, Davies MA,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Aplin AE. Metabolic adaptations to MEK and CDK4/6 co-targeting in uveal melanoma.&nbsp;<strong><em>Mol Cancer Ther</em></strong>. (2020) May 19: molcanther.1016.2019. doi: 10.1158/1535-7163.MCT-19-1016. Epub ahead of print. PMID: 32430489.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">6.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Liu PH, Shah RB, Li Y, Arora A, Ung PM, Raman R, Gorbatenko A, Kozono S, Zhou XZ, Brechin V, Barbaro JM, Thompson R, White RM,&nbsp;<strong>Aguirre-Ghiso&nbsp;JA</strong>, Heymach JV, Lu KP,&nbsp;Silva JM, Panageas KS, Schlessinger A, Maki RG, Skinner HD, de Stanchina E, Sidi S. An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy.&nbsp;<strong><em>Nat Cell Biol.&nbsp;</em></strong>(2019) Feb;21(2):203-213. doi: 10.1038/s41556-018-0260-7. Epub 2019 Jan 21.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpLast" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">7.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt; color: black;">Lapadula D, Farias E, Randolph CE, Purwin TJ,&nbsp;McGrath D, Charpentier TH, Zhang L, Wu S, Terai M, Sato T, Tall GG, Zhou N, Wedegaertner PB, Aplin AE,&nbsp;<strong>Aguirre-Ghiso&nbsp;JA</strong>, Benovic JL. Effects of Oncogenic G&alpha;q&nbsp;and G&alpha;11&nbsp;Inhibition by FR900359 in Uveal Melanoma.&nbsp;<strong><em>Mol Cancer Res</em></strong>. (2019) Apr;17(4):963-973. doi: 10.1158/1541-7786.MCR-18-0574. Epub 2018 Dec 19.</span><strong><em><span style="font-size: 12pt; color: #ff6600; background-color: white;">&nbsp;In the top 5% of all research outputs scored by Altmetric and picked up by 16 news stories from 15 outlets.</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-family: inherit, serif;">&nbsp;</span></p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">8.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt; font-family: inherit, serif;">Borgen E, Rypdal MC, Sosa MS, Renolen A, Schlichting E, L&oslash;nning PE, Synnestvedt M,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Naume B. NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients.&nbsp;<strong><em>Breast Cancer Research</em></strong>(2018) 20 (1), 120.&nbsp;</span><strong><em><span style="font-size: 12pt; color: #ff6600; background-color: white;">In the top 5% of all research outputs scored by Altmetric and picked up by 9 news stories from 9 outlets.</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; vertical-align: baseline;"><span style="font-family: inherit, serif;">&nbsp;</span></p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l9 level1 lfo8; vertical-align: baseline;"><!-- [if !supportLists]--><span style="font-family: 'inherit',serif; mso-fareast-font-family: inherit; mso-bidi-font-family: inherit;"><span style="mso-list: Ignore;">9.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-family: inherit, serif;">Linde<span style="border: 1pt none windowtext; padding: 0in;">&nbsp;N</span>, Casanova-Acebes<span style="border: 1pt none windowtext; padding: 0in;">&nbsp;M</span>, Sosa<span style="border: 1pt none windowtext; padding: 0in;">&nbsp;MS</span>, Mortha<span style="border: 1pt none windowtext; padding: 0in;">&nbsp;A</span>, Rahman<span style="border: 1pt none windowtext; padding: 0in;">&nbsp;A</span>, Farias EF,&nbsp;Harper K, Tardio E, Reyes Torres I, Jones<span style="border: 1pt none windowtext; padding: 0in;">&nbsp;J</span>, Condeelis J, Merad&nbsp;<span style="border: 1pt none windowtext; padding: 0in;">M,</span>&nbsp;and&nbsp;<strong><span style="border: 1pt none windowtext; padding: 0in;">Aguirre-Ghiso JA.</span></strong><br /><span style="border: 1pt none windowtext; padding: 0in;">Macrophages orchestrate breast cancer early dissemination and metastasis.&nbsp;<strong><em>Nature Communications</em></strong></span>&nbsp;9, 21(2018)&nbsp;doi:10.1038/s41467-017-02481-5.&nbsp;</span><strong><em><span style="color: #ff6600; background-color: white;">In the top 5% of all research outputs scored by Altmetric. Highlighted in Faculty of 1000 Prime: El-Deiry W and Zhao S: F1000Prime Recommendation of [Linde N et al., Nat Commun 2018 9(1):21]. In F1000Prime, 11 Jan 2018; 10.3410/f.732394311.793541160. Highlighted in Science Translational Medicine:</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: 22.5pt; vertical-align: baseline;"><a style="color: #903638; text-decoration: underline;" href="https://stm.sciencemag.org/content/10/425/eaar7521?intcmp=trendmd-stm">… style="background-color: white;">https://stm.sciencemag.org/content/10/425/eaar7521?intcmp=trendmd-stm</…;
<p class="MsoListParagraphCxSpFirst" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpLast" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; tab-stops: 535.5pt; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; mso-bidi-font-weight: bold;"><span style="mso-list: Ignore;">10.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Entenberg D, Pastoriza JM, Oktay MH, Voiculescu S, Wang Y, Sosa MS,&nbsp;<strong>Aguirre-Ghiso</strong>&nbsp;<strong>JA</strong>, Condeelis J.&nbsp;Time-lapsed, large-volume, high-resolution intravital imaging for tissue-wide analysis of single cell dynamics.&nbsp;<strong><em>Methods</em></strong>(2017) Sep 1; 128:65-77. doi: 10.1016/j.ymeth.2017.07.019.</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; tab-stops: 535.5pt; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">11.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Fluegen G, Avivar-Valderas A, WangY, PadgenM, WilliamsJK, Verkhusha V, Cheung JF, Entenberg D, Castracane J, Keely PJ, Condeelis J,&nbsp;<strong>Aguirre-Ghiso&nbsp;JA</strong>.&nbsp;^&nbsp;Phenotypic heterogeneity of disseminated tumor cells is predetermined by primary tumor hypoxic microenvironments.<strong><em>&nbsp;Nature Cell Biology&nbsp;</em><span style="color: #262626;">(2017)<em>&nbsp;</em></span></strong><span style="color: #262626;">doi:10.1038/ncb3465.</span><strong><em><span style="color: #ff6600;">Cover Article.&nbsp;</span></em></strong></span><strong><em><span style="font-size: 12pt; font-family: inherit, serif; color: #ff6600; border: 1pt none windowtext; padding: 0in;">Highlighted in Science Translational Medicine Editor&rsquo;s&nbsp;Choice,&nbsp;Science Translational Medicine&nbsp;15 Feb 2017:&nbsp;Vol. 9, Issue 377, eaam6063&nbsp;DOI: 10.1126/scitranslmed.aam6063</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraphCxSpFirst" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">12.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Harper K, Sosa MS, Hosseini H, Entenberg D, Avivar-Valderas A, Nagi C, Davis RJ, Farias EF, Condeelis J, Klein C,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Mechanism of early dissemination and metastasis during early stages of HER2+ mammary cancer.<strong>&nbsp;<em>Nature&nbsp;</em></strong><span style="color: #262626;">(2016) Dec 14. doi: 10.1038/nature20785. [Epub ahead of print] PMID:27974799</span><strong>.<em><span style="color: #ff6600;">&nbsp;Paper highlighted in Nature News and Views.&nbsp;Nature. 2016 Dec 14. doi: 10.1038/nature21104. Highlighted by Faculty of 1000.&nbsp;</span></em></strong></span><a style="color: #903638; text-decoration: underline;" href="https://f1000.com/prime/727099751"><strong><em><span style="font-size: 12pt;">https://f1000.com/prime/727099751</span></em></strong></a><strong><em><… style="font-size: 12pt; color: #ff6600;">; Highlighted in Nature Reviews &nbsp;Cancer&nbsp;</span></em></strong><a style="color: #903638; text-decoration: underline;" href="http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html"><strong>… style="font-size: 12pt;">http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html</span></e…;
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpLast" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">13.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Hosseini, H, Harper K, Obradovic M, Sosa MS, Nanduri LK, Werno C, Hoffman, M, Ehrl C, Maneck M, Patwary N, Haunschild G, Reimelt C, Weeber F, Hartkopf A, Taran FA, Brucker SY, Fehm T, Meister G,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Klein CA.&nbsp;Early dissemination seeds metastasis&nbsp;in breast cancer.<em>&nbsp;<strong>Nature</strong></em>. (2016)<strong>&nbsp;</strong>Dec 14. doi: 10.1038/nature20609. [Epub ahead of print] PMID:27974798.&nbsp;<strong><em><span style="color: #ff6600;">Paper highlighted in Nature News and Views.&nbsp;Nature. 2016 Dec 14. doi: 10.1038/nature21104.&nbsp;Highlighted in Nature Reviews Cancer&nbsp;</span></em></strong></span><a style="color: #903638; text-decoration: underline;" href="http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html"><strong>… style="font-size: 12pt;">http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html</span></e…;
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">14.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Yumoto K, Eber MR, Wang J, Cackowski FC, Decker AM, Lee E,&nbsp;Nobre AR,<strong>&nbsp;</strong><strong>Aguirre-Ghiso JA</strong>, Jung Y, Taichman RS. Axl is required for TGF-&beta;2-induced dormancy of prostate cancer cells in the bone marrow.&nbsp;<strong><em>Scientific Reports</em></strong>&nbsp;(2016)<strong><em>&nbsp;</em></strong>Nov 7; 6:36520. doi: 10.1038/srep36520.</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">15.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Morris BA, Burkel B, Ponik SM, Fan J, Condeelis JS,<strong>&nbsp;Aguire-Ghiso JA</strong>, Castracane J, Denu JM, Keely PJ. Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells.&nbsp;<strong><em>EBioMedicine</em>&nbsp;</strong>(2016) Nov; 13:146-156. doi: 10.1016/j.ebiom.2016.10.012. PubMed PMID: 27743905.</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">16.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Cackowski FC, Eber MR, Rhee J, Decker A, Yumoto K, Berry JE, Lee E, Shiozawa Y, Jung Y,&nbsp;<strong>Aguirre-Ghiso</strong><strong>&nbsp;JA</strong>,Taichman RS.&nbsp;Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cellular Dormancy.&nbsp;<strong><em>J Cell Biochem</em></strong>(2016) Oct 18. doi: 10.1002/jcb.25768. PMID: 27753136</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">17.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Chung CY, Sun Z, Mullokandov G, Bosch A, Qadeer ZA, Cihan E, Rapp Z, Parsons R,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Farias EF, Brown BD, Gaspar-Maia A, Bernstein E. Cbx8 acts non-canonically in breast cancer to promote Notch signaling.&nbsp;<strong><em>Cell Reports&nbsp;</em></strong>(2016)&nbsp;Jul 12;16(2):472-86. doi: 10.1016/j.celrep.2016.06.002. Epub 2016 Jun 23. PMID: 27346354</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">18.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Williams JK, Entenberg D, Wang Y, Avivar-Valderas A, Padgen M, Clark A,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Castracane J, Condeelis JS. Validation of a device for the active manipulation of the tumor microenvironment during intravital imaging.&nbsp;<strong><em>Intravital</em></strong>. (2016)</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraph" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">19.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Szulczewski JM, Inman DR, Entenberg D,&nbsp;</span><strong><span style="font-size: 12pt;">Aguirre-Ghiso JA</span></strong><span style="font-size: 12pt;">, Castracane J, Condeelis J, Eliceiri KW, Keely PJ. In Vivo Visualization of Stromal Macrophages via label-free FLIM-based metabolite imaging.&nbsp;<strong><em>Scientific Reports</em></strong>(2016)<strong>&nbsp;</strong></span><span style="font-size: 12pt;">May 25; 6:25086. doi: 10.1038/srep25086. PMID: 27220760</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l9 level1 lfo8; text-autospace: none;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">20.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Li M, Pathak RR, Lopez-Rivera E, Friedman SL,&nbsp;<strong>Aguirre-Ghiso</strong><strong>&nbsp;JA</strong>, Sikora AG.&nbsp;The In Ovo Chick Chorioallantoic Membrane (CAM) Assay as an Efficient Xenograft Model of Hepatocellular Carcinoma<em>.&nbsp;</em><strong><em>J Vis Exp</em></strong>. (2015) Oct 9; (104). doi: 10.3791/52411.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l9 level1 lfo8; text-autospace: none;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">21.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Alsadeq A, Strube S, Krause S, Carlet M, Jeremias I, Vokuhl C, Loges S,&nbsp;<strong>Aguirre-Ghiso</strong><strong>&nbsp;JA</strong>, Trauzold A, Cario G, Stanulla M, Schrappe M, Schewe DM.&nbsp;Effects of p38&alpha;/&beta; inhibition on acute lymphoblastic leukemia proliferation and survival in vivo.&nbsp;<strong><em>Leukemia</em></strong>. (2015) Jun 24. doi: 10.1038/leu.2015.153. [Epub ahead of print] PMID: 26104660</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoListParagraphCxSpFirst" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">Adomako A, Calvo V, Biran N, Osman K, Chari A, Paton JC, Paton AW, Moore K, Schewe DM,&nbsp;<strong>Aguirre-Ghiso</strong><strong>JA</strong>.&nbsp;Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatment.&nbsp;<strong><em>BMC Cancer</em></strong>&nbsp;(2015) May 30; 15:444. doi: 10.1186/s12885-015-1460-1. PMCID: PMC4448210.&nbsp;<strong><em><span style="color: #ff6600;">Highlighted by BMC Cancer in the &ldquo;Highly Accessed&rdquo; category.</span></em></strong></span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><em><span style="font-size: 12pt; color: #ff6600;">&nbsp;</span></em></strong></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">22.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Hasegawa D, Calvo V, Avivar-Valderas A, Lade A, Chou HI, Lee YA, Farias EF,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Friedman SL.&nbsp;Epithelial Xbp1 is Required for Cellular Proliferation and Differentiation During Mammary Gland Development.&nbsp;<strong><em>Mol Cell Biol</em></strong>. (2015) Feb 23. pii: MCB.00136-15. PMID: 25713103.&nbsp;<strong><em><span style="color: #ff6600;">Cover article for the Feb 23 issue of Mol Cell Biol.</span></em></strong></span></p>
<p class="MsoListParagraphCxSpLast" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l9 level1 lfo8; text-autospace: none;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">23.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Sosa MS, Parikh F, Maia AG, Estrada Y, Bosch A, Bragado P, Ekpin E, George A, Zheng Y, Lam HM, Morrissey C, Chung CY, Farias EF, Bernstein E,&nbsp;<strong>Aguirre-Ghiso JA</strong>. NR2F1 controls tumour cell dormancy via SOX9- and RAR&beta;-driven quiescence programmes.&nbsp;<strong><em>Nat Commun</em></strong>&nbsp;(2015) Jan 30; 6:6170. doi: 10.1038/ncomms7170. PubMed PMID:25636082; PubMed Central PMCID: PMC4313575.&nbsp;<strong><em><span style="color: #ff6600;">In the top 10% of all articles ever tracked by Altmetric.</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l9 level1 lfo8; text-autospace: none;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">24.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Ch&eacute;ry L, Lam HM, Coleman I, Lakely B, Coleman R, Larson S,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Xia J, Gulati R, Nelson PS, Montgomery B, Lange P, Snyder LA, Vessella RL, Morrissey C. Characterization of single disseminated prostate cancer cells Reveals tumor cell heterogeneity and identifies dormancy associated pathways.&nbsp;<strong><em>Oncotarget</em></strong>&nbsp;(2014) Oct 30;5(20):9939-51. PubMed PMID: 25301725; PubMed Central PMCID: PMC4259449.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoListParagraphCxSpFirst" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">25.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Lopez-Rivera E, Jayaraman P, Parikh F, Davies MA, Ekmekcioglu S, Izadmehr S, Milton DR, Chipuk JE, Grimm EA, Estrada Y,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Sikora AG.&nbsp;Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2.<strong><em>Cancer Res</em></strong>. (2014) Feb 15;74(4):1067-78. doi: 10.1158/0008-5472.CAN-13-0588. Epub 2014 Jan 7. PMID: 24398473 [PubMed - indexed for MEDLINE]</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l9 level1 lfo8; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">26.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span lang="EN-GB" style="font-size: 12pt;">Bragado P, Estrada Y, Parikh F, Krause S, Capobianco C, Farina HG, Schewe DM,&nbsp;</span><strong><span style="font-size: 12pt;">Aguirre-Ghiso JA</span></strong><span style="font-size: 12pt;">.</span><span lang="EN-GB" style="font-size: 12pt;">&nbsp;TGF&beta;2 dictates disseminated tumour cell fate in target organs through TGF&beta;-RIII and p38&alpha;/&beta; signalling.&nbsp;<strong><em>Nat. Cell. Bio.&nbsp;</em></strong>(2013).</span><span style="font-size: 12pt;">Nov;15(11):1351-61. doi: 10.1038/ncb2861. Epub 2013 Oct 27.</span><span lang="EN-GB" style="font-size: 12pt;">&nbsp;PMID: 24161934;</span><span style="font-size: 12pt;">PMCID: not available.&nbsp;<strong><em><span style="color: #ff6600;">Featured in Nat Cell Bio Cover same issue. Highlighted in Science Signaling Editor&rsquo;s Choice, Cancer Research Breaking Advances section and several public news outlets. Featured in the Cover of the November 15th issue of Nat Cell Bio. Ranks #6 for articles of similar age in Nat Rev Cancer and is in the top 5% of all articles ever tracked by Altmetric.&nbsp;</span></em></strong></span></p>
<p class="MsoListParagraphCxSpLast" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><em><span style="font-size: 12pt; color: #ff6600;">&nbsp;</span></em></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">27.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Begley U, Sosa MS, Avivar-Valderas A, Patil A, Endres L, Estrada Y, Chan CTY, Su D, Dedon PC,&nbsp;<strong>Aguirre-Ghiso JA</strong>,&nbsp;Begley T. A human tRNAmethyltransferase 9-like protein prevents tumor growth by regulating LIN9 and the hypoxic response.&nbsp;<strong><em>EMBO Mol Med&nbsp;</em></strong>(2013)&nbsp;Feb 4. doi: 10.1002/emmm.201201161.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">28.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Avivar-Valderas A,&nbsp;Bobrovnikova-Marjon E, Diehl JA, Bardeesy N,&nbsp;Debnath J,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Regulation of autophagy during ECM detachment is linked to a&nbsp;selective inhibition of mTORC1 by PERK.&nbsp;&nbsp;<strong><em>Oncogene</em></strong>(2012), Nov 19. doi: 10.1038/onc.2012.512.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">29.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Kim RS, Avivar-Valderas A, Estrada A, Bragado P, Sosa MS,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Segall JE. Dormancy signatures and metastasis in estrogen receptor positive breast cancer.&nbsp;<strong><em>PLoS One&nbsp;</em></strong>(2012); 7(4):e35569. Epub 2012 Apr 18.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">30.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Bragado P, Estrada Y, Sosa MS, Avivar-Valderas A, Cannan D, Genden E, Teng M, Ranganathan AC, Wen HC, Kapoor A, Bernstein E,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties.&nbsp;<strong><em>PLoS One</em>.&nbsp;</strong>(2012); 7(1):e29974. PMCID: PMC3262798.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong><span style="text-transform: uppercase;">&nbsp;</span></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">31.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Tong CC, Lau KH, Rivera M, Cannan D,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Sikora AG, Gupta V, Forsythe K, Ko EC, Misiukiewicz K, Gurudutt V, Teng MS, Packer SH, Genden EM, Kao J.&nbsp;Prognostic significance of p16 in locoregionally advanced head and neck cancer treated with concurrent 5-fluorouracil, hydroxyurea, cetuximab and intensity-modulated radiation therapy.&nbsp;<strong><em>Oncol Rep.</em>&nbsp;</strong>(2012)&nbsp;May; 27(5):1580-6. doi: 10.3892/or.2012.1679.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><span lang="ES">&nbsp;</span></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">32.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span lang="ES">Guti&eacute;rrez-Uzquiza &Aacute;, Arechederra M, Bragado P,&nbsp;</span><strong>Aguirre-Ghiso JA</strong><span lang="ES">, Porras A.&nbsp;</span>p38a mediates cell survival in response to oxidative stress via induction of antioxidant genes. Effect on p70S6K pathway.&nbsp;<strong><em>J Biol Chem.&nbsp;</em></strong>(2012)Jan 20;287(4):2632-42. Epub 2011 Dec 2.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">33.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Fu S, Rivera M, Ko EC, Sikora AG, Chen CT, Vu HL, Cannan D, Eisenstein S, Rosenstein BS,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Chen SH, Kao J. Combined Inhibition of Epidermal Growth Factor Receptor and Cyclooxygenase-2 as a Novel Approach to Enhance Radiotherapy<strong><em>. J Cell SciTher&nbsp;</em></strong>(2011)&nbsp;S1:002. doi:10.4172/2157-7013.S1-002.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong><span style="text-transform: uppercase;">&nbsp;</span></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">34.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><span lang="ES-AR">Avivar-Valderas A, Salas E,&nbsp;</span>Bobrovnikova-Marjon E, Diehl JS<span lang="ES-AR">, Nagi C, Debnath J,&nbsp;</span><strong>Aguirre-Ghiso JA</strong>,<strong>&nbsp;</strong>PERK integrates autophagy and oxidative stress&nbsp;&nbsp;responses to promote survival during ECM detachment.&nbsp;<strong><em>Mol Cell Biol</em></strong>.&nbsp;(2011)&nbsp;Sep; 31(17):3616-29. PMC3165554&nbsp;<strong><em><span style="color: #ff6600;">(Cover article)&nbsp;</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong>&nbsp;</strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">35.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span lang="ES-AR">Wen HC, Avivar-Valderas A, Sosa MS, Girinius N, Farias EF, Davis R,&nbsp;</span><strong>Aguirre-Ghiso JA</strong>.<strong>&nbsp;</strong>p38 signaling regulates ATF2/c-Jun and BimEL to induce anoikis and lumen formation during mammary morphogenesis<em>.&nbsp;<strong>Science Signaling</strong></em><strong>&nbsp;</strong>(2011) 4 (174), ra34. [DOI: 10.1126/scisignal.2001684].<strong><em><u><span style="color: #ff6600;">http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/174/ra34</sp…;
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong><span style="text-transform: uppercase;">&nbsp;</span></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase; mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">36.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Ishii Y, Papa Y, Bahadur U, Yue Z,&nbsp;<strong>Aguirre-Ghiso&nbsp;</strong><strong>JA</strong>,&nbsp;Shioda T, Waxman S, Germain D. Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of theestrogen receptor, which leads to a pro-apoptotic unfolded protein response.&nbsp;<strong><em>Clin. Cancer Res.&nbsp;</em></strong>(2011)&nbsp;Feb 3.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">37.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Sequeira SJ, Wen HC, Avivar-Valderas A,&nbsp;<strong>Aguirre-Ghiso JA</strong>.<strong>&nbsp;</strong>Inhibition of eIF2a dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis.<strong><em>BMC Cell Biology.&nbsp;</em></strong>(2009)&nbsp;Sep 15;10:64.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">38.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Schewe DM.&nbsp;<strong>Aguirre-Ghiso JA</strong>.<strong>&nbsp;</strong>Inhibition of eIF2 dephosphorylation eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy.<strong><em>&nbsp;Cancer Res.&nbsp;</em></strong>(2009)<strong>&nbsp;</strong>Feb 15;69(4):1545-52.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">39.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><span lang="PT-BR">Adam AP, George A, Bragado P, Iglesias BV, Schewe D, Ranganathan A,&nbsp;</span>Kourtidis A, Conklin DS,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Computational identification of a p38^SAPK&nbsp;regulated transcription factor network required for tumor cell quiescence.&nbsp;<strong><em>Cancer Res</em></strong><em>.</em>&nbsp;(2009)&nbsp;Jul 15; 69(14):5664-72. Epub 2009 Jul 7.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><em>&nbsp;</em></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: center 3.5in; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">40.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Schewe DM,&nbsp;<strong>Aguirre-Ghiso JA</strong>. ATF6&alpha;-Rheb-mTOR signaling promotes survival of dormant tumor cells&nbsp;<em>in vivo</em>.&nbsp;<strong><em>Proc Natl Acad Sci USA&nbsp;</em></strong>(2008)<strong>&nbsp;</strong>Jul 29;105(30):10519-24<strong><em>.&nbsp;<span style="color: #ff6600;">Highlighted in &ldquo;This week in PNAS&rdquo; section of the journal.&nbsp;</span></em></strong><a style="color: #903638; text-decoration: underline;" href="http://www.pnas.org/content/105/30/10271.full?sid=79541a8a-11a2-41cc-ae… style="color: #ff6600;">&nbsp;Faculty of 1000 evaluation:&nbsp;</span></em></strong><a style="color: #903638; text-decoration: underline;" href="http://www.f1000biology.com/article/id/1119501/evaluation"><strong><em>…;
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong><em>&nbsp;</em></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: center 3.5in; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">41.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Ranganathan AC, Ohja S, Kourtidis A, Conklin D,&nbsp;<strong>Aguirre-Ghiso JA</strong>.&nbsp;Dual function of PERK in tumor cell growth arrest and survival.&nbsp;<strong><em>Cancer Res&nbsp;</em></strong>(2008); 68(9): 1&ndash;9.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong><em>&nbsp;</em></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">42.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Sequeira SJ, Ranganathan AC, Adam AP, Iglesias BV, Farias EF,&nbsp;<strong>Aguirre-Ghiso JA</strong><em>.</em>&nbsp;Inhibition of Proliferation by PERK Regulates Mammary Acinar Morphogenesis and Tumor Formation.&nbsp;<strong><em>PLoS ONE</em></strong>. (2007) Jul 18; 2:e615.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><em>&nbsp;</em></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: center 3.5in; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-bidi-font-weight: bold; mso-bidi-font-style: italic;"><span style="mso-list: Ignore;">43.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Baron TE, Lastro MT, Ranganathan AC, Tenenbaum SA, Conklin DS,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Ribonomic and Short Hairpin RNA Gene Silencing Methods to Explore Functional Gene Programs Associated with Tumor Growth Arrest.&nbsp;<strong><em>Methods Mol Biol</em></strong>. (2007);<strong><em>&nbsp;</em></strong>383:227-44.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">44.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Shinohara M, Mikhailov AV,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Rieder CL. ERK1/2 activation is required for timely progress through early G2 but it is not directly involved in the G2/M or M/A transitions in mammalian cells<strong>.&nbsp;<em>Molecular Biology of the Cell.</em></strong><em>&nbsp;</em>(2006)<strong>&nbsp;</strong>Dec 1^st.17: 5227-5240.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">45.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Chaurasia P,&nbsp;<strong>Aguirre-Ghiso JA</strong><u>,</u>&nbsp;Liang OD, Gardsvoll H, Ploug M, Ossowski LA. Region in uPAR domain III controlling a functional association with a5b1 integrin and tumor growth.&nbsp;<strong><em>J. Biol. Chem.&nbsp;</em></strong>(2006)&nbsp;May 26; 281(21): 14852-63.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong>&nbsp;</strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">46.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Ranganathan AC, Zhang L, Adam AP,&nbsp;<strong>Aguirre-Ghiso JA</strong>.&nbsp;<a name="OLE_LINK9"></a>Functional coupling of p38-induced upregulation of BiP and activation of RNA-dependent protein kinase&ndash;like ER kinase (PERK) to drug resistance of dormant carcinoma cells.&nbsp;<strong><em>Cancer Research&nbsp;</em></strong>(2006);&nbsp;66: (3) 1702-11.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">47.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Connor KM, Subbaram S, Regan KJ, Nelson KK, Mazurkiewicz JE, Bartholomew PJ, Aplin AE, Tai YT,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Flores&nbsp;&nbsp;SC, Melendez JA. Mitochondrial H2O2 Regulates the Angiogenic Phenotype Via PTEN Oxidation.&nbsp;&nbsp;<strong><em>J. Biol. Chem.</em>&nbsp;</strong>(2005)<strong>&nbsp;</strong>29; 280(17): 16916-24.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong>&nbsp;</strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; tab-stops: 56.0pt 84.0pt 112.0pt 140.0pt 168.0pt 196.0pt 224.0pt 3.5in 280.0pt 308.0pt 336.0pt; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">48.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong><strong>,&nbsp;</strong>Ossowski L, Rosenbaum SK. GFP tagging of ERK and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth.&nbsp;<strong><em>Cancer Res&nbsp;</em></strong>(2004);<strong>&nbsp;</strong>64(20): 7336-45.<strong><em><span style="color: #ff6600;">Faculty of 1000 evaluation at:&nbsp;</span></em></strong><a style="color: #903638; text-decoration: underline;" href="http://www.f1000biology.com/article/15492254/evaluation"><strong><em>ww…;
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">49.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Mazzoni E, Adam A, Bal de Kier Joffe E,&nbsp;<strong>Aguirre-Ghiso JA.</strong>&nbsp;Immortalized mammary epithelial cells overexpressing PKC acquire a malignant phenotype and become tumorigenic in vivo.&nbsp;<strong><em>Molecular Cancer Res</em></strong>. (2003)<strong>&nbsp;</strong>1:776-787</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;">&nbsp;</span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">50.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>,&nbsp;Estrada Y, Liu D, Ossowski L. ERK (MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38 (SAPK).&nbsp;<strong><em>Cancer Res.</em></strong>&nbsp;(2003); 63(7): 1684-95.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase;"><span style="mso-list: Ignore;">51.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Puricelli L, Proiettii CJ, Labriola L, Salatino M, Balana ME,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Lupu R, Pignataro OP, Charreau EH, Bal de Kier Joffe E, Elizalde PV. Heregulin inhibits proliferation via ERKs and phosphatidyl-inositol 3-kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells.&nbsp;<strong><em>Int. J. Cancer</em></strong>. (2002)&nbsp;100(6): 642-53.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l9 level1 lfo8; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="text-transform: uppercase;"><span style="mso-list: Ignore;">52.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Liu D,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Estrada Y, Ossowski L. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma.&nbsp;<strong><em>Cancer Cell&nbsp;</em></strong>(2002)<strong>;&nbsp;</strong>1: 445-457<strong><em><span style="color: #ff6600;">(Cover). Preview in the same issue:</span></em></strong>&nbsp;<a style="color: #903638; text-decoration: underline;" href="http://www.cell.com/cancer-cell/abstract/S1535-6108(02)00076-4"><strong… style="text-transform: uppercase;">&nbsp;</span><em><u><span style="color: #ff6600;">Faculty of 1000 Evaluation at:&nbsp;</span></u></em></strong><a style="color: #903638; text-decoration: underline;" href="http://www.f1000biology.com/article/12124174/evaluation"><strong><em>ww…;
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;">&nbsp;</span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">53.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA.</strong>&nbsp;Inhibition of FAK signaling activated by urokinase receptor induces human carcinoma dormancy in vivo.&nbsp;<strong>Oncogene&nbsp;</strong>(2002)&nbsp;21(16): 2513-24.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">54.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Ladeda V, Frankel P, Feig LA, Foster DA, Bal de Kier Joffe E,&nbsp;<strong>Aguirre-Ghiso JA</strong><strong>.&nbsp;</strong>RalA mediates v-Src, v-Ras, and v-Raf regulation of CD44 and fibronectin expression in NIH3T3 fibroblasts<em>.&nbsp;<strong>BiochemBiophys Res Commun.</strong></em><strong>&nbsp;</strong>(2001)<strong>&nbsp;</strong>283(4): 854-61.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;">&nbsp;</span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">55.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA,</strong>&nbsp;Liu D, Mignatti D, Kovalski K, Ossowski L. Urokinase receptor and fibronectin regulate the ERK^MAPK&nbsp;to p38^MAPK&nbsp;activity ratios that determine carcinoma cell proliferation or dormancy in vivo.&nbsp;<strong><em>Mol. Biol. Cell&nbsp;</em></strong>(2001). 12, 4, 863-879.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">56.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA,</strong>&nbsp;Kovalski K, Ossowski L. Tumor dormancy due to urokinase receptor down-regulation in human carcinoma involves integrin and MAPK signaling.&nbsp;<strong><em>J. Cell Biol.&nbsp;</em></strong>(1999)<strong>&nbsp;</strong>147, 89-103.&nbsp;<strong><em><span style="color: #ff6600;">Highlighted in the In Brief section of JCB.</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><em>&nbsp;</em></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">57.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Frankel P, Far&iacute;as E, Lu Z, Jiang H, Olsen A, Feig L, Bal de Kier Joff&eacute; E, Foster D. Ral-A requirement for v-Src- and v-Ras-induced tumorigenicity and overproduction of urokinase-type plasminogen activator. Involvement of metalloproteinases<em><span style="text-transform: uppercase;">.&nbsp;</span><strong>Oncogene&nbsp;</strong></em>(1999<em>)</em><strong><em>,&nbsp;</em></strong>18, 4718-4725.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">58.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Urtreger AJ,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Werbahj S, Puricelli L, Muro A, Bal de Kier Joff&eacute; E. Involvement of fibronectin in the regulation of urokinase production and binding in murine mammary tumor cells<em>.<strong>Int. J. Cancer,&nbsp;</strong></em>(1999),<strong>&nbsp;</strong>vol. 82, 748-753.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">59.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Ladeda V,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Bal de Kier Joff&eacute; E. Function and Expression of CD44 During Spreading and Migration of Murine Carcinoma cells<em><span style="text-transform: uppercase;">.&nbsp;</span><strong>Exp. Cell Res</strong>.&nbsp;</em>(1998);<strong>&nbsp;</strong>242:515-527.</p>
<p class="ColorfulList-Accent11" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><strong><span style="font-size: 12pt;">&nbsp;</span></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">60.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Far&iacute;as EF, Alonso DF, Bal de Kier Joff&eacute; E. Secretion of urokinase and metalloproteinase-9 induced by staurosporine is dependent on a tyrosine-kinase pathway in mammary tumor cells.&nbsp;<strong><em>Int. J.&nbsp;&nbsp;Cancer&nbsp;</em></strong>(1998)<strong>&nbsp;</strong>76: 362-367.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">61.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Far&iacute;as EF,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Ladeda V, Bal de Kier Joff&eacute; E. Verapamil Inhibits Proteases Production, Local Invasion and Metastasis Development of Murine Carcinoma Cells<em><span style="text-transform: uppercase;">.&nbsp;</span><strong>Int. J. Cancer</strong></em><strong>.&nbsp;</strong>(1998)<strong>&nbsp;</strong>78 (6): 727-734.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;">&nbsp;</span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">62.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Far&iacute;as EF, Alonso DF, Arregui C, Bal de Kier Joff&eacute; E E.<em>&nbsp;A&nbsp;</em>Phospholipase D and Protein Kinase C Inhibitor Blocks the Spreading of Murine Mammary Adenocarcinoma Cells Altering F-Actin and Integrin Point Contact Distribution<em>.&nbsp;<strong>Int. J. Cancer</strong>.&nbsp;</em>(1997) 71: 881-890.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;">&nbsp;</span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">63.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Alonso DF, Far&iacute;as E, Bal de Kier Joff&eacute; E. Overproduction of urokinase-type plasminogen activator is regulated by phospholipase D and protein kinase C pathways in murine mammary adenocarcinoma cells<em>.&nbsp;<strong>Biochem. Biophys. Acta&nbsp;</strong></em>(1997)&nbsp;1356: 171-184.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;">&nbsp;</span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">64.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Diament M, D'elia I, Bal de Kier Joff&eacute; E, Klein S. Effect of in vivo culture of murine mammary adenocarcinoma cells on tumor and metastatic growth.&nbsp;<strong><em>Tumor Biol.</em>&nbsp;</strong>(1997); 18: 41-52.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;"><u><span style="text-decoration: none;">&nbsp;</span></u></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">65.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>, Far&iacute;as E, Fernandez DM, Alonso DF, Bal de Kier Joff&eacute; E. Down modulation of tumor cells-associated proteolytic activity by n-butanol treatment in cultured murine mammary adenocarcinoma cells<em>.&nbsp;<strong>Int. J Oncol</strong>.&nbsp;</em>(1996);<strong>&nbsp;</strong>8: 35-39.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l9 level1 lfo8; tab-stops: 22.5pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">66.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Klein S, Jasnis MA, Diament M, Davel L,&nbsp;<strong>Aguirre Ghiso JA</strong>, de Bonaparte YP. Immunomodulation by soluble factors from tumor cells cultured in vivo in diffusion chambers<em>.&nbsp;<strong>Tumor Biol</strong>.&nbsp;</em>(1994);15: 160-165.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 14pt; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal; color: #66a6b8;">&nbsp;</span></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 16pt; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal; color: #66a6b8;">Reviews, Commentaries, Perspectives and other Peer Reviewed Publications&nbsp;</span></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraphCxSpFirst" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">1.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><strong><span style="font-size: 12pt;">Aguirre-Ghiso JA</span></strong><span style="font-size: 12pt;">. Translating the Science of Cancer Dormancy to the Clinic.&nbsp;<strong><em>Cancer Res</em></strong>&nbsp;(2021)August 24.</span>&nbsp;<span style="font-size: 12pt;">DOI: 10.1158/0008-5472.CAN-21-1407</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">2.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Atkins MB, Curiel-Lewandrowski C, Fisher DE, Swetter SM, Tsao H,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Soengas MS, Weeraratna AT, Flaherty KT, Herlyn M, Sosman JA, Tawbi HA, Pavlick AC, Cassidy PB, Chandra S, Chapman PB, Daud A, Eroglu Z, Ferris LK, Fox BA, Gerhsenwald JE, Gibney GT, Grossman D, Hanks BA, Hanniford D, Hernando E, Jeter JM, Johnson DB, Khleif SN, Kirkwood JM, Leachman SA, Mays D, Nelson KC, Sondak VK, Sullivan RJ, Merlino G. The State of Melanoma: Emergent Challenges and Opportunities.&nbsp;<strong><em>Clin Cancer Res</em></strong>. (2021) Jan 7:clincanres.4092.2020. doi: 10.1158/1078-0432.CCR-20-4092.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt; background-color: white;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">3.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt; background-color: white;">Risson E, Nobre AR, Maguer-Satta V,<strong>&nbsp;Aguirre-Ghiso JA</strong><em>.&nbsp;</em>The current paradigm and challenges ahead for the dormancy of disseminated tumor cells.&nbsp;<strong><em>Nat Cancer</em></strong>&nbsp;(2020).&nbsp;</span><a style="color: #903638; text-decoration: underline;" href="https://doi.org/10.1038/s43018-020-0088-5"><span style="font-size: 12pt; color: windowtext; background-color: white; text-decoration: none;">https://doi.org/10.1038/s43018-020-0088-5</span></a><span style="font-size: 12pt; background-color: white;">.&nbsp;<strong><em><span style="color: #ff6600;">In the top 5% of all research outputs scored by Altmetric</span></em></strong></span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">4.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Vabret N, Britton GJ, Gruber C, Hegde S, Kim J, Kuksin M, Levantovsky R, Malle L, Moreira A, Park MD, Pia L, Risson E, Saffern M, Salom&eacute; B, Esai Selvan M, Spindler MP, Tan J, van der Heide V, Gregory JK, Alexandropoulos K, Bhardwaj N, Brown BD, Greenbaum B, G&uuml;m&uuml;ş ZH, Homann D, Horowitz A, Kamphorst AO, Curotto de Lafaille MA, Mehandru S, Merad M, Samstein RM; Sinai Immunology Review Project. Immunology of COVID-19: Current State of the Science.&nbsp;<strong><em>Immunity</em></strong>. (2020) Jun 16;52(6):910-941. doi: 10.1016/j.immuni.2020.05.002. Epub 2020 May 6.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 0.5in; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt; color: black; background-color: white;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">5.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt; color: black; background-color: white;">Zijlstra A, Von Lersner A, Yu D, Borrello L, Oudin M, Kang Y, Sahai E, Fingleton B, Stein U, Cox TR, Price JT, Kato Y, Welm AL,<span class="apple-converted-space">&nbsp;</span></span><strong><span style="font-size: 12pt; color: black;">Aguirre-Ghiso<span class="apple-converted-space"><span style="background-color: white;">&nbsp;</span></span><span style="background-color: white;">JA</span></span></strong><span style="font-size: 12pt; color: black; background-color: white;">; Board Members of the Metastasis Research Society.</span><span style="font-size: 12pt; color: black;">&nbsp;The importance of developing therapies targeting the biological spectrum of metastatic disease.&nbsp;<strong><em>Clin. Exp. Metastasis</em></strong>.</span><span class="apple-converted-space"><span style="font-size: 12pt; color: black; background-color: white;">&nbsp;</span></span><span style="font-size: 12pt; color: black; background-color: white;">(2019) Aug;36(4):305-309. doi: 10.1007/s10585-019-09972-3. Epub 2019 May 17.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">6.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><strong><span style="font-size: 12pt;">Aguirre-Ghiso</span></strong><span style="font-size: 12pt;">&nbsp;<strong>JA</strong>.&nbsp;How dormant cancer persists and reawakens.&nbsp;<strong><em>Science</em></strong>. (2018) Sep 28;361(6409):1314-1315. doi: 10.1126/science.aav0191.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-size: 12pt;">&nbsp;</span></strong></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">7.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><strong><span style="font-size: 12pt;">Aguirre-Ghiso JA</span></strong><span style="font-size: 12pt;">, MS Sosa. Emerging topics on disseminated cancer cell dormancy and the paradigm of metastasis.&nbsp;<strong>Annual Review of Cancer Biology&nbsp;</strong>(2018), 2, 377-393</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">8.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Nobre AR, Entenberg D, Wang Y, Condeelis J,&nbsp;<strong>Aguirre-Ghiso&nbsp;JA.</strong>&nbsp;The Different Routes to Metastasis via Hypoxia-Regulated Programs.&nbsp;<strong><em>Trends Cell Biol</em></strong>. (2018<strong>)</strong>&nbsp;Jul 21. pii: S0962-8924(18)30109-0. doi: 10.1016/j.tcb.2018.06.008. [Epub ahead of print] Review. PMID: 30041830</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">9.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Fingleton B, Lange K, Caldwell B, Bankaitis KV; Board of the Metastasis Research<strong>&nbsp;</strong>Society.&nbsp;Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example.&nbsp;<span class="jrnl"><strong><em>ClinExp Metastasis</em></strong></span>. (2017) Dec;34(8):443-447. doi: 10.1007/s10585-017-9872-8. Epub 2018 Feb 26 PMID: 29484519</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l17 level1 lfo7; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">10.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Linde N, Fluegen G,&nbsp;<strong>Aguirre-Ghiso&nbsp;JA.</strong>&nbsp;The Relationship Between Dormant Cancer Cells and Their Microenvironment.&nbsp;<strong><em>Adv Cancer Res.&nbsp;</em></strong>(2016); 132:45-71. doi: 10.1016/bs.acr.2016.07.002. Epub 2016 Aug 25. PMID:27613129.</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-pagination: none; mso-list: l17 level1 lfo7; mso-layout-grid-align: none; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">11.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV,&nbsp;<strong>Aguirre-Ghiso</strong>&nbsp;<strong>JA</strong>, et al.&nbsp;Guidelines for the use and interpretation of assays for monitoring autophagy.&nbsp;<strong><em>Autophagy</em></strong>&nbsp;(2016) Jan 2;12(1):1-222. No abstract available. PMID: 26799652</span></p>
<p class="MsoListParagraphCxSpLast" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l17 level1 lfo7; text-autospace: none;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">12.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Goossens N, Hoshida Y,&nbsp;<strong>Aguirre-Ghiso JA</strong>.&nbsp;Origin and interpretation of cancer transcriptome profiling: the essential role of the stroma in determining prognosis and drug resistance.&nbsp;<strong><em>EMBO Mol Med&nbsp;</em></strong>(2015) Aug 3. pii: e201505284. doi: 10.15252/emmm.201505284. [Epub ahead of print]</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="margin-left: 22.5pt; text-indent: -.25in; mso-list: l17 level1 lfo7; text-autospace: none;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">13.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Sosa MS, Bragado P,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Mechanisms of disseminated cancer cell</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">dormancy: an awakening field.&nbsp;<strong><em>Nat Rev Cancer</em></strong>&nbsp;(2014) Sep;14(9):611-22. doi:</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">10.1038/nrc3793. Epub 2014 Aug 14. Review. PubMed PMID: 25118602; PubMed Central&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">PMCID: PMC4230700.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><em><span style="color: #ff6600;">-Cover article for the September 14^th&nbsp;issue of Nat Rev Cancer</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><em><span style="color: #ff6600;">-Ranks 6 for articles of similar age in Nat Rev Cancer and is in the top 5% of all articles ever tracked by Altmetric.&nbsp;</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 0.5in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoListParagraphCxSpFirst" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">14.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Linde N, Sosa MS,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Integration of microenvironmental and stress signaling antagonizes colorectal cancer progression.&nbsp;<strong><em>EMBO J</em></strong>. (2014) Aug 18;33(16):1737-9. doi: 10.15252/embj.201489364. Epub 2014 Jul 14. PubMed PMID: 25024435; PubMed Central PMCID: PMC4195757.&nbsp;</span></p>
<p class="MsoListParagraphCxSpMiddle" style="margin: 0in 0in 0.0001pt 22.5pt; font-size: 10pt; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><span style="font-size: 12pt;">&nbsp;</span></p>
<p class="MsoListParagraphCxSpLast" style="margin-left: 22.5pt; mso-add-space: auto; text-indent: -.25in; mso-list: l17 level1 lfo7; text-autospace: none;"><!-- [if !supportLists]--><span style="font-size: 12.0pt;"><span style="mso-list: Ignore;">15.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><span style="font-size: 12pt;">Avivar-Valderas A, Wen HC,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Stress signaling and the shaping&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">of the mammary tissue in development and cancer.&nbsp;<strong><em>Oncogene</em></strong>&nbsp;(2014) Nov</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">27;33(48):5483-90. doi: 10.1038/onc.2013.554. Epub 2014 Jan 13. Review. PubMed</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">PMID: 24413078; PubMed Central PMCID: PMC4096615.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">16.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso, JA,&nbsp;</strong>Bragado P, Sosa MS.&nbsp;Metastasis awakening: targeting dormant cancer.&nbsp;<strong><em>Nat Med.</em></strong>&nbsp;(2013) Mar;19(3):276-7. doi: 10.1038/nm.3120. PMID: 23467238 [PubMed - indexed for MEDLINE] PMCID: PMC3651698&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">17.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Sosa MS, Bragado P, Debnath J,&nbsp;<strong>Aguirre-Ghiso</strong><strong>&nbsp;JA.</strong>&nbsp;Regulation of tumor cell dormancy by tissue microenvironments and autophagy.&nbsp;<strong><em>AdvExp Med Biol</em>.&nbsp;</strong>(2013);734:73-89. doi: 10.1007/978-1-4614-1445-2_5.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">18.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P,&nbsp;<strong>Aguirre-Ghiso</strong><strong>&nbsp;JA</strong>, et al.,&nbsp;Guidelines for the use and interpretation of assays for monitoring autophagy.&nbsp;<strong><em>Autophagy</em></strong>&nbsp;(2012) Apr;8(4):445-544.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">19.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Bragado P, Sosa MS, Keely P, Condeelis J,&nbsp;<strong>Aguirre-Ghiso JA.</strong>&nbsp;Microenvironments dictating tumor cell dormancy.&nbsp;<strong><em>Recent Results Cancer Res.&nbsp;</em></strong>(2012); 195:25-39.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">20.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Cagan RL,&nbsp;<strong>Aguirre-Ghiso JA</strong>. A local view of cancer.&nbsp;<strong><em>Dev Cell</em>.&nbsp;</strong>(2012)&nbsp;Mar 13;22(3):472-4.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">21.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Genden EM,&nbsp;<strong>Aguirre-Ghiso JA</strong>.&nbsp;Oropharyngeal cancer biology and treatment: insights from messenger RNA sequence analysis and transoral robotic surgery.&nbsp;<strong><em>Mayo Clin Proc</em></strong>.&nbsp;<strong>(</strong>2012)&nbsp;Mar;87(3):211-2.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">22.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Sosa MS, Avivar-Valderas A, Bragado P, Wen HC,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Molecular Pathways: ERK1/2 and p38&alpha;/&beta; signaling in tumor cell quiescence: opportunities to control dormant residual disease. Invited Article.&nbsp;<strong><em>Clin. Cancer Res</em></strong><em>.&nbsp;</em>(2011)&nbsp;Sep 15;17(18):5850-7.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">23.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Prince A,<strong>&nbsp;Aguirre-Ghiso JA,&nbsp;</strong>Genden E, Posner M, Sikora A. Head and neck squamous cell carcinoma: new translational therapies<strong><em>. Mt. Sinai J. Med.&nbsp;</em></strong>(2010). 77 (6): 684-99.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">24.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>. On the theory of tumor self-seeding: implications for metastasis progression in humans.&nbsp;<strong><em>Breast Cancer Res</em></strong>.&nbsp;(2010)&nbsp;Apr 28;12(2):304. Viewpoint&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 2pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l17 level1 lfo7; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt 2.0pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">25.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Ossowski L,&nbsp;<strong>Aguirre-Ghiso JA.</strong>&nbsp;Dormancy of metastatic melanoma.&nbsp;<strong><em>Pigment Cell Melanoma Res</em></strong>.&nbsp;(2010)Feb;23(1):41-56. Epub 2009 Oct 19.&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 27pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">26.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Allgayer H,&nbsp;<strong>Aguirre-Ghiso JA.</strong>&nbsp;The urokinase receptor (u-PAR) - a link between tumor cell dormancy and minimal residual disease in bone marrow?&nbsp;<strong><em>APMIS&nbsp;</em></strong>(2008);116 (7-8) 602-614.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><u><span style="text-decoration: none;">&nbsp;</span></u></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="color: #ff6600;"><span style="mso-list: Ignore;">27.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>. Models, mechanisms and clinical evidence for cancer dormancy.&nbsp;<strong><em>Nature Reviews Cancer</em></strong>.&nbsp;(2007). Nov; 7(11): 834-46. Invited peer reviewed article&nbsp;<strong><em><span style="color: #ff6600;">(Cover and featured article).&nbsp;&nbsp;</span></em></strong><a style="color: #903638; text-decoration: underline;" href="http://www.nature.com/nrc/journal/v7/n11/index.html"><strong><em>http:/…;
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 41.05pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -35.65pt;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">28.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong>. The problem of cancer dormancy: understanding the basic mechanisms and identifying therapeutic opportunities.&nbsp;<strong><em>Cell Cycle.&nbsp;</em></strong>(2006)&nbsp;Aug; 5(16): 1740-3. (Guest Editor). Introductory Review. Invited peer reviewed article. Cover.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="color: #ff6600;"><span style="mso-list: Ignore;">29.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span></span><!--[endif]-->Ranganathan AC, Adam AP and&nbsp;<strong>Aguirre-Ghiso JA</strong>. Opposing roles of mitogenic and stress signaling pathways in the induction of cancer dormancy.&nbsp;<strong><em>Cell Cycle</em></strong>. (2006)&nbsp;Aug; 5(16): 1799-807.&nbsp;<strong><em><span style="color: #ff6600;">Cover.</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">30.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Ranganathan AC, Adam AP, Zhang L, and&nbsp;<strong>Aguirre-Ghiso JA</strong>. Tumor cell dormancy induced by p38SAPK and ER-stress signaling; an adaptive advantage for metastatic cells?&nbsp;<strong><em>Cancer Biology &amp; Therapy&nbsp;</em></strong>(2006)&nbsp;Jul; 5(7): 729-35.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 0in; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-pagination: none; mso-list: l17 level1 lfo7; tab-stops: 45.0pt; mso-layout-grid-align: none; text-autospace: none; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">31.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Tenenbaum SA,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Dephosphorylation Shows SR Proteins the Way Out.<strong><em>&nbsp;Molecular Cell&nbsp;</em></strong>(2005);&nbsp;20 (4); 499-501.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;"><strong>&nbsp;</strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; tab-stops: 22.5pt 45.0pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">32.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Ossowski L,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth<em>.&nbsp;<strong>Current Opinion in Cell Biology</strong>&nbsp;</em>(2000)<strong>&nbsp;</strong>12(5): 613-20.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;"><strong><em>&nbsp;</em></strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; tab-stops: 22.5pt 45.0pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">33.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Bal de Kier Joffe E, Mazzoni EO,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Signaling pathways regulating the expression of proteases during tumor progression<strong><em>.&nbsp;</em></strong>(In Spanish)<strong>&nbsp;<em>Medicina (B Aires)&nbsp;</em></strong>(2000)<strong>;</strong>&nbsp;60:34-40.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;"><strong>&nbsp;</strong></p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; tab-stops: 22.5pt 45.0pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">34.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]-->Ossowski L,&nbsp;<strong>Aguirre-Ghiso JA</strong>, Liu D, Yu W, Kovalski K. The role of plasminogen activator receptor in cancer invasion and dormancy.&nbsp;<strong><em>Medicina (Buenos Aires)&nbsp;</em></strong>(1999)&nbsp;59, 547-552.</p>
<p class="MsoNormal" style="margin: 0in 9pt 0.0001pt 45pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.5in;">&nbsp;</p>
<p class="MsoNormal" style="text-indent: -.25in; mso-list: l17 level1 lfo7; tab-stops: 22.5pt 45.0pt; margin: 0in 9.0pt .0001pt 22.5pt;"><!-- [if !supportLists]--><span style="mso-list: Ignore;">35.<span style="font: 7.0pt 'Times New Roman';">&nbsp;&nbsp;</span></span><!--[endif]--><strong>Aguirre-Ghiso JA</strong><u>,</u>&nbsp;Alonso DF, Far&iacute;as EF, Gomez D, Bal de Kier Joff&eacute; E. Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype<em>.&nbsp;<strong>Eur. J. Biochem.</strong></em>(1999)<strong>&nbsp;</strong>263, 2, 295-304<strong><em><span style="color: #ff6600;">&nbsp;(Cover).</span></em></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal;">&nbsp;</span></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><strong><span style="font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-caps: small-caps; font-variant-alternates: normal; font-variant-position: normal; font-variant-east-asian: normal;">Books and Book Chapters</span></strong></p>
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<li class="MsoNormal" style="margin-right: 9.0pt; mso-list: l16 level1 lfo2; tab-stops: list .5in;">Sosa MS, Bragado P, Debnath J,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Regulation of Tumor Cell Dormancy by Tissue Microenvironments and Autophagy.&nbsp;<strong><em>Systems Biology of Tumor Dormancy</em></strong>. Editors, Enderling H, Almog N and Hlatky L.&nbsp;(2012)<strong>&nbsp;</strong><em>Springer Science + Business Media, INC.</em><a style="color: #903638; text-decoration: underline;" href="http://www.springerlink.com/content/u44l178561014r11/">http://www.sprin…;
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<li class="MsoNormal" style="margin-right: 9.0pt; mso-list: l16 level1 lfo2; tab-stops: list .5in;"><span lang="ES-TRAD">Bragado P, Sosa MS, Keely P, Condeelis</span>&nbsp;J,&nbsp;<strong>Aguirre-Ghiso JA</strong>. Microenvironments dictating tumor cell dormancy. Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer.<em>&nbsp;</em>(Eds: K. Pantel, C. Sotiriou, M. Ignatiadis).&nbsp;<strong><em>Recent Results Cancer Res</em>.</strong>&nbsp;(2012); 195:25-39. doi: 10.1007/978-3-642-28160-0_3<strong>.&nbsp;</strong></li>
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<ol style="margin-bottom: 0in; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; margin-top: 0in;" start="3" type="1">
<li class="MsoNormal" style="margin-right: 9.0pt; mso-pagination: none; mso-list: l16 level1 lfo2; tab-stops: list .5in; mso-layout-grid-align: none; text-autospace: none;"><strong>Aguirre-Ghiso JA,</strong>&nbsp;Alonso DF, Farias EF. Function and expression of the uPA/uPAR system in cancer metastasis.&nbsp;&nbsp;Cancer Metastasis: Biologic Basis and Therapeutics.<strong>&nbsp;<em>Cambridge University Press</em></strong>, Editors: Danny Welch, Danny R. Welch, Ph.D., David C. Lyden, MD, PhD, and Beth Psaila, MD. (2009).<a style="color: #903638; text-decoration: underline;" href="http://www.springer.com/biomed/cancer/book/978-1-4419-6614-8">http://ww…;
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<li class="MsoNormal" style="margin-right: 9.0pt; mso-list: l16 level1 lfo2; tab-stops: list .5in;"><span lang="PT-BR">Bragado P, Ranganathan AC,&nbsp;</span><strong>Aguirre-Ghiso JA.</strong>&nbsp;Dormancy of Disseminated Tumor Cells: Reciprocal crosstalk with the microenvironment.&nbsp;The Tumor Microenvironment-Cancer Drug Discovery and Development.&nbsp;<strong><em>Springer Science + Business Media LLC</em></strong>, Humana Press. Dr. Rebecca Bagley, Editor. (<span lang="PT-BR">2010), Part 2, pp229-254.</span><strong><span lang="PT-BR">&nbsp;</span></strong><a href="http://www.cambridge.org/gb/knowledge/isbn/item5738926/?site_locale=en_…;
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